Andrew P Holmes

Andrew P Holmes

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Andrew P Holmes

Andrew P Holmes

Publications by authors named "Andrew P Holmes"

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Dynamic monitoring of single-terminal norepinephrine transporter rate in the rodent cardiovascular system: A novel fluorescence imaging method.

Auton Neurosci 2020 Jan 26;223:102611. Epub 2019 Dec 26.

School of Biomedical Science, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.autneu.2019.102611DOI Listing
January 2020

Temporal irregularity quantification and mapping of optical action potentials using wave morphology similarity.

Prog Biophys Mol Biol 2019 Dec 30. Epub 2019 Dec 30.

Institute of Cardiovascular Sciences, University of Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pbiomolbio.2019.12.004DOI Listing
December 2019

Adrenaline activation of the carotid body: Key to CO and pH homeostasis in hypoglycaemia and potential pathological implications in cardiovascular disease.

Respir Physiol Neurobiol 2019 07 25;265:92-99. Epub 2018 May 25.

Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B12 2TT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.resp.2018.05.008DOI Listing
July 2019

Ecto-5'-nucleotidase (CD73) regulates peripheral chemoreceptor activity and cardiorespiratory responses to hypoxia.

J Physiol 2018 08 9;596(15):3137-3148. Epub 2017 Jul 9.

Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.1113/JP274498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068227PMC
August 2018

Is Carotid Body Physiological O Sensitivity Determined by a Unique Mitochondrial Phenotype?

Front Physiol 2018 16;9:562. Epub 2018 May 16.

Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.3389/fphys.2018.00562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964187PMC
May 2018

Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring.

Org Biomol Chem 2017 Sep;15(37):7770-7782

Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA.

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http://dx.doi.org/10.1039/c7ob01448aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614861PMC
September 2017

PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers.

J Am Coll Cardiol 2016 10;68(17):1881-1894

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom; Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany; Atrial Fibrillation NETwork, Muenster, Germany; University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.07.766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075046PMC
October 2016

A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse Heart.

Circ Res 2016 Sep 8;119(8):909-20. Epub 2016 Aug 8.

From the Cardiovascular Research Institute, Centre for Translational Medicine MD6, National University Health System, Singapore (M.A.-J., P.Y.L., R.S.F.); Genome Institute of Singapore (M.A.-J., R.S.F.); and Institute of Cardiovascular Sciences, University of Birmingham, UK (A.P.H., S.-M.O., D.P.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965670PMC
September 2016

Adrenaline release evokes hyperpnoea and an increase in ventilatory CO2 sensitivity during hypoglycaemia: a role for the carotid body.

J Physiol 2016 08 5;594(15):4439-52. Epub 2016 May 5.

Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1113/JP272191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967760PMC
August 2016

Adjuvant Lapatinib and Trastuzumab for Early Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: Results From the Randomized Phase III Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Trial.

J Clin Oncol 2016 Apr 23;34(10):1034-42. Epub 2015 Nov 23.

Martine Piccart-Gebhart, Université Libre de Bruxelles, Brussels, Belgium; Eileen Holmes, Eleanor McFadden, and Andrew P. Holmes, Frontier Science (Scotland), Kincraig, Kingussie, United Kingdom; José Baselga, Memorial Sloan Kettering Cancer Center, New York, NY; Evandro de Azambuja, Institut Jules Bordet, Brussels, Belgium; Evandro de Azambuja and Stella Dolci, Breast European Adjuvant Study Team, Brussels, Belgium; Amylou C. Dueck and Anne E. McCullough, Mayo Clinic, Scottsdale, AZ; Giuseppe Viale, University of Milan, Milan, Italy; Giuseppe Viale and Aron Goldhirsch, Istituto Europeo di Oncologia, Milan, Italy; Jo Anne Zujewski, National Cancer Institute, Bethesda, MD; Aron Goldhirsch, Ospedale Regionale di Lugano, Viganello-Lugano, Switzerland; Alison Armour, GlaxoSmithKline, Collegeville, PA; Kathleen I. Pritchard, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; Kathleen I. Pritchard, University of Toronto, Toronto, Ontario, Canada; Liu Tonghua, Peking Union Medical College Hospital, Beijing, People's Republic of China; Liu Tonghua and Binghe Xu, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China; Holger Eidtmann, University Hospital Kiel, Kiel, Germany; Phuong Dinh, Breast International Group, Brussels, Belgium; Serena Di Cosimo, Istituto Nazionale del Tumori, Milan, Italy; Serena Di Cosimo, SOLTI Breast Cancer Research Group, Barcelona, Spain; Nadia Harbeck, Frauenklinik der Universität München, Munich, Germany; Sergei Tjulandin, Blokhin Russian Cancer Research Center of RAMS, Moscow, Russia; Young-Hyuck Im, Korean Cancer Study Group, Seoul, South Korea; Young-Hyuck Im, Samsung Medical Center, Seoul, South Korea; Chiun-Shen Huang, National Taiwan University Hospital, Taipei, Republic of China; Véronique Diéras, Institut Curie, Paris, France; David W. Hillman, Mayo Clinic, Rochester, MN; Antonio C. Wolff, The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Christian Jackisch, Klinikum Offenba

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http://dx.doi.org/10.1200/JCO.2015.62.1797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872016PMC
April 2016

Reductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient mice.

