Publications by authors named "Andrew J Theobald"

5Publications

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.

Authors:
Pan F Chan Velupillai Srikannathasan Jianzhong Huang Haifeng Cui Andrew P Fosberry Minghua Gu Michael M Hann Martin Hibbs Paul Homes Karen Ingraham Jason Pizzollo Carol Shen Anthony J Shillings Claus E Spitzfaden Robert Tanner Andrew J Theobald Robert A Stavenger Benjamin D Bax Michael N Gwynn

Nat Commun 2015 Dec 7;6:10048. Epub 2015 Dec 7.

Antibacterial Discovery Performance Unit, Infectious Diseases, Therapy Area Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, USA.

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December 2015

Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.

Authors:
Velupillai Srikannathasan Alexandre Wohlkonig Anthony Shillings Onkar Singh Pan F Chan Jianzhong Huang Michael N Gwynn Andrew P Fosberry Paul Homes Martin Hibbs Andrew J Theobald Claus Spitzfaden Benjamin D Bax

Acta Crystallogr F Struct Biol Commun 2015 Oct 23;71(Pt 10):1242-6. Epub 2015 Sep 23.

Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.

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October 2015

Discovery and biochemical characterization of Plasmodium thioredoxin reductase inhibitors from an antimalarial set.

Authors:
Andrew J Theobald Iván Caballero Isabel Coma Gonzalo Colmenarejo Concepcion Cid Francisco-Javier Gamo Martin J Hibbs Amy L Bass Daniel A Thomas

Biochemistry 2012 Jun 1;51(23):4764-71. Epub 2012 Jun 1.

GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK.

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June 2012

High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay.

Authors:
Praveen K Singh Pan F Chan Martin J Hibbs Maria-Jesus Vazquez Delfina C Segura Daniel A Thomas Andrew J Theobald Kathleen T Gallagher Namir J Hassan

Protein Expr Purif 2011 Apr 13;76(2):165-72. Epub 2010 Aug 13.

Biological Reagents & Assay Development, GlaxoSmithKline R&D, New Frontiers Science Park, Harlow, Essex, UK.

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April 2011

Type IIA topoisomerase inhibition by a new class of antibacterial agents.

Authors:
Benjamin D Bax Pan F Chan Drake S Eggleston Andrew Fosberry Daniel R Gentry Fabrice Gorrec Ilaria Giordano Michael M Hann Alan Hennessy Martin Hibbs Jianzhong Huang Emma Jones Jo Jones Kristin Koretke Brown Ceri J Lewis Earl W May Martin R Saunders Onkar Singh Claus E Spitzfaden Carol Shen Anthony Shillings Andrew J Theobald Alexandre Wohlkonig Neil D Pearson Michael N Gwynn

Nature 2010 Aug 4;466(7309):935-40. Epub 2010 Aug 4.

Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.

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August 2010