Publications by authors named "Angel Porgador"

98Publications

N-Glycans Mediate the Ebola Virus-GP1 Shielding of Ligands to Immune Receptors and Immune Evasion.

Front Cell Infect Microbiol 2020 6;10:48. Epub 2020 Mar 6.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel.

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March 2020

Detection, prediction, and prognosis: blood circulating microRNA as novel molecular markers of head and neck cancer patients.

Expert Rev Mol Diagn 2020 01 3;20(1):31-39. Epub 2019 Dec 3.

Department of Human Physiology, Medical University of Lublin, Lublin, Poland.

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January 2020

Datasets of RT spoofing attacks on MIL-STD-1553 communication traffic.

Data Brief 2019 Apr 20;23:103863. Epub 2019 Mar 20.

Department of Software and Information System Engineering, Ben-Gurion University of the Negev, Be'er Sheva 84105, P.O. Box 653, Israel.

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April 2019

Multiple viral proteins and immune response pathways act to generate robust long-term immunity in Sudan virus survivors.

EBioMedicine 2019 Aug 17;46:215-226. Epub 2019 Jul 17.

Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; Department of Arbovirology, Emerging and Re-Emerging Infection Uganda Virus Research Institute, Plot No: 51 -59, Nakiwogo Road, P.O.Box 49, Entebbe, Uganda.

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August 2019

Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA.

Cancer Immunol Res 2019 07 4;7(7):1120-1134. Epub 2019 Jun 4.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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July 2019

Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy.

Front Oncol 2019 22;9:17. Epub 2019 Jan 22.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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January 2019

Human anti-NKp46 antibody for studies of NKp46-dependent NK cell function and its applications for type 1 diabetes and cancer research.

Eur J Immunol 2019 02 17;49(2):228-241. Epub 2018 Dec 17.

The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, The BioMedical Research Institute Israel Canada of the Faculty of Medicine (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel.

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February 2019

Nanoscale Mechanosensing of Natural Killer Cells is Revealed by Antigen-Functionalized Nanowires.

Adv Mater 2019 Jan 28;31(4):e1805954. Epub 2018 Nov 28.

Department of Materials Engineering, Ben-Gurion University of the Negev, Beer Sheva, 84105, Israel.

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January 2019

The Ebola-Glycoprotein Modulates the Function of Natural Killer Cells.

Front Immunol 2018 2;9:1428. Epub 2018 Jul 2.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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July 2018

NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death.

Front Immunol 2018 23;9:1114. Epub 2018 May 23.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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July 2019

Splice variants of human natural cytotoxicity receptors: novel innate immune checkpoints.

Cancer Immunol Immunother 2018 Dec 20;67(12):1871-1883. Epub 2017 Dec 20.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Goldman Building, Room 143, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, 84105, Israel.

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December 2018

Targeting Multiple Tumors Using T-Cells Engineered to Express a Natural Cytotoxicity Receptor 2-Based Chimeric Receptor.

Front Immunol 2017 29;8:1212. Epub 2017 Sep 29.

The Laboratory of Tumor Immunology and Immunotherapy, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.

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September 2017

Nitric Oxide Sensing through Azo-Dye Formation on Carbon Dots.

ACS Sens 2017 Aug 16;2(8):1215-1224. Epub 2017 Aug 16.

Department of Chemistry, ‡The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, and §Ilse Katz Institute for Nanotechnology, Ben Gurion University of the Negev , Beer Sheva 84105, Israel.

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August 2017

Sudan ebolavirus long recovered survivors produce GP-specific Abs that are of the IgG1 subclass and preferentially bind FcγRI.

Sci Rep 2017 07 20;7(1):6054. Epub 2017 Jul 20.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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July 2017

Regulation of the Functions of Natural Cytotoxicity Receptors by Interactions with Diverse Ligands and Alterations in Splice Variant Expression.

