Andrew Tinker

Andrew Tinker

UNVERIFIED PROFILE

Are you Andrew Tinker?   Register this Author

Register author
Andrew Tinker

Andrew Tinker

Publications by authors named "Andrew Tinker"

Are you Andrew Tinker?   Register this Author

100Publications

1450Reads

14Profile Views

Potassium channels in the sinoatrial node and their role in heart rate control.

Channels (Austin) 2018 ;12(1):356-366

a William Harvey Heart Centre, Barts & The London School of Medicine & Dentistry , Queen Mary, University of London , London , UK.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/19336950.2018.1
Publisher Site
http://dx.doi.org/10.1080/19336950.2018.1532255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207292PMC
August 2019

Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages.

Physiol Genomics 2019 Aug 7;51(8):323-332. Epub 2019 Jun 7.

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00012.2019DOI Listing
August 2019

Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function.

Hum Mol Genet 2019 Aug 19. Epub 2019 Aug 19.

Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddz198DOI Listing
August 2019

Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome.

Am J Physiol Cell Physiol 2019 Jul 10. Epub 2019 Jul 10.

William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00028.2019DOI Listing
July 2019

Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals.

Authors:
Raymond Noordam William J Young Reem Salman Jørgen K Kanters Marten E van den Berg Diana van Heemst Henry J Lin Sandhi Maria Barreto Mary L Biggs Ginevra Biino Eulalia Catamo Maria Pina Concas Jun Ding Daniel S Evans Luisa Foco Niels Grarup Leo-Pekka Lyytikäinen Massimo Mangino Hao Mei Peter J van der Most Martina Müller-Nurasyid Christopher P Nelson Yong Qian Linda Repetto M Abdullah Said Nabi Shah Katharina Schramm Pedro G Vidigal Stefan Weiss Jie Yao Nuno R Zilhao Jennifer A Brody Peter S Braund Marco Brumat Eric Campana Paraskevi Christofidou Mark J Caulfield Alessandro De Grandi Anna F Dominiczak Alex S F Doney Gudny Eiriksdottir Christina Ellervik Luana Giatti Martin Gögele Claus Graff Xiuqing Guo Pim van der Harst Peter K Joshi Mika Kähönen Bryan Kestenbaum Maria F Lima-Costa Allan Linneberg Arie C Maan Thomas Meitinger Sandosh Padmanabhan Cristian Pattaro Annette Peters Astrid Petersmann Peter Sever Mortiz F Sinner Xia Shen Alice Stanton Konstantin Strauch Elsayed Z Soliman Kirill V Tarasov Kent D Taylor Chris H L Thio André G Uitterlinden Simona Vaccargiu Melanie Waldenberger Antonietta Robino Adolfo Correa Francesco Cucca Steven R Cummings Marcus Dörr Giorgia Girotto Vilmundur Gudnason Torben Hansen Susan R Heckbert Christian R Juhl Stefan Kääb Terho Lehtimäki Yongmei Liu Paulo A Lotufo Colin N A Palmer Mario Pirastu Peter P Pramstaller Antonio Luiz P Ribeiro Jerome I Rotter Nilesh J Samani Harold Snieder Tim D Spector Bruno H Stricker Niek Verweij James F Wilson James G Wilson J Wouter Jukema Andrew Tinker Christopher H Newton-Cheh Nona Sotoodehnia Dennis O Mook-Kanamori Patricia B Munroe Helen R Warren

J Am Coll Cardiol 2019 Jun;73(24):3118-3131

Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2019.03.519DOI Listing
June 2019

Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method.

J Cardiovasc Electrophysiol 2019 May 5;30(5):691-701. Epub 2019 Mar 5.

Electrophysiology Department, The Barts Heart Centre, Barts Health NHS trust, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jce.13882DOI Listing
May 2019

Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D.

Front Physiol 2019 18;10:259. Epub 2019 Mar 18.

The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2019.00259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430739PMC
March 2019

Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).

Circ Arrhythm Electrophysiol 2018 10;11(10):e006740

Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology & Pharmacology, University College London, United Kingdom (R.A., S.M., P.S.H., M.B., A.V.G.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCEP.118.006740
Publisher Site
http://dx.doi.org/10.1161/CIRCEP.118.006740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553567PMC
October 2018

ATP-Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles.

