Andrew J Cant

Andrew J Cant

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Andrew J Cant

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Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of -encoded phosphoinositide 3-kinase δ.

Authors:
David J Swan Dominik Aschenbrenner Christopher A Lamb Krishnendu Chakraborty Jonathan Clark Sumeet Pandey Karin R Engelhardt Rui Chen Athena Cavounidis Yuchun Ding Natalio Krasnogor Christopher D Carey Meghan Acres Stephanie Needham Andrew J Cant Peter D Arkwright Anita Chandra Klaus Okkenhaug Holm H Uhlig Sophie Hambleton

Haematologica 2019 Oct 9;104(10):e483-e486. Epub 2019 May 9.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne

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http://dx.doi.org/10.3324/haematol.2018.208397DOI Listing
October 2019

Novel Gain-of-Function Mutation in Stat1 Sumoylation Site Leads to CMC/CID Phenotype Responsive to Ruxolitinib.

Authors:
Tariq Al Shehri Kimberly Gilmour Florian Gothe Sam Loughlin Shahnaz Bibi Andrew D Rowan Angela Grainger Thivytra Mohanadas Andrew J Cant Mary A Slatter Sophie Hambleton Desa Lilic Timothy R Leahy

J Clin Immunol 2019 Sep 11. Epub 2019 Sep 11.

Department of Paediatric Immunology and Infectious Diseases, Children's Health Ireland, Crumlin, Dublin, D12 N512, Ireland.

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http://dx.doi.org/10.1007/s10875-019-00687-4DOI Listing
September 2019

New graft manipulation strategies improve the outcome of mismatched stem cell transplantation in children with primary immunodeficiencies.

Authors:
Reem Elfeky Ravi M Shah Mohamed N M Unni Giorgio Ottaviano Kanchan Rao Robert Chiesa Persis Amrolia Austen Worth Terry Flood Mario Abinun Sophie Hambleton Andrew J Cant Kimberly Gilmour Stuart Adams Gul Ahsan Dawn Barge Andrew R Gennery Waseem Qasim Mary Slatter Paul Veys

J Allergy Clin Immunol 2019 Jul 4;144(1):280-293. Epub 2019 Feb 4.

Molecular and Cellular Immunology Unit, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom; Blood and Bone Marrow Transplant Unit, Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2019.01.030DOI Listing
July 2019

Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients.

Authors:
Bethany A Pillay Danielle T Avery Joanne M Smart Theresa Cole Sharon Choo Damien Chan Paul E Gray Katie Frith Richard Mitchell Tri Giang Phan Melanie Wong Dianne E Campbell Peter Hsu John B Ziegler Jane Peake Frank Alvaro Capucine Picard Jacinta Bustamante Benedicte Neven Andrew J Cant Gulbu Uzel Peter D Arkwright Jean-Laurent Casanova Helen C Su Alexandra F Freeman Nirali Shah Dennis D Hickstein Stuart G Tangye Cindy S Ma

JCI Insight 2019 Apr 25;5. Epub 2019 Apr 25.

Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1172/jci.insight.127527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629099PMC
April 2019

An essential role for the Zn transporter ZIP7 in B cell development.

Authors:
Consuelo Anzilotti David J Swan Bertrand Boisson Mukta Deobagkar-Lele Catarina Oliveira Pauline Chabosseau Karin R Engelhardt Xijin Xu Rui Chen Luis Alvarez Rolando Berlinguer-Palmini Katherine R Bull Eleanor Cawthorne Adam P Cribbs Tanya L Crockford Tarana Singh Dang Amy Fearn Emma J Fenech Sarah J de Jong B Christoffer Lagerholm Cindy S Ma David Sims Bert van den Berg Yaobo Xu Andrew J Cant Gary Kleiner T Ronan Leahy M Teresa de la Morena Jennifer M Puck Ralph S Shapiro Mirjam van der Burg J Ross Chapman John C Christianson Benjamin Davies John A McGrath Stefan Przyborski Mauro Santibanez Koref Stuart G Tangye Andreas Werner Guy A Rutter Sergi Padilla-Parra Jean-Laurent Casanova Richard J Cornall Mary Ellen Conley Sophie Hambleton

Nat Immunol 2019 03 4;20(3):350-361. Epub 2019 Feb 4.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://www.nature.com/articles/s41590-018-0295-8
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http://dx.doi.org/10.1038/s41590-018-0295-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561116PMC
March 2019

Hematopoietic stem cell transplantation for cytidine triphosphate synthase 1 (CTPS1) deficiency.

Authors:
Zohreh Nademi Robert F Wynn Mary Slatter Stephen M Hughes Denise Bonney Waseem Qasim Sylvain Latour Johannes Trück Smita Patel Mario Abinun Terry Flood Sophie Hambleton Andrew J Cant Andrew R Gennery Peter D Arkwright

Bone Marrow Transplant 2019 01 8;54(1):130-133. Epub 2018 Jun 8.

University of Manchester, Royal Manchester Children's Hospital, Manchester, UK.

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http://dx.doi.org/10.1038/s41409-018-0246-xDOI Listing
January 2019

The Treatment of Activated PI3Kδ Syndrome.

Authors:
Tanya I Coulter Andrew J Cant

Front Immunol 2018 7;9:2043. Epub 2018 Sep 7.

Department of Paediatric Immunology and Stem Cell Transplant Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.02043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137162PMC
September 2018

Non-posttransplant lymphoproliferative disorder malignancy after hematopoietic stem cell transplantation in patients with primary immunodeficiency: UK experience.

Authors:
Mohamed Najib Mohamed Unni Reem Elfeky Kanchan Rao Zohreh Nademi Robert Chiesa Persis Amrolia Roderick Skinner Olga Slater Austen Worth Terence Flood Mario Abinun Sophie Hambleton Waseem Qasim Hubert B Gaspar Andrew J Cant Andrew R Gennery Paul Veys Mary A Slatter

J Allergy Clin Immunol 2018 06 7;141(6):2319-2321.e1. Epub 2018 Mar 7.

Children's Haemopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.02.038DOI Listing
June 2018

Early-onset autoimmune disease due to a heterozygous loss-of-function mutation in (A20).

Authors:
Christopher J A Duncan Emma Dinnigan Rachel Theobald Angela Grainger Andrew J Skelton Rafiqul Hussain Joseph D P Willet David J Swan Jonathan Coxhead Matthew F Thomas Julian Thomas Veena Zamvar Mary A Slatter Andrew J Cant Karin R Engelhardt Sophie Hambleton

Ann Rheum Dis 2018 05 28;77(5):783-786. Epub 2017 Jun 28.

