Andrew Issekutz

Andrew Issekutz

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Andrew Issekutz

Andrew Issekutz

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Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders.

Authors:
Asbjørg Stray-Pedersen Hanne Sørmo Sorte Pubudu Samarakoon Tomasz Gambin Ivan K Chinn Zeynep H Coban Akdemir Hans Christian Erichsen Lisa R Forbes Shen Gu Bo Yuan Shalini N Jhangiani Donna M Muzny Olaug Kristin Rødningen Ying Sheng Sarah K Nicholas Lenora M Noroski Filiz O Seeborg Carla M Davis Debra L Canter Emily M Mace Timothy J Vece Carl E Allen Harshal A Abhyankar Philip M Boone Christine R Beck Wojciech Wiszniewski Børre Fevang Pål Aukrust Geir E Tjønnfjord Tobias Gedde-Dahl Henrik Hjorth-Hansen Ingunn Dybedal Ingvild Nordøy Silje F Jørgensen Tore G Abrahamsen Torstein Øverland Anne Grete Bechensteen Vegard Skogen Liv T N Osnes Mari Ann Kulseth Trine E Prescott Cecilie F Rustad Ketil R Heimdal John W Belmont Nicholas L Rider Javier Chinen Tram N Cao Eric A Smith Maria Soledad Caldirola Liliana Bezrodnik Saul Oswaldo Lugo Reyes Francisco J Espinosa Rosales Nina Denisse Guerrero-Cursaru Luis Alberto Pedroza Cecilia M Poli Jose L Franco Claudia M Trujillo Vargas Juan Carlos Aldave Becerra Nicola Wright Thomas B Issekutz Andrew C Issekutz Jordan Abbott Jason W Caldwell Diana K Bayer Alice Y Chan Alessandro Aiuti Caterina Cancrini Eva Holmberg Christina West Magnus Burstedt Ender Karaca Gözde Yesil Hasibe Artac Yavuz Bayram Mehmed Musa Atik Mohammad K Eldomery Mohammad S Ehlayel Stephen Jolles Berit Flatø Alison A Bertuch I Celine Hanson Victor W Zhang Lee-Jun Wong Jianhong Hu Magdalena Walkiewicz Yaping Yang Christine M Eng Eric Boerwinkle Richard A Gibbs William T Shearer Robert Lyle Jordan S Orange James R Lupski

J Allergy Clin Immunol 2017 01 16;139(1):232-245. Epub 2016 Jul 16.

Baylor-Hopkins Center for Mendelian Genomics of the Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex; Department of Pediatrics, Baylor College of Medicine, and Texas Children's Hospital, Houston, Tex; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Tex. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222743PMC
January 2017

Potentiation of cytokine-induced proliferation of human Natural Killer cells by intravenous immunoglobulin G.

Clin Immunol 2015 Dec 22;161(2):373-83. Epub 2015 Aug 22.

Departments of Pediatrics, Dalhousie University, Halifax, NS, Canada.

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http://dx.doi.org/10.1016/j.clim.2015.08.005DOI Listing
December 2015

Epidermodysplasia verruciformis in lipoid proteinosis: case report and discussion of pathophysiology.

Pediatr Dermatol 2015 Jan-Feb;32(1):118-21. Epub 2013 Mar 28.

Division of Clinical Dermatology and Cutaneous Science, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1111/pde.12124DOI Listing
October 2015

Regulatory T cells dynamically regulate selectin ligand function during multiple challenge contact hypersensitivity.

J Immunol 2014 Nov 1;193(10):4934-44. Epub 2014 Oct 1.

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria 3168, Australia;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1400641
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http://dx.doi.org/10.4049/jimmunol.1400641DOI Listing
November 2014

Differing requirements for CCR4, E-selectin, and α4β1 for the migration of memory CD4 and activated T cells to dermal inflammation.

J Immunol 2012 Jul 4;189(1):337-46. Epub 2012 Jun 4.

Department of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3K 6R8, Canada.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1102315
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http://dx.doi.org/10.4049/jimmunol.1102315DOI Listing
July 2012

Intravenous immunoglobulin G (IVIG) inhibits IL-1- and TNF-α-dependent, but not chemotactic-factor-stimulated, neutrophil transendothelial migration.

