Andrew Gennery

Andrew Gennery

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Andrew Gennery

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Primary Immunodeficiency Diseases and Bacillus Calmette-Guérin (BCG)-Vaccine-Derived Complications: A Systematic Review.

J Allergy Clin Immunol Pract 2020 Jan 30. Epub 2020 Jan 30.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.01.038DOI Listing
January 2020

Hematopoietic Stem Cell Transplantation for DNA Double Strand Breakage Repair Disorders.

Front Pediatr 2019 15;7:557. Epub 2020 Jan 15.

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.3389/fped.2019.00557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974535PMC
January 2020

An update on X-Linked agammaglobulinaemia: clinical manifestations and management.

Curr Opin Allergy Clin Immunol 2019 Dec;19(6):571-577

Institute of Cellular Medicine, Newcastle University.

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http://dx.doi.org/10.1097/ACI.0000000000000584DOI Listing
December 2019

Hematopoietic Cell Transplantation for MHC Class II Deficiency.

Front Pediatr 2019 11;7:516. Epub 2019 Dec 11.

Children's Haematopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.3389/fped.2019.00516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917634PMC
December 2019

Universal donor strategy for primary immunodeficiency.

Authors:
Andrew R Gennery

Blood 2019 11;134(20):1688-1689

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http://dx.doi.org/10.1182/blood.2019003222DOI Listing
November 2019

Hematopoietic Stem Cell Transplantation for Primary Immunodeficiencies.

Front Pediatr 2019 30;7:445. Epub 2019 Oct 30.

Department of Pediatrics, Stem Cell Transplantation Program, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.3389/fped.2019.00445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831554PMC
October 2019

Long Term Outcome and Immune Function After Hematopoietic Stem Cell Transplantation for Primary Immunodeficiency.

Front Pediatr 2019 24;7:381. Epub 2019 Sep 24.

Stem Cell Transplantation Program, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.3389/fped.2019.00381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768963PMC
September 2019

Interleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight?

Front Immunol 2018 8;9:979. Epub 2018 May 8.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.00979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951928PMC
July 2019

New graft manipulation strategies improve the outcome of mismatched stem cell transplantation in children with primary immunodeficiencies.

J Allergy Clin Immunol 2019 Jul 4;144(1):280-293. Epub 2019 Feb 4.

Molecular and Cellular Immunology Unit, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom; Blood and Bone Marrow Transplant Unit, Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2019.01.030DOI Listing
July 2019

Editorial: The Relationship Between Cancer Predisposition and Primary Immunodeficiency.

Front Immunol 2019 30;10:1781. Epub 2019 Jul 30.

Research Unit for Pediatric Hematology and Immunology, Division of Pediatric Hemato-Oncology, Department of Pediatric and Adolescent Medicine, Medical University Graz, Graz, Austria.

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http://dx.doi.org/10.3389/fimmu.2019.01781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683758PMC
July 2019

Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study.

J Allergy Clin Immunol 2019 Jun 17;143(6):2238-2253. Epub 2019 Jan 17.

Department of Pediatric Immunology and HSCT, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193003
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http://dx.doi.org/10.1016/j.jaci.2018.12.1010DOI Listing
June 2019

Two decades of excellent transplant survival for chronic granulomatous disease: a supraregional immunology transplant center report.

Blood 2019 06 5;133(23):2546-2549. Epub 2019 Apr 5.

Department of Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Great North Children's Hospital, Newcastle upon Tyne Hospital National Health Service (NHS) Foundation Trust, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1182/blood.2019000021DOI Listing
June 2019

Recombination activity of human recombination-activating gene 2 (RAG2) mutations and correlation with clinical phenotype.

J Allergy Clin Immunol 2019 02 18;143(2):726-735. Epub 2018 Jun 18.

Pediatric Department A and the Immunology Service, "Edmond and Lily Safra" Children's Hospital, Jeffrey Modell Foundation Center, Sheba Medical Center, Tel Hashomer, Ramat-Gan and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295349PMC
February 2019

Recent advances in understanding RAG deficiencies.

