Andrew J Souers

Andrew J Souers

UNVERIFIED PROFILE

Are you Andrew J Souers?   Register this Author

Register author
Andrew J Souers

Andrew J Souers

Publications by authors named "Andrew J Souers"

Are you Andrew J Souers?   Register this Author

46Publications

1645Reads

10Profile Views

Coamplification of protects -amplified breast cancers from targeted therapy.

Proc Natl Acad Sci U S A 2018 03 23;115(11):E2594-E2603. Epub 2018 Feb 23.

Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1717820115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856537PMC
March 2018

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.

Nat Rev Drug Discov 2017 Apr 17;16(4):273-284. Epub 2017 Feb 17.

AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrd.2016.253
Publisher Site
http://dx.doi.org/10.1038/nrd.2016.253DOI Listing
April 2017

Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells.

Oncotarget 2016 Oct;7(43):70000-70010

Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.12132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342530PMC
October 2016

Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.

Bioorg Med Chem Lett 2014 Mar 14;24(6):1484-8. Epub 2014 Feb 14.

Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2014.02.010DOI Listing
March 2014

The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax (ABT-263) and ABT-199.

Drug Metab Dispos 2014 Feb 8;42(2):207-12. Epub 2013 Nov 8.

Departments of Drug Metabolism and Pharmacokinetics (E.F.C., J.B.) and Pharmaceutics (J.W.L.), Genentech Inc, South San Francisco, California; Department of Drug Metabolism and Pharmacokinetics, WuXi AppTec (Suzhou) Co., Ltd, Suzhou, Jiangsu Province ,China (C.Z.); Departments of Physical Chemistry (N.D.C.), Drug Metabolism (G.J., R.V.) and Cancer Research (A.J.S.), AbbVie, North Chicago, Illinois.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.113.055053DOI Listing
February 2014

In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia.

Eur J Pharmacol 2010 Jul 10;637(1-3):155-61. Epub 2010 Apr 10.

Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2010.03.056DOI Listing
July 2010

Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents.

Expert Opin Ther Pat 2010 Jan;20(1):19-29

Global Pharmaceutical Research & Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/13543770903499305DOI Listing
January 2010

Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster.

J Pharmacol Exp Ther 2009 Aug 28;330(2):526-31. Epub 2009 May 28.

Department of Integrative Pharmacology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.109.154047DOI Listing
August 2009

Lead optimization of melanin concentrating hormone receptor 1 antagonists with low hERG channel activity.

Curr Top Med Chem 2008 ;8(13):1152-7

Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/156802608785700052DOI Listing
March 2009

Lead optimization strategies and tactics applied to the discovery of melanin concentrating hormone receptor 1 antagonists.

Curr Top Med Chem 2007 ;7(15):1471-88

Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/156802607782194699DOI Listing
November 2007

The use of three-dimensional shape and electrostatic similarity searching in the identification of a melanin-concentrating hormone receptor 1 antagonist.

Chem Biol Drug Des 2006 Feb;67(2):174-6

Department of Structural Biology, Abbott Laboratories, Abbott Park, IL 60048, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1747-0285.2006.00341.xDOI Listing
February 2006

Identification of aminopiperidine benzamides as MCHr1 antagonists.

Bioorg Med Chem Lett 2005 Jul;15(14):3412-6

Metabolic Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2005.05.023DOI Listing
July 2005

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1.

Bioorg Med Chem Lett 2004 Oct;14(19):4873-7

Metabolic Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2004.07.032DOI Listing
October 2004

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2.

Bioorg Med Chem Lett 2004 Oct;14(19):4879-82

Metabolic Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2004.07.034DOI Listing
October 2004

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3.

Bioorg Med Chem Lett 2004 Oct;14(19):4883-6

Metabolic Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2004.07.035DOI Listing
October 2004

Microwave-assisted C-H bond activation: a rapid entry into functionalized heterocycles.

Org Lett 2003 Jun;5(12):2131-4

Center for New Directions in Organic Synthesis, Department of Chemistry, University of California-Berkeley, Berkeley, California 94720, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol030050jDOI Listing
June 2003

The preparation and utility of bis(sulfinyl)imidoamidine ligands for the copper-catalyzed Diels-Alder reaction.

J Org Chem 2003 Jan;68(1):3-10

Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, California 94720, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jo020524c
Publisher Site
http://dx.doi.org/10.1021/jo020524cDOI Listing
January 2003