Publications by authors named "Andrew H Sims"

93Publications

Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling.

Cancers (Basel) 2020 Sep 30;12(10). Epub 2020 Sep 30.

MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.3390/cancers12102823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652213PMC
September 2020

Breast cancer gene expression datasets do not reflect the disease at the population level.

NPJ Breast Cancer 2020 25;6:39. Epub 2020 Aug 25.

Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41523-020-00180-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447772PMC
August 2020

Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth.

J Exp Med 2020 Nov;217(11)

Medical Research Council Centre for Reproductive Health, College of Medicine and Veterinary Medicine, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1084/jem.20191820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596825PMC
November 2020

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation.

Dev Cell 2020 Aug 10;54(3):317-332.e9. Epub 2020 Jul 10.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435699PMC
August 2020

Evaluation of Gene Expression Data From Cybrids and Tumours Highlights Elevated -Driven Proliferation in Triple-Negative Breast Cancer.

Breast Cancer (Auckl) 2020 22;14:1178223420934447. Epub 2020 Jun 22.

Applied Bioinformatics of Cancer, Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1177/1178223420934447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309340PMC
June 2020

Combined administration of a small-molecule inhibitor of TRAF6 and Docetaxel reduces breast cancer skeletal metastasis and osteolysis.

Cancer Lett 2020 Sep 28;488:27-39. Epub 2020 May 28.

Department of Oncology and Metabolism, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK; Bone and Cancer Group, Edinburgh Cancer Research Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2020.05.021DOI Listing
September 2020

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity.

Elife 2020 Jan 21;9. Epub 2020 Jan 21.

Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.7554/eLife.48092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974352PMC
January 2020

Exercise Window Trial in Newly Diagnosed Breast Cancer-Letter.

Clin Cancer Res 2019 12;25(24):7609-7610

School of Applied Sciences, Edinburgh Napier University, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-2571DOI Listing
December 2019

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling.

Nat Commun 2019 11 1;10(1):5016. Epub 2019 Nov 1.

Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Wilmslow Road, Manchester, M20 4GJ, UK.

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http://dx.doi.org/10.1038/s41467-019-12807-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825219PMC
November 2019

The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts.

J Mammary Gland Biol Neoplasia 2019 09 12;24(3):245-256. Epub 2019 Sep 12.

Breast Biology Group, Breast Cancer Now Research Unit, Division of Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Manchester, M20 4GJ, UK.

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http://dx.doi.org/10.1007/s10911-019-09435-1DOI Listing
September 2019

Development of mouse models of angiosarcoma driven by p53.

Dis Model Mech 2019 07 9;12(7). Epub 2019 Jul 9.

Edinburgh Cancer Research UK Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK

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http://dx.doi.org/10.1242/dmm.038612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679377PMC
July 2019

On-treatment biomarkers can improve prediction of response to neoadjuvant chemotherapy in breast cancer.

Breast Cancer Res 2019 06 14;21(1):73. Epub 2019 Jun 14.

University of Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.

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http://dx.doi.org/10.1186/s13058-019-1159-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570893PMC
June 2019

PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer.

Cancer Lett 2019 08 20;458:66-75. Epub 2019 May 20.

Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Oglesby Cancer Research Building, University of Manchester, Manchester, M20 4GJ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.05.014DOI Listing
August 2019

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.

Cancer Cell 2019 04 28;35(4):588-602.e10. Epub 2019 Mar 28.

MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472943PMC
April 2019

Neoadjuvant Therapy for Breast Cancer as a Model for Translational Research.

Breast Cancer (Auckl) 2019 19;13:1178223419829072. Epub 2019 Feb 19.

Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research UK Centre, MRC Institute of Genetics & Molecular Medicine, Edinburgh, UK.

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http://dx.doi.org/10.1177/1178223419829072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381436PMC
February 2019

Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer.

Cancer Lett 2019 05 18;450:76-87. Epub 2019 Feb 18.

Department of Oncology and Metabolism, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK; Bone and Cancer Group, Edinburgh Cancer Research Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XR, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835193011
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http://dx.doi.org/10.1016/j.canlet.2019.02.032DOI Listing
May 2019

HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer.

Breast Cancer Res 2019 01 22;21(1):10. Epub 2019 Jan 22.

Cancer Research UK Edinburgh Centre and Division of Pathology Laboratory, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1186/s13058-019-1097-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343358PMC
January 2019

Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours.

Breast Cancer Res 2019 01 7;21(1). Epub 2019 Jan 7.

Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.

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https://breast-cancer-research.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s13058-018-1089-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323855PMC
January 2019

Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors.