Authors:
Andrew Gennery

F1000Res 2019 4;8. Epub 2019 Feb 4.

Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Great North Childrens' Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.12688/f1000research.17056.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364374PMC
February 2019

Health-Related Quality of Life and Emotional Health in X-Linked Carriers of Chronic Granulomatous Disease in the United Kingdom.

J Clin Immunol 2019 02 13;39(2):195-199. Epub 2019 Mar 13.

Great North Children's Hospital, Clinical Resource Building, Floor 4, Block 2, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK.

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http://dx.doi.org/10.1007/s10875-019-00607-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445821PMC
February 2019

Outcome of domino hematopoietic stem cell transplantation in human subjects: An international case series.

J Allergy Clin Immunol 2018 11 5;142(5):1628-1631.e4. Epub 2018 Jul 5.

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; Department of Pediatric Hematology and Stem Cell Transplantation, Wilhelmina Children's Hospital, Utrecht, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183099
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http://dx.doi.org/10.1016/j.jaci.2018.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226332PMC
November 2018

Corrigendum: Interleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight?

Front Immunol 2018 1;9:2197. Epub 2018 Oct 1.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.02197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174291PMC
October 2018

Predicting the future with TRECs.

Authors:
Andrew R Gennery

Blood 2018 10;132(17):1731-1733

University of Newcastle upon Tyne.

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http://dx.doi.org/10.1182/blood-2018-09-873638DOI Listing
October 2018

Non-posttransplant lymphoproliferative disorder malignancy after hematopoietic stem cell transplantation in patients with primary immunodeficiency: UK experience.

J Allergy Clin Immunol 2018 06 7;141(6):2319-2321.e1. Epub 2018 Mar 7.

Children's Haemopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.02.038DOI Listing
June 2018

Multicenter phase 1/2 application of adenovirus-specific T cells in high-risk pediatric patients after allogeneic stem cell transplantation.

Cytotherapy 2018 06 9;20(6):830-838. Epub 2018 May 9.

Molecular and Cellular Immunology Section, Institute of Child Health, University College of London, London, United Kingdom; Department of Immunology, Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jcyt.2018.03.040DOI Listing
June 2018

Endothelial cell damage in idiopathic pneumonia syndrome.

Bone Marrow Transplant 2018 04 15;53(4):515-518. Epub 2018 Jan 15.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1038/s41409-017-0042-zDOI Listing
April 2018

Clinical considerations in the hematopoietic stem cell transplant management of primary immunodeficiencies.

Expert Rev Clin Immunol 2018 04 11;14(4):297-306. Epub 2018 Apr 11.

b Primary Immunodeficiency Group, Institute of Cellular Medicine , Newcastle University , Newcastle upon Tyne , UK.

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http://dx.doi.org/10.1080/1744666X.2018.1459189DOI Listing
April 2018

Adenosine deaminase deficiency: a review.

Orphanet J Rare Dis 2018 04 24;13(1):65. Epub 2018 Apr 24.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1186/s13023-018-0807-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916829PMC
April 2018

Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study.

J Allergy Clin Immunol 2018 03 11;141(3):1036-1049.e5. Epub 2017 Dec 11.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050203PMC
March 2018

Hematopoietic cell transplantation in primary immunodeficiency - conventional and emerging indications.

Expert Rev Clin Immunol 2018 02 16;14(2):103-114. Epub 2018 Jan 16.

a Institute of Cellular Medicine , Newcastle University , Newcastle Upon Tyne , UK.

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http://dx.doi.org/10.1080/1744666X.2018.1424627DOI Listing
February 2018

Approaches to the removal of T-lymphocytes to minimize graft-versus-host disease in patients with primary immunodeficiencies who do not have a matched sibling donor.