Compr Physiol 2018 09 14;8(4):1463-1511. Epub 2018 Sep 14.

William Harvey Heart Centre, Barts & The London School of Medicine & Dentistry, Queen Mary, University of London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cphy.c170048DOI Listing
September 2018

Defective Vagal Innervation in Murine Mutant Hearts.

J Cardiovasc Dev Dis 2018 Sep 23;5(4). Epub 2018 Sep 23.

UCL Great Ormond Street-Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcdd5040049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306933PMC
September 2018

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Authors:
Bram P Prins Timothy J Mead Jennifer A Brody Gardar Sveinbjornsson Ioanna Ntalla Nathan A Bihlmeyer Marten van den Berg Jette Bork-Jensen Stefania Cappellani Stefan Van Duijvenboden Nikolai T Klena George C Gabriel Xiaoqin Liu Cagri Gulec Niels Grarup Jeffrey Haessler Leanne M Hall Annamaria Iorio Aaron Isaacs Ruifang Li-Gao Honghuang Lin Ching-Ti Liu Leo-Pekka Lyytikäinen Jonathan Marten Hao Mei Martina Müller-Nurasyid Michele Orini Sandosh Padmanabhan Farid Radmanesh Julia Ramirez Antonietta Robino Molly Schwartz Jessica van Setten Albert V Smith Niek Verweij Helen R Warren Stefan Weiss Alvaro Alonso David O Arnar Michiel L Bots Rudolf A de Boer Anna F Dominiczak Mark Eijgelsheim Patrick T Ellinor Xiuqing Guo Stephan B Felix Tamara B Harris Caroline Hayward Susan R Heckbert Paul L Huang J W Jukema Mika Kähönen Jan A Kors Pier D Lambiase Lenore J Launer Man Li Allan Linneberg Christopher P Nelson Oluf Pedersen Marco Perez Annette Peters Ozren Polasek Bruce M Psaty Olli T Raitakari Kenneth M Rice Jerome I Rotter Moritz F Sinner Elsayed Z Soliman Tim D Spector Konstantin Strauch Unnur Thorsteinsdottir Andrew Tinker Stella Trompet André Uitterlinden Ilonca Vaartjes Peter van der Meer Uwe Völker Henry Völzke Melanie Waldenberger James G Wilson Zhijun Xie Folkert W Asselbergs Marcus Dörr Cornelia M van Duijn Paolo Gasparini Daniel F Gudbjartsson Vilmundur Gudnason Torben Hansen Stefan Kääb Jørgen K Kanters Charles Kooperberg Terho Lehtimäki Henry J Lin Steven A Lubitz Dennis O Mook-Kanamori Francesco J Conti Christopher H Newton-Cheh Jonathan Rosand Igor Rudan Nilesh J Samani Gianfranco Sinagra Blair H Smith Hilma Holm Bruno H Stricker Sheila Ulivi Nona Sotoodehnia Suneel S Apte Pim van der Harst Kari Stefansson Patricia B Munroe Dan E Arking Cecilia W Lo Yalda Jamshidi

Genome Biol 2018 07 17;19(1):87. Epub 2018 Jul 17.

Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's University of London, London, SW17 0RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-018-1457-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048820PMC
July 2018

ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia.

J Biol Chem 2018 06 17;293(23):8912-8921. Epub 2018 Apr 17.

From the Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, EC1M 6BQ, United Kingdom,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.002775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995522PMC
June 2018

A critical role for the ATP-sensitive potassium channel subunit K6.1 in the control of cerebral blood flow.

J Cereb Blood Flow Metab 2018 06 4:271678X18780602. Epub 2018 Jun 4.

2 Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology & Pharmacology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0271678X18780602DOI Listing
June 2018

Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K currents in adult murine atria.

Am J Physiol Cell Physiol 2018 05 17;314(5):C616-C626. Epub 2018 Jan 17.

The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry , London , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00271.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008071PMC
May 2018

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.

Nat Commun 2018 05 16;9(1):1947. Epub 2018 May 16.

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-018-04148-1
Publisher Site
http://dx.doi.org/10.1038/s41467-018-04148-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955978PMC
May 2018

Erratum to "The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation" [Pharmacol. Res. 105 (2016) 54-61].

