Andrew J Brown

Andrew J Brown

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-Palmitoylglycine and other -acylamides activate the lipid receptor G2A/GPR132.

Pharmacol Res Perspect 2019 Dec 21;7(6):e00542. Epub 2019 Nov 21.

GlaxoSmithKline R&D Ltd, Medicines Research Centre Stevenage UK.

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http://dx.doi.org/10.1002/prp2.542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868653PMC
December 2019

Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Nov 15;1864(11):1656-1668. Epub 2019 Aug 15.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2019.08.006DOI Listing
November 2019

A wolf in sheep's clothing: unmasking the lanosterol-induced degradation of HMG-CoA reductase.

J Lipid Res 2019 Oct 28;60(10):1643-1645. Epub 2019 Aug 28.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia

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http://dx.doi.org/10.1194/jlr.C119000358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795080PMC
October 2019

Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron.

Biochem J 2019 Sep 20;476(18):2545-2560. Epub 2019 Sep 20.

School of Biotechnology and Biomolecular Sciences, UNSW Sydney, New South Wales 2052, Australia

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http://dx.doi.org/10.1042/BCJ20190418DOI Listing
September 2019

The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4.

Int J Mol Sci 2019 Jun 2;20(11). Epub 2019 Jun 2.

Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.3390/ijms20112714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600606PMC
June 2019

Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase.

J Biol Chem 2019 05 2;294(20):8134-8147. Epub 2019 Apr 2.

From the School of Biotechnology and Biomolecular Sciences, UNSW Sydney, New South Wales 2052, Australia.

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA119.007798
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http://dx.doi.org/10.1074/jbc.RA119.007798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527178PMC
May 2019

Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation.

J Biol Chem 2019 02 13;294(7):2436-2448. Epub 2018 Dec 13.

From the School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, New South Wales 2052, Australia and

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http://dx.doi.org/10.1074/jbc.RA118.005069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378986PMC
February 2019

ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P).

Mol Cell 2019 02 20;73(3):458-473.e7. Epub 2018 Dec 20.

School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.11.014DOI Listing
February 2019

A detour to sterol synthesis.

Nat Microbiol 2019 02;4(2):214-215

The School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, Australia.

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http://dx.doi.org/10.1038/s41564-018-0347-8DOI Listing
February 2019

Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P/PI(3,4)P.

Nat Commun 2019 02 19;10(1):829. Epub 2019 Feb 19.

Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1038/s41467-019-08791-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381110PMC
February 2019

The shape of human squalene epoxidase expands the arsenal against cancer.

Nat Commun 2019 02 21;10(1):888. Epub 2019 Feb 21.

Department of Molecular Biology, Princeton, NJ, 08544-1014, USA.

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http://dx.doi.org/10.1038/s41467-019-08866-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384927PMC
February 2019

Mallostery: Filling a niche between quality and metabolic control.

J Biol Chem 2018 09;293(38):14951-14952

From the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia

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http://dx.doi.org/10.1074/jbc.H118.005031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153292PMC
September 2018

The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Apr 3;1863(4):359-368. Epub 2018 Jan 3.

Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.12.011DOI Listing
April 2018

Cholesterol, cancer, and rebooting a treatment for athlete's foot.

Sci Transl Med 2018 04;10(437)

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1126/scitranslmed.aat3741DOI Listing
April 2018

Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling.

J Biol Chem 2018 03 22;293(10):3806-3818. Epub 2018 Jan 22.

From the School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, New South Wales 2052, Australia

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http://dx.doi.org/10.1074/jbc.RA117.001558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846161PMC
March 2018

An Overview of Cholesterol Homeostasis.

Methods Mol Biol 2017 ;1583:1-6

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/978-1-4939-6875-6_1DOI Listing
February 2018

Manipulating Cholesterol Status Within Cells.

Methods Mol Biol 2017 ;1583:41-52

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Biological Sciences Building D26, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/978-1-4939-6875-6_4DOI Listing
February 2018

Identifying Sterol Response Elements Within Promoters of Genes.

Methods Mol Biol 2017 ;1583:185-191

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/978-1-4939-6875-6_13DOI Listing
February 2018

Determining the Topology of Membrane-Bound Proteins Using PEGylation.