Cancer Immunol Res 2018 11 28;6(11):1388-1400. Epub 2018 Sep 28.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-18-0342DOI Listing
November 2018

Neoadjuvant Endocrine Therapy in Breast Cancer Upregulates the Cytotoxic Drug Pump ABCG2/BCRP, and May Lead to Resistance to Subsequent Chemotherapy.

Clin Breast Cancer 2018 12 6;18(6):481-488. Epub 2018 Jul 6.

School of Medicine, University of Leeds, Leeds, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.clbc.2018.07.002DOI Listing
December 2018

Epigenome-wide SRC-1-Mediated Gene Silencing Represses Cellular Differentiation in Advanced Breast Cancer.

Clin Cancer Res 2018 08 22;24(15):3692-3703. Epub 2018 Mar 22.

Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2615DOI Listing
August 2018

Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis.

Cancer Res 2018 03 12;78(6):1484-1496. Epub 2018 Jan 12.

Cancer Research UK Edinburgh Centre, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857359PMC
March 2018

Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations.

BMC Cancer 2018 01 3;18(1):16. Epub 2018 Jan 3.

Nicola Murray Centre for Ovarian Cancer Research, Edinburgh Cancer Research UK Centre, MRC IGMM, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-017-3981-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753521PMC
January 2018

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment.

Breast Cancer Res 2017 Dec 6;19(1):129. Epub 2017 Dec 6.

Breast Cancer Now Research Unit, Division of Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M204GJ, UK.

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http://dx.doi.org/10.1186/s13058-017-0923-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719673PMC
December 2017

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.

Cancer Res 2017 10 14;77(19):5301-5312. Epub 2017 Aug 14.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126615PMC
October 2017

Accurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkers.

Breast Cancer Res 2016 12 1;18(1):118. Epub 2016 Dec 1.

Applied Bioinformatics of Cancer, Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Edinburgh, EH4 2XR, UK.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s13058-016-0779-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131493PMC
December 2016

Differential expression of store-operated calcium- and proliferation-related genes in hepatocellular carcinoma cells following TRPC1 ion channel silencing.

Mol Cell Biochem 2016 Sep 22;420(1-2):129-40. Epub 2016 Jul 22.

Department of Pharmacology, Faculty of Pharmacy, Ege University, 35040, Izmir, Turkey.

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http://dx.doi.org/10.1007/s11010-016-2776-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992024PMC
September 2016

Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors.

Clin Cancer Res 2016 06 13;22(11):2765-77. Epub 2016 Jan 13.

Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1583DOI Listing
June 2016

Accurate Prediction and Validation of Response to Endocrine Therapy in Breast Cancer.

J Clin Oncol 2015 Jul 1;33(20):2270-8. Epub 2015 Jun 1.

Arran K. Turnbull, Laura M. Arthur, Lorna Renshaw, Alexey A. Larionov, Charlene Kay, Jeremy S. Thomas, Andrew H. Sims, J. Michael Dixon, University of Edinburgh Cancer Research UK Centre, Edinburgh; Anita K. Dunbier, Mitch Dowsett, Institute of Cancer Research, London, United Kingdom; and Anita K. Dunbier, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1200/JCO.2014.57.8963DOI Listing
July 2015

Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment.

Oncotarget 2015 Jun;6(16):14687-99

Breakthrough Breast Cancer Unit, Institute of Cancer Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546497PMC
http://dx.doi.org/10.18632/oncotarget.4189DOI Listing
June 2015

Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance.

Cancer Res 2015 Apr;75(7):1457-69

Sahlgrenska Cancer Center, Gothenburg University, Gothenburg, Sweden. Molecular Pathology, Breakthrough Breast Cancer Research Unit, University of Manchester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1583DOI Listing
April 2015

Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas.

Oral Oncol 2015 Mar 2;51(3):237-46. Epub 2015 Jan 2.

Head and Neck Directorate NHS Lothian and University of Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2014.12.004DOI Listing
March 2015

Increased STAT1 signaling in endocrine-resistant breast cancer.

PLoS One 2014 11;9(4):e94226. Epub 2014 Apr 11.

Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094226PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984130PMC
December 2014

Engineering a synthetic cell panel to identify signalling components reprogrammed by the cell growth regulator anterior gradient-2.

Mol Biosyst 2014 Jun 7;10(6):1409-25. Epub 2014 Apr 7.

Cell Signalling Unit, p53 Signal Transduction Laboratories, Edinburgh Cancer Research Centre, Western General Hospital, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UKEH4 2XR.

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http://dx.doi.org/10.1039/c4mb00113cDOI Listing
June 2014

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity.