Pharmacol Res 2018 03;129:544

The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M6BQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phrs.2018.02.019DOI Listing
March 2018

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response.

Nat Commun 2018 03 9;9(1):1021. Epub 2018 Mar 9.

Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-03470-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844915PMC
March 2018

Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology.

Circ Genom Precis Med 2018 02;11(2):e001813

From the Institute of Cardiovascular Science (R.C.L., V.K.K., R.E.F., N.H.C., R.P.H., P.J.T., P.D.L., P.M.E., L.C.) and Metabolism and Experimental Therapeutics, Division of Medicine (R.B.), University College London, United Kingdom; European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, United Kingdom (P.R., D.O.-S.); Gene Ontology Consortium (P.R., T.Z.B., D.O.-S., J.A.B., D.P.H.); The Zebrafish Model Organism Database, University of Oregon, Eugene (D.G.H.); Rat Genome Database, Human Molecular Genetics Center, Medical College of Wisconsin, Milwaukee (S.J.F.L.); Arabidopsis Information Resource, Phoenix Bioinformatics, Fremont, CA (T.Z.B.); FlyBase, University of Cambridge, United Kingdom (S.T.); Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME (J.A.B., D.P.H.); Oxbridge BHF Centre of Regenerative Medicine, Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom (P.R.R.); and William Harvey Heart Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (A.T.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGEN.117.001813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821137PMC
February 2018

Heritability of resting heart rate and association with mortality in middle-aged and elderly twins.

Heart 2018 01 28;104(1):6-7. Epub 2017 Jun 28.

Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/heartjnl-2017-311657DOI Listing
January 2018

Endothelial biology and ATP-sensitive potassium channels.

Channels (Austin) 2018 01 2;12(1):45-46. Epub 2018 Jan 2.

a William Harvey Heart Centre, Barts & The London School of Medicine & Dentistry, Queen Mary, University of London , Charterhouse Square, London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19336950.2017.1412151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774186PMC
January 2018

Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths.

Circ Genom Precis Med 2018 01 11;11(1):e001817. Epub 2018 Jan 11.

From the Clinical Pharmacology (P.B.M., S.A., J.C., A.T., S.C.H., Q.A., H.R.W.) and National Institute for Health Research Barts Cardiovascular Biomedical Research Unit (P.B.M., A.T., H.R.W.), William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, United Kingdom; Genome Centre, Queen Mary University of London, United Kingdom (I.D., C.M., A.T., M.S., B.V.); Centre for Perinatal Neuroscience, Imperial College London, United Kingdom (S.A., P.J.L., S.T.); Paediatric Cardiology, Children's Hospital Boston, MA (D.J.A.); Histopathology, Great Ormond Street Hospital, London, United Kingdom (N.J.S.); Histopathology, Sheffield Children's Hospital, United Kingdom (M.M.C.); Histopathology, Southampton General Hospital, United Kingdom (D.J.F.); Institute for Women's Health, San Antonio, TX (D.P.); and Institute for Cardiovascular Science, University College London, United Kingdom (A.M.T.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGEN.117.001817DOI Listing
January 2018

Ajmaline blocks I and I without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters.

Stem Cell Res 2017 12 7;25:233-244. Epub 2017 Nov 7.

William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727153PMC
December 2017

Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology?

Front Physiol 2017 6;8:890. Epub 2017 Nov 6.

William Harvey Heart Centre, Barts and The London School of Medicine and Dentistry, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2017.00890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681497PMC
November 2017

Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation.

J Membr Biol 2017 10 1;250(5):471-481. Epub 2017 Aug 1.

William Harvey Heart Centre, Barts & The London School of Medicine and Dentistry, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00232-017-9973-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613071PMC
October 2017

Molecular and functional characterization of the endothelial ATP-sensitive potassium channel.

J Biol Chem 2017 10 11;292(43):17587-17597. Epub 2017 Sep 11.

From the Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M117.810325
Publisher Site
http://dx.doi.org/10.1074/jbc.M117.810325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663864PMC
October 2017

Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.

PLoS One 2017 11;12(10):e0186293. Epub 2017 Oct 11.

William Harvey Research Institute, The Heart Centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186293PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636153PMC
October 2017

The mechanisms of ventricular arrhythmia in Chagas disease.