Primary Immunodeficiency Group, Institute for Cellular Medicine, Newcastle University, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-210944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909743PMC
May 2018

Aortic Calcification in a Patient with a Gain-of-Function STAT1 Mutation.

Authors:
Anna E Smyth Epp Kaleviste Aisling Snow Kai Kisand Colin J McMahon Andrew J Cant T Ronan Leahy

J Clin Immunol 2018 05 26;38(4):468-470. Epub 2018 May 26.

Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

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http://dx.doi.org/10.1007/s10875-018-0513-zDOI Listing
May 2018

The International Alliance of Primary Immune Deficiency Societies.

Authors:
Andrew R Gennery Roshini S Abraham Troy R Torgerson Amos Etzioni Andrew J Cant Isabelle Meyts James Chipeta Ahmed Aziz Bousfiha Tandakha D Dieye Antonio Condino-Neto Francisco Espinosa Liliana Besrodnik Yu-Lung Lau Surjit Singh Godfrey C F Chan Jordan S Orange

J Clin Immunol 2018 05 5;38(4):447-449. Epub 2018 Jun 5.

Clinical Immunology Society, Milwaukee, WI, USA.

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http://link.springer.com/10.1007/s10875-018-0517-8
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http://dx.doi.org/10.1007/s10875-018-0517-8DOI Listing
May 2018

T-cell receptor αβ and CD19 cell-depleted haploidentical and mismatched hematopoietic stem cell transplantation in primary immune deficiency.

Authors:
Ravi M Shah Reem Elfeky Zohreh Nademi Waseem Qasim Persis Amrolia Robert Chiesa Kanchan Rao Giovanna Lucchini Juliana M F Silva Austen Worth Dawn Barge David Ryan Jane Conn Andrew J Cant Roderick Skinner Intan Juliana Abd Hamid Terence Flood Mario Abinun Sophie Hambleton Andrew R Gennery Paul Veys Mary Slatter

J Allergy Clin Immunol 2018 04 3;141(4):1417-1426.e1. Epub 2017 Aug 3.

Department of Immunology and BMT, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.07.008DOI Listing
April 2018

Allogeneic hematopoietic stem cell transplantation for severe, refractory juvenile idiopathic arthritis.

Authors:
Juliana M F Silva Fani Ladomenou Ben Carpenter Sharat Chandra Petr Sedlacek Renata Formankova Vicky Grandage Mark Friswell Andrew J Cant Zohreh Nademi Mary A Slatter Andrew R Gennery Sophie Hambleton Terence J Flood Giovanna Lucchini Robert Chiesa Kanchan Rao Persis J Amrolia Paul Brogan Lucy R Wedderburn Julie M Glanville Rachael Hough Rebecca Marsh Mario Abinun Paul Veys

Blood Adv 2018 04;2(7):777-786

Department of BMT, Great Ormond Street Hospital for Children, National Health Service (NHS) Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1182/bloodadvances.2017014449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894259PMC
April 2018

Treosulfan and Fludarabine Conditioning for Hematopoietic Stem Cell Transplantation in Children with Primary Immunodeficiency: UK Experience.

Authors:
Mary A Slatter Kanchan Rao Intan Juliana Abd Hamid Zohreh Nademi Robert Chiesa Reem Elfeky Mark S Pearce Persis Amrolia Austen Worth Terence Flood Mario Abinun Sophie Hambleton Waseem Qasim Hubert B Gaspar Andrew J Cant Andrew R Gennery Paul Veys

Biol Blood Marrow Transplant 2018 03 16;24(3):529-536. Epub 2017 Nov 16.

Great Ormond Street Hospital NHS Trust, London, United Kingdom.

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http://dx.doi.org/10.1016/j.bbmt.2017.11.009DOI Listing
March 2018

In vivo T-depleted reduced-intensity transplantation for -related immune dysfunction.

Authors:
Eleni Tholouli Katherine Sturgess Rachel E Dickinson Andrew Gennery Andrew J Cant Graham Jackson Jim Lordan Sophie Hambleton Mary A Slatter Venetia Bigley Matthew Collin

Blood 2018 03 2;131(12):1383-1387. Epub 2018 Jan 2.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1182/blood-2017-10-811489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992650PMC
March 2018

Enterovirus-Related Immune Reconstitution Inflammatory Syndrome (IRIS) Following Haploidentical Stem Cell Transplantation in an MHC Class II-Deficient Child.

Authors:
Ravi M Shah Sheila Waugh Khuen F Ng Andrew R Gennery Mary Slatter Andrew J Cant

J Clin Immunol 2017 07 16;37(5):419-421. Epub 2017 May 16.

Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s10875-017-0402-xDOI Listing
July 2017

Allele-level HLA matching for umbilical cord blood transplantation for non-malignant diseases in children: a retrospective analysis.

Authors:
Mary Eapen Tao Wang Paul A Veys Jaap J Boelens Andrew St Martin Stephen Spellman Carmem Sales Bonfim Colleen Brady Andrew J Cant Jean-Hugues Dalle Stella M Davies John Freeman Katherine C Hsu Katharina Fleischhauer Chantal Kenzey Joanne Kurtzberg Gerard Michel Paul J Orchard Annalisa Paviglianiti Vanderson Rocha Michael R Veneris Fernanda Volt Robert Wynn Stephanie J Lee Mary M Horowitz Eliane Gluckman Annalisa Ruggeri

Lancet Haematol 2017 Jul 13;4(7):e325-e333. Epub 2017 Jun 13.

Service d'Haematologie et Therapie Cellulaire, Hôpital Saint Antoine, Paris, France.

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http://dx.doi.org/10.1016/S2352-3026(17)30104-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699478PMC
July 2017

Prevalence of Cryptosporidium Carriage and Disease in Children With Primary Immune Deficiencies Undergoing Hematopoietic Stem Cell Transplant in Northern Europe.

Authors:
Angharad P Davies Mary Slatter Andrew R Gennery Guy Robinson Nigel Crouch Kristin Elwin Stephen J Hadfield Andrew J Cant E Graham Davies Rachel M Chalmers

Pediatr Infect Dis J 2017 May;36(5):504-506

From the *Swansea University Medical School, Singleton Park, Swansea, United Kingdom; †Cryptosporidium Reference Unit, Public Health Wales Microbiology Swansea, Singleton Hospital, Sketty Lane, Swansea, United Kingdom; ‡Paediatric Immunology Department, Great North Children's Hospital, Queen Victoria Road, Newcastle upon Tyne, United Kingdom; §Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; and ¶Centre for Immunodeficiency, Institute of Child Health, University College London and Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.1097/INF.0000000000001517DOI Listing
May 2017

Hematopoietic stem cell transplant in patients with activated PI3K delta syndrome.

