Anette G Ziegler

Anette G Ziegler

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Anette G Ziegler

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Age, HLA, and Sex Define a Marked Risk of Organ-Specific Autoimmunity in First-Degree Relatives of Patients With Type 1 Diabetes.

Diabetes Care 2019 Sep 18;42(9):1684-1691. Epub 2019 Jun 18.

Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany

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http://dx.doi.org/10.2337/dc19-0315DOI Listing
September 2019

Landmark models to define the age-adjusted risk of developing stage 1 type 1 diabetes across childhood and adolescence.

BMC Med 2019 07 9;17(1):125. Epub 2019 Jul 9.

Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764, Munich-Neuherberg, Germany.

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http://dx.doi.org/10.1186/s12916-019-1360-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615150PMC
July 2019

Blood draws up to 3% of blood volume in clinical trials are safe in children.

Acta Paediatr 2019 May 30;108(5):940-944. Epub 2018 Oct 30.

Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, Germany.

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http://dx.doi.org/10.1111/apa.14607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587985PMC
May 2019

Screening for asymptomatic β-cell autoimmunity in young children.

Lancet Child Adolesc Health 2019 May 10;3(5):288-290. Epub 2019 Feb 10.

DFG-Center for Regenerative Therapies Dresden, Faculty of Medicine, Technical University of Dresden, Dresden, Germany.

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http://dx.doi.org/10.1016/S2352-4642(19)30028-8DOI Listing
May 2019

Cytoplasmic ends of tetraspanin 7 harbour epitopes recognised by autoantibodies in type 1 diabetes.

Diabetologia 2019 05 21;62(5):805-810. Epub 2019 Feb 21.

DFG-Centre for Regenerative Therapies Dresden, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 105, 01307, Dresden, Germany.

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http://dx.doi.org/10.1007/s00125-019-4832-2DOI Listing
May 2019

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.

Curr Diab Rep 2018 10 23;18(12):136. Epub 2018 Oct 23.

Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1007/s11892-018-1113-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415767PMC
October 2018

Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12.

Diabetologia 2018 07 4;61(7):1644-1649. Epub 2018 Apr 4.

Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK.

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http://dx.doi.org/10.1007/s00125-018-4605-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445455PMC
July 2018

Allele-specific methylation of type 1 diabetes susceptibility genes.

J Autoimmun 2018 05 8;89:63-74. Epub 2017 Dec 8.

Institute of Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany; Center for Regenerative Therapies - Dresden, Faculty of Medicine Carl Gustav Carus, Technische Universität, Dresden, Germany; Forschergruppe Diabetes e.V., Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.11.008DOI Listing
May 2018

Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study.

J Pediatr Gastroenterol Nutr 2018 03;66(3):417-424

*Dr. v. Hauner Children's Hospital, University Munich Medical Center, Munich, Germany †Health Informatics Institute, Department of Paediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL, USA ‡Institute of Diabetes Research, Helmholtz Zentrum München, Klinikum rechts der Isar, Technische Universität München, and Forschergruppe Diabetes e.V., Neuherberg, Germany §Department of Clinical Sciences, Lund University, Skane University Hosptial, Malmo, Sweden ||Digestive Health Institute, University of Colorado, Children's Hospital Colorado, Aurora, CO, USA ¶Medicity Laboratory, University of Turku, Turku, Finland #Tampere Centre for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland **Pacific Northwest Diabetes Research Institute, Seattle WA, USA ††Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora CO, USA ‡‡Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta GA, USA §§Department of Paediatrics, Turku University Hospital, Turku, Finland ||||Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland ¶¶Departments of Physiology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1097/MPG.0000000000001682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787038PMC
March 2018

Efficacy of vildagliptin for prevention of postpartum diabetes in women with a recent history of insulin-requiring gestational diabetes: A phase II, randomized, double-blind, placebo-controlled study.

Mol Metab 2018 03 3;9:168-175. Epub 2018 Jan 3.

Forschergruppe Diabetes e.V. am Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany; Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869734PMC
March 2018

Vaccinations in early life are not associated with development of islet autoimmunity in type 1 diabetes high-risk children: Results from prospective cohort data.

Vaccine 2017 03 3;35(14):1735-1741. Epub 2017 Mar 3.

Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany; Forschergruppe Diabetes der Technischen Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2017.02.049DOI Listing
March 2017

Peptide serum markers in islet autoantibody-positive children.

Diabetologia 2017 02 4;60(2):287-295. Epub 2016 Nov 4.

Research Unit Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, D-85764, München, Germany.

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http://dx.doi.org/10.1007/s00125-016-4150-xDOI Listing
February 2017

A divergent population of autoantigen-responsive CD4 T cells in infants prior to β cell autoimmunity.

Sci Transl Med 2017 02;9(378)

DFG-Center for Regenerative Therapies Dresden, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.

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http://dx.doi.org/10.1126/scitranslmed.aaf8848DOI Listing
February 2017

Diet Quality during Infancy and Early Childhood in Children with and without Risk of Type 1 Diabetes: A DEDIPAC Study.

Nutrients 2017 Jan 9;9(1). Epub 2017 Jan 9.

Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg 85764, Germany.

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http://dx.doi.org/10.3390/nu9010048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295092PMC
January 2017

3 Screen ELISA for High-Throughput Detection of Beta Cell Autoantibodies in Capillary Blood.

Diabetes Technol Ther 2016 11 23;18(11):687-693. Epub 2016 Aug 23.

1 Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München , Neuherberg, Germany .

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http://dx.doi.org/10.1089/dia.2016.0199DOI Listing
November 2016

Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease.

Diabetes 2016 11;65(11):3233-3239

Departments of Pathology and Pediatrics, UF Diabetes Institute, University of Florida, Gainesville, FL

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http://dx.doi.org/10.2337/db16-0687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860440PMC
November 2016

miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity.

Proc Natl Acad Sci U S A 2016 10 10;113(43):E6659-E6668. Epub 2016 Oct 10.

Institute for Diabetes Research, Independent Young Investigator Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany;

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http://dx.doi.org/10.1073/pnas.1606646113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087025PMC
October 2016

Tetraspanin 7 autoantibodies in type 1 diabetes.

Diabetologia 2016 09 25;59(9):1973-6. Epub 2016 May 25.

DFG Research Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Fetscherstrasse 105, 01307, Dresden, Germany.

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http://dx.doi.org/10.1007/s00125-016-3997-1DOI Listing
September 2016

Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study.

Diabetes Care 2016 Sep 16;39(9):1535-42. Epub 2016 Jun 16.

Health Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL.

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http://dx.doi.org/10.2337/dc16-0181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001144PMC
September 2016

[Early diagnosis, early care--"Fr1da" screening of children for type 1 diabetes].

MMW Fortschr Med 2016 Mar;158(4):65-6

Institut für Diabetesforschung, Helmholtz Zentrum München, und Lehrstuhl für Diabetes und Gestationsdiabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, D-85764, Neuherberg, Deutschland.

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http://dx.doi.org/10.1007/s15006-016-7884-yDOI Listing
March 2016

Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study.

JAMA Pediatr 2016 Jan;170(1):20-8

National Institute for Health and Welfare, Nutrition Unit, Helsinki, Finland12School of Health Sciences and Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland 13The Science Center of Pirkanmaa Hospita.

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http://www.melk.no/sitefiles/6/EarlyExposureofProbioticsandI
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http://archpedi.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamapediatrics.2015.2757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803028PMC
January 2016

Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes.

Diabetologia 2015 Oct 3;58(10):2317-23. Epub 2015 Jul 3.

Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.

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http://link.springer.com/10.1007/s00125-015-3672-y
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http://dx.doi.org/10.1007/s00125-015-3672-yDOI Listing
October 2015

General population screening for type 1 diabetes: has its time come?

Curr Opin Endocrinol Diabetes Obes 2015 Aug;22(4):270-6

aJDRF, New York, USA bInstitute of Diabetes Research, Helmholtz Zentrum München, Munich cForschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, Germany.

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http://dx.doi.org/10.1097/MED.0000000000000173DOI Listing
August 2015

Early infant feeding and risk of developing islet autoimmunity and type 1 diabetes.

Acta Diabetol 2015 Jun 20;52(3):621-4. Epub 2014 Jul 20.

Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, Germany.

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http://dx.doi.org/10.1007/s00592-014-0628-5DOI Listing
June 2015

Maternal anxiety about a child's diabetes risk in the TEDDY study: the potential role of life stress, postpartum depression, and risk perception.

Pediatr Diabetes 2015 Jun 1;16(4):287-98. Epub 2014 Aug 1.

Institut für Diabetesforschung, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany; Institute of Psychology, University of Graz, Universitaetsplatz 2/III, Graz, 8010, Austria.

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http://dx.doi.org/10.1111/pedi.12168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312746PMC
June 2015

HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.

Am J Gastroenterol 2015 Jun 26;110(6):915-20. Epub 2015 May 26.

1] Pediatric Epidemiology Center, University of South Florida, Tampa, Florida, USA [2] Department of Clinical Sciences, Lund University, Malmo, Sweden.

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http://dx.doi.org/10.1038/ajg.2015.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487515PMC
June 2015

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study.

Diabetologia 2015 May 10;58(5):980-7. Epub 2015 Feb 10.

Department of Pediatrics, Morsani College of Medicine, University of South Florida, 3650 Spectrum Boulevard, Suite 100, Tampa, FL, 33612, USA,

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http://dx.doi.org/10.1007/s00125-015-3514-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393776PMC
May 2015

Widespread seasonal gene expression reveals annual differences in human immunity and physiology.

Nat Commun 2015 May 12;6:7000. Epub 2015 May 12.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1038/ncomms8000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432600PMC
May 2015

Vagaries of the ELISpot assay: specific detection of antigen responsive cells requires purified CD8(+) T cells and MHC class I expressing antigen presenting cell lines.

Clin Immunol 2015 Apr 27;157(2):216-25. Epub 2015 Feb 27.

