Publications by authors named "Angel F Lopez"

77Publications

14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance.

Mol Metab 2020 Nov 12;41:101052. Epub 2020 Jul 12.

Département de médecine, Université de Montréal, Montréal, QC, Canada; Axe cardio-métabolique, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.101052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394917PMC
November 2020

Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases.

Immunity 2019 11 22;51(5):949-965.e6. Epub 2019 Oct 22.

Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5000, Australia; Laboratory of NF-κB Signaling, Institute of Molecular and Cell Biology (IMCB), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.09.021DOI Listing
November 2019

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.

MAbs 2018 10 12;10(7):1018-1029. Epub 2018 Sep 12.

a St. Vincent's Institute of Medical Research , Australian Cancer Research Foundation Rational Drug Discovery Centre , Fitzroy , Victoria , Australia.

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http://dx.doi.org/10.1080/19420862.2018.1494107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204844PMC
October 2018

NLS-Cholic Acid Conjugation to IL-5Rα-Specific Antibody Improves Cellular Accumulation and In Vivo Tumor-Targeting Properties in a Bladder Cancer Model.

Bioconjug Chem 2018 04 1;29(4):1352-1363. Epub 2018 Mar 1.

Sherbrooke Molecular Imaging Centre (CIMS), Centre de Recherche du CHUS , UdeS , 3001 12 Avenue Nord , Sherbrooke , Québec J1H 5N4 , Canada.

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http://dx.doi.org/10.1021/acs.bioconjchem.8b00077DOI Listing
April 2018

Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer.

Oncoimmunology 2017 19;6(10):e1331195. Epub 2017 May 19.

Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences (FMHS), Centre hospitalier universitaire de Sherbrooke (CHUS), Université de Sherbrooke (UdeS), Sherbrooke, Québec, Canada.

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2017.1
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http://dx.doi.org/10.1080/2162402X.2017.1331195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665064PMC
May 2017

Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity.

J Biol Chem 2018 01 6;293(1):89-99. Epub 2017 Nov 6.

the Research School of Chemistry, Australian National University, Acton, Australian Capital Territory 2601, Australia.

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http://dx.doi.org/10.1074/jbc.M117.801019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766903PMC
January 2018

The transcriptional program, functional heterogeneity, and clinical targeting of mast cells.

J Exp Med 2017 Sep 15;214(9):2491-2506. Epub 2017 Aug 15.

Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia

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http://www.jem.org/lookup/doi/10.1084/jem.20170910
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http://dx.doi.org/10.1084/jem.20170910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584128PMC
September 2017

Proteome Analysis of Drosophila Mutants Identifies a Regulatory Role for 14-3-3ε in Metabolic Pathways.

J Proteome Res 2017 05 13;16(5):1976-1987. Epub 2017 Apr 13.

Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia , Adelaide, South Australia 5001, Australia.

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http://dx.doi.org/10.1021/acs.jproteome.6b01032DOI Listing
May 2017

Comment on "KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study".

Leuk Res 2017 04 9;55:55-57. Epub 2017 Jan 9.

Department of Haematology, SA Pathology, Adelaide, South Australia, Australia; Cancer Theme, South Australia Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia; The University of Adelaide, School of Medicine, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1016/j.leukres.2017.01.009DOI Listing
April 2017

GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells .

Clin Transl Immunology 2016 Dec 23;5(12):e119. Epub 2016 Dec 23.

Translational Oncology, Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, Australia; Cancer Clinical Trials Unit, Royal Adelaide Hospital, Adelaide, Australia; Discipline of Medicine, University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1038/cti.2016.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192067PMC
December 2016

The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation.

Nat Commun 2016 10 27;7:13198. Epub 2016 Oct 27.

Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia 5000, Australia.

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http://dx.doi.org/10.1038/ncomms13198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095291PMC
October 2016

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.

Structure 2016 08 7;24(8):1271-1281. Epub 2016 Jul 7.

ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.05.017DOI Listing
August 2016

Ywhaz/14-3-3ζ Deletion Improves Glucose Tolerance Through a GLP-1-Dependent Mechanism.

Endocrinology 2016 07 11;157(7):2649-59. Epub 2016 May 11.

Department of Cellular and Physiological Sciences (G.E.L., M.P., J.D.J.), University of British Columbia, Vancouver, BC, Canada; ALPCO (J.E.L.), Salem, New Hampshire; and The Centre for Cancer Biology (H.S.R., A.F.L.), South Australia Pathology and University of South Australia, Adelaide, Australia.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2016-1016DOI Listing
July 2016

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis.

