Publications by authors named "Andrew J Murphy"

100Publications

Apoptotic Ablation of Platelets Reduces Atherosclerosis in Mice With Diabetes.

Arterioscler Thromb Vasc Biol 2021 Jan 14:ATVBAHA120315369. Epub 2021 Jan 14.

Haematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, Australia (M.K.S.L., M.J.K., D.D., N.M.J.H., M.C.F., A.A.-S., C.B.-V., O.D.C., F.B., E.M., A.J.M.).

View Article and Find Full Text PDF
January 2021

DAMPening Mortality in COVID19: Therapeutic Insights from Basic Cardiometabolic Studies on S100A8/A9.

Circulation 2021 Jan 12. Epub 2021 Jan 12.

Haematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Immunology, Monash University, Melbourne, Australia.

View Article and Find Full Text PDF
January 2021

Origins and diversity of macrophages in health and disease.

Clin Transl Immunology 2020 20;9(12):e1222. Epub 2020 Dec 20.

Division of Cardiac Surgery Department of Surgery The Ohio State University Wexner Medical Center Columbus OH USA.

View Article and Find Full Text PDF
December 2020

The use of computed tomography versus clinical acumen in diagnosing appendicitis in children: A two-institution international study.

J Pediatr Surg 2020 Nov 4. Epub 2020 Nov 4.

Division of Pediatric Surgery, Department of Surgery, Le Bonheur Children's Hospital, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA.. Electronic address:

View Article and Find Full Text PDF
November 2020

Postprandial Glucose Spikes, an Important Contributor to Cardiovascular Disease in Diabetes?

Front Cardiovasc Med 2020 18;7:570553. Epub 2020 Sep 18.

Haematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.

View Article and Find Full Text PDF
September 2020

Characterisation of the circulating and tissue-specific alterations to the lipidome in response to moderate and major cold stress in mice.

Am J Physiol Regul Integr Comp Physiol 2020 Nov 11. Epub 2020 Nov 11.

Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Australia, 3004; Department of Immunology, Monash University, Melbourne, Australia, 3004.

View Article and Find Full Text PDF
November 2020

Emerging roles of neutrophil-borne S100A8/A9 in cardiovascular inflammation.

Pharmacol Res 2020 11 28;161:105212. Epub 2020 Sep 28.

Division of Cardiac Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

View Article and Find Full Text PDF
November 2020

Apo AI Nanoparticles Delivered Post Myocardial Infarction Moderate Inflammation.

Circ Res 2020 Nov 21;127(11):1422-1436. Epub 2020 Sep 21.

Baker Heart and Diabetes Institute, Melbourne, Australia (A.L.R., M.R., M.K., A.L.N., S.E.H., G.L.L., A.J.M., B.G.D., B.A.K.).

View Article and Find Full Text PDF
November 2020

NETosis Is Required for S100A8/A9-Induced Granulopoiesis After Myocardial Infarction.

Arterioscler Thromb Vasc Biol 2020 11 3;40(11):2805-2807. Epub 2020 Sep 3.

Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia (G.P., A.J.M.).

View Article and Find Full Text PDF
November 2020

Lack of Strategic Funding and Long-Term Job Security Threaten to Have Profound Effects on Cardiovascular Researcher Retention in Australia.

Heart Lung Circ 2020 Nov 21;29(11):1588-1595. Epub 2020 Aug 21.

Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University, Melbourne, Vic, Australia; Baker Heart and Diabetes Institute, Melbourne, Vic, Australia. Electronic address:

View Article and Find Full Text PDF
November 2020

S100 family proteins in inflammation and beyond.

Adv Clin Chem 2020 17;98:173-231. Epub 2020 Apr 17.

Department of Surgery, Ohio State University, Columbus, OH, United States. Electronic address:

View Article and Find Full Text PDF
April 2020

Attack of the NETs! NETosis primes IL-1β-mediated inflammation in diabetic foot ulcers.

Clin Sci (Lond) 2020 06;134(12):1399-1401

Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia.

View Article and Find Full Text PDF
June 2020

Activin A does not drive post-traumatic heterotopic ossification.

Bone 2020 09 15;138:115473. Epub 2020 Jun 15.

Department of Surgery, University of Michigan, Ann Arbor, MI, United States of America; Division of Plastic Surgery, Department of Surgery, University of Michigan Health System, 1500 E Medical Center Drive, SPC 5340, Ann Arbor, MI 48109-5340, United States of America. Electronic address:

View Article and Find Full Text PDF
September 2020

Interplay between Clonal Hematopoiesis of Indeterminate Potential and Metabolism.

Trends Endocrinol Metab 2020 07 3;31(7):525-535. Epub 2020 Mar 3.

Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Central Clinical School, Monash University, Melbourne, Victoria, Australia; Department Medicine, University of Melbourne, Melbourne, Victoria, Australia. Electronic address:

View Article and Find Full Text PDF
July 2020

Incidence of and risk factors for late cholecystectomy in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Eur J Cancer 2020 07 15;133:4-13. Epub 2020 May 15.

Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Department of Paediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
July 2020

Alternative approaches to retroperitoneal lymph node dissection for paratesticular rhabdomyosarcoma.

J Pediatr Surg 2020 Dec 1;55(12):2677-2681. Epub 2020 Apr 1.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN. Electronic address:

View Article and Find Full Text PDF
December 2020

Single-site retroperitoneoscopy in pediatric metastatic lymphadenopathy.

J Pediatr Surg 2020 Nov 24;55(11):2430-2434. Epub 2020 Mar 24.

Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA.

View Article and Find Full Text PDF
November 2020

Combined reduction in the expression of MCL-1 and BCL-2 reduces organismal size in mice.

Cell Death Dis 2020 03 13;11(3):185. Epub 2020 Mar 13.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia.

View Article and Find Full Text PDF
March 2020

Splenic function is not maintained long-term after partial splenectomy in children with sickle cell disease.

J Pediatr Surg 2020 Nov 7;55(11):2471-2474. Epub 2020 Jan 7.

Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38105, USA. Electronic address:

View Article and Find Full Text PDF
November 2020

Management of pancreatic pseudocysts in pediatric oncology patients.

J Pediatr Surg 2020 Sep 27;55(9):1727-1731. Epub 2019 Dec 27.

Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38105, USA. Electronic address:

View Article and Find Full Text PDF
September 2020

Fat for fuel: lipid metabolism in haematopoiesis.

Clin Transl Immunology 2019 24;8(12):e1098. Epub 2019 Dec 24.

Haematopoiesis and Leukocyte Biology Baker Heart and Diabetes Institute Melbourne VIC Australia.

View Article and Find Full Text PDF
December 2019

Complications Following Nephron-Sparing Surgery for Wilms Tumor.

J Pediatr Surg 2020 Jan 26;55(1):126-129. Epub 2019 Oct 26.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN. Electronic address:

View Article and Find Full Text PDF
January 2020

Impact of MYCN status on response of high-risk neuroblastoma to neoadjuvant chemotherapy.

J Pediatr Surg 2020 Jan 25;55(1):130-134. Epub 2019 Oct 25.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN. Electronic address:

View Article and Find Full Text PDF
January 2020

Apolipoprotein AI) Promotes Atherosclerosis Regression in Diabetic Mice by Suppressing Myelopoiesis and Plaque Inflammation.

Circulation 2019 10 30;140(14):1170-1184. Epub 2019 Sep 30.

Department of Medicine, Division of Cardiology (T.J.B., E.D., M.S.G., Y.O., E.A.F.), New York University School of Medicine.

View Article and Find Full Text PDF
October 2019

Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: connections with cardiovascular diseases.

J Lipid Res 2020 05 30;61(5):667-675. Epub 2019 Aug 30.

Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia.

View Article and Find Full Text PDF
May 2020

Current Management of Pleuropulmonary Blastoma: A Surgical Perspective.

Children (Basel) 2019 Jul 25;6(8). Epub 2019 Jul 25.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

View Article and Find Full Text PDF
July 2019

Therapeutic Impact and Complications Associated with Surgical Lung Biopsy after Allogeneic Hematopoietic Stem Cell Transplantation in Children.

Biol Blood Marrow Transplant 2019 11 28;25(11):2181-2185. Epub 2019 Jun 28.

Boston Children's Hospital, Boston, Massachusetts; Dana-Farber and Boston Children's Hospital Cancer and Blood Disorders Center, Boston, Massachusetts.

View Article and Find Full Text PDF
November 2019

Monocytes, Macrophages, and Metabolic Disease in Atherosclerosis.

Front Pharmacol 2019 13;10:666. Epub 2019 Jun 13.

Haematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.

View Article and Find Full Text PDF
June 2019

Acute Chest Syndrome After Splenectomy in Children With Sickle Cell Disease.

J Surg Res 2019 10 23;242:336-341. Epub 2019 May 23.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee. Electronic address:

View Article and Find Full Text PDF
October 2019

FXR1 expression domain in Wilms tumor.

J Pediatr Surg 2019 Jun 28;54(6):1198-1205. Epub 2019 Feb 28.

Vanderbilt University Medical Center, Department of Pediatric Surgery, Nashville, TN.

View Article and Find Full Text PDF
June 2019

Neutropenia at the time of subcutaneous port insertion may not be a risk factor for early infectious complications in pediatric oncology patients.

J Pediatr Surg 2019 Jan 5;54(1):145-149. Epub 2018 Oct 5.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center and Le Bonheur Children's Hospital, Memphis, TN. Electronic address:

View Article and Find Full Text PDF
January 2019

The haematopoietic stem cell niche: a new player in cardiovascular disease?

Cardiovasc Res 2019 02;115(2):277-291

Division of Immunometabolism, Haematopoiesis and Leukocyte Biology, Baker Heart & Diabetes Institute, 75 Commercial Road, Melbourne, VIC, Australia.