Methods Mol Biol 2017 ;1583:201-210

School of Biotechnology and Biomolecular Sciences, Biological Sciences Building D26, The University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/978-1-4939-6875-6_15DOI Listing
February 2018

Measuring Activity of Cholesterol Synthesis Enzymes Using Gas Chromatography/Mass Spectrometry.

Methods Mol Biol 2017 ;1583:211-219

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/978-1-4939-6875-6_16DOI Listing
February 2018

Enforcing Ising-like magnetic anisotropy trigonal distortion in the design of a W(v)-Co(ii) cyanide single-chain magnet.

Chem Sci 2018 Jan 13;9(1):119-124. Epub 2017 Nov 13.

Department of Chemistry , Texas A & M University , College Station , TX 77842 , USA . Email:

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http://dx.doi.org/10.1039/c7sc02925jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873217PMC
January 2018

A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.

J Biol Chem 2017 12 27;292(49):19959-19973. Epub 2017 Sep 27.

From the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia and

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http://dx.doi.org/10.1074/jbc.M117.794230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723984PMC
December 2017

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P ) and regulate its level at the plasma membrane.

Nat Commun 2017 10 2;8(1):757. Epub 2017 Oct 2.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1038/s41467-017-00861-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624964PMC
October 2017

Site-1 protease, a novel metabolic target for glioblastoma.

Biochem Biophys Res Commun 2017 08 20;490(3):760-766. Epub 2017 Jun 20.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2017.06.114DOI Listing
August 2017

New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Jul 23;1862(7):647-657. Epub 2017 Mar 23.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.03.009DOI Listing
July 2017

Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis.

J Steroid Biochem Mol Biol 2017 01 9;165(Pt B):363-368. Epub 2016 Aug 9.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.08.003DOI Listing
January 2017

Using nearly full-genome HIV sequence data improves phylogeny reconstruction in a simulated epidemic.

Sci Rep 2016 12 23;6:39489. Epub 2016 Dec 23.

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/srep39489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180198PMC
December 2016

Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases.

Immunol Cell Biol 2016 11 5;94(10):994-999. Epub 2016 Jul 5.

Garvan Institute of Medical Research and St Vincent's Clinical School, UNSW Australia, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1038/icb.2016.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122740PMC
November 2016

DHCR7: A vital enzyme switch between cholesterol and vitamin D production.

Prog Lipid Res 2016 10 30;64:138-151. Epub 2016 Sep 30.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.plipres.2016.09.003DOI Listing
October 2016

Trigonal antiprismatic Co(ii) single molecule magnets with large uniaxial anisotropies: importance of Raman and tunneling mechanisms.

Chem Sci 2016 Oct 17;7(10):6519-6527. Epub 2016 Jun 17.

Department of Chemistry , Texas A & M University , College Station , TX 77842-3012 , USA . ; Email:

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http://dx.doi.org/10.1039/c6sc02035fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125373PMC
October 2016

Navigating the Shallows and Rapids of Cholesterol Synthesis Downstream of HMGCR.

J Nutr Sci Vitaminol (Tokyo) 2015 ;61 Suppl:S154-6

School of Biotechnology and Biomolecular Sciences, The University of New South Wales.

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http://dx.doi.org/10.3177/jnsv.61.S154DOI Listing
September 2016

Oxysterols: Old Tale, New Twists.

Annu Rev Pharmacol Toxicol 2016 ;56:447-67

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia; email: , , ,

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http://dx.doi.org/10.1146/annurev-pharmtox-010715-103233DOI Listing
September 2016

Cholesterol homeostasis: How do cells sense sterol excess?

Chem Phys Lipids 2016 Sep 15;199:170-178. Epub 2016 Mar 15.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.chemphyslip.2016.02.011DOI Listing
September 2016

GPR55: Metabolic Help or Hindrance?

Trends Endocrinol Metab 2016 09 21;27(9):606-608. Epub 2016 May 21.

Department of Incretin Biology, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.

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http://dx.doi.org/10.1016/j.tem.2016.04.012DOI Listing
September 2016

Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis.

J Biol Chem 2016 Apr 17;291(16):8363-73. Epub 2016 Feb 17.

From the School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.699546
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http://dx.doi.org/10.1074/jbc.M115.699546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861412PMC
April 2016

Foiling IDOL to Help Control Cholesterol.

