Andrey S Shaw

Andrey S Shaw

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Andrey S Shaw

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A systems mechanism for KRAS mutant allele-specific responses to targeted therapy.

Sci Signal 2019 Sep 24;12(600). Epub 2019 Sep 24.

Integrative Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scisignal.aaw8288DOI Listing
September 2019

Kinase domain dimerization drives RIPK3-dependent necroptosis.

Sci Signal 2018 08 21;11(544). Epub 2018 Aug 21.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/scisignal.aar2188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310155PMC
August 2018

Quantitative Systems Pharmacology Analysis of KRAS G12C Covalent Inhibitors.

CPT Pharmacometrics Syst Pharmacol 2018 05 25;7(5):342-351. Epub 2018 Mar 25.

Research Biology, Genentech, South San Francisco, California, USA.

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http://dx.doi.org/10.1002/psp4.12291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980551PMC
May 2018

The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection.

PLoS Pathog 2018 05 7;14(5):e1007053. Epub 2018 May 7.

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957453PMC
May 2018

TRP'ing up chronic kidney disease.

Science 2017 12;358(6368):1256-1257

Research Biology, Genentech, South San Francisco, CA, USA.

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http://dx.doi.org/10.1126/science.aar3572DOI Listing
December 2017

B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement.

JCI Insight 2017 11 2;2(21). Epub 2017 Nov 2.

Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1172/jci.insight.81836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752294PMC
November 2017

Injury-induced actin cytoskeleton reorganization in podocytes revealed by super-resolution microscopy.

JCI Insight 2017 Aug 17;2(16). Epub 2017 Aug 17.

Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1172/jci.insight.94137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621879PMC
August 2017

NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo.

J Immunol 2016 06 2;196(11):4805-13. Epub 2016 May 2.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110; Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, KS 66160.

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http://dx.doi.org/10.4049/jimmunol.1501982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875802PMC
June 2016

New approaches in renal microscopy: volumetric imaging and superresolution microscopy.

Curr Opin Nephrol Hypertens 2016 May;25(3):159-67

aDivision of Rheumatology, Department of Internal Medicine bDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA.

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http://dx.doi.org/10.1097/MNH.0000000000000220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910820PMC
May 2016

Real-Time Analysis of Calcium Signals during the Early Phase of T Cell Activation Using a Genetically Encoded Calcium Biosensor.

J Immunol 2016 Feb 8;196(4):1471-9. Epub 2016 Jan 8.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110; Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110;

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http://www.jimmunol.org/content/early/2016/01/07/jimmunol.15
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1502414
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http://dx.doi.org/10.4049/jimmunol.1502414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744592PMC
February 2016

Role of NKG2D in obesity-induced adipose tissue inflammation and insulin resistance.

PLoS One 2014 15;9(10):e110108. Epub 2014 Oct 15.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110108PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198197PMC
December 2015

Integration of signaling in the kinome: Architecture and regulation of the αC Helix.

Biochim Biophys Acta 2015 Oct 17;1854(10 Pt B):1567-74. Epub 2015 Apr 17.

Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, 0654, La Jolla, CA 92093, San Diego, USA.

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http://dx.doi.org/10.1016/j.bbapap.2015.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577442PMC
October 2015

Clinical phenotype of APOL1 nephropathy in young relatives of patients with end-stage renal disease.

Pediatr Nephrol 2015 Jun 23;30(6):983-9. Epub 2014 Dec 23.

Department of Pediatrics (Pediatric Nephrology), Washington University School of Medicine, 5th Fl MPRB, 660 South Euclid Avenue, Campus Box 8208, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s00467-014-3031-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406792PMC
June 2015

What is the point of pseudokinases?

Elife 2015 May 6;4:e07771. Epub 2015 May 6.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, United States

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http://elifesciences.org/content/4/e07771.full.pdf
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http://elifesciences.org/lookup/doi/10.7554/eLife.07771
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http://dx.doi.org/10.7554/eLife.07771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421857PMC
May 2015

New lamp posts allow for new views of the immunological synapse.

Immunity 2015 May;42(5):781-3

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.05.008DOI Listing
May 2015

Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.