Front Immunol 2017 30;8:369. Epub 2017 Mar 30.

Blood Cell Development and Function Program, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA.

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March 2017

Adipose tissue supports normalization of macrophage and liver lipid handling in obesity reversal.

J Endocrinol 2017 06 30;233(3):293-305. Epub 2017 Mar 30.

The Department of Clinical Biochemistry and PharmacologyFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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June 2017

Expression of NKp46 Splice Variants in Nasal Lavage Following Respiratory Viral Infection: Domain 1-Negative Isoforms Predominate and Manifest Higher Activity.

Front Immunol 2017 15;8:161. Epub 2017 Feb 15.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel; National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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February 2017

Detection of Reactive Oxygen Species by a Carbon-Dot-Ascorbic Acid Hydrogel.

Anal Chem 2017 01 19;89(1):830-836. Epub 2016 Dec 19.

Department of Chemistry, Ben-Gurion University of the Negev , Beer Sheva 84105, Israel.

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January 2017

NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint.

Oncotarget 2016 Oct;7(43):70912-70923

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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October 2016

Survival in acute myeloid leukemia is associated with NKp44 splice variants.

Oncotarget 2016 May;7(22):32933-45

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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May 2016

NKp46 Clusters at the Immune Synapse and Regulates NK Cell Polarization.

Front Immunol 2015 25;6:495. Epub 2015 Sep 25.

Department of Surgery, Division of Abdominal Transplantation, Stanford University , Stanford, CA , USA.

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October 2015

Extracting tumor tissue immune status from expression profiles: correlating renal cancer prognosis with tumor-associated immunome.

Oncotarget 2015 Oct;6(32):33191-205

The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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October 2015

First Trimester Pregnancy Loss and the Expression of Alternatively Spliced NKp30 Isoforms in Maternal Blood and Placental Tissue.

Front Immunol 2015 1;6:189. Epub 2015 Jun 1.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev , Beer Sheva , Israel ; Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer Sheva , Israel.

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June 2015

Central nervous system acute lymphoblastic leukemia: role of natural killer cells.

Blood 2015 May 20;125(22):3420-31. Epub 2015 Apr 20.

Childhood Leukemia Research Section, Department of Pediatric Oncology and the Cancer Research Center, Edmond and Lily Safra Children Hospital and Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel;

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May 2015

Development of stage-dependent glycans on the Fc domains of IgG antibodies of ALS animals.

Exp Neurol 2015 May 26;267:95-106. Epub 2015 Feb 26.

Avram and Stella Goren-Goldstein Department of Biotechnology Engineering, Faculty of Engineering, University of the Negev, Beer-Sheva 84105, Israel; Regenerative Medicine and Stem Cell (RMSC) Research Center Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. Electronic address:

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May 2015

Targeting natural killer cell reactivity by employing antibody to NKp46: implications for type 1 diabetes.

PLoS One 2015 26;10(2):e0118936. Epub 2015 Feb 26.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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January 2016

Colorimetric polymer assay for the diagnosis of plasma lipids atherogenic quality in hypercholesterolemic patients.

Mol Diagn Ther 2015 Feb;19(1):35-43

Faculty of Natural Sciences, The Ilse Katz Institute, Ben Gurion University of the Negev, 84105, Beer Sheva, Israel.

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February 2015

Regulation of natural cytotoxicity receptors by heparan sulfate proteoglycans in -cis: A lesson from NKp44.

Eur J Immunol 2015 Apr 21;45(4):1180-91. Epub 2015 Jan 21.

The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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April 2015

Classification of current anticancer immunotherapies.

Oncotarget 2014 Dec;5(24):12472-508

Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. INSERM, U1138, Paris, France. Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France. Pôle de Biologie, Hôpital Européen Georges Pompidou (HEGP), AP-HP, Paris, France.

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December 2014

An NCR1-based chimeric receptor endows T-cells with multiple anti-tumor specificities.