Clin Immunol 2011 Nov 16;141(2):187-96. Epub 2011 Aug 16.

Department of Pediatrics, Dalhousie University, IWK Health Centre, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1016/j.clim.2011.08.003DOI Listing
November 2011

Dengue virus infection of mast cells triggers endothelial cell activation.

J Virol 2011 Jan 10;85(2):1145-50. Epub 2010 Nov 10.

Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada.

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http://dx.doi.org/10.1128/JVI.01630-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019992PMC
January 2011

Intravenous immunoglobulin G selectively inhibits IL-1α-induced neutrophil-endothelial cell adhesion.

Autoimmunity 2010 Dec 12;43(8):619-27. Epub 2010 Apr 12.

Department of Pathology, Dalhousie University, Halifax, NS, Canada.

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http://dx.doi.org/10.3109/08916931003599062DOI Listing
December 2010

Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.

J Allergy Clin Immunol 2010 Aug;126(2):332-7, 337.e1-2

Division of Immunology, Children's Hospital, Boston, and the Department of Pediatrics, Harvard Medical School, Boston, Mass, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749100081
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http://dx.doi.org/10.1016/j.jaci.2010.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917474PMC
August 2010

Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function.

FASEB J 2009 Oct 17;23(10):3361-7. Epub 2009 Jun 17.

Department of Mechanical Engineering, Temple University, 1947 N. 12th St., Philadelphia, PA 19122, USA.

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http://www.fasebj.org/doi/10.1096/fj.08-127373
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http://dx.doi.org/10.1096/fj.08-127373DOI Listing
October 2009

Intravenous immunoglobulin G-mediated inhibition of T-cell proliferation reflects an endogenous mechanism by which IgG modulates T-cell activation.

Clin Immunol 2009 Aug 17;132(2):222-33. Epub 2009 May 17.

Department of Pathology, Dalhousie University, Nova Scotia, Canada.

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http://dx.doi.org/10.1016/j.clim.2009.04.002DOI Listing
August 2009

Platelets enhance endothelial adhesiveness in high tidal volume ventilation.

Am J Respir Cell Mol Biol 2008 Nov 15;39(5):569-75. Epub 2008 May 15.

Department of Pediatrics, College of Physicians and Surgeons, Columbia University and St Luke's-Roosevelt Hospital Center, New York, NY 10019, USA.

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http://dx.doi.org/10.1165/rcmb.2007-0332OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574527PMC
November 2008

Alveolar epithelium down-modulates endotoxin-but not tumor necrosis factor alpha-induced activation of endothelium and selectively inhibits neutrophil transendothelial migration.

Exp Lung Res 2008 Sep;34(7):425-53

Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1080/01902140802130105DOI Listing
September 2008

Modulation of adjuvant arthritis in the rat by 2-methoxyestradiol: an effect independent of an anti-angiogenic action.

Int Immunopharmacol 2008 May 12;8(5):708-16. Epub 2008 Feb 12.

Department of Pediatrics Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1016/j.intimp.2008.01.016DOI Listing
May 2008

Effect of G-1 column (Adacolumn) therapy in rats with adjuvant arthritis on the migration and immunoreactivity of peripheral and splenic leukocytes.

Mod Rheumatol 2005 ;15(4):249-57

G-1 Group, Oncology & Immunology Research Lab., Department of Advanced Pharmacology, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan.

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http://dx.doi.org/10.1007/s10165-005-0402-1DOI Listing
June 2007

Targeted delivery of antibody conjugated liposomal drug carriers to rat myocardial infarction.

Biotechnol Bioeng 2007 Mar;96(4):795-802

Department of Mechanical Engineering, Temple University, 1947 North, 12th Street, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1002/bit.21233DOI Listing
March 2007

Modulation of endotoxin-induced neutrophil transendothelial migration by alveolar epithelium in a defined bilayer model.

Exp Lung Res 2006 Nov-Dec;32(10):455-82

Department of Microbiology-Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1080/01902140601059463DOI Listing
February 2007

Olive oil-based lipid emulsion's neutral effects on neutrophil functions and leukocyte-endothelial cell interactions.

JPEN J Parenter Enteral Nutr 2006 Jul-Aug;30(4):286-96

Department of Pharmacology and Central Research Unit, Faculty of Medicine, University of Valencia, Valencia, Spain.