Curr Opin Allergy Clin Immunol 2017 Dec;17(6):414-420

aInstitute of Cellular Medicine, Newcastle University, Medical School, Framlington Place bPaediatric Immunology and HSCT, Great North Children's Hospital, Queen Victoria Road, Newcastle Upon Tyne, UK.

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http://Insights.ovid.com/crossref?an=00130832-201712000-0000
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http://dx.doi.org/10.1097/ACI.0000000000000402DOI Listing
December 2017

X-Linked Agammaglobulinaemia: Outcomes in the modern era.

Clin Immunol 2017 10 17;183:54-62. Epub 2017 Jul 17.

Institute of Cellular Medicine, Newcastle University, 4th Floor, William Leech Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1016/j.clim.2017.07.008DOI Listing
October 2017

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56 NKG2A Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Front Immunol 2017 10;8:1244. Epub 2017 Oct 10.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01
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http://dx.doi.org/10.3389/fimmu.2017.01244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641412PMC
October 2017

Inflammatory and autoimmune manifestations in X-linked carriers of chronic granulomatous disease in the United Kingdom.

J Allergy Clin Immunol 2017 08 23;140(2):628-630.e6. Epub 2017 Mar 23.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Paediatric Immunology, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.02.029DOI Listing
August 2017

Recent advances in understanding and treating chronic granulomatous disease.

Authors:
Andrew Gennery

F1000Res 2017 11;6:1427. Epub 2017 Aug 11.

Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Great North Childrens' Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.12688/f1000research.11789.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558100PMC
August 2017

Enterovirus-Related Immune Reconstitution Inflammatory Syndrome (IRIS) Following Haploidentical Stem Cell Transplantation in an MHC Class II-Deficient Child.

J Clin Immunol 2017 07 16;37(5):419-421. Epub 2017 May 16.

Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s10875-017-0402-xDOI Listing
July 2017

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56 NKG2A Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Front Immunol 2017 17;8:798. Epub 2017 Jul 17.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00
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http://dx.doi.org/10.3389/fimmu.2017.00798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511964PMC
July 2017

Infusion of Sibling Marrow in a Patient with Purine Nucleoside Phosphorylase Deficiency Leads to Split Mixed Donor Chimerism and Normal Immunity.

Front Pediatr 2017 19;5:143. Epub 2017 Jun 19.

Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.

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http://dx.doi.org/10.3389/fped.2017.00143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5475337PMC
June 2017

Prevalence of Cryptosporidium Carriage and Disease in Children With Primary Immune Deficiencies Undergoing Hematopoietic Stem Cell Transplant in Northern Europe.

Pediatr Infect Dis J 2017 May;36(5):504-506

From the *Swansea University Medical School, Singleton Park, Swansea, United Kingdom; †Cryptosporidium Reference Unit, Public Health Wales Microbiology Swansea, Singleton Hospital, Sketty Lane, Swansea, United Kingdom; ‡Paediatric Immunology Department, Great North Children's Hospital, Queen Victoria Road, Newcastle upon Tyne, United Kingdom; §Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; and ¶Centre for Immunodeficiency, Institute of Child Health, University College London and Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.1097/INF.0000000000001517DOI Listing
May 2017

Long-term outcome of hematopoietic stem cell transplantation for IL2RG/JAK3 SCID: a cohort report.

Blood 2017 04 16;129(15):2198-2201. Epub 2017 Feb 16.

Pediatric Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1182/blood-2016-11-748616DOI Listing
April 2017

Raised Serum IL-8 Levels Are Associated with Excessive Fatigue in Female Carriers of X-Linked Chronic Granulomatous Disease in the UK.

J Clin Immunol 2017 04 23;37(3):279-281. Epub 2017 Mar 23.

Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1007/s10875-017-0384-8DOI Listing
April 2017

Hematopoietic stem cell transplant in patients with activated PI3K delta syndrome.

J Allergy Clin Immunol 2017 03 12;139(3):1046-1049. Epub 2016 Nov 12.

Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle upon Tyne University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.09.040DOI Listing
March 2017

Treatment of Pediatric Acute Graft-versus-Host Disease-Lessons from Primary Immunodeficiency?

