Andy Hudmon

Andy Hudmon

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Andy Hudmon

Andy Hudmon

Publications by authors named "Andy Hudmon"

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Assemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spines.

Proc Natl Acad Sci U S A 2019 Sep 27;116(38):18937-18942. Epub 2019 Aug 27.

Center for Theoretical Biological Physics, Rice University, Houston, TX 77005;

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http://dx.doi.org/10.1073/pnas.1911452116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754556PMC
September 2019

Calcium/calmodulin-dependent protein kinase II regulation of I during sustained β-adrenergic receptor stimulation.

Heart Rhythm 2018 06 2;15(6):895-904. Epub 2018 Feb 2.

Department of Pharmacy Practice, College of Pharmacy, Purdue University, West Lafayette, Indiana; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984714PMC
June 2018

Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice.

Pain 2018 May;159(5):849-863

Biochemistry Interdisciplinary Graduate Program, Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, IN, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000001152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085107PMC
May 2018

Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth.

Bioorg Med Chem 2017 06 23;25(12):2995-3005. Epub 2017 Mar 23.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, United States; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668347PMC
June 2017

Structure-Based Target-Specific Screening Leads to Small-Molecule CaMKII Inhibitors.

ChemMedChem 2017 05 18;12(9):660-677. Epub 2017 Apr 18.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Van Nuys Medical Science Building, MS 4023, 635 Barnhill Drive, Indianapolis, IN, 46202-5122, USA.

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http://dx.doi.org/10.1002/cmdc.201600636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554713PMC
May 2017

Constitutive regulation of the glutamate/aspartate transporter EAAT1 by Calcium-Calmodulin-Dependent Protein Kinase II.

J Neurochem 2017 02 12;140(3):421-434. Epub 2017 Jan 12.

Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1111/jnc.13913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5257287PMC
February 2017

Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A.

J Neuroinflammation 2016 07 11;13(1):181. Epub 2016 Jul 11.

Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Dr., A449, Indianapolis, IN, 46202, USA.

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http://dx.doi.org/10.1186/s12974-016-0645-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940832PMC
July 2016

Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation.

Nat Commun 2016 06 23;7:12035. Epub 2016 Jun 23.

Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1038/ncomms12035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931030PMC
June 2016

Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress.

PLoS Pathog 2015 6;11(11):e1005268. Epub 2015 Nov 6.

Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636360PMC
April 2016

Novel Roles for Peroxynitrite in Angiotensin II and CaMKII Signaling.

Sci Rep 2016 Apr 15;6:23416. Epub 2016 Apr 15.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261 USA.

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http://dx.doi.org/10.1038/srep23416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832198PMC
April 2016

Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii.

PLoS One 2015 18;10(3):e0117966. Epub 2015 Mar 18.

Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America; Department of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117966PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364782PMC
February 2016

Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics.

Neuropharmacology 2015 Oct 10;97:464-75. Epub 2015 Jun 10.

Biochemistry Interdisciplinary Graduate Program, Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, IN, USA; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA; Gill Center for Biomolecular Science, Bloomington, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2015.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539046PMC
October 2015

CaMKII Controls Whether Touch Is Painful.

J Neurosci 2015 Oct;35(42):14086-102

Department of Anesthesiology and Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin 53295

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http://dx.doi.org/10.1523/JNEUROSCI.1969-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683679PMC
October 2015

Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or β1-Adrenergic Stimulation.

Circ Heart Fail 2015 May 4;8(3):595-604. Epub 2015 Mar 4.

From the Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison (C.W.T., P.A.P., R.L.M.); Department of Medical Physiology (C.W.T., Y.L., P.C.R., M.M.) and Neuroscience and Experimental Therapeutics (X.W.), Texas A&M University Health Science Center College of Medicine, Temple; Baylor Scott & White Health, Temple, TX (C.W.T.); Department of Physiology, Loyola University Chicago Stritch School of Medicine, IL (S.S.); Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (A.H.); and Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor (H.H.V.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439328PMC
May 2015

Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cells.

Biochem J 2014 Dec;464(2):251-8

*Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, U.S.A.

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http://dx.doi.org/10.1042/BJ20140845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418448PMC
December 2014

Regulation of voltage-gated Ca(2+) currents by Ca(2+)/calmodulin-dependent protein kinase II in resting sensory neurons.

Mol Cell Neurosci 2014 Sep 24;62:10-8. Epub 2014 Jul 24.

