Andrew Owen

Andrew Owen

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Andrew Owen

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Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies.

Eur J Pharm Sci 2019 Dec 10;140:105068. Epub 2019 Sep 10.

Department of Pharmaceutical Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria; Department of Molecular and Clinical Pharmacology, University of Liverpool, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.105068DOI Listing
December 2019

Meta-analysis of the effect of CYP2B6, CYP2A6, UGT2B7 and CAR polymorphisms on efavirenz plasma concentrations.

J Antimicrob Chemother 2019 Nov;74(11):3281-3290

Infection Pharmacology Group, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1093/jac/dkz329DOI Listing
November 2019

Modelling the intradermal delivery of microneedle array patches for long-acting antiretrovirals using PBPK.

Eur J Pharm Biopharm 2019 Nov 13;144:101-109. Epub 2019 Sep 13.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2019.09.011DOI Listing
November 2019

CYP2B6*6 Genotype Specific Differences in Artemether-Lumefantrine Disposition in Healthy Volunteers.

J Clin Pharmacol 2019 Sep 23. Epub 2019 Sep 23.

Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1002/jcph.1527DOI Listing
September 2019

Critical considerations for targeting colorectal liver metastases with nanotechnology.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2019 Sep 30:e1588. Epub 2019 Sep 30.

Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1002/wnan.1588DOI Listing
September 2019

Long-Acting Injectable Statins-Is It Time for a Paradigm Shift?

Molecules 2019 Jul 24;24(15). Epub 2019 Jul 24.

Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool L7 3NY, UK.

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http://dx.doi.org/10.3390/molecules24152685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695729PMC
July 2019

Rifampicin effect on intracellular and plasma pharmacokinetics of tenofovir alafenamide.

J Antimicrob Chemother 2019 Jun;74(6):1670-1678

St Stephen's AIDS Trust, Chelsea and Westminster Hospital, London, UK.

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http://dx.doi.org/10.1093/jac/dkz068DOI Listing
June 2019

Towards a Maraviroc long-acting injectable nanoformulation.

Eur J Pharm Biopharm 2019 May 21;138:92-98. Epub 2018 Apr 21.

Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GF, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09396411183020
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http://dx.doi.org/10.1016/j.ejpb.2018.04.009DOI Listing
May 2019

Improving maraviroc oral bioavailability by formation of solid drug nanoparticles.

Eur J Pharm Biopharm 2019 May 17;138:30-36. Epub 2018 May 17.

Department of Molecular and Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool L69 3GF, UK.

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http://dx.doi.org/10.1016/j.ejpb.2018.05.015DOI Listing
May 2019

Vertebroplasty for acute painful osteoporotic vertebral compression fractures: An update.

J Med Imaging Radiat Oncol 2019 May 20. Epub 2019 May 20.

Interventional Radiology Service - Department of Radiology, Austin Hospital, Melbourne, Victoria, Australia.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1754-9485.12
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http://dx.doi.org/10.1111/1754-9485.12900DOI Listing
May 2019

Pharmacogenetics of artemether-lumefantrine influence on nevirapine disposition: Clinically significant drug-drug interaction?

Br J Clin Pharmacol 2019 03 2;85(3):540-550. Epub 2019 Jan 2.

Department of Molecular and Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.

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http://dx.doi.org/10.1111/bcp.13821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379214PMC
March 2019

A Lower Dose of Efavirenz Can Be Coadministered With Rifampicin and Isoniazid in Tuberculosis Patients.

Open Forum Infect Dis 2019 Feb 16;6(2):ofz035. Epub 2019 Jan 16.

Jeffriess Research Trust Laboratories, Department of Medicine, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1093/ofid/ofz035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386798PMC
February 2019

Pharmacokinetics of dolutegravir with and without darunavir/cobicistat in healthy volunteers.

J Antimicrob Chemother 2019 01;74(1):149-156

St Stephen's Clinical Research, Chelsea and Westminster Hospital, 369 Fulham Road, London, UK.

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http://dx.doi.org/10.1093/jac/dky384DOI Listing
January 2019

Inhibitory Effects of Commonly Used Excipients on P-Glycoprotein in Vitro.

