Publications by authors named "Andrew R Reynolds"

40Publications

Vessel co-option and resistance to anti-angiogenic therapy.

Angiogenesis 2020 02 21;23(1):55-74. Epub 2019 Dec 21.

Oncology R&D, AstraZeneca, Cambridge, UK.

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February 2020

Vessel co-option in cancer.

Nat Rev Clin Oncol 2019 08;16(8):469-493

Tumour Biology Team, Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

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August 2019

Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology.

Radiology 2018 09 5;288(3):739-747. Epub 2018 Jun 5.

From the Centre for Imaging Sciences (R.A.L., J.H.N., Y.W., S.C., K.F.H., H.L., D.J.M., G.J.M.P., J.C.W.) and Division of Cancer Sciences (J.I., C.M.L.W., N.W.C., J.P.B.O.), University of Manchester, Manchester, England; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, England (Y.J., J.K.R.B., S.P.R.); Department of Pathology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, England (G.N.B.); Department of Histology, CRUK Manchester Institute, Manchester, England (G.A.); Tumour Biology Team, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, England (A.R.R.); Department of Urology, Salford Royal Hospitals NHS Foundation Trust, Salford, England (S.M., N.W.C.); Bioxydyn Ltd, Manchester, England (G.J.M.P., J.C.W.); and Department of Radiology, The Christie NHS Foundation Trust, Manchester, England (J.P.B.O.).

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September 2018

Non-angiogenic tumours and their influence on cancer biology.

Nat Rev Cancer 2018 05 9;18(5):323-336. Epub 2018 Mar 9.

Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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May 2018

Monitoring the Vascular Response and Resistance to Sunitinib in Renal Cell Carcinoma with Susceptibility Contrast MRI.

Cancer Res 2017 08 31;77(15):4127-4134. Epub 2017 May 31.

Tumour Biology Team, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.

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August 2017

The role of bevacizumab in solid tumours: A literature based meta-analysis of randomised trials.

Eur J Cancer 2017 04 24;75:245-258. Epub 2017 Feb 24.

Department of Medical, Surgery and Health Sciences, University of Trieste, Piazza Ospitale 1, 34129 Trieste, Italy; Unit of Molecular Therapy and Pharmacogenomic, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.

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April 2017

Apatinib for the treatment of gastric cancer.

Expert Rev Gastroenterol Hepatol 2016 Aug 15;10(8):887-92. Epub 2016 Jul 15.

b Unit of Molecular Therapy and Pharmacogenomic , ASST Cremona , Cremona , Italy.

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August 2016

Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma.

J Natl Cancer Inst 2016 08 8;108(8). Epub 2016 Apr 8.

Affiliations of authors: Department of Medical Biophysics, University of Toronto, Toronto, Canada (EAK, FSF, RSK); Physical Sciences Platform (MY, FSF) and Biological Sciences Platform (CRL, SM, RSK), Sunnybrook Research Institute, Toronto, Canada; Department of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa, Israel (ABZ); Keenan Research Centre, St. Michael's Hospital, Toronto, Canada (HB, GMY); The Breast Cancer Now Toby Robins Research Centre, Mary-Jean Mitchell Green Building, The Institute of Cancer Research, London, UK (FD, PBV, ARR); Translational Cancer Research Unit, GZA Hospitals St. Augustinus, Antwerp, Belgium (PBV).

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August 2016

Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma.

Mol Cancer Ther 2016 Jan 20;15(1):172-83. Epub 2015 Oct 20.

Tumour Biology Team, The Breast Cancer Now Toby Robins Research Centre, Mary-Jean Mitchell Green Building, The Institute of Cancer Research (ICR), London, United Kingdom.

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January 2016

Lessons from the first ecancer symposium on angiogenesis in gastric cancer.

Ecancermedicalscience 2015 21;9:553. Epub 2015 Jul 21.

European Institute of Oncology, Milan 20146, Italy; University of Milan, Italy; University of Glasgow, G12 8QQ, United Kingdom; University of Wales, Cardiff, South Glam CF10 3NS, United Kingdom; Founding editor of ecancer.org.

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August 2015

Bevacizumab beyond progression in breast cancer.

Lancet Oncol 2014 Oct 28;15(11):1190-1. Epub 2014 Sep 28.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.

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October 2014

Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions.

Angiogenesis 2014 Jul 31;17(3):471-94. Epub 2014 Jan 31.

Tumour Biology Team, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK.

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July 2014

The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer.

Clin Cancer Res 2013 Dec 15;19(24):6924-34. Epub 2013 Oct 15.

Authors' Affiliations: Barts Cancer Institute, Queen Mary University of London; Experimental Cancer Medicine Centre, University College; The Institute of Cancer Research; Guys and St Thomas' Hospital; The Royal Free Hospital London, London; Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh; Astra Zeneca, Manchester; School of Medicine, University of St Andrews, Fife, United Kingdom; National Cancer Institute, Amsterdam, the Netherlands; and University of Ghent, Ghent, Belgium.

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December 2013

Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells.

J Biol Chem 2013 Mar 22;288(11):7467-80. Epub 2013 Jan 22.

Tumour Biology Team, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, United Kingdom.

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March 2013

Targeting angiogenesis in esophagogastric adenocarcinoma.

Oncologist 2011 31;16(6):844-58. Epub 2011 May 31.

The Royal Marsden Hospital NHS Foundation Trust London & Surrey, Surrey, UK.

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October 2011

Potential relevance of bell-shaped and u-shaped dose-responses for the therapeutic targeting of angiogenesis in cancer.

Dose Response 2010 Apr 23;8(3):253-84. Epub 2010 Apr 23.

Tumor Angiogenesis Group, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, U.K.

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April 2010

Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis.

J Biol Chem 2009 Dec 16;284(49):33966-81. Epub 2009 Oct 16.

Adhesion and Angiogenesis Laboratory, Tumour Biology Centre, Institute of Cancer, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom.

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December 2009

Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis.

Angiogenesis 2008 30;11(4):337-46. Epub 2008 Aug 30.

Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK.

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April 2009

Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis.

Arterioscler Thromb Vasc Biol 2007 Jan 26;27(1):63-9. Epub 2006 Oct 26.

Cardiac, Vascular & Inflammation Research, William Harvey Research Institute, Barts and the London, Queen Mary University London, Charterhouse Sq, London EC1M 6BQ, UK.

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January 2007

Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice.

Cancer Res 2004 Dec;64(23):8643-50

Tumour Biology Laboratory, Cancer Research UK Clinical Centre, Barts and the London, Queen Mary's School of Medicine and Dentistry, John Vane Science Centre, London, United Kingdom.

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December 2004

Integrins in angiogenesis: multitalented molecules in a balancing act.

Cell Tissue Res 2003 Oct 10;314(1):131-44. Epub 2003 Sep 10.

Cell Adhesion and Disease Laboratory, Cancer Research UK, Richard Dimbleby Department of Cancer Research, St. Thomas' Hospital, Lambeth Palace Road, SE1 7EH, London, UK.

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October 2003

EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation.

Nat Cell Biol 2003 May;5(5):447-53

Cell Biophysics Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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May 2003

Nanoparticle-mediated gene delivery to tumour neovasculature.

Trends Mol Med 2003 Jan;9(1):2-4

Cell Adhesion and Disease Laboratory, Cancer Research UK, Richard Dimbleby Department of Cancer Research, St. Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.

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January 2003