Andrew Tutt

Andrew Tutt

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Andrew Tutt

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Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.

NPJ Breast Cancer 2020 12;6:17. Epub 2020 May 12.

21Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC Australia.

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http://dx.doi.org/10.1038/s41523-020-0156-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217863PMC
May 2020

Controversial issues in the neoadjuvant treatment of triple-negative breast cancer.

Ther Adv Med Oncol 2019 1;11:1758835919882581. Epub 2019 Nov 1.

Breast Cancer Now Research Centre, Institute of Cancer Research, London, UK Faculty of Life Sciences and Medicine, King's College London, London, UK.

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http://dx.doi.org/10.1177/1758835919882581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826917PMC
November 2019

Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer.

Cell Rep 2019 05;27(7):1967-1978.e4

Richard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, Kings College London, London, UK; Breast Cancer Now Research Unit, King's College London, Guy's Hospital, London, UK; UCL Cancer Institute, University College London, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193055
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http://dx.doi.org/10.1016/j.celrep.2019.04.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527923PMC
May 2019

Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells.

Front Immunol 2018 23;9:493. Epub 2018 Mar 23.

St. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.00493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876289PMC
April 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41586-019-0883-2
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http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells.

Cancer Immunol Res 2018 04 22;6(4):448-457. Epub 2018 Jan 22.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Portugal.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0327DOI Listing
April 2018

Engineering and stable production of recombinant IgE for cancer immunotherapy and AllergoOncology.

J Allergy Clin Immunol 2018 04 31;141(4):1519-1523.e9. Epub 2018 Jan 31.

St John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London, United Kingdom; NIHR Biomedical Research Centre at Guy's and St Thomas's Hospitals and King's College London, London, United Kingdom; Breast Cancer Now Unit, School of Cancer & Pharmaceutical Sciences, King's College London, Guy's Cancer Centre, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.12.986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286379PMC
April 2018

Driver Oncogenes but Not as We Know Them: Targetable Fusion Genes in Breast Cancer.

Cancer Discov 2018 03;8(3):272-275

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372062PMC
March 2018

Chondroitin Sulfate Proteoglycan 4 and Its Potential As an Antibody Immunotherapy Target across Different Tumor Types.

Front Immunol 2017 10;8:1911. Epub 2018 Jan 10.

St. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London & NIHR Biomedical Research Centre at Guy's and St. Thomas' Hospitals and King's College London, Guy's Hospital, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2017.01911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767725PMC
January 2018

Histological scoring of immune and stromal features in breast and axillary lymph nodes is prognostic for distant metastasis in lymph node-positive breast cancers.

J Pathol Clin Res 2018 Jan 8;4(1):39-54. Epub 2018 Jan 8.

School of Cancer and Pharmaceutical SciencesCRUK King's Health Partners Centre, King's College London, Innovation Hub, Cancer Centre at Guy's Hospital, Great Maze PondLondonUK.

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http://dx.doi.org/10.1002/cjp2.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783956PMC
January 2018

Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.

Mol Cancer Ther 2017 11 22;16(11):2410-2421. Epub 2017 Aug 22.

King's College London, School of Cancer Sciences, New Hunt's House, Guy's Campus, Great Maze Pond, London, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0077DOI Listing
November 2017

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs).

Oncoimmunology 2018 20;7(3):e1395127. Epub 2017 Nov 20.

St. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Tower Wing, Guy's Hospital, London, United Kingdom.

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http://dx.doi.org/10.1080/2162402X.2017.1395127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769674PMC
November 2017

Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.

PLoS One 2016 10;11(5):e0155391. Epub 2016 May 10.

Department of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155391PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862684PMC
July 2017

Molecular alterations in triple-negative breast cancer-the road to new treatment strategies.

Lancet 2017 Jun 7;389(10087):2430-2442. Epub 2016 Dec 7.

German Breast Group, Neu-Isenburg, Germany.

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http://dx.doi.org/10.1016/S0140-6736(16)32454-0DOI Listing
June 2017

Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment.

J Immunol Res 2016 12;2016:7803091. Epub 2016 Oct 12.

Breast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK; Richard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, King's College London, Guy's Medical School Campus, London SE1 1ULK, UK; UCL Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK.

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http://dx.doi.org/10.1155/2016/7803091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110869PMC
March 2017

Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survival.

Sci Rep 2017 01 6;7:40177. Epub 2017 Jan 6.

Guy's and St Thomas' NHS Foundation Trust and King's College London NIHR Biomedical Research Centre - Translational Bioinformatics Platform, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1038/srep40177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216415PMC
January 2017

Tandem duplications contribute to not one but two distinct phenotypes.

Proc Natl Acad Sci U S A 2016 09 19;113(36):E5257-8. Epub 2016 Aug 19.