Authors:
Andrew Tinker

Int J Cardiol 2017 08;240:372-373

The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M6BQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2017.03.094DOI Listing
August 2017

The control of cardiac ventricular excitability by autonomic pathways.

Pharmacol Ther 2017 Jun 14;174:97-111. Epub 2017 Feb 14.

The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M6BQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2017.02.023DOI Listing
June 2017

Discovery of novel heart rate-associated loci using the Exome Chip.

Authors:
Marten E van den Berg Helen R Warren Claudia P Cabrera Niek Verweij Borbala Mifsud Jeffrey Haessler Nathan A Bihlmeyer Yi-Ping Fu Stefan Weiss Henry J Lin Niels Grarup Ruifang Li-Gao Giorgio Pistis Nabi Shah Jennifer A Brody Martina Müller-Nurasyid Honghuang Lin Hao Mei Albert V Smith Leo-Pekka Lyytikäinen Leanne M Hall Jessica van Setten Stella Trompet Bram P Prins Aaron Isaacs Farid Radmanesh Jonathan Marten Aiman Entwistle Jan A Kors Claudia T Silva Alvaro Alonso Joshua C Bis Rudolf de Boer Hugoline G de Haan Renée de Mutsert George Dedoussis Anna F Dominiczak Alex S F Doney Patrick T Ellinor Ruben N Eppinga Stephan B Felix Xiuqing Guo Yanick Hagemeijer Torben Hansen Tamara B Harris Susan R Heckbert Paul L Huang Shih-Jen Hwang Mika Kähönen Jørgen K Kanters Ivana Kolcic Lenore J Launer Man Li Jie Yao Allan Linneberg Simin Liu Peter W Macfarlane Massimo Mangino Andrew D Morris Antonella Mulas Alison D Murray Christopher P Nelson Marco Orrú Sandosh Padmanabhan Annette Peters David J Porteous Neil Poulter Bruce M Psaty Lihong Qi Olli T Raitakari Fernando Rivadeneira Carolina Roselli Igor Rudan Naveed Sattar Peter Sever Moritz F Sinner Elsayed Z Soliman Timothy D Spector Alice V Stanton Kathleen E Stirrups Kent D Taylor Martin D Tobin André Uitterlinden Ilonca Vaartjes Arno W Hoes Peter van der Meer Uwe Völker Melanie Waldenberger Zhijun Xie Magdalena Zoledziewska Andrew Tinker Ozren Polasek Jonathan Rosand Yalda Jamshidi Cornelia M van Duijn Eleftheria Zeggini J Wouter Jukema Folkert W Asselbergs Nilesh J Samani Terho Lehtimäki Vilmundur Gudnason James Wilson Steven A Lubitz Stefan Kääb Nona Sotoodehnia Mark J Caulfield Colin N A Palmer Serena Sanna Dennis O Mook-Kanamori Panos Deloukas Oluf Pedersen Jerome I Rotter Marcus Dörr Chris J O'Donnell Caroline Hayward Dan E Arking Charles Kooperberg Pim van der Harst Mark Eijgelsheim Bruno H Stricker Patricia B Munroe

Hum Mol Genet 2017 06;26(12):2346-2363

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddx113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458336PMC
June 2017

Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells.

Mol Cell Endocrinol 2017 05 21;447:12-22. Epub 2017 Feb 21.

Centre for Endocrinology, Queen Mary University of London, London, EC1M 6BQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2017.02.030DOI Listing
May 2017

