Publications by authors named "Andrew J Cant"

83Publications

Germline TET2 loss of function causes childhood immunodeficiency and lymphoma.

Authors:
Jarmila Stremenova Spegarova Dylan Lawless Siti Mardhiana Binti Mohamad Karin R Engelhardt Gina Doody Jennifer Shrimpton Anne Rensing-Ehl Stephan Ehl Frederic Rieux-Laucat Catherine Cargo Helen Griffin Aneta Mikulasova Meghan Acres Neil V Morgan James A Poulter Eamonn G Sheridan Philip Chetcuti Sean O'Riordan Rashida Anwar Clive R Carter Stefan Przyborski Kevin Windebank Andrew J Cant Majlinda Lako Chris M Bacon Sinisa Savic Sophie Hambleton

Blood 2020 Aug;136(9):1055-1066

Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom.

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August 2020

New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT.

Authors:
Reem Elfeky Giovanna Lucchini Su-Han Lum Giorgio Ottaviano Natalia Builes Zohreh Nademi Alexandra Battersby Terence Flood Stephen Owens Andrew J Cant Helen Young Sinéad Greener Patrick Walsh David Kavanagh Srinivas Annavarapu Kanchan Rao Persis Amrolia Robert Chiesa Austen Worth Claire Booth Roderick Skinner Bilyana Doncheva Joseph Standing Andrew R Gennery Waseem Qasim Mary Slatter Paul Veys

Blood Adv 2020 06;4(11):2418-2429

Department of Blood and Marrow Transplantation, Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust, University College London GOS Institute of Child Health, and NIHR GOSH BRC, London, United Kingdom.

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June 2020

Proposed Therapeutic Range of Treosulfan in Reduced Toxicity Pediatric Allogeneic Hematopoietic Stem Cell Transplant Conditioning: Results From a Prospective Trial.

Authors:
Robert Chiesa Joseph F Standing Robert Winter Zohreh Nademi Jan Chu Danielle Pinner Frank Kloprogge Susan McLellen Persis J Amrolia Kanchan Rao Giovanna Lucchini Juliana Silva Oana Ciocarlie Arina Lazareva Andrew R Gennery Bilyana Doncheva Andrew J Cant Sophie Hambleton Terence Flood Elizabeth Rogerson Kirsty Devine Helen Prunty Simon Heales Paul Veys Mary Slatter

Clin Pharmacol Ther 2020 Aug 14;108(2):264-273. Epub 2019 Dec 14.

Bone Marrow Transplantation Department, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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August 2020

Novel Gain-of-Function Mutation in Stat1 Sumoylation Site Leads to CMC/CID Phenotype Responsive to Ruxolitinib.

Authors:
Tariq Al Shehri Kimberly Gilmour Florian Gothe Sam Loughlin Shahnaz Bibi Andrew D Rowan Angela Grainger Thivytra Mohanadas Andrew J Cant Mary A Slatter Sophie Hambleton Desa Lilic Timothy R Leahy

J Clin Immunol 2019 11 11;39(8):776-785. Epub 2019 Sep 11.

Department of Paediatric Immunology and Infectious Diseases, Children's Health Ireland, Crumlin, Dublin, D12 N512, Ireland.

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November 2019

Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of -encoded phosphoinositide 3-kinase δ.

Authors:
David J Swan Dominik Aschenbrenner Christopher A Lamb Krishnendu Chakraborty Jonathan Clark Sumeet Pandey Karin R Engelhardt Rui Chen Athena Cavounidis Yuchun Ding Natalio Krasnogor Christopher D Carey Meghan Acres Stephanie Needham Andrew J Cant Peter D Arkwright Anita Chandra Klaus Okkenhaug Holm H Uhlig Sophie Hambleton

Haematologica 2019 10 9;104(10):e483-e486. Epub 2019 May 9.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne

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October 2019

Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients.

Authors:
Bethany A Pillay Danielle T Avery Joanne M Smart Theresa Cole Sharon Choo Damien Chan Paul E Gray Katie Frith Richard Mitchell Tri Giang Phan Melanie Wong Dianne E Campbell Peter Hsu John B Ziegler Jane Peake Frank Alvaro Capucine Picard Jacinta Bustamante Benedicte Neven Andrew J Cant Gulbu Uzel Peter D Arkwright Jean-Laurent Casanova Helen C Su Alexandra F Freeman Nirali Shah Dennis D Hickstein Stuart G Tangye Cindy S Ma

JCI Insight 2019 04 25;5. Epub 2019 Apr 25.

Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

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April 2019

New graft manipulation strategies improve the outcome of mismatched stem cell transplantation in children with primary immunodeficiencies.