Authors:
Zohreh Nademi Mary A Slatter Christopher C Dvorak Benedicte Neven Alain Fischer Felipe Suarez Claire Booth Kanchan Rao Alexandra Laberko Julia Rodina Yves Bertrand Sylwia Kołtan Robert Dębski Terence Flood Mario Abinun Andrew R Gennery Sophie Hambleton Stephan Ehl Andrew J Cant

J Allergy Clin Immunol 2017 03 12;139(3):1046-1049. Epub 2016 Nov 12.

Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle upon Tyne University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.09.040DOI Listing
March 2017

Identification of Heterozygous Single- and Multi-exon Deletions in IL7R by Whole Exome Sequencing.

Authors:
Karin R Engelhardt Yaobo Xu Angela Grainger Mila G C Germani Batacchi David J Swan Joseph D P Willet Intan J Abd Hamid Philipp Agyeman Dawn Barge Shahnaz Bibi Lucy Jenkins Terence J Flood Mario Abinun Mary A Slatter Andrew R Gennery Andrew J Cant Mauro Santibanez Koref Kimberly Gilmour Sophie Hambleton

J Clin Immunol 2017 01 2;37(1):42-50. Epub 2016 Nov 2.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s10875-016-0343-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226981PMC
January 2017

Biallelic mutations in IRF8 impair human NK cell maturation and function.

Authors:
Emily M Mace Venetia Bigley Justin T Gunesch Ivan K Chinn Laura S Angelo Matthew A Care Sheetal Maisuria Michael D Keller Sumihito Togi Levi B Watkin David F LaRosa Shalini N Jhangiani Donna M Muzny Asbjørg Stray-Pedersen Zeynep Coban Akdemir Jansen B Smith Mayra Hernández-Sanabria Duy T Le Graham D Hogg Tram N Cao Aharon G Freud Eva P Szymanski Sinisa Savic Matthew Collin Andrew J Cant Richard A Gibbs Steven M Holland Michael A Caligiuri Keiko Ozato Silke Paust Gina M Doody James R Lupski Jordan S Orange

J Clin Invest 2017 01 28;127(1):306-320. Epub 2016 Nov 28.

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http://dx.doi.org/10.1172/JCI86276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199714PMC
January 2017

Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function.

Authors:
Yifang Gao Peter D Arkwright Rachel Carter Angelica Cazaly Rebecca J Harrison Alexandra Mant Andrew J Cant Stephan Gadola Tim J Elliott Salim I Khakoo Anthony P Williams

J Allergy Clin Immunol 2016 12 27;138(6):1733-1736.e2. Epub 2016 Jul 27.

Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton National Institute for Health Research Experimental Cancer Medicine Centre, Southampton, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138155PMC
December 2016

Hematopoietic stem cell transplantation for CTLA4 deficiency.

Authors:
Mary A Slatter Karin R Engelhardt Lauri M Burroughs Peter D Arkwright Zohreh Nademi Suzanne Skoda-Smith David Hagin Alan Kennedy Dawn Barge Terence Flood Mario Abinun Robert F Wynn Andrew R Gennery Andrew J Cant David Sansom Sophie Hambleton Troy R Torgerson

J Allergy Clin Immunol 2016 08 18;138(2):615-619.e1. Epub 2016 Apr 18.

University of Washington and Seattle Children's Hospital, Seattle, Wash.

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http://dx.doi.org/10.1016/j.jaci.2016.01.045DOI Listing
August 2016

Respiratory Health and Related Quality of Life in Patients with Congenital Agammaglobulinemia in the Northern Region of the UK.

Authors:
Branwen A Bryan Alex Battersby Benjamin Martin James Shillitoe Dawn Barge Helen Bourne Terry Flood Andrew J Cant Catherine Stroud Andrew R Gennery

J Clin Immunol 2016 07 18;36(5):472-9. Epub 2016 Apr 18.

Institute of Cellular Medicine, Newcastle University, 4th Floor, William Leech Building, Medical School, Framlington Place, Newcastle upon Tyne, E2 4HH, UK.

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http://dx.doi.org/10.1007/s10875-016-0284-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896978PMC
July 2016

Immunodeficiency in a Child with 22q11.2 Microduplication Syndrome.

Authors:
Robyn Traynor Karina M Butler Andrew J Cant Timothy Ronan Leahy

J Clin Immunol 2016 07 20;36(5):418-9. Epub 2016 Apr 20.

Department of Paediatric Infectious Diseases and Immunology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

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http://dx.doi.org/10.1007/s10875-016-0286-1DOI Listing
July 2016

Erratum to: Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency.

Authors:
Tarana Singh Dang Joseph D P Willet Helen R Griffin Neil V Morgan Graeme O'Boyle Peter D Arkwright Stephen M Hughes Mario Abinun Louise J Tee Dawn Barge Karin R Engelhardt Michael Jackson Andrew J Cant Eamonn R Maher Mauro Santibanez Koref Louise N Reynard Simi Ali Sophie Hambleton

J Clin Immunol 2016 Apr;36(3):336-7

Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s10875-016-0248-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970337PMC
April 2016

Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency.

Authors:
Tarana Singh Dang Joseph D P Willet Helen R Griffin Neil V Morgan Graeme O'Boyle Peter D Arkwright Stephen M Hughes Mario Abinun Louise J Tee Dawn Barge Karin R Engelhardt Michael Jackson Andrew J Cant Eamonn R Maher Mauro Santibanez Koref Louise N Reynard Simi Ali Sophie Hambleton

J Clin Immunol 2016 Feb 22;36(2):117-22. Epub 2016 Jan 22.

Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s10875-016-0232-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769310PMC
February 2016

Astute Clinician Report: A Novel 10 bp Frameshift Deletion in Exon 2 of ICOS Causes a Combined Immunodeficiency Associated with an Enteritis and Hepatitis.

Authors:
Nic Robertson Karin R Engelhardt Neil V Morgan Dawn Barge Andrew J Cant Stephen M Hughes Mario Abinun Yaobo Xu Mauro Santibanez Koref Peter D Arkwright Sophie Hambleton

J Clin Immunol 2015 Oct 23;35(7):598-603. Epub 2015 Sep 23.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s10875-015-0193-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628077PMC
October 2015

Human IFNAR2 deficiency: Lessons for antiviral immunity.