Mol Pharm 2018 11 23;15(11):4835-4842. Epub 2018 Oct 23.

Department of Molecular and Clinical Pharmacology , University of Liverpool , Liverpool L69 3GF , United Kingdom.

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http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00482
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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00482DOI Listing
November 2018

Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and Lumefantrine in HIV-Malaria Coinfection.

Antimicrob Agents Chemother 2018 10 24;62(10). Epub 2018 Sep 24.

Department of Pharmaceutical Chemistry, Obafemi Awolowo University, Ile Ife, Nigeria.

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http://dx.doi.org/10.1128/AAC.01252-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153791PMC
October 2018

Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach.

Drug Metab Pharmacokinet 2018 Aug 16;33(4):179-187. Epub 2018 Mar 16.

Department of Molecular and Clinical Pharmacology, The University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.dmpk.2018.01.004DOI Listing
August 2018

Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics of Efavirenz 400 mg Once Daily During Pregnancy and Post-Partum.

Clin Infect Dis 2018 08;67(5):785-790

Jeffriess Research Trust Laboratories, Department of Medicine, Imperial College, St Mary's Campus, London.

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http://dx.doi.org/10.1093/cid/ciy161DOI Listing
August 2018

The potential value of nanomedicine and novel oral dosage forms in the treatment of HIV.

Nanomedicine (Lond) 2018 08 6;13(16):1963-1965. Epub 2018 Sep 6.

Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK.

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http://dx.doi.org/10.2217/nnm-2018-0182DOI Listing
August 2018

Analysis of Clinical Drug-Drug Interaction Data To Predict Magnitudes of Uncharacterized Interactions between Antiretroviral Drugs and Comedications.

Antimicrob Agents Chemother 2018 07 26;62(7). Epub 2018 Jun 26.

Division of Infectious Diseases and Hospital Epidemiology Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland

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http://dx.doi.org/10.1128/AAC.00717-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021627PMC
July 2018

Quantifying low levels (<0.5% w/w) of warfarin sodium salts in oral solid dose forms using Transmission Raman spectroscopy.

J Pharm Biomed Anal 2018 Jun 10;155:276-283. Epub 2018 Apr 10.

Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell, Oxford, OX11 0QX, UK.

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http://dx.doi.org/10.1016/j.jpba.2018.04.008DOI Listing
June 2018

The emerging role of physiologically based pharmacokinetic modelling in solid drug nanoparticle translation.

Adv Drug Deliv Rev 2018 06 27;131:116-121. Epub 2018 Jun 27.

Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1016/j.addr.2018.06.016DOI Listing
June 2018

Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.

Diab Vasc Dis Res 2018 05 21;15(3):233-242. Epub 2018 Feb 21.

1 Department of Molecular and Clinical Pharmacology, The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1177/1479164118757924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949706PMC
May 2018

Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease.

Antimicrob Agents Chemother 2018 04 27;62(4). Epub 2018 Mar 27.

Antimicrobial Pharmacodynamics and Therapeutics, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, Liverpool, United Kingdom

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http://dx.doi.org/10.1128/AAC.01909-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913986PMC
April 2018

The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery.

Expert Rev Gastroenterol Hepatol 2018 Mar 8;12(3):223-236. Epub 2017 Nov 8.

b Molecular and Clinical Pharmacology, Institute of Translational Medicine , University of Liverpool , Liverpool , UK.

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http://dx.doi.org/10.1080/17474124.2018.1399794DOI Listing
March 2018

Assessment of interactions of efavirenz solid drug nanoparticles with human immunological and haematological systems.

J Nanobiotechnology 2018 Mar 15;16(1):22. Epub 2018 Mar 15.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, The University of Liverpool, 70 Pembroke Place, Block H, First Floor, Liverpool, L69 3GF, UK.

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http://dx.doi.org/10.1186/s12951-018-0349-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853089PMC
March 2018

In Silico Dose Prediction for Long-Acting Rilpivirine and Cabotegravir Administration to Children and Adolescents.

Clin Pharmacokinet 2018 02;57(2):255-266

Department of Molecular and Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.