Dev Cell 2015 Dec;35(6):759-74

Centre for Cancer Biology, SA Pathology and the University of South Australia, Frome Road, Adelaide 5000, Australia; Faculty of Health Sciences, School of Medicine, University of Adelaide, Adelaide 5000, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.11.026DOI Listing
December 2015

Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling.

Haematologica 2016 Mar 20;101(3):e77-80. Epub 2015 Nov 20.

Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane School of Medicine, University of Queensland Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia

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http://dx.doi.org/10.3324/haematol.2015.136705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815732PMC
March 2016

14-3-3ζ coordinates adipogenesis of visceral fat.

Nat Commun 2015 Jul 29;6:7671. Epub 2015 Jul 29.

Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.

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http://dx.doi.org/10.1038/ncomms8671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532800PMC
July 2015

The βc receptor family - Structural insights and their functional implications.

Cytokine 2015 Aug 14;74(2):247-58. Epub 2015 May 14.

Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S10434666150006
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http://dx.doi.org/10.1016/j.cyto.2015.02.005DOI Listing
August 2015

Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics.

Oncotarget 2015 Jun;6(16):14522-36

Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546484PMC
http://dx.doi.org/10.18632/oncotarget.3995DOI Listing
June 2015

Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties.

Stem Cell Res 2015 May 9;14(3):380-95. Epub 2015 Apr 9.

Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia, Australia; Co-operative Research Centre for Biomarker Translation, La Trobe University, Melbourne, Victoria, Australia; School of Medicine, University of Adelaide, Adelaide, South Australia, Australia; Centre for Stem Cell Research, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.04.002DOI Listing
May 2015

Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

Mol Cell Oncol 2014 Oct-Dec;1(4):e969129. Epub 2014 Dec 31.

The Centre for Cancer Biology; SA Pathology and the University of South Australia ; Adelaide, South Australia.

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http://dx.doi.org/10.4161/23288604.2014.969129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905208PMC
June 2016

14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain.

J Neurosci 2014 Sep;34(36):12168-81

Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco School of Medicine, San Francisco, California 94143, Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

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http://dx.doi.org/10.1523/JNEUROSCI.2513-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152612PMC
September 2014

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

Acta Crystallogr F Struct Biol Commun 2014 Mar 19;70(Pt 3):358-61. Epub 2014 Feb 19.

Australian Cancer Research Foundation Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.

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http://dx.doi.org/10.1107/S2053230X14002593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944702PMC
March 2014

Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia.

J Leukoc Biol 2014 Jul 5;96(1):83-91. Epub 2014 Mar 5.

Centre for Cancer Biology and School of Molecular and Biomedical Science and Centre for Stem Cell Research and Departments of Haematology and Department of Pharmacy and Medical Sciences, The University of South Australia, Adelaide, South Australia, Australia School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia;

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http://dx.doi.org/10.1189/jlb.2AB1013-559RDOI Listing
July 2014

Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation.

J Allergy Clin Immunol 2014 May 22;133(5):1356-64, 1364.e1-14. Epub 2014 Jan 22.

Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia; University of Adelaide, Adelaide, Australia; University of South Australia, Adelaide, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154631PMC
May 2014

IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses.

Immune Netw 2013 Dec 20;13(6):249-56. Epub 2013 Dec 20.

Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.4110/in.2013.13.6.249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875783PMC
December 2013

Signalling by the βc family of cytokines.

Cytokine Growth Factor Rev 2013 Jun 25;24(3):189-201. Epub 2013 Mar 25.

The Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, South Australia 5000, Australia.

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http://dx.doi.org/10.1016/j.cytogfr.2013.03.002DOI Listing
June 2013

Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state.

J Cell Sci 2013 May 22;126(Pt 10):2256-66. Epub 2013 Mar 22.

Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia.

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http://dx.doi.org/10.1242/jcs.122275DOI Listing
May 2013

Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor.

Br J Haematol 2013 May 25;161(3):389-401. Epub 2013 Feb 25.

Centro di Ricerca Matilde Tettamanti, Department of Paediatrics, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy.

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http://dx.doi.org/10.1111/bjh.12282DOI Listing
May 2013

Cytokine receptor activation at the cell surface.

Curr Opin Struct Biol 2012 Jun 20;22(3):350-9. Epub 2012 Apr 20.

St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3065, Australia.

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http://dx.doi.org/10.1016/j.sbi.2012.03.015DOI Listing
June 2012

Drosophila 14-3-3ε has a crucial role in anti-microbial peptide secretion and innate immunity.

