Andrew Parkinson

Andrew Parkinson

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Andrew Parkinson

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Regulatory Recommendations for Calculating the Unbound Maximum Hepatic Inlet Concentration: A Complicated Story with a Surprising and Happy Ending.

Authors:
Andrew Parkinson

Drug Metab Dispos 2019 07 2;47(7):779-784. Epub 2019 May 2.

XPD Consulting, Shawnee, Kansas

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http://dx.doi.org/10.1124/dmd.119.086496DOI Listing
July 2019

An Assessment of the In Vitro Inhibition of Cytochrome P450 Enzymes, UDP-Glucuronosyltransferases, and Transporters by Phosphodiester- or Phosphorothioate-Linked Oligonucleotides.

Drug Metab Dispos 2018 Aug 7;46(8):1066-1074. Epub 2018 May 7.

Sekisui XenoTech LLC, Kansas City, Kansas (F.K., P.Y., C.M., D.B.B., B.W.O.); Janssen Research & Development LLC, Spring House, Pennsylvania (F.K.); XPD Consulting, Shawnee, Kansas (A.P.); and Roivant Sciences, Durham, North Carolina (D.B.B.).

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http://dx.doi.org/10.1124/dmd.118.081729DOI Listing
August 2018

A new era for collaboration?

Rheumatology (Oxford) 2018 05;57(5):775-776

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.

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http://dx.doi.org/10.1093/rheumatology/kex083DOI Listing
May 2018

Let's Talk about Inclusion: A Report on Patient Research Partner Involvement in the GRAPPA 2015 Annual Meeting.

J Rheumatol 2016 05;43(5):970-3

From the VU Medical Centre, Amsterdam, The Netherlands; Krembil Research Institute of Toronto Western Hospital, and the University of Toronto, and the Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; University of Pennsylvania, Philadelphia, Pennsylvania, USA; Johns Hopkins Division of Rheumatology, Baltimore, Maryland, USA; St. Vincent's University Hospital, Dublin, Ireland; Cleveland Clinic, Cleveland, Ohio, USA; Royal National Hospital for Rheumatic Diseases, Bath, UK; Duke University School of Medicine, Durham, North Carolina, USA.M. de Wit, PhD, Patient Research Partner, VU Medical Centre, Amsterdam, The Netherlands; W. Campbell, BEd, LLB, Patient Research Partner, Toronto Western Hospital; L.C. Coates, MBChB, PhD, UK National Institute for Health Research Clinical Lecturer, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Senior Scientist, Krembil Research Institute, Director, Psoriatic Arthritis Program, University Health Network; J. James, Patient Research Partner; C.A. Lindsay, PharmD, Patient Research Partner; R. MacDonald, Patient Research Partner; A.R. Moverley, MB, BS, BSc, MRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; A. Ogdie, University of Pennsylvania; A.M. Orbai, MD, MHS, Johns Hopkins Division of Rheumatology; D. O'Sullivan, BE, Patient Research Partner; A. Parkinson, Patient Research Partner; I. Steinkoenig, BA, Patient Research Partner; W. Tillett, BSc, MB ChB, PhD, MRCP, Royal National Hospital for Rheumatic Diseases; N. Goel, MD, Patient Research Partner, Duke University School of Medicine.

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http://dx.doi.org/10.3899/jrheum.160117DOI Listing
May 2016

Development of a Flare Instrument for Use in Psoriatic Disease: A Report from the 2015 GRAPPA Annual Meeting.

J Rheumatol 2016 05;43(5):974-8

From the Clinical Trials Research Unit, Leeds Institute of Molecular Medicine, University of Leeds; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, UK; VU Medical Centre, Amsterdam, The Netherlands; Toronto Western Hospital, Toronto, Ontario, Canada; PsAZZ Psoriatic Arthritis Support Group, Bath, UK; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Univ Paris 06, Institut Pierre Louis d'Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS); AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology, Paris, France; Bradford Hospitals UK National Health Service (NHS) Foundation Trust, Bradford, UK.A.R. Moverley, MRCP, Research Fellow, Clinical Trials Research Unit, Leeds Institute of Molecular Medicine, University of Leeds; R. Waxman, MPH, Research Coordinator, Leeds Institute of Rheumatic and Musculoskeletal Medicine; M. de Wit, PhD, Patient Research Partner, VU Medical Centre; A. Parkinson, Patient Research Partner; W. Campbell, BEd, LLB, Patient Research Partner, Toronto Western Hospital; M. Brooke, Patient Research Partner, Chair, PsAZZ Psoriatic Arthritis Support Group; L. Gossec, MD, PhD, Sorbonne Universités, UPMC Univ Paris 06, Institut Pierre Louis d'Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS), AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology; P.S. Helliwell, DM, PhD, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and Bradford Hospitals NHS Foundation Trust.