Authors:
Christopher J A Duncan Siti M B Mohamad Dan F Young Andrew J Skelton T Ronan Leahy Diane C Munday Karina M Butler Sofia Morfopoulou Julianne R Brown Mike Hubank Jeff Connell Patrick J Gavin Cathy McMahon Eugene Dempsey Niamh E Lynch Thomas S Jacques Manoj Valappil Andrew J Cant Judith Breuer Karin R Engelhardt Richard E Randall Sophie Hambleton

Sci Transl Med 2015 Sep;7(307):307ra154

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK. Pediatric Immunology Service, Great North Children's Hospital, Newcastle upon Tyne NE1 4LP, UK.

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http://dx.doi.org/10.1126/scitranslmed.aac4227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926955PMC
September 2015

The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency.

Authors:
Karin R Engelhardt Michael E Gertz Sevgi Keles Alejandro A Schäffer Elena C Sigmund Cristina Glocker Shiva Saghafi Zahra Pourpak Ruben Ceja Atfa Sassi Laura E Graham Michel J Massaad Fethi Mellouli Imen Ben-Mustapha Monia Khemiri Sara Sebnem Kilic Amos Etzioni Alexandra F Freeman Jens Thiel Ilka Schulze Waleed Al-Herz Ayse Metin Özden Sanal Ilhan Tezcan Mehdi Yeganeh Tim Niehues Gregor Dueckers Sebastian Weinspach Turkan Patiroglu Ekrem Unal Majed Dasouki Mustafa Yilmaz Ferah Genel Caner Aytekin Necil Kutukculer Ayper Somer Mehmet Kilic Ismail Reisli Yildiz Camcioglu Andrew R Gennery Andrew J Cant Alison Jones Bobby H Gaspar Peter D Arkwright Maria C Pietrogrande Zeina Baz Salem Al-Tamemi Vassilios Lougaris Gerard Lefranc Andre Megarbane Jeannette Boutros Nermeen Galal Mohamed Bejaoui Mohamed-Ridha Barbouche Raif S Geha Talal A Chatila Bodo Grimbacher

J Allergy Clin Immunol 2015 Aug 25;136(2):402-12. Epub 2015 Feb 25.

Department of Immunology and Molecular Pathology, Royal Free Hospital and University College London, London, United Kingdom; Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.12.1945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530066PMC
August 2015

The importance of vaccination and immunoglobulin treatment for patients with primary immunodeficiency diseases (PIDs)--World PI Week April 22-29, 2015.

Authors:
Shereen M Reda Andrew J Cant

Eur J Immunol 2015 May;45(5):1285-6

President of ESID, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust & Institute of Cellular Medicine, Newcastle University, Lead, UK.

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http://dx.doi.org/10.1002/eji.201570054DOI Listing
May 2015

Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations.

Authors:
Joshua D Milner Tiphanie P Vogel Lisa Forbes Chi A Ma Asbjørg Stray-Pedersen Julie E Niemela Jonathan J Lyons Karin R Engelhardt Yu Zhang Nermina Topcagic Elisha D O Roberson Helen Matthews James W Verbsky Trivikram Dasu Alexander Vargas-Hernandez Nidhy Varghese Kenneth L McClain Lina B Karam Karen Nahmod George Makedonas Emily M Mace Hanne S Sorte Gøri Perminow V Koneti Rao Michael P O'Connell Susan Price Helen C Su Morgan Butrick Joshua McElwee Jason D Hughes Joseph Willet David Swan Yaobo Xu Mauro Santibanez-Koref Voytek Slowik Darrell L Dinwiddie Christina E Ciaccio Carol J Saunders Seth Septer Stephen F Kingsmore Andrew J White Andrew J Cant Sophie Hambleton Megan A Cooper

Blood 2015 Jan 30;125(4):591-9. Epub 2014 Oct 30.

Departments of Pediatrics, Division of Rheumatology, and Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1182/blood-2014-09-602763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304103PMC
January 2015

Gut immune reconstitution in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome after hematopoietic stem cell transplantation.

Authors:
Eleonora Gambineri Sara Ciullini Mannurita Helen Robertson Marina Vignoli Beate Haugk Paolo Lionetti Sophie Hambleton Dawn Barge Andrew R Gennery Mary Slatter Zohreh Nademi Terence J Flood Anthony Jackson Mario Abinun Andrew J Cant

J Allergy Clin Immunol 2015 Jan 25;135(1):260-2. Epub 2014 Oct 25.

Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, United Kingdom; Department of Pediatric Immunology, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2014.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282727PMC
January 2015

Dual proteolytic pathways govern glycolysis and immune competence.

Authors:
Wei Lu Yu Zhang David O McDonald Huie Jing Bernadette Carroll Nic Robertson Qian Zhang Helen Griffin Sharon Sanderson Jeremy H Lakey Neil V Morgan Louise N Reynard Lixin Zheng Heardley M Murdock Stuart E Turvey Scott J Hackett Tim Prestidge Julie M Hall Andrew J Cant Helen F Matthews Mauro F Santibanez Koref Anna Katharina Simon Viktor I Korolchuk Michael J Lenardo Sophie Hambleton Helen C Su

Cell 2014 Dec;159(7):1578-90

Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297473PMC
December 2014

Primary Immune Deficiency Treatment Consortium (PIDTC) report.

Authors:
Linda M Griffith Morton J Cowan Luigi D Notarangelo Donald B Kohn Jennifer M Puck Sung-Yun Pai Barbara Ballard Sarah C Bauer Jack J H Bleesing Marcia Boyle Amy Brower Rebecca H Buckley Mirjam van der Burg Lauri M Burroughs Fabio Candotti Andrew J Cant Talal Chatila Charlotte Cunningham-Rundles Mary C Dinauer Christopher C Dvorak Alexandra H Filipovich Thomas A Fleisher Hubert Bobby Gaspar Tayfun Gungor Elie Haddad Emily Hovermale Faith Huang Alan Hurley Mary Hurley Sumathi Iyengar Elizabeth M Kang Brent R Logan Janel R Long-Boyle Harry L Malech Sean A McGhee Fred Modell Vicki Modell Hans D Ochs Richard J O'Reilly Robertson Parkman David J Rawlings John M Routes William T Shearer Trudy N Small Heather Smith Kathleen E Sullivan Paul Szabolcs Adrian Thrasher Troy R Torgerson Paul Veys Kenneth Weinberg Juan Carlos Zuniga-Pflucker

J Allergy Clin Immunol 2014 Feb 15;133(2):335-47. Epub 2013 Oct 15.

Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960312PMC
February 2014

Low-dose serotherapy improves early immune reconstitution after cord blood transplantation for primary immunodeficiencies.

Authors:
Jonathan P Lane Philippa T G Evans Zohreh Nademi Dawn Barge Anthony Jackson Sophie Hambleton Terry J Flood Andrew J Cant Mario Abinun Mary A Slatter Andrew R Gennery

Biol Blood Marrow Transplant 2014 Feb 10;20(2):243-9. Epub 2013 Nov 10.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2013.11.005DOI Listing
February 2014

Clinical outcome in children with chronic granulomatous disease managed conservatively or with hematopoietic stem cell transplantation.

Authors:
Theresa Cole Mark S Pearce Andrew J Cant Catherine M Cale David Goldblatt Andrew R Gennery

J Allergy Clin Immunol 2013 Nov 16;132(5):1150-5. Epub 2013 Jul 16.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.05.031DOI Listing
November 2013

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.

Authors:
Ivan Angulo Oscar Vadas Fabien Garçon Edward Banham-Hall Vincent Plagnol Timothy R Leahy Helen Baxendale Tanya Coulter James Curtis Changxin Wu Katherine Blake-Palmer Olga Perisic Deborah Smyth Mailis Maes Christine Fiddler Jatinder Juss Deirdre Cilliers Gašper Markelj Anita Chandra George Farmer Anna Kielkowska Jonathan Clark Sven Kracker Marianne Debré Capucine Picard Isabelle Pellier Nada Jabado James A Morris Gabriela Barcenas-Morales Alain Fischer Len Stephens Phillip Hawkins Jeffrey C Barrett Mario Abinun Menna Clatworthy Anne Durandy Rainer Doffinger Edwin R Chilvers Andrew J Cant Dinakantha Kumararatne Klaus Okkenhaug Roger L Williams Alison Condliffe Sergey Nejentsev

Science 2013 Nov 17;342(6160):866-71. Epub 2013 Oct 17.

Department of Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1126/science.1243292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930011PMC
November 2013

Cognitive ability in children with chronic granulomatous disease: a comparison of those managed conservatively with those who have undergone hematopoietic stem cell transplant.

Authors:
Theresa S Cole Fiona McKendrick Andrew J Cant Mark S Pearce Catherine M Cale David R Goldblatt Andrew R Gennery Penny Titman

Neuropediatrics 2013 Aug 8;44(4):230-2. Epub 2013 Feb 8.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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August 2013

STAT2 deficiency and susceptibility to viral illness in humans.

Authors:
Sophie Hambleton Stephen Goodbourn Dan F Young Paul Dickinson Siti M B Mohamad Manoj Valappil Naomi McGovern Andrew J Cant Scott J Hackett Peter Ghazal Neil V Morgan Richard E Randall

Proc Natl Acad Sci U S A 2013 Feb 7;110(8):3053-8. Epub 2013 Feb 7.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1220098110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581986PMC
February 2013

Health related quality of life and emotional health in children with chronic granulomatous disease: a comparison of those managed conservatively with those that have undergone haematopoietic stem cell transplant.

Authors:
Theresa Cole Fiona McKendrick Penny Titman Andrew J Cant Mark S Pearce Catherine M Cale David Goldblatt Andrew R Gennery

J Clin Immunol 2013 Jan 12;33(1):8-13. Epub 2012 Aug 12.

Institutes of Cellular Medicine, Newcastle University, Newcastle, UK.

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http://dx.doi.org/10.1007/s10875-012-9758-0DOI Listing
January 2013

The 10 warning signs: a time for a change?

Authors:
Michael D OʼSullivan Andrew J Cant

Curr Opin Allergy Clin Immunol 2012 Dec;12(6):588-94

Immunology Department, PathWest Laboratory Medicine, Perth, Western Australia, Australia.

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December 2012

Emotional and behavioural difficulties in chronic granulomatous disease.

Authors:
Theresa S Cole Laura K R Jones Paraic McGrogan Mark S Pearce Terry J Flood Andrew J Cant David Goldblatt Adrian J Thrasher Andrew R Gennery Fiona McKendrick Penny Titman

Arch Dis Child 2012 Jan 12;97(1):87. Epub 2011 Oct 12.

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http://dx.doi.org/10.1136/archdischild-2011-300780DOI Listing
January 2012

Hematopoietic stem cell transplantation for primary immunodeficiency diseases.

Authors:
Mary A Slatter Andrew J Cant

Ann N Y Acad Sci 2011 Nov;1238:122-31

Department of Paediatric Immunology, Newcastle upon Tyne Hospital NHS Foundation Trust, United Kingdom.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06243.xDOI Listing
November 2011

Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative study.

Authors:
Daniele Moratto Silvia Giliani Carmem Bonfim Evelina Mazzolari Alain Fischer Hans D Ochs Andrew J Cant Adrian J Thrasher Morton J Cowan Michael H Albert Trudy Small Sung-Yun Pai Elie Haddad Antonella Lisa Sophie Hambleton Mary Slatter Marina Cavazzana-Calvo Nizar Mahlaoui Capucine Picard Troy R Torgerson Lauri Burroughs Adriana Koliski Jose Zanis Neto Fulvio Porta Waseem Qasim Paul Veys Kristina Kavanau Manfred Hönig Ansgar Schulz Wilhelm Friedrich Luigi D Notarangelo

Blood 2011 Aug 9;118(6):1675-84. Epub 2011 Jun 9.

A. Nocivelli Institute for Molecular Medicine, Pediatric Clinic, University of Brescia, and Laboratory of Genetic Disorders of Childhood, Spedali Civili, Brescia, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156052PMC
August 2011

Clinical features that identify children with primary immunodeficiency diseases.

Authors:
Anbezhil Subbarayan Gloria Colarusso Stephen M Hughes Andrew R Gennery Mary Slatter Andrew J Cant Peter D Arkwright

Pediatrics 2011 May 11;127(5):810-6. Epub 2011 Apr 11.

Department of Paediatric Allergy and Immunology, Royal Manchester Children's Hospital, University of Manchester, Oxford Road, Manchester M13 9WL, United Kingdom.

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http://dx.doi.org/10.1542/peds.2010-3680DOI Listing
May 2011

Polymorphous lymphoproliferative disorder with Hodgkin-like features in common γ-chain-deficient severe combined immunodeficiency.

