Publications by authors named "Andrew V Kossenkov"

100Publications

Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment.

Dev Cell 2020 Aug 10. Epub 2020 Aug 10.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA 19104, USA; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.07.014DOI Listing
August 2020

Sialyl-Lewis Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy.

Cell Rep 2020 Aug;32(5):107991

The Wistar Institute, Philadelphia, PA 19104, USA; Penn Center for AIDS Research (Penn CFAR), University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432956PMC
August 2020

The G protein coupled receptor CCR5 in cancer.

Adv Cancer Res 2020 10;145:29-47. Epub 2020 Jan 10.

Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Pennsylvania Biotechnology Center, Wynnewood, PA, United States; Wistar Institute, Philadelphia, PA, United States; Xavier University School of Medicine, Woodbury, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2019.11.001DOI Listing
September 2020

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

Mol Cell 2020 02 11;77(3):633-644.e5. Epub 2019 Dec 11.

Immunology, Microenvironment and Metastasis, The Wistar Institute, Philadelphia, PA, 19104, U.S.A.; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419227PMC
February 2020

Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology.

Cancer Res 2019 10 10;79(19):4801-4807. Epub 2019 Jul 10.

Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Pennsylvania Biotechnology Center, Wynnewood, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-1167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810651PMC
October 2019

The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer.

Carcinogenesis 2020 03;41(1):67-77

Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/carcin/bgz087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316406PMC
March 2020

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.

Matrix Biol 2018 09 9;70:20-35. Epub 2018 Mar 9.

Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081240PMC
September 2018

RNA-Seq of Kaposi's sarcoma reveals alterations in glucose and lipid metabolism.

PLoS Pathog 2018 01 19;14(1):e1006844. Epub 2018 Jan 19.

Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792027PMC
January 2018

A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy.

Oncotarget 2017 Dec 11;8(68):112184-112198. Epub 2017 Dec 11.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.23097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762502PMC
December 2017

Baseline Immunoglobulin E Levels as a Marker of Doxorubicin- and Trastuzumab-Associated Cardiac Dysfunction.

Circ Res 2016 Oct 31;119(10):1135-1144. Epub 2016 Aug 31.

From the Center for Systems and Computational Biology, and Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA (L.A.B., A.V.K., Q.L., D.W.S.); Department of Pathology and Laboratory Medicine (E.L.P.), Division of Hematology and Oncology (S.D.), Abramson Cancer Center (S.D., B.K.), and Division of Cardiovascular Medicine (B.K.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085891PMC
http://dx.doi.org/10.1161/CIRCRESAHA.116.309004DOI Listing
October 2016

TIGIT and Helios Are Highly Expressed on CD4 T Cells in Sézary Syndrome Patients.

J Invest Dermatol 2017 01 1;137(1):257-260. Epub 2016 Sep 1.

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.jid.2016.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358509PMC
January 2017

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.

Cancer Cell 2016 08;30(2):257-272

Prostate Cancer Discovery and Development Program, Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131882PMC
August 2016

Unlinking an lncRNA from Its Associated cis Element.

Mol Cell 2016 Apr 31;62(1):104-10. Epub 2016 Mar 31.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877494PMC
April 2016

The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis.

Nat Commun 2016 Feb 12;7:10715. Epub 2016 Feb 12.

Department of Tumor Microenvironment and Metastasis, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ncomms10715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754346PMC
February 2016

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.

Proc Natl Acad Sci U S A 2015 Jul 29;112(28):8638-43. Epub 2015 Jun 29.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA 19104; Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1500722112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507184PMC
July 2015

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

J Natl Cancer Inst 2015 Mar 3;107(3). Epub 2015 Feb 3.

Prostate Cancer Discovery and Development Program (JCG, MT, YCC, SL, MCC, JHS, LRL, DCA), Tumor Microenvironment and Metastasis Program (JCG, MT, YCC, SL, MCC, JHS, DCA), Center for Systems and Computational Biology (AVK), and Center for Chemical Biology and Translational Medicine (DCS), The Wistar Institute, Philadelphia, PA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY (MDS); Istituto Nazionale Genetica Molecolare "Romeo and Enrica Invernizzi," Milan, Italy (VV); Division of Pathology (VV, AF, SB), Division of Neurosurgery (PR), and Division of Surgery (MG), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Metabolon, Inc. Durham, NC (RDM); Department of Pathophysiology and Organ Transplant, University of Milan, Milan, Italy (SB); Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA (LRL).

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http://dx.doi.org/10.1093/jnci/dju502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565533PMC
March 2015

ID1 promotes breast cancer metastasis by S100A9 regulation.

Mol Cancer Res 2014 Sep 19;12(9):1334-43. Epub 2014 Jun 19.

The Wistar Institute, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163515PMC
September 2014

Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark.

Nucleic Acids Res 2014 Jun 26;42(11):7028-38. Epub 2014 May 26.

Fox Chase Cancer Center, Philadelphia, PA, 19111 USA

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http://dx.doi.org/10.1093/nar/gku415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066802PMC
June 2014

O-linked β-N-acetylglucosamine (O-GlcNAc) site thr-87 regulates synapsin I localization to synapses and size of the reserve pool of synaptic vesicles.

J Biol Chem 2014 Feb 26;289(6):3602-12. Epub 2013 Nov 26.

From the Department of Biochemistry, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102.

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http://dx.doi.org/10.1074/jbc.M113.512814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916560PMC
February 2014

The peripheral immune response and lung cancer prognosis.

Oncoimmunology 2012 Nov;1(8):1414-1416

The Wistar Institute; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/onci.21096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518521PMC
November 2012

Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles.

BMC Med Genomics 2012 Sep 6;5:39. Epub 2012 Sep 6.

Department of Surgery, Division of Endocrine and Oncologic Surgery, Rena Rowan Breast Center, Abramson Cancer Center, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1186/1755-8794-5-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505468PMC
September 2012

Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer.

Cancer Res 2012 Jul 14;72(13):3251-9. Epub 2012 May 14.

Prostate Cancer Discovery and Development Program, Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-4035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695608PMC
July 2012