Andrew M Fry

Andrew M Fry

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Andrew M Fry

Andrew M Fry

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Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.

Sci Signal 2019 Aug 13;12(594). Epub 2019 Aug 13.

Department of Molecular and Cell Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1126/scisignal.aaw2939DOI Listing
August 2019

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.

Sci Signal 2018 08 14;11(543). Epub 2018 Aug 14.

Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1126/scisignal.aao2464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166782PMC
August 2018

Mitotic Regulation by NEK Kinase Networks.

Front Cell Dev Biol 2017 1;5:102. Epub 2017 Dec 1.

Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona, Spain.

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http://dx.doi.org/10.3389/fcell.2017.00102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716973PMC
December 2017

Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.

Cancer Res 2017 09 18;77(18):4785-4796. Epub 2017 Jul 18.

Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3233DOI Listing
September 2017

Recent advances in pericentriolar material organization: ordered layers and scaffolding gels.

F1000Res 2017 31;6:1622. Epub 2017 Aug 31.

Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.12688/f1000research.11652.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583744PMC
August 2017

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase.

Malar J 2016 11 7;15(1):535. Epub 2016 Nov 7.

Centre for Translational Pharmacology, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, G12 8QQ, UK.

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http://dx.doi.org/10.1186/s12936-016-1580-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100313PMC
November 2016

EML proteins in microtubule regulation and human disease.

Biochem Soc Trans 2016 10;44(5):1281-1288

Cancer Research UK Leeds Centre, Faculty of Biological Sciences, University of Leeds, Astbury Building, Leeds LS2 9JT, U.K.

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http://dx.doi.org/10.1042/BST20160125DOI Listing
October 2016

Novel insights into the mechanisms of mitotic spindle assembly by NEK kinases.

Mol Cell Oncol 2016 May 6;3(3):e1062952. Epub 2015 Jul 6.

University of Leicester, Department of Biochemistry , Leicester, UK.

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http://dx.doi.org/10.1080/23723556.2015.1062952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909405PMC
May 2016

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs.

Cell Mol Life Sci 2016 Mar 11;73(6):1209-24. Epub 2016 Jan 11.

Department of Molecular and Cell Biology, University of Leicester, Lancaster Road, Leicester, LE2 9HN, UK.

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http://dx.doi.org/10.1007/s00018-015-2117-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761370PMC
March 2016

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.

Nat Commun 2015 Nov 2;6:8771. Epub 2015 Nov 2.

Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1038/ncomms9771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632185PMC
November 2015

Hsp70 proteins in mitosis and disease.

Oncotarget 2015 Oct;6(32):32293-4

Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.18632/oncotarget.5965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741684PMC
October 2015

Nek5: a new regulator of centrosome integrity.

Oncotarget 2015 Sep;6(28):24594-5

University of Leicester, Department of Biochemistry, Leicester, UK.

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http://dx.doi.org/10.18632/oncotarget.5139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694778PMC
September 2015

OFD1 and flotillins are integral components of a ciliary signaling protein complex organized by polycystins in renal epithelia and odontoblasts.

PLoS One 2014 2;9(9):e106330. Epub 2014 Sep 2.

Department of Pathology MSC08-4640 and Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106330PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152239PMC
May 2015

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.

Biochem J 2015 May;467(3):529-36

*Department of Biochemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.

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http://dx.doi.org/10.1042/BJ20150039DOI Listing
May 2015

Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis.

J Cell Biol 2015 May;209(3):339-48

Department of Biochemistry, University of Leicester, Leicester LE1 9HN, England, UK

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http://dx.doi.org/10.1083/jcb.201412099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427792PMC
May 2015

Solving the centriole disengagement puzzle.

Authors:
Andrew M Fry

Nat Cell Biol 2015 Jan;17(1):3-5

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January 2015

Overexpression of the Nek2 kinase in colorectal cancer correlates with beta-catenin relocalization and shortened cancer-specific survival.

J Surg Oncol 2014 Dec 16;110(7):828-38. Epub 2014 Jul 16.

Cancer Studies and Molecular Medicine, The Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom.

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http://dx.doi.org/10.1002/jso.23717DOI Listing
December 2014

The primary cilium: guardian of organ development and homeostasis.

Organogenesis 2014 Jan 17;10(1):62-8. Epub 2014 Apr 17.

Department of Biochemistry; University of Leicester; Leicester, UK.