J Cell Sci 2011 Jul;124(Pt 13):2165-74

Division of Human Immunology, Centre for Cancer Biology, Adelaide SA5000, Australia.

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http://dx.doi.org/10.1242/jcs.080598DOI Listing
July 2011

Vitamin D(3) signalling to mast cells: A new regulatory axis.

Int J Biochem Cell Biol 2011 Jan 23;43(1):41-6. Epub 2010 Oct 23.

Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide 5000, South Australia, Australia.

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http://dx.doi.org/10.1016/j.biocel.2010.10.011DOI Listing
January 2011

Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.

Cell Signal 2010 Sep 18;22(9):1291-9. Epub 2010 Apr 18.

Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S08986568100009
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http://dx.doi.org/10.1016/j.cellsig.2010.04.004DOI Listing
September 2010

14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival.

J Biol Chem 2009 May 13;284(18):12080-90. Epub 2009 Feb 13.

Cell Growth and Differentiation Laboratory, Division of Human Immunology, Hanson Institute, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000, Australia.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M807637200
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http://dx.doi.org/10.1074/jbc.M807637200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673277PMC
May 2009

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation.

Blood 2009 Feb 24;113(9):2108-17. Epub 2008 Dec 24.

Division of Human Immunology, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1182/blood-2008-07-166942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651020PMC
February 2009

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

Cell 2008 Aug;134(3):496-507

Biota Structural Biology Laboratory, St. Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.

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http://dx.doi.org/10.1016/j.cell.2008.05.053DOI Listing
August 2008

Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 Aug 5;64(Pt 8):711-4. Epub 2008 Jul 5.

Biota Structural Biology Laboratory, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.

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http://scripts.iucr.org/cgi-bin/paper?S1744309108019404
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http://dx.doi.org/10.1107/S1744309108019404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494959PMC
August 2008

The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation.

J Immunol 2008 Jan;180(2):1199-206

Centre for Asthma and Respiratory Diseases, School of Biomedical Sciences, Faculty of Health, University of Newcastle and Hunter Medical Research Institute, Callaghan, Australia.

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http://dx.doi.org/10.4049/jimmunol.180.2.1199DOI Listing
January 2008

The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis.

Blood 2007 Nov 16;110(10):3582-90. Epub 2007 Jul 16.

Cytokine Receptor Laboratory, Division of Human Immunology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, Australia.

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http://dx.doi.org/10.1182/blood-2007-01-070391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077308PMC
November 2007

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.

EMBO J 2006 Feb 26;25(3):479-89. Epub 2006 Jan 26.

Cytokine Receptor Laboratory, Department of Human Immunology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, SA, Australia.

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http://dx.doi.org/10.1038/sj.emboj.7600948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383532PMC
February 2006

The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kappaB and induction of bcl-2.

Blood 2004 Feb 14;103(3):820-7. Epub 2003 Aug 14.

Cytokine Receptor Laboratory, Department of Human Immunology, Institute of Medical and Veterinary Science, Frome Rd, Adelaide, South Australia, Australia 5000.

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http://dx.doi.org/10.1182/blood-2003-06-1999DOI Listing
February 2004

The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface.

J Biol Chem 2003 Sep 15;278(38):36323-7. Epub 2003 Jul 15.

Cytokine Receptor Laboratory, Division of Human Immunology, Hanson Institute, Institute of Medical and Veterinary Science, G. P. O. Box 14 Rundle Mall, Adelaide, SA 5000, Australia.

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http://dx.doi.org/10.1074/jbc.M304689200DOI Listing
September 2003

Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.

J Biol Chem 2003 Aug 20;278(35):32929-35. Epub 2003 Jun 20.

Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, 1G Royal Parade, Victoria 3050, Australia.

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http://dx.doi.org/10.1074/jbc.M302910200DOI Listing
August 2003

Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex.

Blood 2003 Feb 10;101(4):1308-15. Epub 2002 Oct 10.

Cytokine Receptor Laboratory and Protein Laboratory, Division of Human Immunology, Institute of Medical and Veterinary Science (IMVS), Adelaide, South Australia.

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http://dx.doi.org/10.1182/blood-2002-06-1903DOI Listing
February 2003

Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo.

Exp Hematol 2002 Oct;30(10):1124-31

Cytokine Receptor Laboratory, Division of Human Immunology, IMVS, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1016/s0301-472x(02)00903-7DOI Listing
October 2002