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Authors:
Praveen Surendran Fotios Drenos Robin Young Helen Warren James P Cook Alisa K Manning Niels Grarup Xueling Sim Daniel R Barnes Kate Witkowska James R Staley Vinicius Tragante Taru Tukiainen Hanieh Yaghootkar Nicholas Masca Daniel F Freitag Teresa Ferreira Olga Giannakopoulou Andrew Tinker Magdalena Harakalova Evelin Mihailov Chunyu Liu Aldi T Kraja Sune Fallgaard Nielsen Asif Rasheed Maria Samuel Wei Zhao Lori L Bonnycastle Anne U Jackson Narisu Narisu Amy J Swift Lorraine Southam Jonathan Marten Jeroen R Huyghe Alena Stančáková Cristiano Fava Therese Ohlsson Angela Matchan Kathleen E Stirrups Jette Bork-Jensen Anette P Gjesing Jukka Kontto Markus Perola Susan Shaw-Hawkins Aki S Havulinna He Zhang Louise A Donnelly Christopher J Groves N William Rayner Matt J Neville Neil R Robertson Andrianos M Yiorkas Karl-Heinz Herzig Eero Kajantie Weihua Zhang Sara M Willems Lars Lannfelt Giovanni Malerba Nicole Soranzo Elisabetta Trabetti Niek Verweij Evangelos Evangelou Alireza Moayyeri Anne-Claire Vergnaud Christopher P Nelson Alaitz Poveda Tibor V Varga Muriel Caslake Anton Jm de Craen Stella Trompet Jian'an Luan Robert A Scott Sarah E Harris David Cm Liewald Riccardo Marioni Cristina Menni Aliki-Eleni Farmaki Göran Hallmans Frida Renström Jennifer E Huffman Maija Hassinen Stephen Burgess Ramachandran S Vasan Janine F Felix Maria Uria-Nickelsen Anders Malarstig Dermot F Reily Maarten Hoek Thomas Vogt Honghuang Lin Wolfgang Lieb Matthew Traylor Hugh F Markus Heather M Highland Anne E Justice Eirini Marouli Jaana Lindström Matti Uusitupa Pirjo Komulainen Timo A Lakka Rainer Rauramaa Ozren Polasek Igor Rudan Olov Rolandsson Paul W Franks George Dedoussis Timothy D Spector Pekka Jousilahti Satu Männistö Ian J Deary John M Starr Claudia Langenberg Nick J Wareham Morris J Brown Anna F Dominiczak John M Connell J Wouter Jukema Naveed Sattar Ian Ford Chris J Packard Tõnu Esko Reedik Mägi Andres Metspalu Rudolf A de Boer Peter van der Meer Pim van der Harst Giovanni Gambaro Erik Ingelsson Lars Lind Paul Iw de Bakker Mattijs E Numans Ivan Brandslund Cramer Christensen Eva Rb Petersen Eeva Korpi-Hyövälti Heikki Oksa John C Chambers Jaspal S Kooner Alexandra If Blakemore Steve Franks Marjo-Riitta Jarvelin Lise L Husemoen Allan Linneberg Tea Skaaby Betina Thuesen Fredrik Karpe Jaakko Tuomilehto Alex Sf Doney Andrew D Morris Colin Na Palmer Oddgeir Lingaas Holmen Kristian Hveem Cristen J Willer Tiinamaija Tuomi Leif Groop AnneMari Käräjämäki Aarno Palotie Samuli Ripatti Veikko Salomaa Dewan S Alam Abdulla Al Shafi Majumder Emanuele Di Angelantonio Rajiv Chowdhury Mark I McCarthy Neil Poulter Alice V Stanton Peter Sever Philippe Amouyel Dominique Arveiler Stefan Blankenberg Jean Ferrières Frank Kee Kari Kuulasmaa Martina Müller-Nurasyid Giovanni Veronesi Jarmo Virtamo Panos Deloukas Paul Elliott Eleftheria Zeggini Sekar Kathiresan Olle Melander Johanna Kuusisto Markku Laakso Sandosh Padmanabhan David Porteous Caroline Hayward Generation Scotland Francis S Collins Karen L Mohlke Torben Hansen Oluf Pedersen Michael Boehnke Heather M Stringham Philippe Frossard Christopher Newton-Cheh Martin D Tobin Børge Grønne Nordestgaard Mark J Caulfield Anubha Mahajan Andrew P Morris Maciej Tomaszewski Nilesh J Samani Danish Saleheen Folkert W Asselbergs Cecilia M Lindgren John Danesh Louise V Wain Adam S Butterworth Joanna Mm Howson Patricia B Munroe

Nat Genet 2016 10 12;48(10):1151-1161. Epub 2016 Sep 12.

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056636PMC
http://dx.doi.org/10.1038/ng.3654DOI Listing
October 2016

GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway.

Cell Rep 2016 07 7;16(4):1026-1038. Epub 2016 Jul 7.

Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK; Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967477PMC
July 2016

The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation.