Authors:
Reem Elfeky Ravi M Shah Mohamed N M Unni Giorgio Ottaviano Kanchan Rao Robert Chiesa Persis Amrolia Austen Worth Terry Flood Mario Abinun Sophie Hambleton Andrew J Cant Kimberly Gilmour Stuart Adams Gul Ahsan Dawn Barge Andrew R Gennery Waseem Qasim Mary Slatter Paul Veys

J Allergy Clin Immunol 2019 07 4;144(1):280-293. Epub 2019 Feb 4.

Molecular and Cellular Immunology Unit, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom; Blood and Bone Marrow Transplant Unit, Great Ormond Street Hospital, London, United Kingdom.

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July 2019

An essential role for the Zn transporter ZIP7 in B cell development.

Authors:
Consuelo Anzilotti David J Swan Bertrand Boisson Mukta Deobagkar-Lele Catarina Oliveira Pauline Chabosseau Karin R Engelhardt Xijin Xu Rui Chen Luis Alvarez Rolando Berlinguer-Palmini Katherine R Bull Eleanor Cawthorne Adam P Cribbs Tanya L Crockford Tarana Singh Dang Amy Fearn Emma J Fenech Sarah J de Jong B Christoffer Lagerholm Cindy S Ma David Sims Bert van den Berg Yaobo Xu Andrew J Cant Gary Kleiner T Ronan Leahy M Teresa de la Morena Jennifer M Puck Ralph S Shapiro Mirjam van der Burg J Ross Chapman John C Christianson Benjamin Davies John A McGrath Stefan Przyborski Mauro Santibanez Koref Stuart G Tangye Andreas Werner Guy A Rutter Sergi Padilla-Parra Jean-Laurent Casanova Richard J Cornall Mary Ellen Conley Sophie Hambleton

Nat Immunol 2019 03 4;20(3):350-361. Epub 2019 Feb 4.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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March 2019

The Treatment of Activated PI3Kδ Syndrome.

Authors:
Tanya I Coulter Andrew J Cant

Front Immunol 2018 7;9:2043. Epub 2018 Sep 7.

Department of Paediatric Immunology and Stem Cell Transplant Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne, United Kingdom.

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October 2019

Hematopoietic stem cell transplantation for cytidine triphosphate synthase 1 (CTPS1) deficiency.

Authors:
Zohreh Nademi Robert F Wynn Mary Slatter Stephen M Hughes Denise Bonney Waseem Qasim Sylvain Latour Johannes Trück Smita Patel Mario Abinun Terry Flood Sophie Hambleton Andrew J Cant Andrew R Gennery Peter D Arkwright

Bone Marrow Transplant 2019 01 8;54(1):130-133. Epub 2018 Jun 8.

University of Manchester, Royal Manchester Children's Hospital, Manchester, UK.

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January 2019

The International Alliance of Primary Immune Deficiency Societies.

Authors:
Andrew R Gennery Roshini S Abraham Troy R Torgerson Amos Etzioni Andrew J Cant Isabelle Meyts James Chipeta Ahmed Aziz Bousfiha Tandakha D Dieye Antonio Condino-Neto Francisco Espinosa Liliana Besrodnik Yu-Lung Lau Surjit Singh Godfrey C F Chan Jordan S Orange

J Clin Immunol 2018 05 5;38(4):447-449. Epub 2018 Jun 5.

Clinical Immunology Society, Milwaukee, WI, USA.

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May 2018

Aortic Calcification in a Patient with a Gain-of-Function STAT1 Mutation.

Authors:
Anna E Smyth Epp Kaleviste Aisling Snow Kai Kisand Colin J McMahon Andrew J Cant T Ronan Leahy

J Clin Immunol 2018 05 26;38(4):468-470. Epub 2018 May 26.

Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

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May 2018

Allogeneic hematopoietic stem cell transplantation for severe, refractory juvenile idiopathic arthritis.

Authors:
Juliana M F Silva Fani Ladomenou Ben Carpenter Sharat Chandra Petr Sedlacek Renata Formankova Vicky Grandage Mark Friswell Andrew J Cant Zohreh Nademi Mary A Slatter Andrew R Gennery Sophie Hambleton Terence J Flood Giovanna Lucchini Robert Chiesa Kanchan Rao Persis J Amrolia Paul Brogan Lucy R Wedderburn Julie M Glanville Rachael Hough Rebecca Marsh Mario Abinun Paul Veys

Blood Adv 2018 04;2(7):777-786

Department of BMT, Great Ormond Street Hospital for Children, National Health Service (NHS) Foundation Trust, London, United Kingdom.