Oncotarget 2014 Nov;5(21):10949-58

Laboratory of Tumor Immunology and Immunotherapy, The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900, Israel.

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November 2014

Carbohydrate-mediated modulation of NK cell receptor function: structural and functional influences of heparan sulfate moieties expressed on NK cell surface.

Front Oncol 2014 16;4:185. Epub 2014 Jul 16.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev , Beer-Sheva , Israel ; National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev , Beer-Sheva , Israel.

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July 2014

Dual fluorescent labelling of the human malaria parasite Plasmodium falciparum for the analysis of the ABC type transporter pfmdr2.

Malar J 2012 Nov 8;11:371. Epub 2012 Nov 8.

The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, P,O, Box 653, Beer-Sheva, 84105, Israel.

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November 2012

A novel "reactomics" approach for cancer diagnostics.

Sensors (Basel) 2012 2;12(5):5572-85. Epub 2012 May 2.

Ilse Katz Institute for Nanoscale Science and Technology, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

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November 2012

A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen.

Oncoimmunology 2012 Jul;1(4):572-574

The Shraga Segal Department of Microbiology and Immunology; Faculty of Health Sciences; Ben-Gurion University of the Negev; Beer Sheva, Israel.

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July 2012

Glycans in sera of amyotrophic lateral sclerosis patients and their role in killing neuronal cells.

PLoS One 2012 30;7(5):e35772. Epub 2012 May 30.

Avram and Stella Goren-Goldstein Department of Biotechnology Engineering, Faculty of Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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October 2012

Dimerization of NKp46 receptor is essential for NKp46-mediated lysis: characterization of the dimerization site by epitope mapping.

J Immunol 2012 Jun 21;188(12):6165-74. Epub 2012 May 21.

The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.

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June 2012

Human NK cell recognition of target cells in the prism of natural cytotoxicity receptors and their ligands.

J Immunotoxicol 2012 Jul-Sep;9(3):267-74. Epub 2012 Apr 23.

The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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December 2012

Upregulation of MHC class I expression following dengue virus infection: the mechanism at the promoter level.

Expert Rev Anti Infect Ther 2012 Mar;10(3):285-7

The Shraga Segal Department of Microbiology and Immunology and the National Institute for Biotechnology in the Negev, Ben Gurion University of the Negev, Beer Sheva, Israel.

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March 2012

Recognition and killing of human and murine pancreatic beta cells by the NK receptor NKp46.

J Immunol 2011 Sep 17;187(6):3096-103. Epub 2011 Aug 17.

The Lautenberg Center for General and Tumor Immunology, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

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September 2011

Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2.

Cancer Res 2011 Sep 15;71(18):5998-6009. Epub 2011 Jul 15.

Innate Immunity Group, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.

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September 2011

Serum apolipoproteins C-I and C-III are reduced in stomach cancer patients: results from MALDI-based peptidome and immuno-based clinical assays.

PLoS One 2011 Jan 18;6(1):e14540. Epub 2011 Jan 18.

The Shraga Segal Department of Microbiology and Immunology and the National Institute for Biotechnology in the Negev, Ben Gurion University of the Negev, Beer Sheva, Israel.

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January 2011

Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting.

J Immunol 2010 Nov 18;185(10):5869-78. Epub 2010 Oct 18.

Department of Biotechnology Engineering, Faculty of Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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November 2010

NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus.

J Virol 2010 Apr 10;84(8):3789-97. Epub 2010 Feb 10.

Department of Microbiology and Immunology and the National Institute for Biotechnology in the Negev, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

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April 2010

Killing of avian and Swine influenza virus by natural killer cells.

J Virol 2010 Apr 3;84(8):3993-4001. Epub 2010 Feb 3.

Lautenberg Center for General and Tumor Immunology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel.

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April 2010

Generating NK cell receptor-Fc chimera proteins from 293T cells and considerations of appropriate glycosylation.

