Andrew J Cant

Andrew J Cant

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Andrew J Cant

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Novel Gain-of-Function Mutation in Stat1 Sumoylation Site Leads to CMC/CID Phenotype Responsive to Ruxolitinib.

J Clin Immunol 2019 Sep 11. Epub 2019 Sep 11.

Department of Paediatric Immunology and Infectious Diseases, Children's Health Ireland, Crumlin, Dublin, D12 N512, Ireland.

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http://dx.doi.org/10.1007/s10875-019-00687-4DOI Listing
September 2019

New graft manipulation strategies improve the outcome of mismatched stem cell transplantation in children with primary immunodeficiencies.

J Allergy Clin Immunol 2019 Jul 4;144(1):280-293. Epub 2019 Feb 4.

Molecular and Cellular Immunology Unit, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom; Blood and Bone Marrow Transplant Unit, Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2019.01.030DOI Listing
July 2019

The Treatment of Activated PI3Kδ Syndrome.

Front Immunol 2018 7;9:2043. Epub 2018 Sep 7.

Department of Paediatric Immunology and Stem Cell Transplant Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.02043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137162PMC
September 2018

Non-posttransplant lymphoproliferative disorder malignancy after hematopoietic stem cell transplantation in patients with primary immunodeficiency: UK experience.

J Allergy Clin Immunol 2018 06 7;141(6):2319-2321.e1. Epub 2018 Mar 7.

Children's Haemopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.02.038DOI Listing
June 2018

Aortic Calcification in a Patient with a Gain-of-Function STAT1 Mutation.

J Clin Immunol 2018 05 26;38(4):468-470. Epub 2018 May 26.

Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

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http://dx.doi.org/10.1007/s10875-018-0513-zDOI Listing
May 2018

Enterovirus-Related Immune Reconstitution Inflammatory Syndrome (IRIS) Following Haploidentical Stem Cell Transplantation in an MHC Class II-Deficient Child.

J Clin Immunol 2017 07 16;37(5):419-421. Epub 2017 May 16.

Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s10875-017-0402-xDOI Listing
July 2017

Prevalence of Cryptosporidium Carriage and Disease in Children With Primary Immune Deficiencies Undergoing Hematopoietic Stem Cell Transplant in Northern Europe.

Pediatr Infect Dis J 2017 May;36(5):504-506

From the *Swansea University Medical School, Singleton Park, Swansea, United Kingdom; †Cryptosporidium Reference Unit, Public Health Wales Microbiology Swansea, Singleton Hospital, Sketty Lane, Swansea, United Kingdom; ‡Paediatric Immunology Department, Great North Children's Hospital, Queen Victoria Road, Newcastle upon Tyne, United Kingdom; §Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; and ¶Centre for Immunodeficiency, Institute of Child Health, University College London and Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.1097/INF.0000000000001517DOI Listing
May 2017

Hematopoietic stem cell transplant in patients with activated PI3K delta syndrome.

J Allergy Clin Immunol 2017 03 12;139(3):1046-1049. Epub 2016 Nov 12.

Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle upon Tyne University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.09.040DOI Listing
March 2017

Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function.

J Allergy Clin Immunol 2016 12 27;138(6):1733-1736.e2. Epub 2016 Jul 27.

Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton National Institute for Health Research Experimental Cancer Medicine Centre, Southampton, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138155PMC
December 2016

Respiratory Health and Related Quality of Life in Patients with Congenital Agammaglobulinemia in the Northern Region of the UK.

J Clin Immunol 2016 07 18;36(5):472-9. Epub 2016 Apr 18.

Institute of Cellular Medicine, Newcastle University, 4th Floor, William Leech Building, Medical School, Framlington Place, Newcastle upon Tyne, E2 4HH, UK.

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http://dx.doi.org/10.1007/s10875-016-0284-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896978PMC
July 2016

Immunodeficiency in a Child with 22q11.2 Microduplication Syndrome.

J Clin Immunol 2016 07 20;36(5):418-9. Epub 2016 Apr 20.

Department of Paediatric Infectious Diseases and Immunology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

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http://dx.doi.org/10.1007/s10875-016-0286-1DOI Listing
July 2016

Human IFNAR2 deficiency: Lessons for antiviral immunity.

Sci Transl Med 2015 Sep;7(307):307ra154

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK. Pediatric Immunology Service, Great North Children's Hospital, Newcastle upon Tyne NE1 4LP, UK.

