Anette Melk

Anette Melk

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Anette Melk

Anette Melk

Publications by authors named "Anette Melk"

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SerpinB2 Regulates Immune Response in Kidney Injury and Aging.

J Am Soc Nephrol 2020 May 24;31(5):983-995. Epub 2020 Mar 24.

Department of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany

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http://dx.doi.org/10.1681/ASN.2019101085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217424PMC
May 2020

High-intensity interval training in allogeneic adoptive T-cell immunotherapy - a big HIT?

J Transl Med 2020 04 1;18(1):148. Epub 2020 Apr 1.

Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1186/s12967-020-02301-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114817PMC
April 2020

Survival after Kidney Transplantation during Childhood and Adolescence.

Clin J Am Soc Nephrol 2020 03 19;15(3):392-400. Epub 2020 Feb 19.

School of Public Health, University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.2215/CJN.07070619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057311PMC
March 2020

Binding to carboxypeptidase M mediates protective effects of fibrinopeptide Bβ.

Transl Res 2019 11 26;213:124-135. Epub 2019 Jul 26.

Department of Nephrology and Hypertension, Medical School Hannover, Germany.

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http://dx.doi.org/10.1016/j.trsl.2019.07.008DOI Listing
November 2019

Time-dependent p53 inhibition determines senescence attenuation and long-term outcome after renal ischemia-reperfusion.

Am J Physiol Renal Physiol 2019 06 20;316(6):F1124-F1132. Epub 2019 Feb 20.

Department of Pediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School , Hannover , Germany.

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http://dx.doi.org/10.1152/ajprenal.00333.2018DOI Listing
June 2019

Computational Drug Screening Identifies Compounds Targeting Renal Age-associated Molecular Profiles.

Comput Struct Biotechnol J 2019 25;17:843-853. Epub 2019 Jun 25.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.csbj.2019.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611921PMC
June 2019

Cardiovascular risk factors and subclinical organ damage after hematopoietic stem cell transplantation in pediatric age.

Bone Marrow Transplant 2018 08 9;53(8):983-992. Epub 2018 Feb 9.

Department of Paediatric Hematooncology, Clinic for Paediatrics III, University Hospital Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1038/s41409-018-0104-xDOI Listing
August 2018

Factors associated with cardiovascular target organ damage in children after renal transplantation.

Pediatr Nephrol 2017 Nov 13;32(11):2143-2154. Epub 2017 Aug 13.

Department of Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1007/s00467-017-3771-8DOI Listing
November 2017

Early and Late Factors Impacting Patient and Graft Outcome in Pediatric Liver Transplantation: Summary of an ESPGHAN Monothematic Conference.