Mol Neurodegener 2015 Mar 19;10:12. Epub 2015 Mar 19.

Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1186/s13024-015-0006-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374406PMC
March 2015

Kinase regulation by hydrophobic spine assembly in cancer.

Mol Cell Biol 2015 Jan 27;35(1):264-76. Epub 2014 Oct 27.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri, USA

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http://dx.doi.org/10.1128/MCB.00943-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295384PMC
January 2015

Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.

Sci Signal 2014 Aug 5;7(337):ra74. Epub 2014 Aug 5.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Department of Pathology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.

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http://dx.doi.org/10.1126/scisignal.2005147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269470PMC
August 2014

Neonatal Fc receptor promotes immune complex-mediated glomerular disease.

J Am Soc Nephrol 2014 May 19;25(5):918-25. Epub 2013 Dec 19.

Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee

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http://www.jasn.org/cgi/doi/10.1681/ASN.2013050498
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http://dx.doi.org/10.1681/ASN.2013050498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005300PMC
May 2014

Kinases and pseudokinases: lessons from RAF.

Mol Cell Biol 2014 May 24;34(9):1538-46. Epub 2014 Feb 24.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/MCB.00057-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993607PMC
May 2014

CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production.

J Immunol 2013 Dec 11;191(12):5933-40. Epub 2013 Nov 11.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1300454
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http://dx.doi.org/10.4049/jimmunol.1300454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858535PMC
December 2013

Immunology. Do T cells have a cilium?

Science 2013 Dec;342(6163):1177-8

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/science.1248078DOI Listing
December 2013

Albuminuria associated with CD2AP knockout mice is primarily due to dysfunction of the renal degradation pathway processing of filtered albumin.

FEBS Lett 2013 Nov 15;587(22):3738-41. Epub 2013 Oct 15.

SalAqua Inc, Suite 277, 331 W 57th St, New York, NY 10019, United States.

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http://dx.doi.org/10.1016/j.febslet.2013.09.045DOI Listing
November 2013

Nanoscale protein architecture of the kidney glomerular basement membrane.

Elife 2013 Oct 8;2:e01149. Epub 2013 Oct 8.

Department of Pathology and Immunology , Washington University School of Medicine , St. Louis , United States.

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http://dx.doi.org/10.7554/eLife.01149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790497PMC
October 2013

Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells.

PLoS One 2013 19;8(2):e57137. Epub 2013 Feb 19.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057137PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576348PMC
August 2013

Allosteric activation of functionally asymmetric RAF kinase dimers.

Cell 2013 Aug;154(5):1036-1046

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Box 8118, St. Louis, MO 63110, USA; Howard Hughes Medical Institute, Washington University School of Medicine, 660 South Euclid, Box 8118, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.07.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844432PMC
August 2013

Heterogeneous distribution of natural zinc isotopes in mice.

Metallomics 2013 Jun;5(6):693-9

Department of Earth and Planetary Science and McDonnell Center for Space Sciences, Washington University, St Louis, USA.

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http://dx.doi.org/10.1039/c3mt00008gDOI Listing
June 2013

CD2AP links cortactin and capping protein at the cell periphery to facilitate formation of lamellipodia.

Mol Cell Biol 2013 Jan 22;33(1):38-47. Epub 2012 Oct 22.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/MCB.00734-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536300PMC
January 2013

A dual function of NKG2D ligands in NK-cell activation.

Eur J Immunol 2012 Sep 27;42(9):2452-8. Epub 2012 Jul 27.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/eji.201141849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641666PMC
September 2012

Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking.

Mol Biol Cell 2012 Sep 18;23(17):3370-9. Epub 2012 Jul 18.

Department of Pathology, Haartman Institute, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1091/mbc.E11-12-1010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431928PMC
September 2012

Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells.

J Immunol 2012 Jun 23;188(11):5421-7. Epub 2012 Apr 23.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.1200242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358357PMC
June 2012

SAP signaling: a dual mechanism of action.

Immunity 2012 Jun;36(6):899-901

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.06.002DOI Listing
June 2012

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.

Proc Natl Acad Sci U S A 2011 Apr 25;108(15):6067-72. Epub 2011 Mar 25.

Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 660 South Euclid, Box 8118, St Louis, MO 63110, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1102554108
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http://dx.doi.org/10.1073/pnas.1102554108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076888PMC
April 2011

Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection.

Eur J Immunol 2010 Nov 24;40(11):3226-34. Epub 2010 Sep 24.

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.

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http://dx.doi.org/10.1002/eji.201040349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976810PMC
November 2010

Understanding the structure and function of the immunological synapse.

Cold Spring Harb Perspect Biol 2010 Oct 15;2(10):a002311. Epub 2010 Sep 15.

Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, New York 10016, USA.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a002311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944359PMC
October 2010

Immunology. CAR'ing for the skin.

Science 2010 Sep;329(5996):1154-5

Department of Pathology and Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/science.1195337DOI Listing
September 2010

The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.

FASEB J 2010 Aug 30;24(8):2818-28. Epub 2010 Mar 30.

Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA.

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http://dx.doi.org/10.1096/fj.09-144295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909277PMC
August 2010

TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes.

J Am Soc Nephrol 2009 Oct 13;20(10):2127-37. Epub 2009 Aug 13.

Division of Nephrology, Department of Medicine, Charles R Bronfman Institute for Personalized Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1681/ASN.2008070806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754100PMC
October 2009

The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization.

J Immunol 2009 Jul 24;183(2):1215-21. Epub 2009 Jun 24.

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0803887
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http://dx.doi.org/10.4049/jimmunol.0803887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837933PMC
July 2009

New roles revealed for T cells and DCs in glomerulonephritis.

J Clin Invest 2009 May;119(5):1074-6

Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673880PMC
http://dx.doi.org/10.1172/jci39071DOI Listing
May 2009

KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs.

Mol Cell Biol 2009 Apr 2;29(8):2082-91. Epub 2009 Feb 2.

Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/MCB.01634-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663292PMC
April 2009

The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse.

Mol Cell Biol 2009 Mar 12;29(6):1554-64. Epub 2009 Jan 12.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/MCB.01421-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648244PMC
March 2009

IL-12 enhances CTL synapse formation and induces self-reactivity.

J Immunol 2009 Feb;182(3):1351-61

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630174PMC
http://dx.doi.org/10.4049/jimmunol.182.3.1351DOI Listing
February 2009

The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage.

Dev Biol 2009 Jan 31;325(1):211-24. Epub 2008 Oct 31.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ydbio.2008.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634829PMC
January 2009

Scaffold proteins and immune-cell signalling.

Nat Rev Immunol 2009 Jan;9(1):47-56

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Saint Louis, Missouri 63110, USA.

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http://www.nature.com/articles/nri2473
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http://dx.doi.org/10.1038/nri2473DOI Listing
January 2009

Regulated movement of CD4 in and out of the immunological synapse.

J Immunol 2008 Dec;181(12):8248-57

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857686PMC
http://dx.doi.org/10.4049/jimmunol.181.12.8248DOI Listing
December 2008

CD45 down-regulates Lck-mediated CD44 signaling and modulates actin rearrangement in T cells.

J Immunol 2008 Nov;181(10):7033-43

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4049/jimmunol.181.10.7033DOI Listing
November 2008

The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality.

Immunity 2008 Sep 28;29(3):414-22. Epub 2008 Aug 28.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.immuni.2008.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962836PMC
September 2008

How T cells 'find' the right dendritic cell.

Authors:
Andrey S Shaw

Nat Immunol 2008 Mar;9(3):229-30

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http://dx.doi.org/10.1038/ni0308-229DOI Listing
March 2008

Podocytes use FcRn to clear IgG from the glomerular basement membrane.

Proc Natl Acad Sci U S A 2008 Jan 15;105(3):967-72. Epub 2008 Jan 15.

Department of Pathology and Immunology, Renal Division, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.0711515105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242706PMC
January 2008

Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse.

Mol Cell Biol 2007 Dec 8;27(24):8583-99. Epub 2007 Oct 8.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/MCB.01477-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169389PMC
December 2007

Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism.

J Immunol 2007 Oct;179(7):4580-8

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.179.7.4580DOI Listing
October 2007

Scaffold proteins confer diverse regulatory properties to protein kinase cascades.