Medical College of Wisconsin, Department of Anesthesiology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; Zablocki VA Medical Center, 5000W. National Avenue, Milwaukee, WI 53295, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2014.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187344PMC
September 2014

Mitochondrial Ca2+ uniporter and CaMKII in heart.

Nature 2014 Sep;513(7519):E1-2

Department of Physiology, University of California San Francisco, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1038/nature13626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476531PMC
September 2014

Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases.

Proc Natl Acad Sci U S A 2013 Oct 7;110(43):17368-73. Epub 2013 Oct 7.

Department of Biochemistry and Molecular Biology, Department of Ophthalmology, Glick Eye Institute, and Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202.

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http://dx.doi.org/10.1073/pnas.1308236110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808603PMC
October 2013

Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP.

J Biol Chem 2013 May 29;288(20):14599-611. Epub 2013 Mar 29.

Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1074/jbc.M113.466235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656312PMC
May 2013

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.

J Physiol 2012 Oct 23;590(20):5123-39. Epub 2012 Jul 23.

Riley Heart Research Center, Department of Pediatrics Herman B. Wells Center for Pediatric Research & Department of Pharmacology and Toxicology, Indiana University School of Medicine, 1044 W. Walnut Street, R4 W302D, Indianapolis, IN 46202, USA.

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http://doi.wiley.com/10.1113/jphysiol.2012.235374
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http://dx.doi.org/10.1113/jphysiol.2012.235374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497567PMC
October 2012

Quantification of gene expression after painful nerve injury: validation of optimal reference genes.

J Mol Neurosci 2012 Mar 24;46(3):497-504. Epub 2011 Aug 24.

Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1007/s12031-011-9628-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273664PMC
March 2012

CaMKII in cerebral ischemia.

Acta Pharmacol Sin 2011 Jul 20;32(7):861-72. Epub 2011 Jun 20.

Department of Pharmacology, University of Colorado Denver-School of Medicine, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1038/aps.2011.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846291PMC
July 2011

Excitotoxic neuroprotection and vulnerability with CaMKII inhibition.

Mol Cell Neurosci 2011 Apr 21;46(4):720-30. Epub 2011 Feb 21.

Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1016/j.mcn.2011.02.003DOI Listing
April 2011

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.

Proc Natl Acad Sci U S A 2007 Dec 3;104(50):19767-72. Epub 2007 Dec 3.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0706233104
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http://dx.doi.org/10.1073/pnas.0706233104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148373PMC
December 2007

Displacement of alpha-actinin from the NMDA receptor NR1 C0 domain By Ca2+/calmodulin promotes CaMKII binding.

Biochemistry 2007 Jul 30;46(29):8485-97. Epub 2007 Jun 30.

Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242-1109, USA.

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http://dx.doi.org/10.1021/bi0623025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2547089PMC
July 2007

Head module control of mediator interactions.

Mol Cell 2006 Aug;23(3):355-64

Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.06.007DOI Listing
August 2006

Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons.

J Neurophysiol 2006 Jul 5;96(1):97-108. Epub 2006 Apr 5.

Department of Neurology, Yale University School of Medicine, New Heaven, CT, USA.

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http://www.physiology.org/doi/10.1152/jn.00854.2005
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http://dx.doi.org/10.1152/jn.00854.2005DOI Listing
July 2006

Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase.

J Neurosci 2005 Jul;25(28):6621-30

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0541-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725417PMC
July 2005

Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH.

J Biol Chem 2003 Nov 18;278(45):43897-900. Epub 2003 Sep 18.

Department of Structural Biology, Stanford University School of Medicine, California 94305-5400, USA.

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http://dx.doi.org/10.1074/jbc.C300417200DOI Listing
November 2003

Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function.

Annu Rev Biochem 2002 9;71:473-510. Epub 2001 Nov 9.

Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Stanford, California 94305, USA.

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http://dx.doi.org/10.1146/annurev.biochem.71.110601.135410DOI Listing
November 2002

Chemical quenched flow kinetic studies indicate an intraholoenzyme autophosphorylation mechanism for Ca2+/calmodulin-dependent protein kinase II.

J Biol Chem 2002 Jun 29;277(23):20991-8. Epub 2002 Mar 29.

Department of Neurobiology, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1074/jbc.M202154200DOI Listing
June 2002

Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.

Biochem J 2002 Jun;364(Pt 3):593-611

Department of Neurobiology, Fairchild Bldg, D217 299 Campus Drive, Stanford University Medical School, Stanford, CA 94305-5125, USA.

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http://dx.doi.org/10.1042/BJ20020228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222606PMC
June 2002