Authors:
Mary A Slatter Brian Angus Kevin Windebank Alison Taylor Cathy Meaney Tracey Lester Gail Norbury Sophie Hambleton Mario Abinun Terence J Flood Andrew J Cant Andrew R Gennery

J Allergy Clin Immunol 2011 Feb 20;127(2):533-5. Epub 2010 Nov 20.

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http://dx.doi.org/10.1016/j.jaci.2010.09.036DOI Listing
February 2011

Impaired T(H)17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

Authors:
Wan-Fai Ng Alexei von Delwig Andrew J Carmichael Peter D Arkwright Mario Abinun Andrew J Cant Stephen Jolles Desa Lilic

J Allergy Clin Immunol 2010 Nov 8;126(5):1006-15, 1015.e1-4. Epub 2010 Oct 8.

Musculoskeletal Research Group, Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2010.08.027DOI Listing
November 2010

Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: entering a new century, do we do better?

Authors:
Andrew R Gennery Mary A Slatter Laure Grandin Pierre Taupin Andrew J Cant Paul Veys Persis J Amrolia H Bobby Gaspar E Graham Davies Wilhelm Friedrich Manfred Hoenig Luigi D Notarangelo Evelina Mazzolari Fulvio Porta Robbert G M Bredius Arjen C Lankester Nico M Wulffraat Reinhard Seger Tayfun Güngör Anders Fasth Petr Sedlacek Benedicte Neven Stephane Blanche Alain Fischer Marina Cavazzana-Calvo Paul Landais

J Allergy Clin Immunol 2010 Sep 31;126(3):602-10.e1-11. Epub 2010 Jul 31.

Institute of Cellular Medicine, Child Health, University of Newcastle upon Tyne, Newcastle Upon Tyne, United Kingdom.

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September 2010

Clinical and immunologic outcome of patients with cartilage hair hypoplasia after hematopoietic stem cell transplantation.

Authors:
Victoria Bordon Andrew R Gennery Mary A Slatter Els Vandecruys Genevieve Laureys Paul Veys Waseem Qasim Qasim Waseem Wilhelm Friedrich Nico M Wulfraat Franziska Scherer Andrew J Cant Alain Fischer Marina Cavazzana-Calvo Marina Cavazanna-Calvo Robbert G M Bredius Luigi D Notarangelo Evelina Mazzolari Benedicte Neven Tayfun Güngör Güngör Tayfun

Blood 2010 Jul 7;116(1):27-35. Epub 2010 Apr 7.

Pediatric Hematology, Oncology and Stem Cell Transplantation, Kliniek voor Kinderziekten C. Hooft, Ghent University Hospital, de Pintelaan 185, Ghent, Belgium.

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http://dx.doi.org/10.1182/blood-2010-01-259168DOI Listing
July 2010

Clinical experience in T cell deficient patients.

Authors:
Theresa S Cole Andrew J Cant

Allergy Asthma Clin Immunol 2010 May 13;6(1). Epub 2010 May 13.

Paediatric Immunology Dept, Ward 23, Newcastle General Hospital, Westgate Road, Newcastle, NE4 6BE, UK.

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http://dx.doi.org/10.1186/1710-1492-6-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877019PMC
May 2010

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I.

Authors:
Anne Puel Rainer Döffinger Angels Natividad Maya Chrabieh Gabriela Barcenas-Morales Capucine Picard Aurélie Cobat Marie Ouachée-Chardin Antoine Toulon Jacinta Bustamante Saleh Al-Muhsen Mohammed Al-Owain Peter D Arkwright Colm Costigan Vivienne McConnell Andrew J Cant Mario Abinun Michel Polak Pierre-François Bougnères Dinakantha Kumararatne László Marodi Amit Nahum Chaim Roifman Stéphane Blanche Alain Fischer Christine Bodemer Laurent Abel Desa Lilic Jean-Laurent Casanova

J Exp Med 2010 Feb 1;207(2):291-7. Epub 2010 Feb 1.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM), U550, 75015 Paris, France.

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http://www.jem.org/lookup/doi/10.1084/jem.20091983
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http://dx.doi.org/10.1084/jem.20091983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822614PMC
February 2010

Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome.

Authors:
Cristina Woellner E Michael Gertz Alejandro A Schäffer Macarena Lagos Mario Perro Erik-Oliver Glocker Maria C Pietrogrande Fausto Cossu José L Franco Nuria Matamoros Barbara Pietrucha Edyta Heropolitańska-Pliszka Mehdi Yeganeh Mostafa Moin Teresa Español Stephan Ehl Andrew R Gennery Mario Abinun Anna Breborowicz Tim Niehues Sara Sebnem Kilic Anne Junker Stuart E Turvey Alessandro Plebani Berta Sánchez Ben-Zion Garty Claudio Pignata Caterina Cancrini Jiri Litzman Ozden Sanal Ulrich Baumann Rosa Bacchetta Amy P Hsu Joie N Davis Lennart Hammarström E Graham Davies Efrem Eren Peter D Arkwright Jukka S Moilanen Dorothee Viemann Sujoy Khan László Maródi Andrew J Cant Alexandra F Freeman Jennifer M Puck Steven M Holland Bodo Grimbacher

J Allergy Clin Immunol 2010 Feb;125(2):424-432.e8

Department of Immunology and Molecular Pathology, Royal Free Hospital, University College London, London NW3 2QG, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878129PMC
February 2010

Autologous T cell depleted haematopoietic stem cell transplantation in children with severe juvenile idiopathic arthritis in the UK (2000-2007).

Authors:
Mario Abinun Terence J Flood Andrew J Cant Paul Veys Andrew R Gennery Helen E Foster Mark Friswell Eileen Baildam Joyce Davidson Taunton R Southwood Polly Livermore Lucy R Wedderburn

Mol Immunol 2009 Nov 8;47(1):46-51. Epub 2009 Feb 8.

Department of Paediatric Immunology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.molimm.2008.12.029DOI Listing
November 2009

Unrelated donor and HLA-identical sibling haematopoietic stem cell transplantation cure chronic granulomatous disease with good long-term outcome and growth.

Authors:
Elena Soncini Mary A Slatter Laura B K R Jones Stephen Hughes Stephen Hodges Terence J Flood Dawn Barge Gavin P Spickett Graham H Jackson Matthew P Collin Mario Abinun Andrew J Cant Andrew R Gennery

Br J Haematol 2009 Apr 16;145(1):73-83. Epub 2009 Feb 16.

Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, UK.

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http://doi.wiley.com/10.1111/j.1365-2141.2009.07614.x
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April 2009

New findings in primary immunodeficiency.

Authors:
Andrew R Gennery Andrew J Cant

Adv Exp Med Biol 2009 ;634:79-93

Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE.

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http://dx.doi.org/10.1007/978-0-387-79838-7_8DOI Listing
March 2009

Autoantibodies against type I interferons as an additional diagnostic criterion for autoimmune polyendocrine syndrome type I.

Authors:
Antonella Meloni Maria Furcas Filomena Cetani Claudio Marcocci Alberto Falorni Roberto Perniola Mikulás Pura Anette S Bøe Wolff Eystein S Husebye Desa Lilic Kelli R Ryan Andrew R Gennery Andrew J Cant Mario Abinun Gavin P Spickett Peter D Arkwright David Denning Colm Costigan Maria Dominguez Vivienne McConnell Nick Willcox Anthony Meager

J Clin Endocrinol Metab 2008 Nov 26;93(11):4389-97. Epub 2008 Aug 26.

Pediatric Clinic II, Ospedale Microcitemico and Dipartimento di Sciencze Biomediche e Biotechno-logiche, University of Cagliari, Cagliari, Sardinia, Italy.

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http://dx.doi.org/10.1210/jc.2008-0935DOI Listing
November 2008

Contamination of the hospital environment with gastroenteric viruses: comparison of two pediatric wards over a winter season.

Authors:
Chris I Gallimore Clive Taylor Andrew R Gennery Andrew J Cant Angela Galloway Jacqueline Xerry Juliet Adigwe Jim J Gray

J Clin Microbiol 2008 Sep 9;46(9):3112-5. Epub 2008 Jul 9.

Virus Reference Department, Enteric Virus Unit, Centre for Infections, Health Protection Agency, Colindale, London NW9 5HT, United Kingdom.

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http://dx.doi.org/10.1128/JCM.00400-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546731PMC
September 2008

Advances in hematopoietic stem cell transplantation for primary immunodeficiency.

Authors:
Andrew R Gennery Andrew J Cant

Immunol Allergy Clin North Am 2008 May;28(2):439-56, x-xi

Institute of Cellular Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU, UK; Children's Bone Marrow Transplant Unit, Ward 23, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.iac.2008.01.006DOI Listing
May 2008

Long-term immune reconstitution after anti-CD52-treated or anti-CD34-treated hematopoietic stem cell transplantation for severe T-lymphocyte immunodeficiency.

Authors:
Mary A Slatter Kenneth Brigham Anne M Dickinson Helen L Harvey Dawn Barge Antony Jackson Nicholas Bown Terence J Flood Andrew J Cant Mario Abinun Andrew R Gennery

J Allergy Clin Immunol 2008 Feb 20;121(2):361-7. Epub 2007 Dec 20.

Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2007.10.035DOI Listing
February 2008

Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation.

Authors:
Hulya Ozsahin Marina Cavazzana-Calvo Luigi D Notarangelo Ansgar Schulz Adrian J Thrasher Evelina Mazzolari Mary A Slatter Francoise Le Deist Stephane Blanche Paul Veys Anders Fasth Robbert Bredius Petr Sedlacek Nico Wulffraat Juan Ortega Carsten Heilmann Anne O'Meara Jacek Wachowiak Krzysztof Kalwak Susanne Matthes-Martin Tayfun Gungor Aydan Ikinciogullari Paul Landais Andrew J Cant Wilhelm Friedrich Alain Fischer

Blood 2008 Jan 27;111(1):439-45. Epub 2007 Sep 27.

Department of Pediatrics, Geneva University Hospital, Geneva, Switzerland.

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January 2008

Cord blood stem cell transplantation in primary immune deficiencies.

Authors:
Andrew R Gennery Andrew J Cant

Curr Opin Allergy Clin Immunol 2007 Dec;7(6):528-34

Institute of Cellular Medicine, Newcastle University, Newcastle General Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1097/ACI.0b013e3282f1d6b6DOI Listing
December 2007

Hematopoietic stem cell transplantation corrects the immunologic abnormalities associated with immunodeficiency-centromeric instability-facial dysmorphism syndrome.

Authors:
Andrew R Gennery Mary A Slatter Robbert G Bredius Melanie M Hagleitner Corry Weemaes Andrew J Cant Arjan C Lankester

Pediatrics 2007 Nov 1;120(5):e1341-4. Epub 2007 Oct 1.

Paediatric Immunology Department, Newcastle General Hospital, Westgate Road, Newcastle Upon Tyne NE4 6BE, United Kingdom.

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http://dx.doi.org/10.1542/peds.2007-0640DOI Listing
November 2007

Reduced anti-PRP antibody response to Hib immunisation in preterm (<32 weeks) UK infants who received inactivated polio (eIPV).

Authors:
Janet E Berrington Alan C Fenton Andrew J Cant Gavin P Spickett Marilyn O'Keeffe John N S Matthews

Vaccine 2007 Nov 16;25(49):8206-8. Epub 2007 Oct 16.

Department of Neonatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.

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http://dx.doi.org/10.1016/j.vaccine.2007.09.060DOI Listing
November 2007

Mevalonic aciduria cured by bone marrow transplantation.

Authors:
Peter D Arkwright Mario Abinun Andrew J Cant

N Engl J Med 2007 09;357(13):1350

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http://dx.doi.org/10.1056/NEJMc072018DOI Listing
September 2007

GvHD-associated cytokine polymorphisms do not associate with Omenn syndrome rather than T-B- SCID in patients with defects in RAG genes.

Authors:
Iram J Haq Laura J Steinberg Manfred Hoenig Mirjam van der Burg Anna Villa Andrew J Cant Peter G Middleton Andrew R Gennery

Clin Immunol 2007 Aug 14;124(2):165-9. Epub 2007 Jun 14.

Institute of Cellular Medicine, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.clim.2007.04.013DOI Listing
August 2007

Anti-pneumococcal antibody titre measurement: what useful information does it yield?

Authors:
Paul Balmer Andrew J Cant Ray Borrow

J Clin Pathol 2007 Apr 1;60(4):345-50. Epub 2006 Sep 1.

Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Laboratory, Manchester Royal Infirmary, Manchester, UK.

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http://dx.doi.org/10.1136/jcp.2006.041210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001126PMC
April 2007

Outcome of hematopoietic stem cell transplantation in severe combined immune deficiency with central nervous system viral infection.