Oncotarget 2014 Feb;5(3):599-612

Breast Biology Group, Institute of Cancer Sciences, Paterson Building, University of Manchester, Wilmslow Road, Manchester,M20 4BX,UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996659PMC
http://dx.doi.org/10.18632/oncotarget.1169DOI Listing
February 2014

Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.

BMC Cancer 2014 Feb 22;14:119. Epub 2014 Feb 22.

Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, 205 02 Malmö, Sweden.

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http://dx.doi.org/10.1186/1471-2407-14-119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937431PMC
February 2014

Modulation of strain-specific differences in gene expression by cannabinoid type 2 receptor deficiency.

Calcif Tissue Int 2014 Apr 27;94(4):423-32. Epub 2013 Dec 27.

Rheumatology and Bone Research Group, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1007/s00223-013-9823-6DOI Listing
April 2014

Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression.

Cancer Res 2013 Dec 14;73(23):6913-25. Epub 2013 Oct 14.

Authors' Affiliations: The CRUK Inositide Laboratory; Breakthrough Breast Cancer Research Unit; Leukaemia Biology, Inositide Group Cancer Research UK Manchester Institute, The University of Manchester, Manchester; Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research UK Centre, Edinburgh, United Kingdom; and Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321494PMC
December 2013

Use of microarray analysis to investigate EMT gene signatures.

Methods Mol Biol 2013 ;1046:85-95

Breakthrough Breast Cancer Research Unit, Western General Hospital, Edinburgh, UK.

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http://link.springer.com/content/pdf/10.1007%2F978-1-62703-5
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http://link.springer.com/10.1007/978-1-62703-538-5_5
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http://dx.doi.org/10.1007/978-1-62703-538-5_5DOI Listing
February 2014

Wnt pathway activity in breast cancer sub-types and stem-like cells.

PLoS One 2013 4;8(7):e67811. Epub 2013 Jul 4.

Breakthrough Breast Cancer Research Unit, University of Manchester, Manchester, England.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067811PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701602PMC
February 2014

Transcript and protein profiling identifies signaling, growth arrest, apoptosis, and NF-κB survival signatures following GNRH receptor activation.

Endocr Relat Cancer 2013 Feb 18;20(1):123-36. Epub 2013 Feb 18.

Breakthrough Breast Cancer Research Unit and Division of Pathology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, UK.

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http://dx.doi.org/10.1530/ERC-12-0192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573841PMC
February 2013

Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer.

Cell Signal 2013 Jan 18;25(1):26-32. Epub 2012 Sep 18.

Centre for Research in Informatics and Systems Pathology (CRISP), University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1016/j.cellsig.2012.09.014DOI Listing
January 2013

Direct integration of intensity-level data from Affymetrix and Illumina microarrays improves statistical power for robust reanalysis.

BMC Med Genomics 2012 Aug 21;5:35. Epub 2012 Aug 21.

Breakthrough Research Unit, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.

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http://dx.doi.org/10.1186/1755-8794-5-35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443058PMC
August 2012

The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells.

PLoS One 2012 23;7(7):e41355. Epub 2012 Jul 23.

Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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https://pdfs.semanticscholar.org/457f/1064eea472abb26c64a673
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http://dx.plos.org/10.1371/journal.pone.0041355
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041355PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402503PMC
November 2012

Targeting of Rac GTPases blocks the spread of intact human breast cancer.

Oncotarget 2012 Jun;3(6):608-19

Breakthrough Breast Cancer Research Unit, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442288PMC
http://dx.doi.org/10.18632/oncotarget.520DOI Listing
June 2012

Relative impact of key sources of systematic noise in Affymetrix and Illumina gene-expression microarray experiments.

BMC Genomics 2011 Dec 1;12:589. Epub 2011 Dec 1.

Applied Bioinformatics of Cancer Group, Breakthrough Breast Cancer Research Unit, Institute of Genetics and Molecular Medicine, Crewe Road South, Edinburgh, Edinburgh, EH4 2XR, UK.

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http://dx.doi.org/10.1186/1471-2164-12-589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269440PMC
December 2011

GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines.

BMC Cancer 2011 Nov 3;11:476. Epub 2011 Nov 3.

Medical Research Council Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1186/1471-2407-11-476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227622PMC
November 2011

Cyclin D1, Id1 and EMT in breast cancer.

BMC Cancer 2011 Sep 28;11:417. Epub 2011 Sep 28.

University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/1471-2407-11-417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192789PMC
September 2011

Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy.

PLoS One 2011 31;6(8):e23772. Epub 2011 Aug 31.

Edinburgh Breakthrough Research Unit and Division of Pathology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023772PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166119PMC
January 2012

Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.

Carcinogenesis 2011 Oct 22;32(10):1540-9. Epub 2011 Aug 22.

