Andrew M L Lever

Andrew M L Lever

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Andrew M L Lever

Publications by authors named "Andrew M L Lever"

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ESCRT-II functions by linking to ESCRT-I in human immunodeficiency virus-1 budding.

Cell Microbiol 2020 May 14;22(5):e13161. Epub 2020 Feb 14.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1111/cmi.13161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187348PMC
May 2020

DDX5 potentiates HIV-1 transcription as a co-factor of Tat.

Retrovirology 2020 03 30;17(1). Epub 2020 Mar 30.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1186/s12977-020-00514-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106839PMC
March 2020

Persistence of Imported Malaria Into the United Kingdom: An Epidemiological Review of Risk Factors and At-risk Groups.

Clin Infect Dis 2019 09;69(7):1156-1162

Department of Medicine, Cambridge University Hospitals National Health Service Foundation Trust, United Kingdom.

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http://dx.doi.org/10.1093/cid/ciy1037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743841PMC
September 2019

A scale-free analysis of the HIV-1 genome demonstrates multiple conserved regions of structural and functional importance.

PLoS Comput Biol 2019 09 23;15(9):e1007345. Epub 2019 Sep 23.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1007345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791557PMC
September 2019

HIV Silencing and Inducibility Are Heterogeneous and Are Affected by Factors Intrinsic to the Virus.

mBio 2019 06 25;10(3). Epub 2019 Jun 25.

Department of Medicine, University of Cambridge, Cambridge, United Kingdom

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http://dx.doi.org/10.1128/mBio.00188-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593397PMC
June 2019

DDX17 Specifically, and Independently of DDX5, Controls Use of the HIV A4/5 Splice Acceptor Cluster and Is Essential for Efficient Replication of HIV.

J Mol Biol 2018 09 2;430(18 Pt B):3111-3128. Epub 2018 Jul 2.

Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK; Department of Medicine, National University of Singapore, Singapore 119228. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.06.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119765PMC
September 2018

An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation.

Retrovirology 2018 03 14;15(1):25. Epub 2018 Mar 14.

Department of Medicine, University of Cambridge, Addenbrookes Hospital, Box 157, Level 5, Hills Rd, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1186/s12977-018-0407-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853050PMC
March 2018

Innovations in the quantitative virus outgrowth assay and its use in clinical trials.

Retrovirology 2017 12 21;14(1):58. Epub 2017 Dec 21.

Department of Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1186/s12977-017-0381-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740843PMC
December 2017

Chronic fatigue syndrome and idiopathic intracranial hypertension: Different manifestations of the same disorder of intracranial pressure?

Med Hypotheses 2017 Aug 24;105:6-9. Epub 2017 Jun 24.

Department of Infectious Diseases, Addenbrooke's Hospital, Cambridge, UK; University of Cambridge, UK.

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http://dx.doi.org/10.1016/j.mehy.2017.06.014DOI Listing
August 2017

Chronic fatigue syndrome and idiopathic intracranial hypertension: Different manifestations of the same disorder of intracranial pressure?

Med Hypotheses 2017 Aug 24;105:6-9. Epub 2017 Jun 24.

Department of Infectious Diseases, Addenbrooke's Hospital, Cambridge, UK; University of Cambridge, UK.

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http://dx.doi.org/10.1016/j.mehy.2017.06.014DOI Listing
August 2017

HIV and Zika: When will we be able to end these epidemics?

Retrovirology 2016 Nov 15;13(1):80. Epub 2016 Nov 15.

Cambridge University, Cambridge, UK.

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http://retrovirology.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12977-016-0315-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111273PMC
November 2016

Characterizing 3D RNA structure by single molecule FRET.

Methods 2016 07 4;103:57-67. Epub 2016 Feb 4.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2016.02.004DOI Listing
July 2016

Disrupted Endothelial Cell Layer and Exposed Extracellular Matrix Proteins Promote Capture of Late Outgrowth Endothelial Progenitor Cells.

Stem Cells Int 2016 16;2016:1406304. Epub 2016 Jun 16.

Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1155/2016/1406304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927957PMC
July 2016

Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1.

Viruses 2016 07 14;8(7). Epub 2016 Jul 14.

Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.3390/v8070192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974527PMC
July 2016

A novel combined RNA-protein interaction analysis distinguishes HIV-1 Gag protein binding sites from structural change in the viral RNA leader.

Sci Rep 2015 Oct 9;5:14369. Epub 2015 Oct 9.

Box 157, Cambridge University Dept. of Medicine, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ.

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http://dx.doi.org/10.1038/srep14369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598872PMC
October 2015

How will the ebola crisis impact the HIV epidemic?

Retrovirology 2014 Nov 30;11:110. Epub 2014 Nov 30.

Department of Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1186/s12977-014-0110-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260236PMC
November 2014

Functional characterization of late outgrowth endothelial progenitor cells in patients with end-stage renal failure.

Transpl Int 2014 May 5;27(5):437-51. Epub 2014 Mar 5.

Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/tri.12277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229358PMC
May 2014

Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle.

Biochemistry 2013 Dec 10;52(51):9269-74. Epub 2013 Dec 10.

Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, CB2 1EW, U.K.

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http://pubs.acs.org/doi/10.1021/bi401270d
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http://dx.doi.org/10.1021/bi401270dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928988PMC
December 2013

In-gel probing of individual RNA conformers within a mixed population reveals a dimerization structural switch in the HIV-1 leader.

Nucleic Acids Res 2013 Oct 8;41(18):e174. Epub 2013 Aug 8.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, Cambridgeshire, CB2 0QQ, UK and HIV-Drug Resistance Program, Centre for Cancer Research, National Cancer Institute, P.O. Box B, Building 535, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1093/nar/gkt690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794615PMC
October 2013

Three-dimensional RNA structure of the major HIV-1 packaging signal region.

Structure 2013 Jun 16;21(6):951-62. Epub 2013 May 16.

Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1016/j.str.2013.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690526PMC
June 2013

HIV Gag polyprotein: processing and early viral particle assembly.

Trends Microbiol 2013 Mar 22;21(3):136-44. Epub 2012 Dec 22.

Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1016/j.tim.2012.11.006DOI Listing
March 2013

Endovascular aortic stent graft infection with Streptococcus equi: the first documented case.

Vascular 2013 Feb 29;21(1):14-6. Epub 2011 Jul 29.

Cambridge Vascular Unit, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1258/vasc.2010.cr0258DOI Listing
February 2013

A cluster of Plasmodium vivax malaria in an expedition group to Ethiopia: prophylactic efficacy of atovaquone/proguanil on liver stages of P. vivax.

J Infect 2012 Sep 16;65(3):269-74. Epub 2012 May 16.

Milford Medical Centre, Sea Road, Milford on Sea SO41 0PG, UK.

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http://dx.doi.org/10.1016/j.jinf.2012.04.015DOI Listing
September 2012

Comparative structural effects of HIV-1 Gag and nucleocapsid proteins in binding to and unwinding of the viral RNA packaging signal.

Biochemistry 2012 Apr 6;51(15):3162-9. Epub 2012 Apr 6.

Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 OQQ, UK.

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http://dx.doi.org/10.1021/bi2017969DOI Listing
April 2012

Case report: Severe typhus group rickettsiosis complicated by pulmonary edema in a returning traveler from Indonesia.

Am J Trop Med Hyg 2011 Dec;85(6):1121-3

Department of Infectious Diseases, Cambridge University Hospitals National Health Service Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.4269/ajtmh.2011.11-0340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225163PMC
December 2011

The molecular biology of feline immunodeficiency virus (FIV).

Viruses 2011 11 9;3(11):2192-213. Epub 2011 Nov 9.

Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.

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http://www.mdpi.com/1999-4915/3/11/2192
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http://dx.doi.org/10.3390/v3112192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230847PMC
November 2011

SHAPE analysis of the FIV Leader RNA reveals a structural switch potentially controlling viral packaging and genome dimerization.

Nucleic Acids Res 2011 Aug 5;39(15):6692-704. Epub 2011 May 5.

University of Cambridge Department of Medicine, Box 157, Level 5 Addenbrooke's Hospital, Hills Rd, Cambridge, CB20QQ, UK.

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http://dx.doi.org/10.1093/nar/gkr252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159445PMC
August 2011

XMRV, prostate cancer and chronic fatigue syndrome.