Technische Universität Dresden, DFG-Center for Regenerative Therapies Dresden, Fetscherstr. 105, 01307 Dresden, Germany; Paul Langerhans Institute Dresden, Germany; Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216616150006
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http://dx.doi.org/10.1016/j.clim.2015.02.012DOI Listing
April 2015

Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes: the Pre-POINT randomized clinical trial.

JAMA 2015 Apr;313(15):1541-9

Forschergruppe Diabetes e.V., Neuherberg, Germany4Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1001/jama.2015.2928DOI Listing
April 2015

Severe pretreatment cerebral edema in newly diagnosed type 1 diabetes.

Horm Res Paediatr 2014 13;81(4):285-8. Epub 2014 Mar 13.

Department of Pediatrics, Kinderklinik München Schwabing, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1159/000357140DOI Listing
January 2015

GAD autoantibody affinity in schoolchildren from the general population.

Diabetologia 2014 Sep 18;57(9):1911-8. Epub 2014 Jun 18.

Pharmazentrum Frankfurt/ZAFES, Goethe University Hospital Frankfurt, Theodor-Stern Kai 7, 60590, Frankfurt am Main, Germany,

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http://dx.doi.org/10.1007/s00125-014-3294-9DOI Listing
September 2014

GAD autoantibody affinity in adult patients with latent autoimmune diabetes, the study participants of a GAD65 vaccination trial.

Diabetes Care 2014 Jun 5;37(6):1675-80. Epub 2014 Mar 5.

Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, GermanyForschergruppe Diabetes e.V., Neuherberg, Germany

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http://dx.doi.org/10.2337/dc13-1719DOI Listing
June 2014

Compromised gut microbiota networks in children with anti-islet cell autoimmunity.

Diabetes 2014 Jun 7;63(6):2006-14. Epub 2014 Mar 7.

Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Germany

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http://dx.doi.org/10.2337/db13-1676DOI Listing
June 2014

Beneficial effects of breastfeeding in women with gestational diabetes mellitus.

Mol Metab 2014 Jun 21;3(3):284-92. Epub 2014 Jan 21.

Institute of Diabetes Research, Helmholtz Zentrum München, Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany ; Forschergruppe Diabetes e.V., Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.molmet.2014.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986583PMC
June 2014

Postpartum outcomes in women with gestational diabetes and their offspring: POGO study design and first-year results.

Rev Diabet Stud 2013 10;10(1):49-57. Epub 2013 May 10.

Institute of Diabetes Research, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1900/RDS.2013.10.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932071PMC
May 2014

Measuring T cell receptor and T cell gene expression diversity in antigen-responsive human CD4+ T cells.

J Immunol Methods 2013 Dec 13;400-401:13-22. Epub 2013 Nov 13.

DFG Research Center for Regenerative Therapies Dresden, Technische Universität Dresden, Germany; Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD). Electronic address:

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http://dx.doi.org/10.1016/j.jim.2013.11.003DOI Listing
December 2013

Continuous rise of insulin resistance before and after the onset of puberty in children at increased risk for type 1 diabetes - a cross-sectional analysis.

Diabetes Metab Res Rev 2013 Nov;29(8):631-5

Forschergruppe Diabetes e.V., Neuherberg, Germany; Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, Germany.

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http://dx.doi.org/10.1002/dmrr.2438DOI Listing
November 2013

Activation of islet autoreactive naïve T cells in infants is influenced by homeostatic mechanisms and antigen-presenting capacity.

Diabetes 2013 Jun 24;62(6):2059-66. Epub 2013 Jan 24.

DFG Research Center and Cluster of Excellence, Center for Regenerative Therapies Dresden, Dresden University of Technology, Dresden, Germany.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db12-09
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http://dx.doi.org/10.2337/db12-0942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661654PMC
June 2013

Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.

JAMA 2013 Jun;309(23):2473-9

Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstaedter Landstrase 1, Neuherberg, Germany 85764.

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http://dx.doi.org/10.1001/jama.2013.6285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878912PMC
June 2013

rs11203203 is associated with type 1 diabetes risk in population pre-screened for high-risk HLA-DR,DQ genotypes.

Pediatr Diabetes 2012 Dec 8;13(8):611-5. Epub 2012 Jul 8.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver (UCD), Aurora, CO 80045, USA.

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http://dx.doi.org/10.1111/j.1399-5448.2012.00888.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886718PMC
December 2012

Long-term protective effect of lactation on the development of type 2 diabetes in women with recent gestational diabetes mellitus.

Diabetes 2012 Dec 15;61(12):3167-71. Epub 2012 Oct 15.

Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Germany.

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http://dx.doi.org/10.2337/db12-0393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501852PMC
December 2012

IA-2 autoantibody affinity in children at risk for type 1 diabetes.

Clin Immunol 2012 Dec 3;145(3):224-9. Epub 2012 Oct 3.

Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.clim.2012.09.010DOI Listing
December 2012

Clinical immunologic interventions for the treatment of type 1 diabetes.

Cold Spring Harb Perspect Med 2012 Aug 1;2(8). Epub 2012 Aug 1.

Université Paris Descartes, INSERM Unité 1013, Hôpital Necker Enfants Malades, Paris, France.

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http://dx.doi.org/10.1101/cshperspect.a007716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405831PMC
August 2012