UCL EGA Institute for Women's Health, University College London, London, UK.

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http://dx.doi.org/10.1093/carcin/bgr140DOI Listing
October 2011

Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies.

Clin Cancer Res 2011 Jul 13;17(13):4451-61. Epub 2011 May 13.

Division of Pathology and Edinburgh Breakthrough Research Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2461DOI Listing
July 2011

Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.

Proc Natl Acad Sci U S A 2011 Mar 28;108(11):4364-9. Epub 2011 Feb 28.

Breakthrough Breast Cancer Research Unit and Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1013224108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060255PMC
March 2011

An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer.

PLoS One 2011 Feb 15;6(2):e17083. Epub 2011 Feb 15.

Breakthrough Breast Cancer Research Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017083PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039655PMC
February 2011

The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers.

Mol Cell Biol 2010 Sep 6;30(17):4267-79. Epub 2010 Jul 6.

Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1128/MCB.01418-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937547PMC
September 2010

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer.

Breast Cancer Res 2010 22;12(3):R39. Epub 2010 Jun 22.

CRUK Cancer Research Centre and Academic Breast Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, UK.

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http://dx.doi.org/10.1186/bcr2593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917034PMC
November 2010

Gene expression profiling of response to mTOR inhibitor everolimus in pre-operatively treated post-menopausal women with oestrogen receptor-positive breast cancer.

Breast Cancer Res Treat 2010 Jul 18;122(2):419-28. Epub 2010 May 18.

Endocrine Cancer Group, University of Edinburgh Cancer Research Centre, Institute of Genetics & Molecular Medicine, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, UK.

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http://dx.doi.org/10.1007/s10549-010-0928-6DOI Listing
July 2010

Biomarkers of dietary energy restriction in women at increased risk of breast cancer.

Cancer Prev Res (Phila) 2009 Aug;2(8):720-31

Breast Biology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, United Kingdom.

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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0008DOI Listing
August 2009

Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen.

Cancer Prev Res (Phila) 2009 Mar 3;2(3):257-64. Epub 2009 Mar 3.

Breast Biology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1940-6207.CAPR-08-0161DOI Listing
March 2009

The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets - improving meta-analysis and prediction of prognosis.

BMC Med Genomics 2008 Sep 21;1:42. Epub 2008 Sep 21.

Applied Bioinformatics of Cancer Research Group, Breakthrough Research Unit, Edinburgh Cancer Research Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, UK.

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http://dx.doi.org/10.1186/1755-8794-1-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563019PMC
September 2008

The origin of estrogen receptor alpha-positive and alpha-negative breast cancer.

Adv Exp Med Biol 2008 ;617:79-86

Breast Biology Group, Division of Cancer Studies, University of Manchester Christie Hospital (NHS) Trust, Manchester, UK.

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http://dx.doi.org/10.1007/978-0-387-69080-3_7DOI Listing
July 2008

Isolation of four pepsin-like protease genes from Aspergillus niger and analysis of the effect of disruptions on heterologous laccase expression.

Fungal Genet Biol 2008 Jan 29;45(1):17-27. Epub 2007 Sep 29.

Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, PR China.

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http://dx.doi.org/10.1016/j.fgb.2007.09.012DOI Listing
January 2008

Origins of breast cancer subtypes and therapeutic implications.

Nat Clin Pract Oncol 2007 Sep;4(9):516-25

Breast Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/ncponc0908DOI Listing
September 2007

High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?

Breast Cancer Res 2006 ;8(5):214

Breast Biology Group, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1186/bcr1605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779487PMC
January 2007

Mechanisms of Disease: prediction and prevention of breast cancer--cellular and molecular interactions.

Nat Clin Pract Oncol 2005 Dec;2(12):635-46

Dept of Medical Oncology, University of Manchester, Christie Hospital, Withington, UK.

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http://dx.doi.org/10.1038/ncponc0361DOI Listing
December 2005

Glutamic protease distribution is limited to filamentous fungi.

FEMS Microbiol Lett 2004 Oct;239(1):95-101

School of Biological Sciences, The Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.femsle.2004.08.023DOI Listing
October 2004

Combining transcriptome data with genomic and cDNA sequence alignments to make confident functional assignments for Aspergillus nidulans genes.

Mycol Res 2004 Aug;108(Pt 8):853-7

School of Biological Sciences, University of Manchester, The Michael Smith Building, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1017/s095375620400067xDOI Listing
August 2004

Use of expressed sequence tag analysis and cDNA microarrays of the filamentous fungus Aspergillus nidulans.

Fungal Genet Biol 2004 Feb;41(2):199-212

School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.fgb.2003.11.005DOI Listing
February 2004