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April 2018

Non-posttransplant lymphoproliferative disorder malignancy after hematopoietic stem cell transplantation in patients with primary immunodeficiency: UK experience.

Authors:
Mohamed Najib Mohamed Unni Reem Elfeky Kanchan Rao Zohreh Nademi Robert Chiesa Persis Amrolia Roderick Skinner Olga Slater Austen Worth Terence Flood Mario Abinun Sophie Hambleton Waseem Qasim Hubert B Gaspar Andrew J Cant Andrew R Gennery Paul Veys Mary A Slatter

J Allergy Clin Immunol 2018 06 7;141(6):2319-2321.e1. Epub 2018 Mar 7.

Children's Haemopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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June 2018

In vivo T-depleted reduced-intensity transplantation for -related immune dysfunction.

Authors:
Eleni Tholouli Katherine Sturgess Rachel E Dickinson Andrew Gennery Andrew J Cant Graham Jackson Jim Lordan Sophie Hambleton Mary A Slatter Venetia Bigley Matthew Collin

Blood 2018 03 2;131(12):1383-1387. Epub 2018 Jan 2.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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March 2018

Treosulfan and Fludarabine Conditioning for Hematopoietic Stem Cell Transplantation in Children with Primary Immunodeficiency: UK Experience.

Authors:
Mary A Slatter Kanchan Rao Intan Juliana Abd Hamid Zohreh Nademi Robert Chiesa Reem Elfeky Mark S Pearce Persis Amrolia Austen Worth Terence Flood Mario Abinun Sophie Hambleton Waseem Qasim Hubert B Gaspar Andrew J Cant Andrew R Gennery Paul Veys

Biol Blood Marrow Transplant 2018 03 16;24(3):529-536. Epub 2017 Nov 16.

Great Ormond Street Hospital NHS Trust, London, United Kingdom.

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March 2018

T-cell receptor αβ and CD19 cell-depleted haploidentical and mismatched hematopoietic stem cell transplantation in primary immune deficiency.

Authors:
Ravi M Shah Reem Elfeky Zohreh Nademi Waseem Qasim Persis Amrolia Robert Chiesa Kanchan Rao Giovanna Lucchini Juliana M F Silva Austen Worth Dawn Barge David Ryan Jane Conn Andrew J Cant Roderick Skinner Intan Juliana Abd Hamid Terence Flood Mario Abinun Sophie Hambleton Andrew R Gennery Paul Veys Mary Slatter

J Allergy Clin Immunol 2018 04 3;141(4):1417-1426.e1. Epub 2017 Aug 3.

Department of Immunology and BMT, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.

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April 2018

Early-onset autoimmune disease due to a heterozygous loss-of-function mutation in (A20).

Authors:
Christopher J A Duncan Emma Dinnigan Rachel Theobald Angela Grainger Andrew J Skelton Rafiqul Hussain Joseph D P Willet David J Swan Jonathan Coxhead Matthew F Thomas Julian Thomas Veena Zamvar Mary A Slatter Andrew J Cant Karin R Engelhardt Sophie Hambleton

Ann Rheum Dis 2018 05 28;77(5):783-786. Epub 2017 Jun 28.

Primary Immunodeficiency Group, Institute for Cellular Medicine, Newcastle University, UK.

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May 2018

Allele-level HLA matching for umbilical cord blood transplantation for non-malignant diseases in children: a retrospective analysis.

Authors:
Mary Eapen Tao Wang Paul A Veys Jaap J Boelens Andrew St Martin Stephen Spellman Carmem Sales Bonfim Colleen Brady Andrew J Cant Jean-Hugues Dalle Stella M Davies John Freeman Katherine C Hsu Katharina Fleischhauer Chantal Kenzey Joanne Kurtzberg Gerard Michel Paul J Orchard Annalisa Paviglianiti Vanderson Rocha Michael R Veneris Fernanda Volt Robert Wynn Stephanie J Lee Mary M Horowitz Eliane Gluckman Annalisa Ruggeri

Lancet Haematol 2017 Jul 13;4(7):e325-e333. Epub 2017 Jun 13.

Service d'Haematologie et Therapie Cellulaire, Hôpital Saint Antoine, Paris, France.

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July 2017

Enterovirus-Related Immune Reconstitution Inflammatory Syndrome (IRIS) Following Haploidentical Stem Cell Transplantation in an MHC Class II-Deficient Child.

Authors:
Ravi M Shah Sheila Waugh Khuen F Ng Andrew R Gennery Mary Slatter Andrew J Cant

J Clin Immunol 2017 07 16;37(5):419-421. Epub 2017 May 16.

Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Newcastle upon Tyne, UK.

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July 2017