Br Med Bull 2011 6;98:61-74. Epub 2011 May 6.

Department of Medicine, University of Cambridge, Addenbrooke’s hospital, Cambridge, UK.

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http://dx.doi.org/10.1093/bmb/ldr010DOI Listing
August 2011

Intracellular defenses against HIV, viral evasion and novel therapeutic approaches.

J Formos Med Assoc 2011 Jun;110(6):350-62

Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S092966461160053
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http://dx.doi.org/10.1016/S0929-6646(11)60053-3DOI Listing
June 2011

Insights into cellular factors that regulate HIV-1 replication in human cells.

Biochemistry 2011 Feb 24;50(6):920-31. Epub 2011 Jan 24.

Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, U.K.

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http://pubs.acs.org/doi/abs/10.1021/bi101805f
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http://dx.doi.org/10.1021/bi101805fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035746PMC
February 2011

Optimal packaging of FIV genomic RNA depends upon a conserved long-range interaction and a palindromic sequence within gag.

J Mol Biol 2010 Oct 21;403(1):103-119. Epub 2010 Aug 21.

Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1016/j.jmb.2010.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987497PMC
October 2010

Rev regulates translation of human immunodeficiency virus type 1 RNAs.

J Gen Virol 2009 May 4;90(Pt 5):1141-1147. Epub 2009 Mar 4.

Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1099/vir.0.007963-0DOI Listing
May 2009

The secondary structure of the 5' end of the FIV genome reveals a long-range interaction between R/U5 and gag sequences, and a large, stable stem-loop.

RNA 2008 Dec 30;14(12):2597-608. Epub 2008 Oct 30.

Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom.

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http://dx.doi.org/10.1261/rna.1284908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590967PMC
December 2008

Steric block high affinity oligonucleotide analogues: a new tool for mapping RNA-protein binding sites.

Nucleosides Nucleotides Nucleic Acids 2008 Feb;27(2):196-212

Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1080/15257770701795961DOI Listing
February 2008

Dimerisation of HIV-2 genomic RNA is linked to efficient RNA packaging, normal particle maturation and viral infectivity.

Retrovirology 2007 Dec 13;4:90. Epub 2007 Dec 13.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

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http://retrovirology.biomedcentral.com/articles/10.1186/1742
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http://dx.doi.org/10.1186/1742-4690-4-90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222663PMC
December 2007

A case of Mycoplasma hominis septic arthritis postpartum.

J Infect 2007 Nov 24;55(5):e135-7. Epub 2007 Sep 24.

Division of Infectious Diseases, Department of Medicine, Addenbrooke's Hospital, Cambridge University, Cambridge, UK.

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http://dx.doi.org/10.1016/j.jinf.2007.08.006DOI Listing
November 2007

HIV-1 RNA packaging.

Authors:
Andrew M L Lever

Adv Pharmacol 2007 ;55:1-32

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S105435890755001
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http://dx.doi.org/10.1016/S1054-3589(07)55001-5DOI Listing
August 2007

Lentivirus-mediated gene expression.

Methods Mol Biol 2007 ;366:343-55

Department of Medicine, Addenbrooke's Hospital, University of Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-59745-030-0_20DOI Listing
July 2007

Reversible parkinsonism in a patient with progressive multifocal leucoencephalopathy.

J Neurol Neurosurg Psychiatry 2007 Apr;78(4):408-10

Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1136/jnnp.2006.103259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077773PMC
April 2007

Rapamycin-induced inhibition of HTLV-I LTR activity is rescued by c-Myb.

Retrovirology 2007 Apr 3;4:24. Epub 2007 Apr 3.

Division of Retrovirology, National Institute for Biological Standards and Control, Blanche Lane, Potters Bar, Hertfordshire, UK.

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http://dx.doi.org/10.1186/1742-4690-4-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852806PMC
April 2007

An update on malaria prevention, diagnosis and treatment for the returning traveller.

Blood Rev 2007 Mar 3;21(2):73-87. Epub 2006 Jul 3.

Department of Infectious Diseases, Box 25, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.

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http://dx.doi.org/10.1016/j.blre.2006.03.004DOI Listing
March 2007

Human immunodeficiency virus type 1 Gag polyprotein modulates its own translation.