J Pediatr Gastroenterol Nutr 2017 09;65(3):e53-e59

*Swiss Center for Liver Disease in Children, University Hospitals Geneva, Geneva, Switzerland †Division of Infectious Diseases and the Transplant and Regenerative Medicine Centre, Hospital for Sick Children, University of Toronto, Toronto, Canada ‡Pediatric Nephrology, Imagine Institute, Necker-Enfants Malades Hospital, APHP, Paris Descartes University-Sorbonne Paris Cité, Paris, France §Pediatric Liver Care Center, Cincinnati Children's Hospital, Cincinnati, OH ||Department of Surgery, Ospedale Papa Giovanni XXIII, Bergamo, Italy ¶Faculté de Médecine, University de Nantes, Nantes, France #Pediatric Hepatology, Gastroenterology and Transplantation, Ospedale Papa Giovanni XXIII, Bergamo, Italy **Pediatric Hepatology Unit, Necker Enfants Malades Hospital, Paris, France ††First Department of Pediatrics, Semmelweis University, Budapest, Hungary ‡‡University Tor Vergata, Rome, Italy §§Pediatric Liver GI and Nutrition Centre, King's College Hospital, London, UK ||||Faculty of Medicine, Istanbul University, Istanbul, Turkey ¶¶Institute of Transplant Immunology, FIB-Tx, Hannover Medical School, Germany ##Abdominal Transplant Surgery, University of California San Francisco, San Francisco, CA ***Department of Pediatrics, Karolinska University Hospital, CLINTEC Karolinska Institutet, Stockholm, Sweden †††Pediatric Radiology Department, Hôpital Bicêtre, Hôpitaux Universitaires Paris Sud- Assistance Publique Hôpitaux de Paris, Le Kremlin-Bicêtre, France ‡‡‡Pediatric Hepatology and Liver Transplantation, Hospital Universitario Infantil La Paz, Madrid, Spain §§§Department of Pediatrics, University Children's Hospital Bonn, Bonn, Germany ||||||Center for Cell and Gene Therapy and Texas Children's Cancer Center, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX ¶¶¶Pediatric Liver GI and Nutrition Centre, King's College, London, UK ###Seattle Children's Hospital and University of Washington, Seattle, WA ****School of Cancer Sciences ††††Department of Cellular Pathology, Queen Elizabeth Hospital, University of Birmingham, Birmingham, UK ‡‡‡‡The European Transplant Registry, APHP Paul Brousse Hospital, Villejuif, France §§§§Liver Unit, Birmingham Children's Hospital, Birmingham, UK ||||||||Department of Pediatric Hematology/Oncology and Integrated Research and Treatment Center for Transplantation, Hannover Medical School, Germany ¶¶¶¶Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh, Pittsburgh, PA ####Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Section of Pediatrics, University of Salerno, Baronissi, Italy *****Bambino Gesu Children's Hospital, Rome, Italy †††††Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Ege University, Izmir, Turkey ‡‡‡‡‡Pediatric Surgery and Transplantation Unit, Cliniques Universitaires de Saint-Luc, Université Catholique de Louvain, Brussels, Belgium §§§§§ISMETT, University of Pittsburgh Medical Center, Palermo, Italy ||||||||||The Children's Memorial Health Institute, Warsaw, Poland ¶¶¶¶¶Divisions of Abdominal and Transplant Surgery, Faculty of Medicine and University Hospitals Geneva, Geneva, Switzerland #####University of Salerno, Baronissi, Italy ******King's College Hospital, Institute of Liver Studies, London, UK ††††††Department for Pediatric Kidney, Liver and Metabolic Disease, Division of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1097/MPG.0000000000001564DOI Listing
September 2017

Antagonism of profibrotic microRNA-21 improves outcome of murine chronic renal allograft dysfunction.

Kidney Int 2017 09 8;92(3):646-656. Epub 2017 Apr 8.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Germany; Department of Nephrology, Hannover Medical School, Germany; University Hospital Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.02.012DOI Listing
September 2017

Molecular mechanisms of renal aging.

Kidney Int 2017 09 18;92(3):569-579. Epub 2017 Jul 18.

Department of Kidney, Liver and Metabolic Diseases, Children's Hospital, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.02.036DOI Listing
September 2017

The yin and yang of autophagy in acute kidney injury.

Autophagy 2016 ;12(3):596-7

b Department of Nephrology , Hannover Medical School , Hannover , Germany.

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http://dx.doi.org/10.1080/15548627.2015.1135284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835952PMC
December 2016

The impact of autophagy on the development of senescence in primary tubular epithelial cells.

Cell Cycle 2016 Nov 7;15(21):2973-2979. Epub 2016 Oct 7.

a Department of Nephrology , Children's Hospital , Hannover , Germany.

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http://dx.doi.org/10.1080/15384101.2016.1234547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105933PMC
November 2016

T Cell CX3CR1 Mediates Excess Atherosclerotic Inflammation in Renal Impairment.

J Am Soc Nephrol 2016 06 8;27(6):1753-64. Epub 2015 Oct 8.

Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany;

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http://dx.doi.org/10.1681/ASN.2015050540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884117PMC
June 2016

Practice recommendations for the monitoring of renal function in pediatric non-renal organ transplant recipients.

Pediatr Transplant 2016 May 25;20(3):352-63. Epub 2016 Feb 25.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/petr.12685DOI Listing
May 2016

Cell aging and kidney repair.

Cell Cycle 2015 ;14(22):3521-2

a Department of Nephrology ; Hannover Medical School ; Hannover , Germany.

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http://dx.doi.org/10.1080/15384101.2015.1032636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825792PMC
March 2016

Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction.

J Gerontol A Biol Sci Med Sci 2016 Feb 3;71(2):161-9. Epub 2015 Mar 3.

Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Children's Hospital, Hannover Medical School, Hannover D-30625, Germany. REBIRTH Excellence Cluster, Hannover Medical School, Hannover D-30625, Germany.

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http://dx.doi.org/10.1093/gerona/glv008DOI Listing
February 2016

Aortic Pulse Wave Velocity in Healthy Children and Adolescents: Reference Values for the Vicorder Device and Modifying Factors.

Am J Hypertens 2015 Dec 5;28(12):1480-8. Epub 2015 May 5.

Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany;

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http://dx.doi.org/10.1093/ajh/hpv048DOI Listing
December 2015

Renal phenotype of young and old telomerase-deficient mice.

Mech Ageing Dev 2015 Sep 12;150:65-73. Epub 2015 Aug 12.

Department of Pediatric Nephrology, Gastroenterology and Metabolic Diseases, Children's Hospital, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2015.08.004DOI Listing
September 2015

Arterial hypertension in children with hemolytic uremic syndrome after kidney transplantation.

Pediatr Transplant 2015 Aug 13;19(5):504-9. Epub 2015 Jun 13.

Children's Hospital, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/petr.12533DOI Listing
August 2015

Molecular aspects of renal senescence.

Curr Opin Organ Transplant 2015 Aug;20(4):412-6

aDepartment of Nephrology and Hypertension, Hannover Medical School bDepartment of Kidney, Liver and Metabolic Diseases, Children's Hospital, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1097/MOT.0000000000000214DOI Listing
August 2015

Vascular importance of the miR-212/132 cluster.

Eur Heart J 2014 Dec 12;35(45):3224-31. Epub 2014 Sep 12.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany Integrated Research and Treatment Center Transplantation, Hannover Medical School, Hannover, Germany National Heart and Lung Institute, Imperial College London, London, UK REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany

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http://eurheartj.oxfordjournals.org/content/ehj/35/45/3224.f
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http://eurheartj.oxfordjournals.org/cgi/doi/10.1093/eurheart
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http://dx.doi.org/10.1093/eurheartj/ehu344DOI Listing
December 2014

Renal tubular Notch signaling triggers a prosenescent state after acute kidney injury.

Am J Physiol Renal Physiol 2014 Apr 26;306(8):F907-15. Epub 2014 Feb 26.

Dept. of Nephrology and Hypertension, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1152/ajprenal.00030.2014DOI Listing
April 2014

Association of single nucleotide polymorphisms on chromosome 9p21.3 with cardiovascular death in kidney transplant recipients.

Transplantation 2013 Apr;95(7):928-32

Department of Pediatric Nephrology, Children's Hospital, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1097/TP.0b013e318282f2b1DOI Listing
April 2013

Cellular senescence limits regenerative capacity and allograft survival.

J Am Soc Nephrol 2012 Sep 12;23(9):1467-73. Epub 2012 Jul 12.

Department of Kidney, Liver and Metabolic Diseases, Children's Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany.

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http://dx.doi.org/10.1681/ASN.2011100967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431409PMC
September 2012

Is cellular senescence important in pediatric kidney disease?

Pediatr Nephrol 2011 Dec 18;26(12):2121-31. Epub 2011 Jan 18.