Circ Res 2016 Feb;118(3):371-3

From the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia (A.J.B.); and Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY (J.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903173PMC
February 2016

Speed kills in more ways than one: Methamphetamine and atherosclerosis.

Atherosclerosis 2015 Dec 9;243(2):654-5. Epub 2015 Oct 9.

School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Australia, Sydney, Australia.

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.09.034DOI Listing
December 2015

Investigating signaling processes in membrane trafficking.

Methods Mol Biol 2015 ;1270:81-90

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/978-1-4939-2309-0_6DOI Listing
November 2015

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.

J Biol Chem 2015 Nov 3;290(46):27533-44. Epub 2015 Oct 3.

From the School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, Australia and

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http://www.jbc.org/content/290/46/27533.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.675181
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http://dx.doi.org/10.1074/jbc.M115.675181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646006PMC
November 2015

Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites.

Curr Opin Cell Biol 2015 Aug 29;35:37-42. Epub 2015 Apr 29.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2015.04.002DOI Listing
August 2015

Analysis of the history and spread of HIV-1 in Uganda using phylodynamics.

J Gen Virol 2015 Jul 27;96(Pt 7):1890-8. Epub 2015 Feb 27.

1Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1099/vir.0.000107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635457PMC
July 2015

Cholesterol sensing by the ABCG1 lipid transporter: Requirement of a CRAC motif in the final transmembrane domain.

Biochim Biophys Acta 2015 Jul 27;1851(7):956-64. Epub 2015 Feb 27.

Faculty of Pharmacy, The University of Sydney, Sydney NSW 2006, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13881981150006
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http://dx.doi.org/10.1016/j.bbalip.2015.02.016DOI Listing
July 2015

Pharmacological properties of acid N-thiazolylamide FFA2 agonists.

Pharmacol Res Perspect 2015 Jun 8;3(3):e00141. Epub 2015 May 8.

Biological Sciences, GlaxoSmithKline Stevenage, United Kingdom.

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http://dx.doi.org/10.1002/prp2.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492757PMC
June 2015

A Trigonal-Pyramidal Erbium(III) Single-Molecule Magnet.

Angew Chem Int Ed Engl 2015 May 24;54(20):5864-8. Epub 2015 Mar 24.

Department of Chemistry, Texas A&M University, College Station, TX 77843 (USA) http://www.chem.tamu.edu/rgroup/dunbar/

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http://dx.doi.org/10.1002/anie.201411190DOI Listing
May 2015

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally.

J Lipid Res 2015 Apr 31;56(4):888-97. Epub 2015 Jan 31.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia.

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http://www.jlr.org/content/early/2015/01/31/jlr.M056986.full
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http://www.jlr.org/content/56/4/888.full.pdf
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http://www.jlr.org/lookup/doi/10.1194/jlr.M056986
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http://dx.doi.org/10.1194/jlr.M056986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373745PMC
April 2015

A practical comparison of ligation-independent cloning techniques.

PLoS One 2013 23;8(12):e83888. Epub 2013 Dec 23.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083888PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871625PMC
March 2015

Liposomes loaded with a dirhenium compound and cisplatin: preparation, properties and improved in vivo anticancer activity.

J Liposome Res 2015 Mar 9;25(1):78-87. Epub 2014 Sep 9.

Department of Chemistry, Texas A&M University, College Station , Texas , USA.

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http://dx.doi.org/10.3109/08982104.2014.954127DOI Listing
March 2015

Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed.

Dev Neurosci 2014 24;36(2):132-42. Epub 2014 May 24.

Research Service, Department of Veterans Affairs Medical Center, East Orange, N.J., USA.

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http://dx.doi.org/10.1159/000362363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106903PMC
February 2015

Universal CG cloning of polymerase chain reaction products.

Anal Biochem 2015 Feb 4;471:80-2. Epub 2014 Nov 4.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2014.10.018DOI Listing
February 2015

Linear trinuclear cobalt(II) single molecule magnet.

Dalton Trans 2015 Feb;44(6):2865-70

Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China.

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http://dx.doi.org/10.1039/c4dt03545cDOI Listing
February 2015

When somebody loses weight, where does the fat go?