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http://dx.doi.org/10.1177/0148607106030004286DOI Listing
November 2006

Platelet-endothelial cell adhesion molecule-1 (CD31) recycles and induces cell growth inhibition on human tumor cell lines.

J Cell Biochem 2006 Aug;98(5):1334-50

Laboratorio de Inmunogenética, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

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http://dx.doi.org/10.1002/jcb.20769DOI Listing
August 2006

Endothelial growth factors VEGF and bFGF differentially enhance monocyte and neutrophil recruitment to inflammation.

J Leukoc Biol 2006 Aug 3;80(2):247-57. Epub 2006 Jul 3.

Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS, Canada B3K 6R8.

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http://dx.doi.org/10.1189/jlb.1205718DOI Listing
August 2006

Connexin 43 mediates spread of Ca2+-dependent proinflammatory responses in lung capillaries.

J Clin Invest 2006 Aug 27;116(8):2193-200. Epub 2006 Jul 27.

Lung Biology Laboratory, St. Luke's-Roosevelt Hospital Center, Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA.

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http://dx.doi.org/10.1172/JCI26605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518791PMC
August 2006

Sequence of endothelial signaling during lung expansion.

Am J Respir Cell Mol Biol 2005 Dec 25;33(6):549-54. Epub 2005 Aug 25.

St. Luke's-Roosevelt Hospital Center, AJA #510, 1000 10th Avenue, New York, NY 10019, USA.

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http://dx.doi.org/10.1165/rcmb.2005-0133OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715332PMC
December 2005

Pressure-induced leukocyte margination in lung postcapillary venules.

Am J Physiol Lung Cell Mol Physiol 2005 Sep 6;289(3):L407-12. Epub 2005 May 6.

lung Biology Laboratory, Department of Physiology and Cellular Biophysics, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1152/ajplung.00048.2005DOI Listing
September 2005

Neutrophil differentiated HL-60 cells model Mac-1 (CD11b/CD18)-independent neutrophil transepithelial migration.

Immunology 2005 May;115(1):108-17

Department of Microbiology & Immunology, and the Dalhousie Inflammation Group, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://doi.wiley.com/10.1111/j.1365-2567.2005.02131.x
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http://dx.doi.org/10.1111/j.1365-2567.2005.02131.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782134PMC
May 2005

Radiation-induced up-regulation of adhesion molecules in brain microvasculature and their modulation by dexamethasone.

Radiat Res 2005 May;163(5):544-51

Department of Biomedical Engineering, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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May 2005

Migration of polymorphonuclear leucocytes is influenced by dendritic cells.

Immunology 2005 Mar;114(3):375-85

Laboratorio de Inmunogenética, Hospital de Clínicas José de San Martín, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.

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http://dx.doi.org/10.1111/j.1365-2567.2005.02104.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782099PMC
March 2005

TNF regulates leukocyte-endothelial cell interactions and microvascular dysfunction during immune complex-mediated inflammation.

Br J Pharmacol 2005 Jan;144(2):265-74

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Vic., 3168, Australia.

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http://doi.wiley.com/10.1038/sj.bjp.0706081
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http://dx.doi.org/10.1038/sj.bjp.0706081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576001PMC
January 2005

Erythromycin exerts in vivo anti-inflammatory activity downregulating cell adhesion molecule expression.

Br J Pharmacol 2005 Jan;144(2):190-201

Department of Pharmacology, Faculty of Medicine, University of Valencia, Avda. Blasco Ibañez 15, Valencia 46010, Spain.

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http://dx.doi.org/10.1038/sj.bjp.0706021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575992PMC
January 2005

Pseudomonas aeruginosa exotoxin A induces human mast cell apoptosis by a caspase-8 and -3-dependent mechanism.

J Biol Chem 2004 Aug 17;279(35):37201-7. Epub 2004 Jun 17.

Department of Microbiology and Immunology, Dalhousie University, 5850 University Avenue, Halifax, Nova Scotia B3J 3G9, Canada.

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http://dx.doi.org/10.1074/jbc.M405594200DOI Listing
August 2004

The CD11/CD18 (beta2) integrins modulate neutrophil caspase activation and survival following TNF-alpha or endotoxin induced transendothelial migration.