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http://dx.doi.org/10.1007/s40262-017-0557-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701864PMC
February 2018

Evaluation of universal versus genotype-guided efavirenz dose reduction in pregnant women using population pharmacokinetic modelling.

J Antimicrob Chemother 2018 Jan;73(1):165-172

Department of Molecular and Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool L693GF, UK.

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http://dx.doi.org/10.1093/jac/dkx334DOI Listing
January 2018

Advances in nanomedicine drug delivery applications for HIV therapy.

Future Sci OA 2018 Jan 6;4(1):FSO230. Epub 2017 Sep 6.

Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.4155/fsoa-2017-0069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729605PMC
January 2018

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis.

Nat Commun 2018 01 22;9(1):315. Epub 2018 Jan 22.

Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1038/s41467-017-02603-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778127PMC
January 2018

Incompatibility of chemical protein synthesis inhibitors with accurate measurement of extended protein degradation rates.

Pharmacol Res Perspect 2017 10;5(5)

Department of Molecular and Clinical Pharmacology, The University of Liverpool, 70 Pembroke Place, Block H (first floor), Liverpool, L69 3GF, United Kingdom.

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http://dx.doi.org/10.1002/prp2.359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625163PMC
October 2017

Evaluating the Safety In Numbers effect for pedestrians at urban intersections.

Accid Anal Prev 2017 Sep 15;106:181-190. Epub 2017 Jun 15.

University of Minnesota, Center for Transportation Studies, United States. Electronic address:

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http://dx.doi.org/10.1016/j.aap.2017.06.004DOI Listing
September 2017

Lack of interaction of lopinavir solid drug nanoparticles with cells of the immune system.

Nanomedicine (Lond) 2017 Sep 14;12(17):2043-2054. Epub 2017 Aug 14.

Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, the University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.2217/nnm-2017-0095DOI Listing
September 2017

Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.

Gastroenterology 2017 07 28;153(1):233-248.e16. Epub 2017 Mar 28.

Birmingham Liver Biomedical Research Unit, National Institute for Health Research, Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511862PMC
July 2017

Safety and Efficacy of Antiviral Therapy for Prevention of Cytomegalovirus Reactivation in Immunocompetent Critically Ill Patients: A Randomized Clinical Trial.

JAMA Intern Med 2017 06;177(6):774-783

Institute of Clinical Sciences, University of Birmingham, Birmingham, England3University Hospitals Birmingham National Health Service Foundation Trust, Birmingham, England.

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http://dx.doi.org/10.1001/jamainternmed.2017.0895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818821PMC
June 2017

Interaction of Rifampin and Darunavir-Ritonavir or Darunavir-Cobicistat .

Antimicrob Agents Chemother 2017 05 24;61(5). Epub 2017 Apr 24.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

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http://dx.doi.org/10.1128/AAC.01776-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404587PMC
May 2017

Multidetector (64+) Computed Tomography Angiography of the Lower Limb in Symptomatic Peripheral Arterial Disease: Assessment of Image Quality and Accuracy in a Tertiary Care Setting.

J Comput Assist Tomogr 2017 Mar/Apr;41(2):327-333

From the *Austin Health; †Centre for Population Health, Burnet Institute; and Departments of ‡Surgery and §Radiology, The University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1097/RCT.0000000000000494DOI Listing
April 2017

Use of a physiologically based pharmacokinetic model to simulate drug-drug interactions between antineoplastic and antiretroviral drugs.

J Antimicrob Chemother 2017 03;72(3):805-811

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1093/jac/dkw485DOI Listing
March 2017

Sound understanding of environmental, health and safety, clinical, and market aspects is imperative to clinical translation of nanomedicines.

Nanotoxicology 2017 03 24;11(2):147-149. Epub 2017 Jan 24.

a Department Materials Meet Life , Swiss Federal Laboratories for Materials Science and Technology (Empa) , St. Gallen , Switzerland.

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http://dx.doi.org/10.1080/17435390.2017.1279361DOI Listing
March 2017

Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation.

Antimicrob Agents Chemother 2017 01 27;61(1). Epub 2016 Dec 27.

Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1128/AAC.01841-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192136PMC
January 2017

How fast is too fast? Chest compression rate revisited from a new perspective.

