Andrew N Lowell

Andrew N Lowell

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Andrew N Lowell

Andrew N Lowell

Publications by authors named "Andrew N Lowell"

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16Publications

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Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway.

Methods Enzymol 2018 9;604:207-236. Epub 2018 Apr 9.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States; Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, United States; Life Sciences Institute, Department of Chemistry, University of Michigan, Ann Arbor, MI, United States; Life Sciences Institute, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00766879183004
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http://dx.doi.org/10.1016/bs.mie.2018.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327954PMC
April 2019

Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units.

J Am Chem Soc 2019 Feb 24;141(5):1961-1969. Epub 2019 Jan 24.

Department of Chemistry , NC State University , Raleigh , North Carolina 27695 , United States.

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http://dx.doi.org/10.1021/jacs.8b10521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556384PMC
February 2019

Larger Substituents on Amide Cavitands Induce Bigger Cavities.

Org Lett 2019 01 19;21(1):201-205. Epub 2018 Dec 19.

Laboratorium für Organische Chemie , ETH Zürich , Vladimir-Prelog-Weg 3 , CH8093 Zürich , Switzerland.

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http://dx.doi.org/10.1021/acs.orglett.8b03660DOI Listing
January 2019

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

J Am Chem Soc 2017 06 5;139(23):7913-7920. Epub 2017 Jun 5.

Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/jacs.7b02875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532807PMC
June 2017

Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.

Nat Chem Biol 2017 05 13;13(5):467-469. Epub 2017 Mar 13.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/nchembio.2327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391265PMC
May 2017

Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.

ACS Chem Biol 2016 09 5;11(9):2642-54. Epub 2016 Aug 5.

Life Sciences Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acschembio.6b00479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026600PMC
September 2016

Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries.

Chem Biol Drug Des 2015 Dec 25;86(6):1331-8. Epub 2015 Jul 25.

Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Ann Arbor, MI, 48109-2216, USA.

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http://dx.doi.org/10.1111/cbdd.12614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888872PMC
December 2015

Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.

J Am Chem Soc 2015 Dec 2;137(49):15366-9. Epub 2015 Dec 2.

Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523, United States.

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http://dx.doi.org/10.1021/jacs.5b10136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681624PMC
December 2015

Functionalized low-density lipoprotein nanoparticles for in vivo enhancement of atherosclerosis on magnetic resonance images.

Bioconjug Chem 2012 Nov 1;23(11):2313-9. Epub 2012 Nov 1.

Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA.

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http://dx.doi.org/10.1021/bc300561eDOI Listing
November 2012

Alternative spiroketalization methods toward purpuromycin: a hemiketal conjugate addition strategy and use of an electron-rich isocoumarin precursor.

J Org Chem 2011 Aug 18;76(16):6475-87. Epub 2011 Jul 18.

Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.

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http://dx.doi.org/10.1021/jo200398vDOI Listing
August 2011

Alternative spiroketalization methods toward purpuromycin: a diketone approach to prevent benzofuran formation.

J Org Chem 2011 Aug 18;76(16):6488-502. Epub 2011 Jul 18.

Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.

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http://dx.doi.org/10.1021/jo200399zDOI Listing
August 2011

LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models.

Chem Commun (Camb) 2011 Aug 8;47(31):8835-7. Epub 2011 Jul 8.

Laboratories of Molecular Imaging, Department of Radiology, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA.

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http://dx.doi.org/10.1039/c1cc10924cDOI Listing
August 2011

A concise synthesis of the naphthalene portion of purpuromycin.

J Org Chem 2008 Mar 8;73(5):1911-8. Epub 2008 Feb 8.

Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.

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http://pubs.acs.org/doi/abs/10.1021/jo7024114
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http://dx.doi.org/10.1021/jo7024114DOI Listing
March 2008