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http://dx.doi.org/10.3899/jrheum.160118DOI Listing
May 2016

The Reliability of Estimating Ki Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC50 Values: A Retrospective Analysis of 343 Experiments.

Drug Metab Dispos 2015 Nov 9;43(11):1744-50. Epub 2015 Sep 9.

XenoTech, LLC, Lenexa, Kansas (L.J.H., F.K., B.W.O., D.B.B., B.D.S., S.L.); and XPD Consulting, Shawnee, Kansas (B.P., O.P., A.P.)

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http://dx.doi.org/10.1124/dmd.115.066597DOI Listing
November 2015

Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor.

Drug Metab Dispos 2015 Sep 1;43(9):1294-302. Epub 2015 Jul 1.

XenoTech, LLC, Lenexa, Kansas (F.K., P.Y., J.E.B.) and XPD Consulting, Shawnee, Kansas (A.P)

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http://dx.doi.org/10.1124/dmd.115.065011DOI Listing
September 2015

A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.

Drug Metab Dispos 2015 Apr 16;43(4):523-33. Epub 2015 Jan 16.

XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.).

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http://dx.doi.org/10.1124/dmd.114.062620DOI Listing
April 2015

Anti-CD28 monoclonal antibody-stimulated cytokines released from blood suppress CYP1A2, CYP2B6, and CYP3A4 in human hepatocytes in vitro.

Drug Metab Dispos 2015 Jan 17;43(1):42-52. Epub 2014 Oct 17.

XenoTech, LLC, Lenexa, Kansas (M.C., F.K., D.B.B.); and XPD Consulting, Shawnee, Kansas (A.P.).

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http://dx.doi.org/10.1124/dmd.114.060186DOI Listing
January 2015

Patient participation in psoriasis and psoriatic arthritis outcome research: a report from the GRAPPA 2013 Annual Meeting.

J Rheumatol 2014 Jun;41(6):1206-11

From the Department of Rheumatology, St. Vincent's University Hospital, Elm Park, Dublin, Ireland; University of Toronto; Toronto Western Research Institute; Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada; University of Leeds, Leeds, UK; Royal National Hospital for Rheumatic Diseases, UK National Health Service (NHS) Foundation Trust, Bath, UK; Swedish Medical Center, University of Washington School of Medicine, Seattle, Washington, USA; Johns Hopkins Arthritis Center, Baltimore, Maryland, USA; Rheumatology Department, Hospital de Clinicas de Porto Alegre, Brazil; Royal National Hospital for Rheumatic Diseases, Bath, UK.M. de Wit, PhD, Patient Research Partner, Amsterdam, The Netherlands; W. Campbell, BA, BEd, LLB, Patient Research Partner, Toronto, Ontario, Canada; O. FitzGerald, MD, FRCPI, FRCP(UK), Newman Clinical Research Professor, Department of Rheumatology, St. Vincent's University Hospital; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto; Senior Scientist, Toronto Western Research Institute and Director, Psoriatic Arthritis Program, University Health Network; P.S. Helliwell, DM, PhD, FRCP, Senior Lecturer in Rheumatology, University of Leeds; J. James, Patient Research Partner, Bath, UK; C. Lindsay, Patient Research Partner, Thousand Oaks, California, USA; R. MacDonald, Patient Research Partner, Toronto, Ontario, Canada; N.J. McHugh, MBChB, MD, FRCP, FRCPath, Royal National Hospital for Rheumatic Diseases, NHS Foundation Trust; P.J. Mease, MD, Director, Rheumatology Research, Swedish Medical Center, Clinical Professor, University of Washington School of Medicine; A-M. Orbai, MD, MHS, Johns Hopkins Arthritis Center; P. Palominos, MD, Rheumatology Department, Hospital de Clinicas de Porto Alegre; A. Parkinson, Patient Research Partner, Leeds, UK; W. Tillett, BSc, MBChB, MRCP, Royal National Hospital for Rheumatic Diseases; N. Goel, MD, Patient Research Partner, Durham, North Carolina, USA.