Resuscitation 2017 01 27;110:A1-A2. Epub 2016 Oct 27.

College of Medical and Dental Sciences, University of Birmingham, UK; Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.resuscitation.2016.10.009DOI Listing
January 2017

Erratum for Siccardi et al., Validation of Computational Approaches for Antiretroviral Dose Optimization.

Antimicrob Agents Chemother 2017 01 27;61(1). Epub 2016 Dec 27.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1128/AAC.02367-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192101PMC
January 2017

A novel way to promote mass public engagement in CPR education.

Resuscitation 2016 12 13;109:e1. Epub 2016 Oct 13.

Resuscitation for Medical Disciplines Research Group, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1016/j.resuscitation.2016.09.030DOI Listing
December 2016

Development and validation of an LC-MS/MS assay for the quantification of efavirenz in different biological matrices.

Bioanalysis 2016 Oct 9;8(20):2125-34. Epub 2016 Sep 9.

Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.4155/bio-2016-0021DOI Listing
October 2016

Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies.

Nat Commun 2016 10 21;7:13184. Epub 2016 Oct 21.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Block H, 70 Pembroke Place, Liverpool L69 3GF, UK.

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http://dx.doi.org/10.1038/ncomms13184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078733PMC
October 2016

Rapid quantification of low level polymorph content in a solid dose form using transmission Raman spectroscopy.

J Pharm Biomed Anal 2016 Sep 12;128:35-45. Epub 2016 May 12.

Cobalt Light Systems Ltd., Milton Park, Abingdon, OX14 4SD, UK; Central Laser Facility, STFC Rutherford Appleton Laboratory, Harwell Campus, OX11 0QX, UK.

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http://dx.doi.org/10.1016/j.jpba.2016.05.017DOI Listing
September 2016

Towards a rational design of solid drug nanoparticles with optimised pharmacological properties.

J Interdiscip Nanomed 2016 Sep 29;1(3):110-123. Epub 2016 Sep 29.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine University of Liverpool Liverpool L693GF UK.

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http://dx.doi.org/10.1002/jin2.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054800PMC
September 2016

Nanoformulation strategies for the enhanced oral bioavailability of antiretroviral therapeutics.

Ther Deliv 2015 ;6(4):469-90

Department of Molecular & Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Block H (First Floor), Liverpool, L69 3GF, UK.

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http://dx.doi.org/10.4155/tde.15.4DOI Listing
August 2016

Considerations for clinically-relevant nanomedicine therapies for chronic diseases.

Nanomedicine (Lond) 2015 8;10(20):3103-7. Epub 2015 Oct 8.

Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK.

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http://dx.doi.org/10.2217/nnm.15.135DOI Listing
August 2016

Strengths, weaknesses, opportunities and challenges for long acting injectable therapies: Insights for applications in HIV therapy.

Adv Drug Deliv Rev 2016 08 23;103:144-56. Epub 2016 Feb 23.

Department of Chemistry, Crown Street, University of Liverpool, L69 3BX, UK.

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http://dx.doi.org/10.1016/j.addr.2016.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935562PMC
August 2016

Pregnancy affects nevirapine pharmacokinetics: evidence from a CYP2B6 genotype-guided observational study.

Pharmacogenet Genomics 2016 08;26(8):381-9

aDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK bFaculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.

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http://dx.doi.org/10.1097/FPC.0000000000000227DOI Listing
August 2016

Validation of Computational Approaches for Antiretroviral Dose Optimization.

Antimicrob Agents Chemother 2016 06 23;60(6):3838-9. Epub 2016 May 23.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00094-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879416PMC
June 2016

Determining the relationship between nanoparticle characteristics and immunotoxicity: key challenges and approaches.

Nanomedicine (Lond) 2016 06 12;11(11):1447-64. Epub 2016 May 12.

European Nanotechnology Characterization Lab, University of Liverpool, Molecular & Clinical Pharmacology, 70 Pembroke Place, Liverpool, L69 3GF, UK.

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http://dx.doi.org/10.2217/nnm-2016-0017DOI Listing
June 2016

Pharmacogenetics of nevirapine excretion into breast milk and infants' exposure through breast milk versus postexposure prophylaxis.