Pharmacol Res 2016 Mar 7;105:54-61. Epub 2016 Jan 7.

The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M6BQ, UK.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10436618153017
Publisher Site
http://dx.doi.org/10.1016/j.phrs.2015.11.008DOI Listing
March 2016

Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve.

Heart Rhythm 2015 Nov 5;12(11):2285-93. Epub 2015 Jun 5.

Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2015.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631809PMC
November 2015

A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging.

Org Biomol Chem 2015 Oct;13(37):9559-63

Department of Chemistry, University College London, 20 Gordon St, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c5ob01468aDOI Listing
October 2015

Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8.

Hum Mol Genet 2015 Sep 19;24(18):5142-53. Epub 2015 Jun 19.

Genetics and Genomic Medicine, UCL Institute of Child Health, London WC1N 1EH, UK, Genetics and Genomic Medicine, UCL Institute of Child Health, London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS, London WC1N 1EH, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddv233DOI Listing
September 2015

Genome-wide association studies and contribution to cardiovascular physiology.

Physiol Genomics 2015 Sep 23;47(9):365-75. Epub 2015 Jun 23.

Clinical Pharmacology and The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00004.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556941PMC
September 2015

ATP-sensitive potassium channels and vascular function.

Channels (Austin) 2015 ;9(1):3-4

a The Heart Center; William Harvey Research Institute; Barts & The London School of Medicine & Dentistry ; London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19336950.2015.1004289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594441PMC
July 2015

Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling.

J Biol Chem 2015 Jul 18;290(31):19233-44. Epub 2015 Jun 18.

From the British Heart Foundation Laboratories, Department of Medicine, University College London, Rayne Institute, London WC1E 6JJ, United Kingdom and the William Harvey Heart Centre, Barts & The London School of Medicine & Dentistry, London EC1M 6BQ, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.666719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521044PMC
July 2015

Connexins in the heart.

Cell Tissue Res 2015 Jun 31;360(3):675-84. Epub 2014 Oct 31.

Institute of Cardiovascular Science, Heart Hospital, UCL, 16-18 Westmoreland Street, London, W1G 8PH, UK,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00441-014-2020-8DOI Listing
June 2015

Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy.

Int J Pediatr Endocrinol 2014 15;2014(1):24. Epub 2014 Dec 15.

London centre for Paediatric Endocrinology, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH and The Institute of Child Health, University College London, London, WC1N 1EH UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1687-9856-2014-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290134PMC
January 2015

The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control.

Hypertension 2014 Sep 9;64(3):523-9. Epub 2014 Jun 9.

From The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom (Q.A., A.M.T., Y.L., K.-E.N., L.G., A.T.); and Department of Medicine, University College London, London, United Kingdom (J.G., R.A., W.R.S., A.T.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03116DOI Listing
September 2014

Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1.

Biochem J 2014 Aug;462(1):133-42

*William Harvey Heart Centre, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20140425DOI Listing
August 2014

The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system.

Br J Pharmacol 2014 Jan;171(1):12-23

William Harvey Heart Centre, Barts and The London School of Medicine and Dentistry, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.12407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874693PMC
January 2014

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents.

Org Biomol Chem 2014 Jan;12(4):557-60

Department of Chemistry, University College London, 20 Gordon St, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3ob42141dDOI Listing
January 2014

Using total internal reflection fluorescence microscopy to observe ion channel trafficking and assembly.

Methods Mol Biol 2013 ;998:201-8

Barts and The London School of Medicine & Dentistry, Queen Mary, University of London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-62703-351-0_15DOI Listing
September 2013

The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins.

Am J Physiol Regul Integr Comp Physiol 2013 Aug 22;305(4):R435-42. Epub 2013 May 22.

William Harvey Heart Centre, Barts and The London School of Medicine and Dentistry, London, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00037.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073991PMC
August 2013

A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂.

Pflugers Arch 2013 Jul 6;465(7):945-53. Epub 2013 Jan 6.

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00424-012-1199-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696465PMC
July 2013

The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias.

Front Physiol 2012 24;3:96. Epub 2012 Apr 24.

Centre for Clinical Pharmacology, Division of Medicine, University College London London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2012.00096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390690PMC
October 2012

Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel.

