Publications by authors named "Andrew N J McKenzie"

140Publications

RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus.

Authors:
Ana C F Ferreira Aydan C H Szeto Morgan W D Heycock Paula A Clark Jennifer A Walker Alastair Crisp Jillian L Barlow Sophie Kitching Alfred Lim Mayuri Gogoi Richard Berks Maria Daly Helen E Jolin Andrew N J McKenzie

Nat Immunol 2021 Jan 11. Epub 2021 Jan 11.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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January 2021

ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung.

Authors:
Martijn J Schuijs Shaun Png Arianne C Richard Anastasia Tsyben Gregory Hamm Julie Stockis Celine Garcia Silvain Pinaud Ashley Nicholls Xavier Romero Ros Jing Su Matthew D Eldridge Angela Riedel Eva M Serrao Hans-Reimer Rodewald Matthias Mack Jacqueline D Shields E Suzanne Cohen Andrew N J McKenzie Richard J A Goodwin Kevin M Brindle John C Marioni Timotheus Y F Halim

Nat Immunol 2020 09 3;21(9):998-1009. Epub 2020 Aug 3.

CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.

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September 2020

Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11.

Authors:
Veera Panova Mayuri Gogoi Noe Rodriguez-Rodriguez Meera Sivasubramaniam Helen E Jolin Morgan W D Heycock Jennifer A Walker Batika M J Rana Lesley F Drynan Michael Hodskinson Richard Pannell Gareth King Mark Wing Andrew J Easton Caroline A Oedekoven David G Kent Padraic G Fallon Jillian L Barlow Andrew N J McKenzie

Mucosal Immunol 2021 01 26;14(1):26-37. Epub 2020 May 26.

Medical Research Council, Laboratory of Molecular Biology, Cambridge, Cambridgeshire, CB2 0QH, UK.

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January 2021

Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages.

Authors:
Yuning Lu Gemma Basatemur Ian C Scott Davide Chiarugi Marc Clement James Harrison Ravin Jugdaohsingh Xian Yu Stephen A Newland Helen E Jolin Xuan Li Xiao Chen Monika Szymanska Guttorm Haraldsen Gaby Palmer Padraic G Fallon E Suzanne Cohen Andrew N J McKenzie Ziad Mallat

Immunity 2020 05 8;52(5):782-793.e5. Epub 2020 Apr 8.

Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK; Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, Paris, France. Electronic address:

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May 2020

OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer.

Authors:
Rune Busk Damgaard Helen E Jolin Michael E D Allison Susan E Davies Hannah L Titheradge Andrew N J McKenzie David Komander

Cell Death Differ 2020 05 30;27(5):1457-1474. Epub 2020 Mar 30.

Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

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May 2020

ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation.

Authors:
Juan Manuel Leyva-Castillo Claire Galand Shunya Mashiko Robert Bissonnette Alex McGurk Steven F Ziegler Chen Dong Andrew N J McKenzie Marika Sarfati Raif S Geha

J Allergy Clin Immunol 2020 Jun 14;145(6):1606-1614.e4. Epub 2020 Mar 14.

Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

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June 2020

Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.

Authors:
Yi-Ling Chen Tomas Gomes Clare S Hardman Felipe A Vieira Braga Danuta Gutowska-Owsiak Maryam Salimi Nicki Gray David A Duncan Gary Reynolds David Johnson Mariolina Salio Vincenzo Cerundolo Jillian L Barlow Andrew N J McKenzie Sarah A Teichmann Muzlifah Haniffa Graham Ogg

J Exp Med 2020 03;217(3)

Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Oxford National Institute for Health Research Biomedical Research Centre, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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March 2020

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue.

Authors:
Batika M J Rana Eric Jou Jillian L Barlow Noe Rodriguez-Rodriguez Jennifer A Walker Claire Knox Helen E Jolin Clare S Hardman Meera Sivasubramaniam Aydan Szeto E Suzanne Cohen Ian C Scott Matthew A Sleeman Chiamaka I Chidomere Sara Cruz Migoni Jorge Caamano Helle F Jorgensen Stefania Carobbio Antonio Vidal-Puig Andrew N J McKenzie

J Exp Med 2019 09 27;216(9):1999-2009. Epub 2019 Jun 27.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK

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September 2019

Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.

Authors:
Jennifer A Walker Paula A Clark Alastair Crisp Jillian L Barlow Aydan Szeto Ana C F Ferreira Batika M J Rana Helen E Jolin Noe Rodriguez-Rodriguez Meera Sivasubramaniam Richard Pannell James Cruickshank Maria Daly Liora Haim-Vilmovsky Sarah A Teichmann Andrew N J McKenzie

Immunity 2019 07 22;51(1):104-118.e7. Epub 2019 May 22.

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom. Electronic address:

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July 2019

Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury.

