Andrew K Shiau

Andrew K Shiau

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Andrew K Shiau

Andrew K Shiau

Publications by authors named "Andrew K Shiau"

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39Publications

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Differential effect of inhibitory strategies of the V617 mutant of JAK2 on cytokine receptor signaling.

J Allergy Clin Immunol 2019 Jul 29;144(1):224-235. Epub 2019 Jan 29.

Ludwig Institute for Cancer Research, Brussels, Belgium; de Duve Institute, Université Catholique de Louvain, Brussels, Belgium; WELBIO (Walloon Excellence in Life Sciences and Biotechnology), Brussels, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193011
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http://dx.doi.org/10.1016/j.jaci.2018.12.1023DOI Listing
July 2019

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Cancer Cell 2019 Mar 28;35(3):504-518.e7. Epub 2019 Feb 28.

Ludwig Institute for Cancer Research, San Diego Branch, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0660, USA; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424615PMC
March 2019

Phenotypic Screening for Inhibitors of a Mutant Thrombopoietin Receptor.

Methods Mol Biol 2018 ;1787:53-66

Experimental Therapeutics Centre, Agency for Science Technology and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1007/978-1-4939-7847-2_4DOI Listing
February 2019

CFI-400945 is not a selective cellular PLK4 inhibitor.

Proc Natl Acad Sci U S A 2018 11 30;115(46):E10808-E10809. Epub 2018 Oct 30.

Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA 92093

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http://dx.doi.org/10.1073/pnas.1813310115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243232PMC
November 2018

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

Mol Cell 2017 Jul 22;67(1):128-138.e7. Epub 2017 Jun 22.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093 USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093 USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521991PMC
July 2017

GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge.

Mol Biol Cell 2016 12 5;27(24):3828-3840. Epub 2016 Oct 5.

Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1091/mbc.E16-01-0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170606PMC
December 2016

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.

Cancer Cell 2016 Nov 13;30(5):683-693. Epub 2016 Oct 13.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479636PMC
November 2016

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.

J Cell Biol 2016 07;214(2):155-66

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093 Ludwig Institute for Cancer Research, La Jolla, CA 92093

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http://dx.doi.org/10.1083/jcb.201604081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949453PMC
July 2016

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

Mol Cancer Ther 2016 06 16;15(6):1217-26. Epub 2016 Mar 16.

Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, Melbourne, Victoria, Australia. Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0724DOI Listing
June 2016

Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.

Biochem J 2016 06 30;473(11):1579-91. Epub 2016 Mar 30.

Ludwig Institute for Cancer Research, 1200 Brussels, Belgium de Duve Institute, Université catholique de Louvain, 1200 Brussels, Belgium

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http://dx.doi.org/10.1042/BCJ20160085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888464PMC
June 2016

EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.

Mol Cell 2015 Oct 8;60(2):307-18. Epub 2015 Oct 8.

Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609298PMC
October 2015

Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.

Science 2015 Jun 30;348(6239):1155-60. Epub 2015 Apr 30.

Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/science.aaa5111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764081PMC
June 2015

Common regulatory control of CTP synthase enzyme activity and filament formation.

Mol Biol Cell 2014 Aug 11;25(15):2282-90. Epub 2014 Jun 11.

Section on Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1091/mbc.E14-04-0912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116302PMC
August 2014

Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly.

Dev Cell 2013 May;25(3):284-98

Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.devcel.2013.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655416PMC
May 2013

Discovery and optimization of a series of liver X receptor antagonists.

Bioorg Med Chem Lett 2012 Sep 21;22(18):5966-70. Epub 2012 Jul 21.

Department of Medicinal Chemistry, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.07.048DOI Listing
September 2012

Discovery of a new binding mode for a series of liver X receptor agonists.

Bioorg Med Chem Lett 2012 Apr 20;22(7):2407-10. Epub 2012 Feb 20.

Department of Medicinal Chemistry, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.02.028DOI Listing
April 2012

Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.

Bioorg Med Chem Lett 2011 Nov 8;21(22):6888-94. Epub 2011 Sep 8.

Department of Medicinal Chemistry, Kalypsys Inc., 10420 Wateridge Circle, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.08.112DOI Listing
November 2011

Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor.

Bioorg Med Chem Lett 2008 Dec 11;18(23):6093-6. Epub 2008 Oct 11.

Department of Chemistry, Kalypsys, Inc., 10420 Wateridge Circle, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.10.029DOI Listing
December 2008

Back to basics: label-free technologies for small molecule screening.

Comb Chem High Throughput Screen 2008 Mar;11(3):231-7

Department of Biology, Kalypsys Inc., San Diego, CA 92121, USA.

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http://dx.doi.org/10.2174/138620708783877807DOI Listing
March 2008

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors.

Bioorg Med Chem Lett 2007 Jul 29;17(13):3562-9. Epub 2007 Apr 29.

Department of Medicinal Chemistry, Kalypsys, Inc., 10420 Wateridge Circle, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.04.076DOI Listing
July 2007

Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.

Cell 2006 Oct;127(2):329-40

Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, 94158, USA.

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http://dx.doi.org/10.1016/j.cell.2006.09.027DOI Listing
October 2006

The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site.

Structure 2004 Jun;12(6):1087-97

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096921260400126
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http://dx.doi.org/10.1016/j.str.2004.03.020DOI Listing
June 2004

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.

Nat Struct Biol 2002 May;9(5):359-64

The Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA.

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http://www.nature.com/doifinder/10.1038/nsb787
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http://dx.doi.org/10.1038/nsb787DOI Listing
May 2002