Proc Natl Acad Sci U S A 2007 Aug 8;104(33):13307-12. Epub 2007 Aug 8.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0706311104
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http://dx.doi.org/10.1073/pnas.0706311104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948937PMC
August 2007

Lipid rafts: now you see them, now you don't.

Authors:
Andrey S Shaw

Nat Immunol 2006 Nov;7(11):1139-42

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/ni1405DOI Listing
November 2006

The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis.

J Immunol 2006 Nov;177(9):6152-8

Department of Pathology and Department of Immunology, Washington University School of Medicine, 660 South Euclid, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.177.9.6152DOI Listing
November 2006

Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation.

J Immunol 2006 Sep;177(5):3260-5

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.177.5.3260DOI Listing
September 2006

T-cell activation and immunologic synapse.

Authors:
Andrey S Shaw

Immunol Res 2005 ;32(1-3):247-52

Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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August 2006

Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier.

J Clin Invest 2006 Aug;116(8):2272-9

Renal Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI28414
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523402PMC
August 2006

Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics.

J Immunol 2006 Aug;177(4):2349-55

Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.177.4.2349DOI Listing
August 2006

Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein.

J Biol Chem 2006 Jul 16;281(28):19196-203. Epub 2006 May 16.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M600166200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581424PMC
July 2006

Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.

J Clin Invest 2006 May 20;116(5):1337-45. Epub 2006 Apr 20.

Department of Pathology and Immunology and Department of Medicine, Renal Division, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1172/JCI27400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440708PMC
May 2006

Glomerular expression of transforming growth factor-beta (TGF-beta) isoforms in mice lacking CD2-associated protein.

Pediatr Nephrol 2006 Mar 31;21(3):333-8. Epub 2005 Dec 31.

Section of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA.

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http://dx.doi.org/10.1007/s00467-005-2102-7DOI Listing
March 2006

The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence.

Mol Cell Biol 2006 Mar;26(6):2202-14

University of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198-7696, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.26.6.2202-2214.2006
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430273PMC
March 2006

Association of CD2AP with dynamic actin on vesicles in podocytes.

Am J Physiol Renal Physiol 2005 Nov 14;289(5):F1134-43. Epub 2005 Jun 14.

Department of Anatomy and Cell Biology, University of Heidelberg, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1152/ajprenal.00178.2005DOI Listing
November 2005

CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency.

J Biol Chem 2005 Aug 10;280(33):29677-81. Epub 2005 Jun 10.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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August 2005

The c-SMAC: sorting it all out (or in).

J Cell Biol 2005 Jul 11;170(2):177-82. Epub 2005 Jul 11.

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200503032
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171426PMC
July 2005

Getting downstream without a Raft.

Cell 2005 Jun;121(6):815-6

Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid, Box 8118, Saint Louis, Missouri 63110, USA.

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June 2005

Live Cell Imaging of ERK and MEK: simple binding equilibrium explains the regulated nucleocytoplasmic distribution of ERK.

J Biol Chem 2005 Feb 16;280(5):3832-7. Epub 2004 Nov 16.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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February 2005

MAPK p38 alpha is dispensable for lymphocyte development and proliferation.

J Immunol 2005 Feb;174(3):1239-44

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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February 2005

A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis.

J Biol Chem 2004 Aug 22;279(35):37004-12. Epub 2004 Jun 22.

Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10461, USA.

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August 2004

Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155).

J Immunol 2004 Apr;172(7):3994-8

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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April 2004

The immunological synapse balances T cell receptor signaling and degradation.

Science 2003 Nov 25;302(5648):1218-22. Epub 2003 Sep 25.

Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/science.1086507DOI Listing
November 2003

In silico models for cellular and molecular immunology: successes, promises and challenges.

Nat Immunol 2003 Oct;4(10):933-6

Department of Chemical Engineering, University of California, Berkeley, California 94720, USA.

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http://www.nature.com/articles/ni1003-933
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October 2003

Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy.

J Biol Chem 2003 Sep 10;278(38):35940-9. Epub 2003 Jul 10.

Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97239, USA.

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September 2003