Pharmacogenomics 2016 06 7;17(8):891-906. Epub 2016 Jun 7.

Department of Molecular & Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool L69 3GF, UK.

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http://dx.doi.org/10.2217/pgs-2015-0016DOI Listing
June 2016

Dolutegravir and elvitegravir plasma concentrations following cessation of drug intake.

J Antimicrob Chemother 2016 Apr 17;71(4):1031-6. Epub 2015 Dec 17.

St Stephen's Centre, Chelsea and Westminster Hospital, London, UK Imperial College, London, UK

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http://dx.doi.org/10.1093/jac/dkv425DOI Listing
April 2016

Toxicity and inflammatory response in Swiss albino mice after intraperitoneal and oral administration of polyurethane nanoparticles.

Toxicol Lett 2016 Mar 25;246:17-27. Epub 2016 Jan 25.

Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina P.O. Box 476, Florianópolis, SC, 88040-900, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2016.01.018DOI Listing
March 2016

Emerging nanomedicine applications and manufacturing: progress and challenges.

Nanomedicine (Lond) 2016 Mar 25;11(6):577-80. Epub 2016 Feb 25.

Department of Molecular & Clinical, Pharmacology, University of Liverpool, Liverpool L69 3GF, UK.

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http://dx.doi.org/10.2217/nnm.16.17DOI Listing
March 2016

A systematic review and meta-analysis of perioperative oral decontamination in patients undergoing major elective surgery.

Perioper Med (Lond) 2016 22;5. Epub 2016 Mar 22.

West Midlands Research Collaborative, University of Birmingham, Edgbaston, Birmingham, B15 2TH UK ; Nottingham Oesophagi-Gastric unit, Nottingham University Hospitals NHS Trust, Queens Medical Centre, Nottingham, NG7 2UH UK.

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http://dx.doi.org/10.1186/s13741-016-0030-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802585PMC
March 2016

Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis.

Antimicrob Agents Chemother 2016 01 19;60(1):617-20. Epub 2015 Oct 19.

TB Research Unit, Medical Research Council, Durban, South Africa KwaZulu-Natal Research Institute for Tuberculosis & HIV (K-RITH), Nelson Mandela School of Medicine, Durban, South Africa.

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http://aac.asm.org/content/early/2015/10/13/AAC.01195-15.ful
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http://aac.asm.org/lookup/doi/10.1128/AAC.01195-15
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http://dx.doi.org/10.1128/AAC.01195-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704238PMC
January 2016

Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment.

J Control Release 2015 Dec 24;219:669-680. Epub 2015 Aug 24.

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.08.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879940PMC
December 2015

Class-specific relative genetic contribution for key antiretroviral drugs.

J Antimicrob Chemother 2015 Nov 28;70(11):3074-9. Epub 2015 Jul 28.

Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1093/jac/dkv207DOI Listing
November 2015

Comprehensive quantification of tablets with multiple active pharmaceutical ingredients using transmission Raman spectroscopy--a proof of concept study.

J Pharm Biomed Anal 2015 Nov 26;115:277-82. Epub 2015 Jul 26.

Cobalt Light Systems Ltd, 174 Brook Drive, Milton Park, Abingdon, Oxfordshire, OX14 4SD, UK; Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, OX11 0QX, UK.

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http://dx.doi.org/10.1016/j.jpba.2015.07.019DOI Listing
November 2015

Use of the learning conversation improves instructor confidence in life support training: An open randomised controlled cross-over trial comparing teaching feedback mechanisms.

Resuscitation 2015 Nov 24;96:199-207. Epub 2015 Aug 24.

Resuscitation for Medical Disciplines Research Group, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

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http://dx.doi.org/10.1016/j.resuscitation.2015.08.010DOI Listing
November 2015

Mesenchymal stromal cell therapy in liver disease: opportunities and lessons to be learnt?

Am J Physiol Gastrointest Liver Physiol 2015 Nov 27;309(10):G791-800. Epub 2015 Aug 27.

National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver Research, Birmingham, United Kingdom; and Liver Unit, University Hospital Birmingham National Health Service Foundation Trust, Birmingham, United Kingdom.