BMJ 2014 Dec 16;349:g7257. Epub 2014 Dec 16.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, 2052, Australia.

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http://dx.doi.org/10.1136/bmj.g7257DOI Listing
December 2014

The UPS and downs of cholesterol homeostasis.

Trends Biochem Sci 2014 Nov 11;39(11):527-35. Epub 2014 Sep 11.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2014.08.008DOI Listing
November 2014

The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis.

Biochim Biophys Acta 2014 Oct 15;1842(10):1431-9. Epub 2014 Jul 15.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2014.07.006DOI Listing
October 2014

Silylated mesoporous silica membranes on polymeric hollow fiber supports: synthesis and permeation properties.

ACS Appl Mater Interfaces 2014 Oct 7;6(20):17877-86. Epub 2014 Oct 7.

School of Chemical & Biomolecular Engineering, Georgia Institute of Technology , 311 Ferst Drive, Atlanta, Georgia 30332-0100, United States.

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http://dx.doi.org/10.1021/am504581jDOI Listing
October 2014

Effects of external rotation on anteroposterior translations in the shoulder: a pilot study.

Clin Orthop Relat Res 2014 Aug;472(8):2397-403

Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/s11999-013-3419-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079883PMC
August 2014

Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids.

Biochem J 2014 Aug;461(3):435-42

*School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia.

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http://www.biochemj.org/content/ppbiochemj/461/3/435.full.pd
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http://biochemj.org/lookup/doi/10.1042/BJ20131404
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http://dx.doi.org/10.1042/BJ20131404DOI Listing
August 2014

Separation membranes. Interfacial microfluidic processing of metal-organic framework hollow fiber membranes.

Science 2014 Jul;345(6192):72-5

School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1126/science.1251181DOI Listing
July 2014

A lipidomic perspective on intermediates in cholesterol synthesis as indicators of disease status.

J Genet Genomics 2014 May 13;41(5):275-82. Epub 2014 Mar 13.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2014.03.001DOI Listing
May 2014

Cholesterol precursors: more than mere markers of biosynthesis.

Curr Opin Lipidol 2014 Apr;25(2):133-9

aSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia bInstitute of Biomedicine, Anatomy, University of Helsinki cMinerva Foundation Institute for Medical Research, Helsinki, Finland.

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http://dx.doi.org/10.1097/MOL.0000000000000038DOI Listing
April 2014

The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.

Mol Cell Biol 2014 Apr 21;34(7):1262-70. Epub 2014 Jan 21.

Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1128/MCB.01140-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993563PMC
April 2014

Statins: protectors or pretenders in prostate cancer?

Trends Endocrinol Metab 2014 Apr 22;25(4):188-96. Epub 2014 Jan 22.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2013.12.007DOI Listing
April 2014

DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme.

Biosci Rep 2014 04 1;34(2). Epub 2014 Apr 1.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia

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http://dx.doi.org/10.1042/BSR20130127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958128PMC
April 2014

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis.

J Lipid Res 2014 Mar 20;55(3):410-20. Epub 2013 Dec 20.

School of Biotechnology and Biomolecular Sciences The University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1194/jlr.M043257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934726PMC
March 2014

Phylogeography of Japanese encephalitis virus: genotype is associated with climate.

PLoS Negl Trop Dis 2013 29;7(8):e2411. Epub 2013 Aug 29.

Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA.

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http://dx.doi.org/10.1371/journal.pntd.0002411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757071PMC
February 2014

Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.

Prog Lipid Res 2013 Oct 2;52(4):666-80. Epub 2013 Oct 2.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.plipres.2013.09.002DOI Listing
October 2013

The role of signalling in cellular cholesterol homeostasis.

IUBMB Life 2013 Aug 11;65(8):675-84. Epub 2013 Jul 11.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, NSW, Australia.

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http://dx.doi.org/10.1002/iub.1182DOI Listing
August 2013

A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function.

J Pharmacol Exp Ther 2013 Jul 2;346(1):54-66. Epub 2013 May 2.

Institute for Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria.

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http://dx.doi.org/10.1124/jpet.113.204180DOI Listing
July 2013

Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression.

Atherosclerosis 2013 Jun 26;228(2):362-9. Epub 2013 Mar 26.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.atherosclerosis.2013.03.016DOI Listing
June 2013

Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR).