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http://dx.doi.org/10.4161/org.28910DOI Listing
January 2014

Cdc20 turnover rate: a key determinant in cancer patient response to anti-mitotic therapies?

Authors:
Andrew M Fry

Bioessays 2013 Sep 16;35(9):762. Epub 2013 May 16.

Department of Biochemistry, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1002/bies.201300053DOI Listing
September 2013

The structural mechanisms that underpin mitotic kinase activation.

Biochem Soc Trans 2013 Aug;41(4):1037-41

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1042/BST20130066DOI Listing
August 2013

EGF-induced centrosome separation promotes mitotic progression and cell survival.

Dev Cell 2013 May 2;25(3):229-40. Epub 2013 May 2.

Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.devcel.2013.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939353PMC
May 2013

Poc1A and Poc1B act together in human cells to ensure centriole integrity.

J Cell Sci 2013 Jan 26;126(Pt 1):163-75. Epub 2012 Sep 26.

Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1242/jcs.111203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603514PMC
January 2013

Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification.

J Cell Sci 2012 Nov 6;125(Pt 22):5353-68. Epub 2012 Sep 6.

Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1242/jcs.106096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939426PMC
November 2012

Cell cycle regulation by the NEK family of protein kinases.

J Cell Sci 2012 Oct 6;125(Pt 19):4423-33. Epub 2012 Nov 6.

Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1242/jcs.111195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500863PMC
October 2012

Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity.

J Med Chem 2012 Apr 23;55(7):3228-41. Epub 2012 Mar 23.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.

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http://dx.doi.org/10.1021/jm201683bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935458PMC
April 2012

The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.

Hum Mol Genet 2012 Mar 21;21(5):1155-71. Epub 2011 Nov 21.

Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1093/hmg/ddr544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277313PMC
March 2012

An undecided coiled coil: the leucine zipper of Nek2 kinase exhibits atypical conformational exchange dynamics.

J Biol Chem 2011 Aug 13;286(31):27537-47. Epub 2011 Jun 13.

Department of Biochemistry, University of Leicester, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.196972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149346PMC
August 2011

Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1.

J Cell Sci 2011 Feb 25;124(Pt 4):600-12. Epub 2011 Jan 25.

Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1242/jcs.077156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031371PMC
February 2011

A role for Nek6 kinase activity in preventing senescence?

Authors:
Andrew M Fry

Cell Cycle 2011 Jan 1;10(1):19-20. Epub 2011 Jan 1.

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January 2011

Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.

Nat Cell Biol 2010 Dec 14;12(12):1166-76. Epub 2010 Nov 14.

Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1038/ncb2120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939356PMC
December 2010

Fluorescence imaging of the centrosome cycle in mammalian cells.

Methods Mol Biol 2009 ;545:165-83

Department of Biochemistry, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1007/978-1-60327-993-2_10DOI Listing
November 2009

The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

Mol Cell Biol 2009 Jul 4;29(14):3975-90. Epub 2009 May 4.

Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, United Kingdom.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01867-08
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http://dx.doi.org/10.1128/MCB.01867-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704745PMC
July 2009

Molecular dissection of the centrosome overduplication pathway in S-phase-arrested cells.

Mol Cell Biol 2009 Apr 12;29(7):1760-73. Epub 2009 Jan 12.

Department of Biochemistry, University of Leicester, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1128/MCB.01124-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655601PMC
April 2009

Pix proteins and the evolution of centrioles.

PLoS One 2008 20;3(11):e3778. Epub 2008 Nov 20.

Department of Biological Sciences, University of Warwick, Coventry, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003778PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582488PMC
February 2009

Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas.

J Pathol 2009 Feb;217(3):431-41

Department of Public Health and Cell Biology, University of Rome Tor Vergata, 00133 Rome, Italy.

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http://doi.wiley.com/10.1002/path.2471
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http://dx.doi.org/10.1002/path.2471DOI Listing
February 2009

Under arrest in mitosis: Cdc20 dies twice.

Nat Cell Biol 2008 Dec;10(12):1385-7

Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1038/ncb1208-1385DOI Listing
December 2008

A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment.

Mol Cell 2008 Nov;32(4):576-83

Cell Cycle Control Laboratory, Marie Curie Research Institute, The Chart, Oxted, RH8 0TL Surrey, UK.