Cancer Bioinformatics, King's College London, London SE1 9RT, United Kingdom; Breast Cancer Now Research Unit, King's College London, London SE1 9RT, United Kingdom; Division of Cancer Studies, King's Health Partners Academic Health Science Centre, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1610228113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018800PMC
September 2016

Targeting folate receptor alpha for cancer treatment.

Oncotarget 2016 08;7(32):52553-52574

St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, Faculty of Life Sciences and Medicine, King's College London & NIHR Biomedical Research Centre at Guy's and St. Thomas' Hospitals and King's College London, Guy's Hospital, London, United Kingdom.

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http://dx.doi.org/10.18632/oncotarget.9651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239573PMC
August 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature17676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors.

Annu Rev Med 2015 17;66:455-70. Epub 2014 Oct 17.

The Breakthrough Breast Cancer Research Center, The Institute of Cancer Research, London, United Kingdom and.

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http://dx.doi.org/10.1146/annurev-med-050913-022545DOI Listing
September 2015

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.

Mol Oncol 2015 Aug 20;9(7):1274-86. Epub 2015 Mar 20.

Department of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands; Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528812PMC
August 2015

New approaches for improving outcomes in breast cancer in Europe.

Breast 2015 Aug 31;24(4):321-30. Epub 2015 Mar 31.

Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.breast.2015.03.001DOI Listing
August 2015

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.

Cancer Discov 2015 May 13;5(5):488-505. Epub 2015 Mar 13.

Breakthrough Breast Cancer Research Unit, King's College London, London, United Kingdom. Department of Research Oncology, King's Health Partners AHSC, Life Sciences and Medicine, King's College London, London, United Kingdom. The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490184PMC
May 2015

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

Sci Signal 2014 Aug 19;7(339):ra78. Epub 2014 Aug 19.

Richard Dimbleby Department of Cancer Research, Randall Division of Cell and Molecular Biophysics, King's College London, Guy's Medical School Campus, London SE1 1UL, UK. Division of Cancer Studies, King's College London, London SE1 1UL, UK. Breakthrough Breast Cancer Research Unit, Research Oncology, King's College London, Guy's Hospital, London SE1 9RT, UK. UCL Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1126/scisignal.2005157DOI Listing
August 2014

Changes in primary breast cancer heterogeneity may augment midtreatment MR imaging assessment of response to neoadjuvant chemotherapy.

Radiology 2014 Jul 19;272(1):100-12. Epub 2014 Mar 19.

From the Departments of Radiology (J.P., H.V., V.G.), Clinical Oncology (J.G., A.T.), and Medical Oncology (J.M., M.H.), Guys and St Thomas' Hospitals NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, England; Division of Imaging Sciences and Biomedical Engineering, King's College, London, England (M.S., G.C., V.G.); and Institute of Nuclear Medicine, University College London, London, England (B.G.).

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http://pubs.rsna.org/doi/10.1148/radiol.14130569
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http://dx.doi.org/10.1148/radiol.14130569DOI Listing
July 2014

A novel model of dormancy for bone metastatic breast cancer cells.

Cancer Res 2013 Dec 21;73(23):6886-99. Epub 2013 Oct 21.

Authors' Affiliations: Stem Cell Group, Breakthrough Breast Cancer Research Unit, Research Oncology, King's College London School of Medicine, Guy's Hospital; Department of Craniofacial Development and Stem Cell Biology, King's College London, Guy's Hospital; Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, London, United Kingdom; and Rutgers New Jersey Medical School, Newark, New Jersey.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0991DOI Listing
December 2013

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Breast Cancer Res 2013 Oct 1;15(5):R92. Epub 2013 Oct 1.

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http://dx.doi.org/10.1186/bcr3493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907091PMC
October 2013

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

Comparison of basal-like triple-negative breast cancer defined by morphology, immunohistochemistry and transcriptional profiles.

Mod Pathol 2013 Jul 8;26(7):955-66. Epub 2013 Feb 8.

Breakthrough Breast Cancer Research Unit, King's College London, School of Medicine, Division of Cancer Studies, Bermondsey Wing, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1038/modpathol.2012.244DOI Listing
July 2013

Differences in breast cancer hormone receptor status in ethnic groups: a London population.

Eur J Cancer 2013 Feb 8;49(3):696-702. Epub 2012 Oct 8.

King's College London, Thames Cancer Registry, 1st Floor Capital House, 42 Weston Street, London SE1 3QD, United Kingdom.

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http://dx.doi.org/10.1016/j.ejca.2012.09.012DOI Listing
February 2013

Molecular characterisation of cell line models for triple-negative breast cancers.