View Article and Find Full Text PDF
February 2019

Bilateral Wilms Tumor: A Surgical Perspective.

Children (Basel) 2018 Sep 24;5(10). Epub 2018 Sep 24.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

View Article and Find Full Text PDF
September 2018

Long-Term Risk of Venous Thromboembolism in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

J Clin Oncol 2018 Sep 14:JCO2018784595. Epub 2018 Sep 14.

Arin L. Madenci, Brent R. Weil, and Christopher B. Weldon, Boston Children's Hospital; Arin L. Madenci and Larissa Nekhlyudov, Brigham and Women's Hospital; Brent R. Weil, Larissa Nekhlyudov, Lisa R. Diller, and Christopher B. Weldon, Dana-Farber Cancer Institute; Arin L. Madenci, Brent R. Weil, Larissa Nekhlyudov, Lisa R. Diller and Christopher B. Weldon, Harvard Medical School, Boston, MA; Qi Liu, University of Alberta, Edmonton, Alberta, Canada; Andrew J. Murphy, Todd M. Gibson, Yutaka Yasui, Christopher L. Tinkle, and Gregory T. Armstrong, St Jude Children's Research Hospital, Memphis, TN; Wendy M. Leisenring, Fred Hutchinson Cancer Research Center, Seattle, WA; Rebecca M. Howell, The University of Texas MD Anderson Cancer Center, Houston, TX; and Kevin C. Oeffinger, Duke University School of Medicine, Durham, NC.

View Article and Find Full Text PDF
September 2018

Disordered haematopoiesis and cardiovascular disease: a focus on myelopoiesis.

Clin Sci (Lond) 2018 09 5;132(17):1889-1899. Epub 2018 Sep 5.

Haematopoiesis and Leukocyte Biology, Division of Immunometabolism, Baker Heart and Diabetes Research Institute, Melbourne, Australia.

View Article and Find Full Text PDF
September 2018

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Nat Commun 2018 06 13;9(1):2252. Epub 2018 Jun 13.

Regeneron Pharmaceuticals, Tarrytown, 10591, NY, USA.

View Article and Find Full Text PDF
June 2018

Desmoplastic small round cell tumor: A nationwide study of a rare sarcoma.

J Surg Oncol 2018 Jun 7;117(8):1759-1767. Epub 2018 Jun 7.

Division of Surgical Oncology, Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.

View Article and Find Full Text PDF
June 2018

It's reticulated: the liver at the heart of atherosclerosis.

J Endocrinol 2018 07 2;238(1):R1-R11. Epub 2018 May 2.

Division of ImmunometabolismBaker Heart and Diabetes Institute, Melbourne, Australia.

View Article and Find Full Text PDF
July 2018

Lipidomic Profiling of Murine Macrophages Treated with Fatty Acids of Varying Chain Length and Saturation Status.

Metabolites 2018 Apr 23;8(2). Epub 2018 Apr 23.

Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.

View Article and Find Full Text PDF
April 2018

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.

Cell Metab 2018 May 19;27(5):1096-1110.e5. Epub 2018 Apr 19.

Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia; Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia; Faculty of Medicine, St Vincent's Clinical School, Faculty of Medicine, University of NSW, Sydney, NSW 2010, Australia. Electronic address:

View Article and Find Full Text PDF
May 2018

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.

N Engl J Med 2018 03;378(12):1096-1106

From the Regeneron Genetics Center (N.S.A.-H., A.H.L., C.S., S. McCarthy, C.O., J.S.P., S.B., N.G., S. Mukherjee, A.E.L., E.D.F., J.P., I.B.B., A.R.S., J.G.R., J.D.O., O.G., T.M.T., A.B., F.E.D.) and Regeneron Pharmaceuticals (X. Cheng, Y.X., P.S., Y.L., D.E., S.Y.K., B.Z., W.O., A.J.M., G.D.Y., J.G.), Tarrytown, NY; the University of Texas Southwestern Medical Center at Dallas, Dallas (J.K., S.S., H.H.H., J.C.C.); and Geisinger Health System, Danville (G.C.W., A.N.S., M.D.S., X. Chu, J.Z.L., U.L.M., D.J.C., C.D.S., T.M.), and Perelman School of Medicine, University of Pennsylvania, Philadelphia (M.D.F., A.S., S.M.D., D.J.R.) - both in Pennsylvania.

View Article and Find Full Text PDF
March 2018

Glucagon contributes to liver zonation.

Proc Natl Acad Sci U S A 2018 04 19;115(17):E4111-E4119. Epub 2018 Mar 19.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591

View Article and Find Full Text PDF
April 2018

SGLT2 inhibition reduces atherosclerosis by enhancing lipoprotein clearance in Ldlr type 1 diabetic mice.

Atherosclerosis 2018 04 2;271:166-176. Epub 2018 Mar 2.

Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University, New York, USA; Dept. of Nutrition Sciences, University of Alabama at Birmingham, USA. Electronic address:

View Article and Find Full Text PDF
April 2018