Authors:
Cathy Waruiru Mary A Slatter Clive Taylor Venkateswaran Ramesh Terence J Flood Mario Abinun Andrew J Cant Andrew R Gennery

Pediatr Infect Dis J 2007 Feb;26(2):129-33

Paediatric Immunology Department, Newcastle General Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1097/01.inf.0000250621.46742.b5DOI Listing
February 2007

Haemophilus influenzae type b immunization in infants in the United Kingdom: effects of diphtheria/tetanus/acellular pertussis/Hib combination vaccine, significant prematurity, and a fourth dose.

Authors:
Janet E Berrington Andrew J Cant John N S Matthews Marilyn O'Keeffe Gavin P Spickett Alan C Fenton

Pediatrics 2006 Apr 20;117(4):e717-24. Epub 2006 Mar 20.

Department of Neonatology, Royal Victoria Infirmary, Newcastle Upon Tyne, England.

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April 2006

Environmental monitoring for gastroenteric viruses in a pediatric primary immunodeficiency unit.

Authors:
Chris I Gallimore Clive Taylor Andrew R Gennery Andrew J Cant Angela Galloway Miren Iturriza-Gomara Jim J Gray

J Clin Microbiol 2006 Feb;44(2):395-9

Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5HT, United Kingdom.

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http://dx.doi.org/10.1128/JCM.44.2.395-399.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392667PMC
February 2006

Omenn's syndrome occurring in patients without mutations in recombination activating genes.

Authors:
Andrew R Gennery Elizabeth Hodges Anthony P Williams Susan Harris Anna Villa Brian Angus Andrew J Cant John L Smith

Clin Immunol 2005 Sep;116(3):246-56

Department of Paediatrics, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.clim.2005.04.014DOI Listing
September 2005

Use of a heminested reverse transcriptase PCR assay for detection of astrovirus in environmental swabs from an outbreak of gastroenteritis in a pediatric primary immunodeficiency unit.

Authors:
Chris I Gallimore Clive Taylor Andrew R Gennery Andrew J Cant Angela Galloway David Lewis Jim J Gray

J Clin Microbiol 2005 Aug;43(8):3890-4

Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, Colindale, London, NW9 5HT, United Kingdom.

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http://dx.doi.org/10.1128/JCM.43.8.3890-3894.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234003PMC
August 2005

Severe food-allergic reactions in children across the UK and Ireland, 1998-2000.

Authors:
Allan F Colver Heidi Nevantaus Colin F Macdougall Andrew J Cant

Acta Paediatr 2005 Jun;94(6):689-95

Sir James Spence Institute, Royal Victoria Infirmary, Northumbria Healthcare NHS Trust and University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1651-2227.2005.tb01966.xDOI Listing
June 2005

Bone marrow transplantation for Nijmegan breakage syndrome.

Authors:
Andrew R Gennery Mary A Slatter Arpita Bhattacharya Penny A Jeggo Mario Abinun Terence J Flood Andrew J Cant

J Pediatr Hematol Oncol 2005 Apr;27(4):239

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http://dx.doi.org/10.1097/01.mph.0000158257.45823.80DOI Listing
April 2005

Adenovirus type F subtype 41 causing disseminated disease following bone marrow transplantation for immunodeficiency.

Authors:
Mary A Slatter Steven Read Clive E Taylor Bruce N A Crooks Mario Abinun Terence J Flood Andrew J Cant Christopher Wright Andrew R Gennery

J Clin Microbiol 2005 Mar;43(3):1462-4

Paediatric Immunology Unit, Ward 23, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom.

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http://dx.doi.org/10.1128/JCM.43.3.1462-1464.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1081290PMC
March 2005

The immunocompromised host: the patient with recurrent infection.

Authors:
Andrew R Gennery Andrew J Cant

Adv Exp Med Biol 2004 ;549:109-17

School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle General Hospital, United Kingdom.

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http://dx.doi.org/10.1007/978-1-4419-8993-2_16DOI Listing
August 2004

Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience, 1993-2002.

Authors:
Andrew R Gennery Khulood Khawaja Paul Veys Robbert G M Bredius Luigi D Notarangelo Evelina Mazzolari Alain Fischer Paul Landais Marina Cavazzana-Calvo Wilhelm Friedrich Anders Fasth Nico M Wulffraat Susanne Matthes-Martin Danielle Bensoussan Pierre Bordigoni Andrzej Lange Antonio Pagliuca Marino Andolina Andrew J Cant E Graham Davies

Blood 2004 Feb 2;103(3):1152-7. Epub 2003 Oct 2.

Newcastle General Hospital, Westgate Rd, Newcastle upon Tyne, NE4 6BE United Kingdom.

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http://dx.doi.org/10.1182/blood-2003-06-2014DOI Listing
February 2004

Deregulated production of protective cytokines in response to Candida albicans infection in patients with chronic mucocutaneous candidiasis.

Authors:
Desa Lilic Ian Gravenor Neil Robson David A Lammas Pam Drysdale Jane E Calvert Andrew J Cant Mario Abinun

Infect Immun 2003 Oct;71(10):5690-9

School of Cell and Molecular Biosciences, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom NE2 4HH.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC201074PMC
http://dx.doi.org/10.1128/iai.71.10.5690-5699.2003DOI Listing
October 2003

Autoimmunity in human primary immunodeficiency diseases.

Authors:
Peter D Arkwright Mario Abinun Andrew J Cant

Blood 2002 Apr;99(8):2694-702

Academic Unit of Child Health, University of Manchester, St Mary's Hospital, Manchester, United Kingdom.

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http://dx.doi.org/10.1182/blood.v99.8.2694DOI Listing
April 2002

Three novel mutations of the CIITA gene in MHC class II-deficient patients with a severe immunodeficiency.

Authors:
Magda Dziembowska Marie-Claude Fondaneche Jocelyn Vedrenne Giovanna Barbieri Wojciech Wiszniewski Capucine Picard Andrew J Cant Viktor Steimle Dominique Charron Catherine Alca-Loridan Alain Fischer Barbara Lisowska-Grospierre

Immunogenetics 2002 Feb 29;53(10-11):821-9. Epub 2002 Jan 29.

INSERM U429, Institut National de la Santé et le Recherche Médicale, Hôpital Necker, 119 rue de Serres, 75015 Paris, France.

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http://link.springer.com/10.1007/s00251-001-0395-7
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http://dx.doi.org/10.1007/s00251-001-0395-7DOI Listing
February 2002