Andrew P Weng

Andrew P Weng

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Andrew P Weng

Andrew P Weng

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Insulin-like growth factor (IGF) signaling in T-cell acute lymphoblastic leukemia.

Adv Biol Regul 2019 12 15;74:100652. Epub 2019 Sep 15.

Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, V5Z 1L3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2019.100652DOI Listing
December 2019

RUNX1 promotes cell growth in human T-cell acute lymphoblastic leukemia by transcriptional regulation of key target genes.

Exp Hematol 2018 08 5;64:84-96. Epub 2018 May 5.

Terry Fox Laboratory/Department of Pathology, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2018.04.008DOI Listing
August 2018

Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia.

Exp Hematol 2017 07 19;51:71-82.e3. Epub 2017 Apr 19.

Department of Biological Science, Florida State University, Tallahassee, FL; Center for Genomics and Personalized Medicine, Florida State University, Tallahassee, FL. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491210PMC
July 2017

Defining the clonality of peripheral T cell lymphomas using RNA-seq.

Bioinformatics 2017 04;33(8):1111-1115

Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btw810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408843PMC
April 2017

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

CD44 promotes chemoresistance in T-ALL by increased drug efflux.

Exp Hematol 2016 Mar 18;44(3):166-71.e17. Epub 2015 Dec 18.

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2015.12.001DOI Listing
March 2016

Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13.

Blood 2014 Dec 22;124(24):3608-12. Epub 2014 Oct 22.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1182/blood-2014-04-564666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256911PMC
December 2014

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Nature 2014 Jul 22;511(7511):616-20. Epub 2014 Jun 22.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244910PMC
July 2014

IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein.

Exp Hematol 2012 Sep 18;40(9):715-723.e6. Epub 2012 May 18.

Terry Fox Laboratory/Department of Pathology, BC Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.exphem.2012.05.003DOI Listing
September 2012

Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia.

Invest New Drugs 2012 Aug 17;30(4):1361-70. Epub 2011 Jun 17.

Vancouver Prostate Centre, Department of Surgery, University of British Columbia, Rm 241, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.

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http://dx.doi.org/10.1007/s10637-011-9700-yDOI Listing
August 2012

Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL.

Leuk Res 2012 Jul 17;36(7):905-11. Epub 2012 Mar 17.

Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.

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http://dx.doi.org/10.1016/j.leukres.2012.02.013DOI Listing
July 2012

CD80 (B7.1) is expressed on both malignant B cells and nonmalignant stromal cells in non-Hodgkin lymphoma.

Cytometry B Clin Cytom 2012 Mar 10;82(2):112-9. Epub 2011 Nov 10.

Global Clinical Assay Group, Pfizer, Inc, San Diego, California 92121, USA.

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http://doi.wiley.com/10.1002/cyto.b.20631
Publisher Site
http://dx.doi.org/10.1002/cyto.b.20631DOI Listing
March 2012

Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.

Blood 2007 Jul 15;110(1):278-86. Epub 2007 Mar 15.

Division of Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-08-03
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http://dx.doi.org/10.1182/blood-2006-08-039883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1896117PMC
July 2007

Notch signaling in T-cell acute lymphoblastic leukemia.

Future Oncol 2005 Aug;1(4):511-9

British Columbia Cancer Agency, Department of Pathology, British Columbia Cancer Research Centre, Terry Fox Laboratory, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada.

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http://dx.doi.org/10.2217/14796694.1.4.511DOI Listing
August 2005

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Science 2004 Oct;306(5694):269-71

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1102160DOI Listing
October 2004

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

Blood 2004 Sep 8;104(6):1696-702. Epub 2004 Jun 8.

Division of Hematology-Oncology, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1182/blood-2004-02-0514DOI Listing
September 2004

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.

J Biol Chem 2004 Jul 3;279(29):30771-80. Epub 2004 May 3.

Department of Pathology and Obstetrics/Gynecology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M309252200DOI Listing
July 2004

Hodgkin disease associated with T-cell non-Hodgkin lymphomas: case reports and review of the literature.

Am J Clin Pathol 2004 May;121(5):701-8

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1309/W1GW-43HT-793U-F86RDOI Listing
May 2004

Multiple niches for Notch in cancer: context is everything.

Curr Opin Genet Dev 2004 Feb;14(1):48-54

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.gde.2003.11.004DOI Listing
February 2004

Differential expression of T-bet, a T-box transcription factor required for Th1 T-cell development, in peripheral T-cell lymphomas.

Am J Clin Pathol 2003 Dec;120(6):866-73

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1309/MLUF-X0HR-5B96-GVAXDOI Listing
December 2003

No T without D3: a critical role for cyclin D3 in normal and malignant precursor T cells.

Cancer Cell 2003 Dec;4(6):417-8

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s1535-6108(03)00305-2DOI Listing
December 2003

Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex.

J Biol Chem 2003 Jun 18;278(23):21232-9. Epub 2003 Mar 18.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M301567200
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http://dx.doi.org/10.1074/jbc.M301567200DOI Listing
June 2003

CXCR4/CD184 immunoreactivity in T-cell non-Hodgkin lymphomas with an overall Th1- Th2+ immunophenotype.

Am J Clin Pathol 2003 Mar;119(3):424-30

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1309/rf4pvceggn2xaf86DOI Listing
March 2003

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

Mol Cell Biol 2003 Jan;23(2):655-64

Departments of Pathology, Brigham and Women's Hospital, Harvard Medical School. Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151540PMC
http://dx.doi.org/10.1128/mcb.23.2.655-664.2003DOI Listing
January 2003

Expression of geminin as a marker of cell proliferation in normal tissues and malignancies.

Am J Pathol 2002 Jul;161(1):267-73

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029440106417
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850683PMC
http://dx.doi.org/10.1016/S0002-9440(10)64178-8DOI Listing
July 2002