Biochem J 2012 May;443(3):635-42

William Harvey Heart Centre, Barts & The London School of Medicine & Dentistry, Charterhouse Square, London EC1M 6BQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20111912DOI Listing
May 2012

Structural requirements of membrane phospholipids for M-type potassium channel activation and binding.

J Biol Chem 2012 Mar 1;287(13):10001-12. Epub 2012 Feb 1.

Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, United Kingdom.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M111.322552
Publisher Site
http://dx.doi.org/10.1074/jbc.M111.322552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322975PMC
March 2012

Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C.

J Biol Chem 2012 Feb 29;287(9):6196-207. Epub 2011 Dec 29.

William Harvey Heart Centre, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, United Kingdom.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M111.243923
Publisher Site
http://dx.doi.org/10.1074/jbc.M111.243923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307292PMC
February 2012

In situ maleimide bridging of disulfides and a new approach to protein PEGylation.

Bioconjug Chem 2011 Feb 27;22(2):132-6. Epub 2011 Jan 27.

Department of Chemistry, University College London, 20 Gordon Street, London,WC1H OAJ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bc1004685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039925PMC
February 2011

Characterization of a binding site for anionic phospholipids on KCNQ1.

J Biol Chem 2011 Jan 17;286(3):2088-100. Epub 2010 Nov 17.

Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.153551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023506PMC
January 2011

Do caveolae have a role in the fidelity and dynamics of receptor activation of G-protein-gated inwardly rectifying potassium channels?

J Biol Chem 2010 Sep 18;285(36):27817-26. Epub 2010 Jun 18.

Department of Medicine, BHF Laboratories, The Rayne Institute, University College London, London WC1E 6JJ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.103598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934649PMC
September 2010

Absence of the inhibitory G-protein Galphai2 predisposes to ventricular cardiac arrhythmia.

Circ Arrhythm Electrophysiol 2010 Aug 21;3(4):391-400. Epub 2010 May 21.

Department of Medicine and Hatter Cardiovascular Institute, University College London, 5 University Street, London, England, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.109.894329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401367PMC
August 2010

HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes.

Pflugers Arch 2010 Jun 26;460(1):99-108. Epub 2010 Feb 26.

Department of Medicine, BHF Laboratories, University College London, The Rayne Institute, 5 University Street, London, WC1E 6JJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00424-010-0799-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872014PMC
June 2010

Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel.

Eur J Pharmacol 2010 May 25;634(1-3):26-32. Epub 2010 Feb 25.

Department of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, United Kingdom.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S001429991000125
Publisher Site
http://dx.doi.org/10.1016/j.ejphar.2010.02.023DOI Listing
May 2010

K+ channels in the heart: new insights and therapeutic implications.

Expert Rev Clin Pharmacol 2010 May;3(3):305-19

BHF Laboratories and Department of Medicine, University College London, 5 University Street, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/ecp.10.14DOI Listing
May 2010

The intracellular localization and function of the ATP-sensitive K+ channel subunit Kir6.1.

J Membr Biol 2010 Apr 20;234(2):137-47. Epub 2010 Mar 20.

Deparment of Medicine, The Rayne Institute, University College London, Room 107, University Street, London, WC1E 6JF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00232-010-9241-xDOI Listing
April 2010

Mechanisms of disease pathogenesis in long QT syndrome type 5.

Am J Physiol Cell Physiol 2010 Feb 11;298(2):C263-73. Epub 2009 Nov 11.

Department of Medicine, University College London, London, WC1E 6JJ, UK.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpcell.00308.2009
Publisher Site
http://dx.doi.org/10.1152/ajpcell.00308.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822495PMC
February 2010

Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior.

J Biol Chem 2010 Feb 23;285(6):3664-75. Epub 2009 Nov 23.

Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.039974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823507PMC
February 2010

Determination of phosphoinositide binding to K(+) channel subunits using a protein-lipid overlay assay.

Methods Mol Biol 2008 ;491:103-11

Department of Medicine, University College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-526-8_8DOI Listing
February 2009

The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics.

Am J Physiol Regul Integr Comp Physiol 2008 Dec 1;295(6):R1822-30. Epub 2008 Oct 1.