J Virol 2006 Nov;80(21):10478-86

Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02596-05
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http://dx.doi.org/10.1128/JVI.02596-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1641787PMC
November 2006

Mutation of the Rev-binding loop in the human immunodeficiency virus 1 leader causes a replication defect characterized by altered RNA trafficking and packaging.

J Gen Virol 2006 Oct;87(Pt 10):3039-44

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1099/vir.0.81658-0DOI Listing
October 2006

Anti-HIV activity of steric block oligonucleotides.

Ann N Y Acad Sci 2006 Oct;1082:103-15

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1196/annals.1348.033DOI Listing
October 2006

Replication of human immunodeficiency virus type 1 from entry to exit.

Int J Hematol 2006 Jul;84(1):23-30

University of Cambridge Department of Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://link.springer.com/10.1532/IJH97.06112
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http://dx.doi.org/10.1532/IJH97.06112DOI Listing
July 2006

Science--a life fully lived: Joe Sodroski wins the 2006 Retrovirology Prize.

Authors:
Andrew M L Lever

Retrovirology 2006 Jul 27;3:45. Epub 2006 Jul 27.

Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.

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http://dx.doi.org/10.1186/1742-4690-3-45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523364PMC
July 2006

Inhibition of HIV-1 replication by oligonucleotide analogues directed to the packaging signal and trans-activating response region.

Antivir Chem Chemother 2006 ;17(1):1-9

University of Cambridge, Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1177/095632020601700101DOI Listing
May 2006

Antiviral activity of steric-block oligonucleotides targeting the HIV-1 trans-activation response and packaging signal stem-loop RNAs.

Nucleosides Nucleotides Nucleic Acids 2005 ;24(5-7):393-6

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ. UK.

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http://dx.doi.org/10.1081/ncn-200059813DOI Listing
December 2005

A husband and wife with left hand rashes.

Lancet Infect Dis 2005 Dec;5(12):802

Department of Infectious Diseases, Addenbrooke's Hospital, Cambridge, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S147330990570300
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http://dx.doi.org/10.1016/S1473-3099(05)70300-5DOI Listing
December 2005

HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET.

Traffic 2005 Sep;6(9):741-55

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK.

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http://dx.doi.org/10.1111/j.1600-0854.2005.00312.xDOI Listing
September 2005

Blockade of chemokine-induced signalling inhibits CCR5-dependent HIV infection in vitro without blocking gp120/CCR5 interaction.

Retrovirology 2005 Apr 4;2:23. Epub 2005 Apr 4.

Department of Medicine, University of Cambridge, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.

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http://retrovirology.biomedcentral.com/articles/10.1186/1742
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http://dx.doi.org/10.1186/1742-4690-2-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082716PMC
April 2005

Lentiviral vectors.

J Biomed Sci 2004 Jul-Aug;11(4):439-49

University of Cambridge, Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1007/BF02256092DOI Listing
March 2005

Hepatocyte-specific gene expression from integrated lentiviral vectors.

J Gene Med 2004 Sep;6(9):974-83

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1002/jgm.591DOI Listing
September 2004

The human T-cell lymphotropic virus type-I dimerization initiation site forms a hairpin loop, unlike previously characterized retroviral dimerization motifs.

Biochemistry 2004 May;43(20):6085-90

Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, UK.

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http://dx.doi.org/10.1021/bi030237iDOI Listing
May 2004

Rev binds specifically to a purine loop in the SL1 region of the HIV-1 leader RNA.

J Biol Chem 2003 Oct 8;278(41):40385-91. Epub 2003 Jul 8.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M301041200DOI Listing
October 2003

Lentiviral vectors for gene delivery to normal and demyelinated white matter.

Glia 2003 Apr;42(1):59-67

Department of Clinical Veterinary Medicine, University of Cambridge, UK.

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http://doi.wiley.com/10.1002/glia.10195
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http://dx.doi.org/10.1002/glia.10195DOI Listing
April 2003

The rapamycin sensitivity of human T-cell leukaemia virus type I-induced T-cell proliferation is mediated independently of the polypyrimidine motifs in the 5' long terminal repeat.

J Gen Virol 2001 Feb;82(Pt 2):435-439

Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK1.

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http://dx.doi.org/10.1099/0022-1317-82-2-435DOI Listing
February 2001