Methods Mol Biol 2010 ;612:275-83

Department of Microbiology and Immunology, Ben Gurion University, Beer Sheva, Israel.

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February 2010

The activating receptor NKp46 is essential for the development of type 1 diabetes.

Nat Immunol 2010 Feb 20;11(2):121-8. Epub 2009 Dec 20.

The Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Institute for Medical Research Israel-Canada, Jerusalem, Israel.

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February 2010

Lipoprotein interactions with chromatic membranes as a novel marker for oxidative stress-related diseases.

Biochim Biophys Acta 2009 Nov 29;1788(11):2436-43. Epub 2009 Sep 29.

Department of Chemistry, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

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November 2009

Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells.

J Immunol 2009 Apr;182(8):4874-81

The Shraga Segal Department of Microbiology and Immunology and Faculty of Health Sciences and The Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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April 2009

Dengue virus replicon expressing the nonstructural proteins suffices to enhance membrane expression of HLA class I and inhibit lysis by human NK cells.

J Virol 2008 Aug 28;82(15):7666-76. Epub 2008 May 28.

Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, and Cancer Research Center, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.

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August 2008

H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44.

J Virol 2008 Feb 12;82(4):2028-32. Epub 2007 Dec 12.

Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

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February 2008

Altered glycosylation of recombinant NKp30 hampers binding to heparan sulfate: a lesson for the use of recombinant immunoreceptors as an immunological tool.

Glycobiology 2008 Jan 15;18(1):28-41. Epub 2007 Nov 15.

The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

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January 2008

CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72.

PLoS One 2007 Sep 5;2(9):e818. Epub 2007 Sep 5.

The Lautenberg Center for General and Tumor Immunology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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September 2007

Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44.

Biochemistry 2007 Jun 31;46(25):7426-36. Epub 2007 May 31.

The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

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June 2007

T7 phage display of Ep15 peptide for the detection of WNV IgG.

J Virol Methods 2007 May 9;141(2):133-40. Epub 2007 Jan 9.

Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

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May 2007

Rapid chromatic detection of bacteria by use of a new biomimetic polymer sensor.

Appl Environ Microbiol 2006 Nov 22;72(11):7339-44. Epub 2006 Sep 22.

Department of Chemistry and Ilse Katz Center for Nanotechnology, Ben Gurion University, Beer Sheva 84105, Israel.

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November 2006

Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1.

Nat Immunol 2006 May 26;7(5):517-23. Epub 2006 Mar 26.

The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel.

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May 2006

Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46.

Biochemistry 2005 Nov;44(44):14477-85

Department of Microbiology and Immunology, Faculty of Health Sciences, and Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

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November 2005

Self HSP60 peptide serves as an immunogenic carrier for a CTL epitope against persistence of murine cytomegalovirus in the salivary gland.

Vaccine 2005 May;23(27):3508-18

Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

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May 2005

Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.

Nat Immunol 2005 May 10;6(5):515-23. Epub 2005 Apr 10.

The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel.

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May 2005

Natural cytotoxicity receptors: pattern recognition and involvement of carbohydrates.

Authors:
Angel Porgador

ScientificWorldJournal 2005 Feb;5:151-4

Department of Microbiology and Immunology, Faculty of Health Sciences and Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

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February 2005

Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46.

J Immunol 2004 Aug;173(4):2392-401

Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel.

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August 2004

Non-replicating mucosal and systemic vaccines: quantitative and qualitative differences in the Ag-specific CD8(+) T cell population in different tissues.

Vaccine 2004 Mar;22(11-12):1390-4

Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

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March 2004

The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46.

Blood 2004 Jan 22;103(2):664-72. Epub 2003 Sep 22.

Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel.

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January 2004

Reliable determination of transposon insertion site in prokaryotes by direct sequencing.

J Microbiol Methods 2003 Jul;54(1):137-40

Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer-Sheva 84105, Israel.

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July 2003