J Biol Chem 2013 Jun 21;288(26):18707-15. Epub 2013 May 21.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1074/jbc.R113.479808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696645PMC
June 2013

Alcohol and water adsorption in zeolitic imidazolate frameworks.

Chem Commun (Camb) 2013 Apr 14;49(31):3245-7. Epub 2013 Mar 14.

School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1039/c3cc39116gDOI Listing
April 2013

What dictates the accumulation of desmosterol in the developing brain?

FASEB J 2013 Mar 10;27(3):865-70. Epub 2012 Dec 10.

Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland.

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http://www.fasebj.org/content/early/2012/12/07/fj.12-211235.
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http://dx.doi.org/10.1096/fj.12-211235DOI Listing
March 2013

Species variation in ABCG1 isoform expression: implications for the use of animal models in elucidating ABCG1 function.

Atherosclerosis 2013 Feb 19;226(2):408-11. Epub 2012 Dec 19.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.atherosclerosis.2012.12.009DOI Listing
February 2013

The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.

Traffic 2013 Jan 14;14(1):107-19. Epub 2012 Oct 14.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1111/tra.12015DOI Listing
January 2013

Effects of simulated injury on the anteroinferior glenohumeral capsule.

Med Biol Eng Comput 2012 Dec 5;50(12):1299-307. Epub 2012 Oct 5.

Department of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, USA.

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http://link.springer.com/10.1007/s11517-012-0961-1
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http://dx.doi.org/10.1007/s11517-012-0961-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515711PMC
December 2012

The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55.

J Biol Chem 2012 Dec 16;287(53):44234-48. Epub 2012 Nov 16.

Institute for Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria.

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http://dx.doi.org/10.1074/jbc.M112.364109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531739PMC
December 2012

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling.

Nat Rev Drug Discov 2012 Dec;11(12):909-22

AstraZeneca R&D, Alderley Park, Cheshire SK10 4TG, UK.

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http://dx.doi.org/10.1038/nrd3845DOI Listing
December 2012

Accumulation of squalene is associated with the clustering of lipid droplets.

FEBS J 2012 Nov 22;279(22):4231-44. Epub 2012 Oct 22.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.

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http://doi.wiley.com/10.1111/febs.12015
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November 2012

Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: studies of apolipoprotein E and VSVGt.

Biochem J 2012 Oct;447(1):51-60

Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1042/BJ20111891DOI Listing
October 2012

Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins.

Biochim Biophys Acta 2012 Oct 15;1821(10):1350-60. Epub 2012 Jul 15.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1016/j.bbalip.2012.07.006DOI Listing
October 2012

Protein kinase A modulates the activity of a major human isoform of ABCG1.

J Lipid Res 2012 Oct 7;53(10):2133-40. Epub 2012 Aug 7.

Faculty of Pharmacy, University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1194/jlr.M028795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435546PMC
October 2012

Continuous polycrystalline zeolitic imidazolate framework-90 membranes on polymeric hollow fibers.

Angew Chem Int Ed Engl 2012 Oct 26;51(42):10615-8. Epub 2012 Sep 26.

School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1002/anie.201206640DOI Listing
October 2012

A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.

Biochem J 2012 Sep;446(2):191-201

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1042/BJ20120545DOI Listing
September 2012

Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses.

J Biol Chem 2012 Sep 6;287(40):33897-904. Epub 2012 Aug 6.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1074/jbc.M112.360537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460484PMC
September 2012

Predicting response to statins by pharmacogenetic testing.

Pharmacogenomics 2012 Aug;13(11):1223-5

Faculty of Pharmacy, University of Sydney, Australia.

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http://dx.doi.org/10.2217/pgs.12.107DOI Listing
August 2012

Effect of venipuncture quality on thromboelastography.

J Vet Emerg Crit Care (San Antonio) 2012 Apr 5;22(2):225-9. Epub 2012 Apr 5.

Departments of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.

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http://dx.doi.org/10.1111/j.1476-4431.2012.00724.xDOI Listing
April 2012

An essential role of Hrs/Vps27 in endosomal cholesterol trafficking.

Cell Rep 2012 Jan 26;1(1):29-35. Epub 2012 Jan 26.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1016/j.celrep.2011.10.004DOI Listing
January 2012