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http://dx.doi.org/10.3899/jrheum.140171DOI Listing
June 2014

The effect of ionizing gamma radiation on natural and synthetic fibers and its implications for the forensic examination of fiber evidence.

J Forensic Sci 2011 May 9;56(3):591-605. Epub 2011 Feb 9.

Australian Nuclear Science & Technology Organisation, PMB 1, Menai, NSW 2234, Australia.

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http://doi.wiley.com/10.1111/j.1556-4029.2010.01654.x
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http://dx.doi.org/10.1111/j.1556-4029.2010.01654.xDOI Listing
May 2011

The development and evaluation of radiological decontamination procedures for documents, document inks, and latent fingermarks on porous surfaces.

J Forensic Sci 2010 May 15;55(3):728-34. Epub 2010 Mar 15.

Australian Nuclear Science & Technology Organisation, PMB 1, Menai, NSW, Australia 2234.

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http://doi.wiley.com/10.1111/j.1556-4029.2010.01346.x
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http://dx.doi.org/10.1111/j.1556-4029.2010.01346.xDOI Listing
May 2010

In vitro inhibition and induction of human liver cytochrome p450 enzymes by milnacipran.

Drug Metab Dispos 2009 Oct 16;37(10):2045-54. Epub 2009 Jul 16.

XenoTech LLC, Lenexa, KS 66219, USA.

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http://dx.doi.org/10.1124/dmd.109.028274DOI Listing
October 2009

Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.

Drug Metab Dispos 2009 Oct 23;37(10):2103-11. Epub 2009 Jul 23.

Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1124/dmd.109.027193DOI Listing
October 2009

The recovery of latent fingermarks from evidence exposed to ionizing radiation*.

J Forensic Sci 2009 May 16;54(3):583-90. Epub 2009 Mar 16.

Australian Nuclear Science & Technology Organisation, Menai, NSW 2234, Australia.

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http://dx.doi.org/10.1111/j.1556-4029.2009.01016.xDOI Listing
May 2009

Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression.

Chem Res Toxicol 2007 Apr 24;20(4):600-8. Epub 2007 Mar 24.

Mechanistic Toxicology, Johnson & Johnson Pharmaceutical Research & Development, LLC, 1001 Route 202 North, Raritan, New Jersey 08869, USA.

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http://dx.doi.org/10.1021/tx600351gDOI Listing
April 2007

The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice.

Toxicol Appl Pharmacol 2006 Jul 20;214(2):178-87. Epub 2006 Mar 20.

Human Health Assessment, Regulatory Laboratories, Dow AgroSciences, LLC 9330 Zionsville Road, Indianapolis, IN 46268, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0041008X0600038
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http://dx.doi.org/10.1016/j.taap.2006.01.017DOI Listing
July 2006

Anabolic androgenic steroids: a survey of 500 users.

Med Sci Sports Exerc 2006 Apr;38(4):644-51

Department of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance, CA 90007, USA.

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http://dx.doi.org/10.1249/01.mss.0000210194.56834.5dDOI Listing
April 2006

Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416.

Toxicol In Vitro 2006 Mar;20(2):154-62

Portola Pharmaceuticals, 270 East Grand Ave. South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.tiv.2005.06.047DOI Listing
March 2006

Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians.

Drug Metab Pharmacokinet 2002 ;17(5):482-7

Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.2133/dmpk.17.482DOI Listing
March 2005

Radiofrequency thermal effects on the human meniscus. An in vitro study of systems with monopolar and bipolar electrodes.

Am J Sports Med 2003 Mar-Apr;31(2):253-6

Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1177/03635465030310021601DOI Listing
July 2003

Regulation of drug transporter gene expression by nuclear receptors.

Drug Metab Dispos 2003 May;31(5):523-7

Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045, USA.

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http://dx.doi.org/10.1124/dmd.31.5.523DOI Listing
May 2003

Analysis of CYP mRNA expression by branched DNA technology.

Methods Enzymol 2002 ;357:170-9

Department of Molecular Biology, XenoTech LLC, Lenexa, Kansas 66219, USA.

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http://dx.doi.org/10.1016/s0076-6879(02)57676-xDOI Listing
January 2003

In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs.

Drug Metab Dispos 2002 Nov;30(11):1206-13

XenoTech, LLC, Lenexa, Kansas 66219, USA.

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http://dx.doi.org/10.1124/dmd.30.11.1206DOI Listing
November 2002