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http://dx.doi.org/10.1126/scitranslmed.aac4227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926955PMC
September 2015

The importance of vaccination and immunoglobulin treatment for patients with primary immunodeficiency diseases (PIDs)--World PI Week April 22-29, 2015.

Eur J Immunol 2015 May;45(5):1285-6

President of ESID, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust & Institute of Cellular Medicine, Newcastle University, Lead, UK.

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http://dx.doi.org/10.1002/eji.201570054DOI Listing
May 2015

Gut immune reconstitution in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome after hematopoietic stem cell transplantation.

J Allergy Clin Immunol 2015 Jan 25;135(1):260-2. Epub 2014 Oct 25.

Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, United Kingdom; Department of Pediatric Immunology, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2014.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282727PMC
January 2015

Dual proteolytic pathways govern glycolysis and immune competence.

Cell 2014 Dec;159(7):1578-90

Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297473PMC
December 2014

Low-dose serotherapy improves early immune reconstitution after cord blood transplantation for primary immunodeficiencies.

Biol Blood Marrow Transplant 2014 Feb 10;20(2):243-9. Epub 2013 Nov 10.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2013.11.005DOI Listing
February 2014

Clinical outcome in children with chronic granulomatous disease managed conservatively or with hematopoietic stem cell transplantation.

J Allergy Clin Immunol 2013 Nov 16;132(5):1150-5. Epub 2013 Jul 16.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.05.031DOI Listing
November 2013

STAT2 deficiency and susceptibility to viral illness in humans.

Proc Natl Acad Sci U S A 2013 Feb 7;110(8):3053-8. Epub 2013 Feb 7.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1220098110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581986PMC
February 2013

The 10 warning signs: a time for a change?

Curr Opin Allergy Clin Immunol 2012 Dec;12(6):588-94

Immunology Department, PathWest Laboratory Medicine, Perth, Western Australia, Australia.

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http://pdfs.journals.lww.com/co-allergy/2012/12000/The_10_wa
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http://dx.doi.org/10.1097/ACI.0b013e3283591534DOI Listing
December 2012

Hematopoietic stem cell transplantation for primary immunodeficiency diseases.

Ann N Y Acad Sci 2011 Nov;1238:122-31

Department of Paediatric Immunology, Newcastle upon Tyne Hospital NHS Foundation Trust, United Kingdom.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06243.xDOI Listing
November 2011

Clinical features that identify children with primary immunodeficiency diseases.

Pediatrics 2011 May 11;127(5):810-6. Epub 2011 Apr 11.

Department of Paediatric Allergy and Immunology, Royal Manchester Children's Hospital, University of Manchester, Oxford Road, Manchester M13 9WL, United Kingdom.

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http://dx.doi.org/10.1542/peds.2010-3680DOI Listing
May 2011

Impaired T(H)17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

J Allergy Clin Immunol 2010 Nov 8;126(5):1006-15, 1015.e1-4. Epub 2010 Oct 8.

Musculoskeletal Research Group, Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2010.08.027DOI Listing
November 2010

Clinical experience in T cell deficient patients.

Allergy Asthma Clin Immunol 2010 May 13;6(1). Epub 2010 May 13.

Paediatric Immunology Dept, Ward 23, Newcastle General Hospital, Westgate Road, Newcastle, NE4 6BE, UK.

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http://dx.doi.org/10.1186/1710-1492-6-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877019PMC
May 2010

New findings in primary immunodeficiency.

Adv Exp Med Biol 2009 ;634:79-93

Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE.

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http://dx.doi.org/10.1007/978-0-387-79838-7_8DOI Listing
March 2009

Contamination of the hospital environment with gastroenteric viruses: comparison of two pediatric wards over a winter season.

J Clin Microbiol 2008 Sep 9;46(9):3112-5. Epub 2008 Jul 9.

Virus Reference Department, Enteric Virus Unit, Centre for Infections, Health Protection Agency, Colindale, London NW9 5HT, United Kingdom.

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http://dx.doi.org/10.1128/JCM.00400-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546731PMC
September 2008

Advances in hematopoietic stem cell transplantation for primary immunodeficiency.

Immunol Allergy Clin North Am 2008 May;28(2):439-56, x-xi

Institute of Cellular Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU, UK; Children's Bone Marrow Transplant Unit, Ward 23, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.iac.2008.01.006DOI Listing
May 2008

Long-term immune reconstitution after anti-CD52-treated or anti-CD34-treated hematopoietic stem cell transplantation for severe T-lymphocyte immunodeficiency.