British Heart Foundation, Laboratories and Department of Medicine, University College London, 5 University St., London, WC1E 6JJ, UK.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpregu.90625.2008
Publisher Site
http://dx.doi.org/10.1152/ajpregu.90625.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395347PMC
December 2008

Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits.

Cardiovasc Res 2008 Sep 3;79(4):621-31. Epub 2008 Jun 3.

BHF Laboratories, Department of Medicine, The Rayne Institute, University College London, Room 107, 5 University Street, London WC1E 6JJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvn138DOI Listing
September 2008

Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby.

J Physiol 2008 Jun 17;586(12):2855-71. Epub 2008 Apr 17.

BHF Laboratories and Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1113/jphysiol.2008.153791
Publisher Site
http://dx.doi.org/10.1113/jphysiol.2008.153791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517197PMC
June 2008

PIP(2)-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP(2) depletion by Gq-coupled receptors in single living neurons.

Pflugers Arch 2007 Oct 20;455(1):115-24. Epub 2007 Apr 20.

Department of Pharmacology, University College London, London, WC1E 6BT, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00424-007-0259-6
Publisher Site
http://dx.doi.org/10.1007/s00424-007-0259-6DOI Listing
October 2007

IP receptor-dependent activation of PPARgamma by stable prostacyclin analogues.

Biochem Biophys Res Commun 2007 Sep 5;360(4):821-7. Epub 2007 Jul 5.

BHF Laboratories, Department of Medicine, Rayne Building, University College London, London WC1E 6JF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2007.06.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1997304PMC
September 2007

Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits.

J Membr Biol 2006 8;213(1):19-29. Epub 2007 Mar 8.

Department of Medicine, BHF Laboratories, Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, United Kingdom.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00232-006-0037-y
Publisher Site
http://dx.doi.org/10.1007/s00232-006-0037-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1973150PMC
August 2007

Complex ABCC8 DNA variations in congenital hyperinsulinism: lessons from functional studies.

Clin Endocrinol (Oxf) 2007 Jul 27;67(1):115-24. Epub 2007 Apr 27.

BHF Laboratories and Department of Medicine, University College London, London, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2265.2007.02847.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2265.2007.02847.xDOI Listing
July 2007

The selective interactions and functions of regulators of G-protein signalling.

Authors:
Andrew Tinker

Semin Cell Dev Biol 2006 Jun 3;17(3):377-82. Epub 2006 Apr 3.

BHF Laboratories and Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2006.03.007DOI Listing
June 2006

Differential phosphoinositide binding to components of the G protein-gated K+ channel.

J Membr Biol 2006 May 18;211(1):43-53. Epub 2006 Sep 18.

Department of Medicine and BHF Laboratories, University College London, 5 University Street, London, WC1E 6JJ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00232-006-0014-5DOI Listing
May 2006

Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells.

Proc Natl Acad Sci U S A 2005 Dec 13;102(51):18706-11. Epub 2005 Dec 13.

British Heart Foundation Laboratories and Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0504778102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1317907PMC
December 2005

PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells.

Am J Physiol Cell Physiol 2005 Sep 27;289(3):C543-56. Epub 2005 Apr 27.

Dept. of Medicine, University College of London, London WC1E 6JJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00025.2005DOI Listing
September 2005

Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1).

Cardiovasc Res 2005 Aug;67(3):476-86

BHF Laboratories and Department of Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cardiores.2005.04.036DOI Listing
August 2005

Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics.

J Biol Chem 2005 Apr 27;280(14):13383-94. Epub 2005 Jan 27.

BHF Laboratories and Department of Medicine, University College London, Room 420, 4th Floor, 5 University Street, London WC1E 6JJ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M410163200DOI Listing
April 2005

Rapid desensitization of G protein-gated inwardly rectifying K(+) currents is determined by G protein cycle.

Am J Physiol Cell Physiol 2004 Jul 10;287(1):C182-91. Epub 2004 Mar 10.

Departmentt of Medicine, University College London, London WC1E 6JJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00540.2003DOI Listing
July 2004

Multisite phosphorylation mechanism for protein kinase A activation of the smooth muscle ATP-sensitive K+ channel.

Circ Res 2004 May 15;94(10):1359-66. Epub 2004 Apr 15.

British Heart Foundation Laboratories and the Department of Medicine, University College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/01.RES.0000128513.34817.c4DOI Listing
May 2004