Immunol Cell Biol 2004 Aug;82(4):435-46

Department of Pediatrics, The Dalhousie Inflammation Group, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1111/j.0818-9641.2004.01268.xDOI Listing
August 2004

Direct evidence of leukocyte adhesion in arterioles by angiotensin II.

Blood 2004 Jul 25;104(2):402-8. Epub 2004 Mar 25.

Departamento de Farmacología, Facultad de Medicina, Universidad de Valencia, Av. Blasco Ibañez, 17, E-46010 Valencia, Spain.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2003-08-29
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http://dx.doi.org/10.1182/blood-2003-08-2974DOI Listing
July 2004

Trauma-hemorrhagic shock-induced up-regulation of endothelial cell adhesion molecules is blunted by mesenteric lymph duct ligation.

Crit Care Med 2004 Mar;32(3):760-5

Department of Surgery, UMDNJ-New Jersey Medical School, Newark, NJ, USA.

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March 2004

Management of hereditary angioedema: a Canadian approach.

Transfus Apher Sci 2003 Dec;29(3):205-14

The Canadian Hereditary, Angioedema Society (CHAES)/ Société d'angioédème héréditaire du Canada, Canada.

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http://dx.doi.org/10.1016/j.transci.2003.08.009DOI Listing
December 2003

Hyperosmolarity enhances the lung capillary barrier.

J Clin Invest 2003 Nov;112(10):1541-9

Division of Pulmonary-Critical Care Medicine, St Luke's-Roosevelt Hospital Center, New York, New York 10019, USA.

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http://dx.doi.org/10.1172/JCI18370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC259125PMC
November 2003

Differential roles of VLA-4(CD49d/CD29) and LFA-1(CD11a/CD18) integrins and E- and P-selectin during developing and established active or adoptively transferred adjuvant arthritis in the rat.

Immunol Cell Biol 2003 Oct;81(5):397-408

Departments of Pediatrics, Pathology and Microbiology-Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1046/j.1440-1711.2003.01187.xDOI Listing
October 2003

Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries.

J Clin Invest 2003 Mar;111(5):691-9

Lung Biology Laboratory, Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, New York 10019, USA.

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http://dx.doi.org/10.1172/JCI17271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151903PMC
March 2003

High tidal volume ventilation induces proinflammatory signaling in rat lung endothelium.

Am J Respir Cell Mol Biol 2003 Feb;28(2):218-24

Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1165/rcmb.4763DOI Listing
February 2003

Mitochondrial reactive oxygen species regulate spatial profile of proinflammatory responses in lung venular capillaries.

J Immunol 2002 Dec;169(12):7078-86

St. Luke's-Roosevelt Hospital Center, Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10019, USA.

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http://dx.doi.org/10.4049/jimmunol.169.12.7078DOI Listing
December 2002

Estrogens inhibit angiotensin II-induced leukocyte-endothelial cell interactions in vivo via rapid endothelial nitric oxide synthase and cyclooxygenase activation.

Circ Res 2002 Dec;91(12):1142-50

Department of Pharmacology, Faculty of Medicine, Clinic Hospital, University of Valencia, Spain.

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December 2002

Pseudomonas aeruginosa activates human mast cells to induce neutrophil transendothelial migration via mast cell-derived IL-1 alpha and beta.

J Immunol 2002 Oct;169(8):4522-30

Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, B3J 3G9.

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http://dx.doi.org/10.4049/jimmunol.169.8.4522DOI Listing
October 2002

Differential role of E-selectin and P-selectin in T lymphocyte migration to cutaneous inflammatory reactions induced by cytokines.

Int Immunol 2002 Jul;14(7):751-60

Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1093/intimm/dxf045DOI Listing
July 2002

Leukocyte-endothelial cell interactions are enhanced in dermal postcapillary venules of MRL/fas(lpr) (lupus-prone) mice: roles of P- and E-selectin.

J Immunol 2002 May;168(9):4728-36

Center for Inflammatory Diseases, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.4049/jimmunol.168.9.4728DOI Listing
May 2002

The role of E-selectin, P-selectin, and very late activation antigen-4 in T lymphocyte migration to dermal inflammation.

J Immunol 2002 Feb;168(4):1934-9

Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.4049/jimmunol.168.4.1934DOI Listing
February 2002