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http://dx.doi.org/10.1152/ajpgi.00036.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652139PMC
November 2015

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation.

AIDS 2015 Nov;29(18):2385-95

aMRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology bDepartment of Chemistry, University of Liverpool, Liverpool, England cLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, USA dDrug Metabolism and Pharmacokinetics, GlaxoSmithKline, Hertfordshire, England.

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http://dx.doi.org/10.1097/QAD.0000000000000867DOI Listing
November 2015

Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast-milk spots.

J Antimicrob Chemother 2015 Oct 24;70(10):2816-22. Epub 2015 Jun 24.

Department of Molecular and Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool L69 3GF, UK

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http://dx.doi.org/10.1093/jac/dkv174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538530PMC
October 2015

Augmented Inhibition of CYP3A4 in Human Primary Hepatocytes by Ritonavir Solid Drug Nanoparticles.

Mol Pharm 2015 Oct 18;12(10):3556-68. Epub 2015 Sep 18.

Department of Molecular and Clinical Pharmacology, University of Liverpool , Block H, 70 Pembroke Place, Liverpool L69 3GF, U.K.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00204DOI Listing
October 2015

Synthesis, nanoprecipitation and pH sensitivity of amphiphilic linear-dendritic hybrid polymers and hyperbranched-polydendrons containing tertiary amine functional dendrons.

Soft Matter 2015 Sep 4;11(35):7005-15. Epub 2015 Aug 4.

Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK.

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http://dx.doi.org/10.1039/c5sm00673bDOI Listing
September 2015

Structured training in assessment increases confidence amongst basic life support instructors.

Resuscitation 2015 Aug 6;93:58-62. Epub 2015 Jun 6.

Resuscitation for Medical Disciplines Research Group, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom; Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2WB, United Kingdom.

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http://dx.doi.org/10.1016/j.resuscitation.2015.05.028DOI Listing
August 2015

Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV.

Clin Pharmacokinet 2015 Jun;54(6):639-50

Department of Molecular and Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.

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http://dx.doi.org/10.1007/s40262-014-0227-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450126PMC
June 2015

Special populations and pharmacogenetic issues in tuberculosis drug development and clinical research.

J Infect Dis 2015 Jun;211 Suppl 3:S115-25

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, United Kingdom.

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http://dx.doi.org/10.1093/infdis/jiu600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551115PMC
June 2015

No relationship between drug transporter genetic variants and tenofovir plasma concentrations or changes in glomerular filtration rate in HIV-infected adults.

J Acquir Immune Defic Syndr 2015 Apr;68(4):e56-9

*Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand †EAU08 University Paris Descartes and CIC1419 Inserm, Paris, France ‡Hopital Cochin, Assistance Publique-Hopitaux de Paris, Paris, France §Unite de Recherche clinique, AP-HP, Hopital Tarnier, Paris, France ‖Institut de Recherche pour le Développement (IRD) UMI 174-Program for HIV Prevention and Treatment (PHPT), Marseille, France ¶Lamphun Hospital, Lamphun, Thailand #Maha Sarakham Hospital, Maha Sarakham, Thailand **Hat Yai Hospital, Songkhla, Thailand ††Harvard School of Public Health, Boston, MA ‡‡Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1097/QAI.0000000000000504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334716PMC
April 2015

Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter.

Front Pharmacol 2015 10;6:78. Epub 2015 Apr 10.

Department of Molecular and Clinical Pharmacology, University of Liverpool Liverpool, UK.

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http://dx.doi.org/10.3389/fphar.2015.00078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392609PMC
April 2015

Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium.

Chem Sci 2015 Jan 3;6(1):326-334. Epub 2014 Oct 3.

Department of Chemistry , University of Liverpool , Crown Street , L69 7ZD , UK . Email:

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http://dx.doi.org/10.1039/c4sc02889aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586204PMC
January 2015

The role of drug transporters in the kidney: lessons from tenofovir.

Front Pharmacol 2014 11;5:248. Epub 2014 Nov 11.

Department of Molecular and Clinical Pharmacology, University of Liverpool Liverpool, UK.

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http://dx.doi.org/10.3389/fphar.2014.00248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227492PMC
November 2014