Andrew M Chan

Andrew M Chan

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Andrew M Chan

Andrew M Chan

Publications by authors named "Andrew M Chan"

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Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease.

Neurobiol Aging 2019 Jan 30;77:128-143. Epub 2019 Jan 30.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong; Kunming Institute of Zoology, Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Kunmin-Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.020DOI Listing
January 2019

Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells.

BMC Biol 2018 12 28;16(1):151. Epub 2018 Dec 28.

School of Biomedical Sciences, CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.

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http://dx.doi.org/10.1186/s12915-018-0616-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310992PMC
December 2018

PTEN PDZ-binding domain suppresses mammary carcinogenesis in the MMTV-PyMT breast cancer model.

Cancer Lett 2018 Aug 14;430:67-78. Epub 2018 May 14.

School of Biomedical Sciences, Room 705, Lo Kwee-Seong Integrated Biomedical Sciences Building, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.05.012DOI Listing
August 2018

A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase.

Cancer Lett 2017 09 10;403:59-65. Epub 2017 Jun 10.

School of Biomedical Sciences, The Chinese University of Hong Kong, Room 705, Lo Kwee-Seong Integrated Biomedical Sciences Building, Shatin, Hong Kong Special Administrative Region. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.06.003DOI Listing
September 2017

A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients.

J Hepatol 2015 May 9;62(5):1100-11. Epub 2014 Dec 9.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Disease and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.11.040DOI Listing
May 2015

An increase in tolerogenic dendritic cell and natural regulatory T cell numbers during experimental autoimmune encephalomyelitis in Rras-/- mice results in attenuated disease.

J Immunol 2014 Jun 25;192(11):5109-17. Epub 2014 Apr 25.

Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201; Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226; and

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http://dx.doi.org/10.4049/jimmunol.1302254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041102PMC
June 2014

Genetic dissection of plexin signaling in vivo.

Proc Natl Acad Sci U S A 2014 Feb 27;111(6):2194-9. Epub 2014 Jan 27.

Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.

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http://dx.doi.org/10.1073/pnas.1308418111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926053PMC
February 2014

Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions.

Cancer Lett 2013 Aug 21;336(2):299-306. Epub 2013 Mar 21.

Department of Pediatrics, Division of Hematology, Oncology, & BMT, Medical College of Wisconsin, 8701, Watertown Plank Road, MFRC-6033, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1016/j.canlet.2013.03.020DOI Listing
August 2013

AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion.

Exp Cell Res 2013 Jul 20;319(12):1732-43. Epub 2013 May 20.

Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1016/j.yexcr.2013.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699957PMC
July 2013

Separation and Characterization of Epithelial and Mesenchymal-like Murine Mammary Tumor Cells Reveals Epithelial Cell Differentiation Plasticity and Enhanced Tumorigenicity of Epithelial-enriched Tumor Cells.

Cancer Microenviron 2013 Apr 12;6(1):79-89. Epub 2012 Jan 12.

Department of Pediatrics, Section of Hematology-Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA,

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http://dx.doi.org/10.1007/s12307-011-0095-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601216PMC
April 2013

Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line.

BMC Cancer 2011 Nov 21;11:490. Epub 2011 Nov 21.

Department of Oncological Sciences, The Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-11-490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247870PMC
November 2011

Cooperative Cross-Talk between Neuroblastoma Subtypes Confers Resistance to Anaplastic Lymphoma Kinase Inhibition.

Genes Cancer 2011 May;2(5):538-49

Division of Hematology, Oncology, and Bone Marrow Transplant (BMT), Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1177/1947601911416003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161418PMC
May 2011

Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment.

Sci Signal 2008 ;1(9):tr2

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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April 2008

Inquiry learning. Integrating content detail and critical reasoning by peer review.

Science 2008 Feb;319(5867):1189-90

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/science.1149875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038128PMC
February 2008

Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain.

J Biol Chem 2007 Aug 12;282(32):23306-15. Epub 2007 Jun 12.

Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, 10029, USA.

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http://dx.doi.org/10.1074/jbc.M611240200DOI Listing
August 2007

TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner.

Cell Signal 2005 Apr;17(4):461-71

Laboratory of Cell Biology, National Cancer Institute, Bethesda, MD 20892-4255, USA.

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http://dx.doi.org/10.1016/j.cellsig.2004.09.012DOI Listing
April 2005

Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.

Oncogene 2004 Jun;23(29):5077-83

The Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1038/sj.onc.1207662DOI Listing
June 2004

A putative link between exocytosis and tumor development.

Cancer Cell 2002 Dec;2(6):427-8

Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA.

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December 2002

Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling.

J Biol Chem 2002 Sep 31;277(39):36624-30. Epub 2002 Jul 31.

AMC Cancer Research Center, Lakewood, Colorado 80214, USA.

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http://dx.doi.org/10.1074/jbc.M204524200DOI Listing
September 2002

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit.

Cancer Cell 2002 Mar;1(2):181-91

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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March 2002