Mol Brain 2016 Apr 14;9:39. Epub 2016 Apr 14.

Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Str, Liverpool, L69 3BX, UK.

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http://dx.doi.org/10.1186/s13041-016-0219-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832494PMC
April 2016

Ecto-5'-Nucleotidase, Adenosine and Transmembrane Adenylyl Cyclase Signalling Regulate Basal Carotid Body Chemoafferent Outflow and Establish the Sensitivity to Hypercapnia.

Adv Exp Med Biol 2015 ;860:279-89

Level 1 IBR, School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK,

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http://dx.doi.org/10.1007/978-3-319-18440-1_32DOI Listing
January 2016

Moderate inhibition of mitochondrial function augments carotid body hypoxic sensitivity.

Pflugers Arch 2016 Jan;468(1):143-155

School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, Birmingham, UK, B15 2TT.

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http://dx.doi.org/10.1007/s00424-015-1745-xDOI Listing
January 2016

Pitx2 Adjacent Noncoding RNA: A New, Long, Noncoding Kid on the 4q25 Block.

Circ Arrhythm Electrophysiol 2016 Jan;9(1):e003808

From the Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom (A.P.H., P.K.); Department of Cardiology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom (P.K.); Department of Cardiology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom (P.K.); and Department of Cardiovascular Medicine, University Hospital Muenster; and Atrial Fibrillation NETwork, Muenster, Germany (P.K.).

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http://dx.doi.org/10.1161/CIRCEP.115.003808DOI Listing
January 2016

Disulfide Sensitivity in the Env Protein Underlies Lytic Inactivation of HIV-1 by Peptide Triazole Thiols.

ACS Chem Biol 2015 Dec 22;10(12):2861-73. Epub 2015 Oct 22.

Department of Biochemistry and Molecular Biology, Drexel University College of Medicine , Philadelphia, Pennsylvania 19102, United States.

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http://dx.doi.org/10.1021/acschembio.5b00381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836388PMC
December 2015

Revisiting cAMP signaling in the carotid body.

Front Physiol 2014 28;5:406. Epub 2014 Oct 28.

CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa Lisboa, Portugal.

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http://dx.doi.org/10.3389/fphys.2014.00406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211388PMC
November 2014

Glycogen metabolism protects against metabolic insult to preserve carotid body function during glucose deprivation.

J Physiol 2014 Oct 25;592(20):4493-506. Epub 2014 Jul 25.

School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

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http://dx.doi.org/10.1113/jphysiol.2014.276105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287740PMC
October 2014

An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials.

Prog Biophys Mol Biol 2014 Aug 15;115(2-3):340-8. Epub 2014 Aug 15.

Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00796107140007
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http://dx.doi.org/10.1016/j.pbiomolbio.2014.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210664PMC
August 2014

Covalent conjugation of a peptide triazole to HIV-1 gp120 enables intramolecular binding site occupancy.

Biochemistry 2014 Jun 19;53(21):3403-14. Epub 2014 May 19.

Chemical and Biological Engineering, Drexel University , Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/bi500136fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045323PMC
June 2014

A-to-I RNA editing does not change with age in the healthy male rat brain.

Biogerontology 2013 Aug 26;14(4):395-400. Epub 2013 May 26.

Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, UK.

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http://dx.doi.org/10.1007/s10522-013-9433-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739863PMC
August 2013

Bicarbonate-sensitive soluble and transmembrane adenylyl cyclases in peripheral chemoreceptors.

Respir Physiol Neurobiol 2013 Aug 31;188(2):83-93. Epub 2013 May 31.

Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287-3200, USA.

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http://dx.doi.org/10.1016/j.resp.2013.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112945PMC
August 2013

The interaction between low glucose and hypoxia in the in vitro, rat carotid body.

Adv Exp Med Biol 2012 ;758:123-7

University of Birmingham, Birmingham, West Midlands, UK.

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http://dx.doi.org/10.1007/978-94-007-4584-1_17DOI Listing
April 2013

Anatomically corresponded regional analysis of cartilage in asymptomatic and osteoarthritic knees by statistical shape modelling of the bone.

IEEE Trans Med Imaging 2010 Aug 8;29(8):1541-59. Epub 2010 Apr 8.

Imaging Science and Biomedical Engineering, School of Cancer and Enabling Sciences, The University of Manchester, M13 9PT Manchester, UK.

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http://dx.doi.org/10.1109/TMI.2010.2047653DOI Listing
August 2010

Improved wrist pannus volume measurement from contrast-enhanced MRI in rheumatoid arthritis using shuffle transform.

Magn Reson Imaging 2007 Jan 8;25(1):110-6. Epub 2006 Dec 8.

Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PT, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S0730725X0600365
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http://dx.doi.org/10.1016/j.mri.2006.10.018DOI Listing
January 2007

Gradient echo MRI characterization of development of atherosclerosis in the abdominal aorta in Watanabe Heritable Hyperlipidemic rabbits.

Cardiovasc Intervent Radiol 2006 Jul-Aug;29(4):605-12

AstraZeneca, 21XF, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.

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http://dx.doi.org/10.1007/s00270-005-0073-5DOI Listing
November 2006

Nonparametric permutation tests for functional neuroimaging: a primer with examples.

Hum Brain Mapp 2002 Jan;15(1):1-25

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1002/hbm.1058DOI Listing
January 2002