Authors:
Guy J M Cameron Kelly M Cautivo Svenja Loering Simon H Jiang Aniruddh V Deshpande Paul S Foster Andrew N J McKenzie Ari B Molofsky Philip M Hansbro Malcolm R Starkey

Front Immunol 2019 16;10:826. Epub 2019 Apr 16.

Priority Research Centre's GrowUpWell and Healthy Lungs, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.

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September 2020

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation.

Authors:
Bernhard Kerscher Jillian L Barlow Batika M Rana Helen E Jolin Mayuri Gogoi Michelle A Bartholomew Deepali Jhamb Ashutosh Pandey David F Tough Antoon J M van Oosterhout Andrew N J McKenzie

Front Immunol 2019 9;10:678. Epub 2019 Apr 9.

Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom.

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August 2020

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.

Authors:
Christian Schwartz Tara Moran Sean P Saunders Agnieszka Kaszlikowska Achilleas Floudas Joana Bom Gabriel Nunez Yoichiro Iwakura Luke O'Neill Alan D Irvine Andrew N J McKenzie Graham Ogg Patrick T Walsh Jocelyne Demengeot Padraic G Fallon

Allergy 2019 10 29;74(10):1920-1933. Epub 2019 Apr 29.

School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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October 2019

Innate Lymphoid Cells of the Lung.

Authors:
Jillian L Barlow Andrew N J McKenzie

Annu Rev Physiol 2019 02;81:429-452

Medical Research Council, Laboratory of Molecular Biology, Cambridge University, Cambridgeshire CB2 0QH, United Kingdom; email:

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February 2019

MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.

Authors:
Martin D Knolle Shau Bing Chin Batika M J Rana Alexandros Englezakis Rinako Nakagawa Padraic G Fallon Anna Git Andrew N J McKenzie

Front Immunol 2018 9;9:2232. Epub 2018 Oct 9.

Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.

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September 2019

Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.

Authors:
Jhuma Pramanik Xi Chen Gozde Kar Johan Henriksson Tomás Gomes Jong-Eun Park Kedar Natarajan Kerstin B Meyer Zhichao Miao Andrew N J McKenzie Bidesh Mahata Sarah A Teichmann

Genome Med 2018 10 24;10(1):76. Epub 2018 Oct 24.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

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October 2018

Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease.

Authors:
Chantal Donovan Malcolm R Starkey Richard Y Kim Batika M J Rana Jillian L Barlow Bernadette Jones Tatt Jhong Haw Prema Mono Nair Kurtis Budden Guy J M Cameron Jay C Horvat Peter A Wark Paul S Foster Andrew N J McKenzie Philip M Hansbro

J Leukoc Biol 2019 01 27;105(1):143-150. Epub 2018 Sep 27.

Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.

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January 2019

Innate Lymphoid Cells: 10 Years On.

Authors:
Eric Vivier David Artis Marco Colonna Andreas Diefenbach James P Di Santo Gérard Eberl Shigeo Koyasu Richard M Locksley Andrew N J McKenzie Reina E Mebius Fiona Powrie Hergen Spits

Cell 2018 08;174(5):1054-1066

Department of Experimental Immunology Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands.

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August 2018

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

Authors:
Timotheus Y F Halim Batika M J Rana Jennifer A Walker Bernhard Kerscher Martin D Knolle Helen E Jolin Eva M Serrao Liora Haim-Vilmovsky Sarah A Teichmann Hans-Reimer Rodewald Marina Botto Timothy J Vyse Padraic G Fallon Zhi Li David R Withers Andrew N J McKenzie

Immunity 2018 06 12;48(6):1195-1207.e6. Epub 2018 Jun 12.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address:

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June 2018

Lack of Type 2 Innate Lymphoid Cells Promotes a Type I-Driven Enhanced Immune Response in Contact Hypersensitivity.

Authors:
David A Rafei-Shamsabadi Saskia van de Poel Britta Dorn Stefanie Kunz Stefan F Martin Christoph S N Klose Sebastian J Arnold Yakup Tanriver Karolina Ebert Andreas Diefenbach Timotheus Y F Halim Andrew N J McKenzie Thilo Jakob

J Invest Dermatol 2018 09 9;138(9):1962-1972. Epub 2018 Mar 9.

Allergy Research Group, Department of Dermatology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Experimental Dermatology and Allergy Research Group, Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Campus Giessen, Justus Liebig University, Giessen, Germany. Electronic address:

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September 2018

CD1a presentation of endogenous antigens by group 2 innate lymphoid cells.

Authors:
Clare S Hardman Yi-Ling Chen Maryam Salimi Rachael Jarrett David Johnson Valtteri J Järvinen Raymond J Owens Emmanouela Repapi David J Cousins Jillian L Barlow Andrew N J McKenzie Graham Ogg

Sci Immunol 2017 12;2(18)

Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, National Institute for Health Research (NIHR) Biomedical Research Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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December 2017