J Allergy Clin Immunol 2008 Feb 20;121(2):361-7. Epub 2007 Dec 20.

Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2007.10.035DOI Listing
February 2008

Cord blood stem cell transplantation in primary immune deficiencies.

Curr Opin Allergy Clin Immunol 2007 Dec;7(6):528-34

Institute of Cellular Medicine, Newcastle University, Newcastle General Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1097/ACI.0b013e3282f1d6b6DOI Listing
December 2007

Hematopoietic stem cell transplantation corrects the immunologic abnormalities associated with immunodeficiency-centromeric instability-facial dysmorphism syndrome.

Pediatrics 2007 Nov 1;120(5):e1341-4. Epub 2007 Oct 1.

Paediatric Immunology Department, Newcastle General Hospital, Westgate Road, Newcastle Upon Tyne NE4 6BE, United Kingdom.

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http://dx.doi.org/10.1542/peds.2007-0640DOI Listing
November 2007

Reduced anti-PRP antibody response to Hib immunisation in preterm (<32 weeks) UK infants who received inactivated polio (eIPV).

Vaccine 2007 Nov 16;25(49):8206-8. Epub 2007 Oct 16.

Department of Neonatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.

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http://dx.doi.org/10.1016/j.vaccine.2007.09.060DOI Listing
November 2007

Mevalonic aciduria cured by bone marrow transplantation.

N Engl J Med 2007 09;357(13):1350

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http://dx.doi.org/10.1056/NEJMc072018DOI Listing
September 2007

GvHD-associated cytokine polymorphisms do not associate with Omenn syndrome rather than T-B- SCID in patients with defects in RAG genes.

Clin Immunol 2007 Aug 14;124(2):165-9. Epub 2007 Jun 14.

Institute of Cellular Medicine, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.clim.2007.04.013DOI Listing
August 2007

Anti-pneumococcal antibody titre measurement: what useful information does it yield?

J Clin Pathol 2007 Apr 1;60(4):345-50. Epub 2006 Sep 1.

Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Laboratory, Manchester Royal Infirmary, Manchester, UK.

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http://dx.doi.org/10.1136/jcp.2006.041210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001126PMC
April 2007

Environmental monitoring for gastroenteric viruses in a pediatric primary immunodeficiency unit.

J Clin Microbiol 2006 Feb;44(2):395-9

Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5HT, United Kingdom.

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http://dx.doi.org/10.1128/JCM.44.2.395-399.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392667PMC
February 2006

Omenn's syndrome occurring in patients without mutations in recombination activating genes.

Clin Immunol 2005 Sep;116(3):246-56

Department of Paediatrics, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.clim.2005.04.014DOI Listing
September 2005

Severe food-allergic reactions in children across the UK and Ireland, 1998-2000.

Acta Paediatr 2005 Jun;94(6):689-95

Sir James Spence Institute, Royal Victoria Infirmary, Northumbria Healthcare NHS Trust and University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1651-2227.2005.tb01966.xDOI Listing
June 2005

Adenovirus type F subtype 41 causing disseminated disease following bone marrow transplantation for immunodeficiency.

J Clin Microbiol 2005 Mar;43(3):1462-4

Paediatric Immunology Unit, Ward 23, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom.

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http://dx.doi.org/10.1128/JCM.43.3.1462-1464.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1081290PMC
March 2005

The immunocompromised host: the patient with recurrent infection.

Adv Exp Med Biol 2004 ;549:109-17

School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle General Hospital, United Kingdom.

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http://dx.doi.org/10.1007/978-1-4419-8993-2_16DOI Listing
August 2004

Deregulated production of protective cytokines in response to Candida albicans infection in patients with chronic mucocutaneous candidiasis.

Infect Immun 2003 Oct;71(10):5690-9

School of Cell and Molecular Biosciences, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom NE2 4HH.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC201074PMC
http://dx.doi.org/10.1128/iai.71.10.5690-5699.2003DOI Listing
October 2003

Autoimmunity in human primary immunodeficiency diseases.

Blood 2002 Apr;99(8):2694-702

Academic Unit of Child Health, University of Manchester, St Mary's Hospital, Manchester, United Kingdom.

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http://dx.doi.org/10.1182/blood.v99.8.2694DOI Listing
April 2002