BMC Genomics 2012 Nov 14;13:619. Epub 2012 Nov 14.

Breakthrough Breast Cancer Research Unit, Guy's Hospital, King's Health Partners AHSC, King's College London School of Medicine, London SE1 9RT, UK.

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http://dx.doi.org/10.1186/1471-2164-13-619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546428PMC
November 2012

Profiling the immune stromal interface in breast cancer and its potential for clinical impact.

Breast Care (Basel) 2012 Aug;7(4):273-80

Breakthrough Breast Cancer Research Unit, Guy's Hospital, Kings College London; Kings Health Partners AHSC, London, UK.

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http://dx.doi.org/10.1159/000341529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515791PMC
August 2012

Prognosis of metachronous contralateral breast cancer: importance of stage, age and interval time between the two diagnoses.

Breast Cancer Res Treat 2011 Nov 14;130(2):609-18. Epub 2011 Jun 14.

Cancer Epidemiology Group, Division of Cancer Studies, School of Medicine, King's College London, London, UK.

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http://dx.doi.org/10.1007/s10549-011-1618-8DOI Listing
November 2011

Molecular heterogeneity of triple-negative breast cancer and its clinical implications.

Curr Opin Oncol 2011 Nov;23(6):566-77

Breakthrough Breast Cancer Research Unit, Research Oncology, Kings College London School of Medicine, Kings Health Partners AHSC, London, UK.

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https://insights.ovid.com/crossref?an=00001622-201111000-000
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http://dx.doi.org/10.1097/CCO.0b013e32834bf8aeDOI Listing
November 2011

DART: Denoising Algorithm based on Relevance network Topology improves molecular pathway activity inference.

BMC Bioinformatics 2011 Oct 19;12:403. Epub 2011 Oct 19.

Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-12-403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228554PMC
October 2011

PARP inhibitors--current status and the walk towards early breast cancer.

Breast 2011 Oct;20 Suppl 3:S12-9

Guy's and St Thomas's Hospitals and Breakthrough Breast Cancer Research Unit Kings Health Partners AHSC, Research Oncology, 3(rd) Floor Bermondsey Wing, Guys Hospital, Great Maze Pond, London SE1 9RT, UK.

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http://dx.doi.org/10.1016/S0960-9776(11)70288-0DOI Listing
October 2011

Risk factors for metachronous contralateral breast cancer suggest two aetiological pathways.

Eur J Cancer 2011 Sep 12;47(13):1919-27. Epub 2011 Jun 12.

King's College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London SE1 9RT, UK.

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http://dx.doi.org/10.1016/j.ejca.2011.05.004DOI Listing
September 2011

Therapeutic potential of PARP inhibitors for metastatic breast cancer.

Expert Rev Anticancer Ther 2011 Aug;11(8):1243-51

Breakthrough Breast Cancer Unit Research Oncology, 3rd Floor Bermondsey Wing, Guy's Hospital Campus, Kings College London School of Medicine, London, SE1 9RT, UK.

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http://dx.doi.org/10.1586/era.11.52DOI Listing
August 2011

Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers.

Cancer Discov 2011 Jun 1;1(1):29-34. Epub 2011 Jun 1.

Breast Cancer Center, Medical Oncology Department, University Hospital Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1158/2159-8274.CD-11-0048DOI Listing
June 2011

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.

Cell Stem Cell 2010 Sep;7(3):403-17

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.stem.2010.07.010DOI Listing
September 2010

Comparative Membranome expression analysis in primary tumors and derived cell lines.

PLoS One 2010 Jul 23;5(7):e11742. Epub 2010 Jul 23.

CRS4 Bioinformatics Laboratory, Parco Scientifico e Tecnologico POLARIS, Pula, Cagliari, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011742PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909215PMC
July 2010

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

N Engl J Med 2009 Jul 24;361(2):123-34. Epub 2009 Jun 24.

Drug Development Unit, Royal Marsden National Health Service Foundation Trust and the Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa0900212DOI Listing
July 2009

Can genetic testing guide treatment in breast cancer?

Eur J Cancer 2008 Dec 20;44(18):2774-80. Epub 2008 Nov 20.

Breakthrough Breast Cancer Research Unit, 3rd Floor Bermondsey Wing Guy's Hospital Campus, Kings College London, London, UK.

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http://dx.doi.org/10.1016/j.ejca.2008.10.009DOI Listing
December 2008

Adjuvant radiotherapy for breast cancer.

BMJ 2008 Dec 30;337:a2843. Epub 2008 Dec 30.

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http://dx.doi.org/10.1136/bmj.a2843DOI Listing
December 2008

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.

EMBO J 2008 May 3;27(9):1368-77. Epub 2008 Apr 3.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/emboj.2008.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374839PMC
May 2008