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http://dx.doi.org/10.1016/j.molcel.2008.09.023DOI Listing
November 2008

Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells.

Exp Cell Res 2008 Feb 6;314(3):574-89. Epub 2007 Nov 6.

Department of Biochemistry, University of Leicester, University Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1016/j.yexcr.2007.10.019DOI Listing
February 2008

Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase.

J Biol Chem 2007 Sep 11;282(36):26431-40. Epub 2007 Jul 11.

Laboratório de Transdução de Sinais, Centro de Biologia Celular, Universidade de Aveiro, 3810-193 Aveiro, Portugal.

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http://dx.doi.org/10.1074/jbc.M704969200DOI Listing
September 2007

Mitotic regulation by NIMA-related kinases.

Cell Div 2007 Aug 29;2:25. Epub 2007 Aug 29.

Department of Biochemistry, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1186/1747-1028-2-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018689PMC
August 2007

Structure and regulation of the human Nek2 centrosomal kinase.

J Biol Chem 2007 Mar 31;282(9):6833-42. Epub 2006 Dec 31.

Structural Genomics Consortium, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M609721200
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http://dx.doi.org/10.1074/jbc.M609721200DOI Listing
March 2007

Sealed with a Kiz: How Plk1 ensures spindle pole integrity.

Dev Cell 2006 Oct;11(4):431-2

Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1016/j.devcel.2006.09.012DOI Listing
October 2006

APC/C-mediated degradation in early mitosis: how to avoid spindle assembly checkpoint inhibition.

Cell Cycle 2006 Jul 17;5(14):1487-91. Epub 2006 Jul 17.

Department of Biochemistry, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.4161/cc.5.14.3003DOI Listing
July 2006

Nek2 kinase in chromosome instability and cancer.

Cancer Lett 2006 Jun 3;237(2):155-66. Epub 2005 Aug 3.

Department of Biochemistry, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350500561
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http://dx.doi.org/10.1016/j.canlet.2005.06.017DOI Listing
June 2006

Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C.

Nat Cell Biol 2006 Jun 30;8(6):607-14. Epub 2006 Apr 30.

Department of Biochemistry, University of Leicester, Leicester, Leics LE1 7RH, UK.

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http://www.nature.com/articles/ncb1410
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http://dx.doi.org/10.1038/ncb1410DOI Listing
June 2006

Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity.

Genes Dev 2005 Feb;19(4):502-13

Chemical Biology, Independent Research Group, Max-Planck-Institute of Biochemistry, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1101/gad.320705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548950PMC
February 2005

OFD1 is a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human nephrogenesis.

J Am Soc Nephrol 2004 Oct;15(10):2556-68

Nephro-Urology Unit, Institute of Child Health, University College London, WC1N 1EH, UK.

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http://www.jasn.org/cgi/doi/10.1097/01.ASN.0000140220.46477.
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http://dx.doi.org/10.1097/01.ASN.0000140220.46477.5CDOI Listing
October 2004

The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer.

Cancer Res 2004 Oct;64(20):7370-6

Department of Biochemistry, University of Leicester, Leicester, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0960DOI Listing
October 2004

Polo-like kinase-2 is required for centriole duplication in mammalian cells.

Curr Biol 2004 Jul;14(13):1200-7

Cell Cycle Control and Carcinogenesis, F045, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, D-69120 Heidelberg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S096098220400467
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http://dx.doi.org/10.1016/j.cub.2004.06.059DOI Listing
July 2004

Nek2B stimulates zygotic centrosome assembly in Xenopus laevis in a kinase-independent manner.

Dev Biol 2004 Jan;265(2):384-98

Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1016/j.ydbio.2003.10.001DOI Listing
January 2004

Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles.

Mol Biol Cell 2003 Jul 17;14(7):2876-89. Epub 2003 Apr 17.

Department of Biochemistry, University of Leicester, Leicester LE1 7RH, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e03-02-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165683PMC
July 2003

The Nek2 protein kinase: a novel regulator of centrosome structure.

Authors:
Andrew M Fry

Oncogene 2002 Sep;21(40):6184-94

Department of Biochemistry, University of Leicester, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/sj.onc.1205711DOI Listing
September 2002

Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis.

Biochem J 2002 Jan;361(Pt 1):77-85

Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222281PMC
http://dx.doi.org/10.1042/0264-6021:3610077DOI Listing
January 2002