Front Immunol 2017 21;8:328. Epub 2017 Mar 21.

Medical School, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.

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http://dx.doi.org/10.3389/fimmu.2017.00328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359217PMC
March 2017

Outcomes after Unrelated Umbilical Cord Blood Transplantation for Children with Osteopetrosis.

Biol Blood Marrow Transplant 2016 11 25;22(11):1997-2002. Epub 2016 Jul 25.

Eurocord, Hopital Saint Louis, Paris, France; Centre Scientifique de Monaco, Principality of Monaco; Churchill Hospital, University of Oxford, NHS Blood and Transplant (NHSBT), Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.bbmt.2016.07.015DOI Listing
November 2016

DNA ligase IV syndrome; a review.

Orphanet J Rare Dis 2016 10 7;11(1):137. Epub 2016 Oct 7.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1186/s13023-016-0520-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055698PMC
October 2016

Haploidentical CD3 TCRαβ and CD19-depleted second stem cell transplant for steroid-resistant acute skin graft versus host disease.

J Allergy Clin Immunol 2016 08 23;138(2):603-605.e1. Epub 2016 Mar 23.

Department of Paediatric Immunology, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle upon Tyne University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2015.12.1335DOI Listing
August 2016

Functional changes in gut microbiota during hematopoietic stem cell transplantation for severe combined immunodeficiency.

J Allergy Clin Immunol 2016 08 6;138(2):622-625.e3. Epub 2016 Apr 6.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.02.019DOI Listing
August 2016

Respiratory Health and Related Quality of Life in Patients with Congenital Agammaglobulinemia in the Northern Region of the UK.

J Clin Immunol 2016 07 18;36(5):472-9. Epub 2016 Apr 18.

Institute of Cellular Medicine, Newcastle University, 4th Floor, William Leech Building, Medical School, Framlington Place, Newcastle upon Tyne, E2 4HH, UK.

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http://dx.doi.org/10.1007/s10875-016-0284-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896978PMC
July 2016

Gene therapy for PID: the end of the beginning?

Authors:
Andrew R Gennery

Blood 2016 07;128(1):7-8

NEWCASTLE UNIVERSITY.

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http://dx.doi.org/10.1182/blood-2016-05-715037DOI Listing
July 2016

Extracoporeal photopheresis treatment of acute graft-versus-host disease following allogeneic haematopoietic stem cell transplantation.

F1000Res 2016 27;5. Epub 2016 Jun 27.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; Paediatric Haematopoietic Stem Cell Unit, Great North Children's Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.12688/f1000research.8118.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926758PMC
July 2016

Presenting features and platelet anomalies in WAS: one centre's experience.

J Clin Immunol 2016 05 7;36(4):354-6. Epub 2016 Mar 7.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1007/s10875-016-0259-4DOI Listing
May 2016

The Evolving Landscape of Primary Immunodeficiencies.

Authors:
Andrew R Gennery

J Clin Immunol 2016 05 23;36(4):339-40. Epub 2016 Mar 23.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s10875-016-0273-6DOI Listing
May 2016

Autosomal Dominant Hyper IgE Syndrome--Treatment Strategies and Clinical Outcomes.

J Clin Immunol 2016 Feb 7;36(2):107-9. Epub 2016 Jan 7.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s10875-015-0231-8DOI Listing
February 2016

Recent advances in treatment of severe primary immunodeficiencies.

Authors:
Andrew Gennery

F1000Res 2015 16;4. Epub 2015 Dec 16.

Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Great North Childrens' Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.12688/f1000research.7013.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754032PMC
February 2016

The sting of WASP deficiency: autoimmunity exposed.

Authors:
Andrew R Gennery

Blood 2016 Jan;127(2):173-5

NEWCASTLE UNIVERSITY; GREAT NORTH CHILDRENS' HOSPITAL.

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http://dx.doi.org/10.1182/blood-2015-10-677237DOI Listing
January 2016