Department of Pediatric Nephrology, Gastroenterology and Metabolic Diseases, Children's Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00467-010-1740-6DOI Listing
December 2011

Validating a new oscillometric device for aortic pulse wave velocity measurements in children and adolescents.

Am J Hypertens 2011 Dec 25;24(12):1294-9. Epub 2011 Aug 25.

Department of Pediatric Nephrology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/ajh.2011.147DOI Listing
December 2011

Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis.

Kidney Int 2011 Nov 6;80(10):1035-44. Epub 2011 Jul 6.

Department of Nephrology, Hannover Medical School, Hannover, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00852538155494
Publisher Site
http://dx.doi.org/10.1038/ki.2011.214DOI Listing
November 2011

Ageing mouse kidney--not always the SAME old story.

Nephrol Dial Transplant 2009 Oct 27;24(10):3002-5. Epub 2009 May 27.

Department of Nephrology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1093/ndt/gfp232DOI Listing
October 2009

Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.

Hypertension 2008 Jul 26;52(1):123-9. Epub 2008 May 26.

Division of Pediatric Nephrology, University Children's Hospital, Heidelberg, Germany.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.107.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.099432DOI Listing
July 2008

Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling.

Kidney Int 2005 Dec;68(6):2667-79

Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S008525381551174
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http://dx.doi.org/10.1111/j.1523-1755.2005.00738.xDOI Listing
December 2005

Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated kidney graft rejection.

Am J Transplant 2005 Aug;5(8):1827-36

Department of Medicine, Division of Nephrology & Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada.

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http://doi.wiley.com/10.1111/j.1600-6143.2005.00974.x
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http://dx.doi.org/10.1111/j.1600-6143.2005.00974.xDOI Listing
August 2005

Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis.

Am J Transplant 2005 Jun;5(6):1367-74

Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada.

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http://doi.wiley.com/10.1111/j.1600-6143.2005.00843.x
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http://dx.doi.org/10.1111/j.1600-6143.2005.00843.xDOI Listing
June 2005

Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney.

Am J Transplant 2005 Jun;5(6):1375-82

Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1111/j.1600-6143.2005.00846.xDOI Listing
June 2005

Longitudinal analysis of T-helper cell phenotypes in renal-transplant recipients undergoing growth hormone therapy.

Transplantation 2004 Dec;78(12):1792-801

Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/01.tp.0000147785.11967.1dDOI Listing
December 2004

Lesions of T-cell-mediated kidney allograft rejection in mice do not require perforin or granzymes A and B.

Am J Transplant 2004 May;4(5):705-12

Department of Medicine, Division of Nephrology & Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada.

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http://doi.wiley.com/10.1111/j.1600-6143.2004.00421.x
Publisher Site
http://dx.doi.org/10.1111/j.1600-6143.2004.00421.xDOI Listing
May 2004

Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney.

Kidney Int 2004 Feb;65(2):510-20

Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1111/j.1523-1755.2004.00438.xDOI Listing
February 2004

Senescence of renal cells: molecular basis and clinical implications.

Authors:
Anette Melk

Nephrol Dial Transplant 2003 Dec;18(12):2474-8

Division of Nephrology and Immunology, University of Alberta, 250 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada.

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http://dx.doi.org/10.1093/ndt/gfg322DOI Listing
December 2003

Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening.

Kidney Int 2003 Jun;63(6):2134-43

Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1046/j.1523-1755.2003.00032.xDOI Listing
June 2003

Quantitative gene expression of TGF-beta1, IL-10, TNF-alpha and Fas Ligand in renal cortex and medulla.

Nephrol Dial Transplant 2002 Apr;17(4):573-9

Department of Paediatric Nephrology and Metabolic Diseases, Children's Hospital, Hannover Medical School, D-30623 Hannover, Germany.

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http://dx.doi.org/10.1093/ndt/17.4.573DOI Listing
April 2002