Publications by authors named "Andrew Fischer"

121 Publications

Indeterminate Cell Histiocytosis Mimicking Rosacea.

Cureus 2021 Jan 22;13(1):e12850. Epub 2021 Jan 22.

Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, USA.

Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder of histiocytes, which display morphologic and immunophenotypic characteristics of both Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (NLCH). We describe an unusual clinical presentation of ICH mimicking rosacea and provide a relevant review of the literature.
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http://dx.doi.org/10.7759/cureus.12850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897367PMC
January 2021

Diagnostic value of a comprehensive, urothelial carcinoma-specific next-generation sequencing panel in urine cytology and bladder tumor specimens.

Cancer Cytopathol 2021 Feb 4. Epub 2021 Feb 4.

Department of Pathology, UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, Massachusetts.

Background: Urine cytology can reliably diagnose high-grade urothelial carcinoma (HGUC) but not low-grade urothelial carcinoma (LGUC), and a more sensitive test is needed. Previously, a pilot study highlighted the possible diagnostic utility of next-generation sequencing (NGS) in identifying both LGUC and HGUC in urine cytology specimens.

Methods: Twenty-eight urine ThinPrep cytology specimens and preceding or subsequent bladder tumor biopsy/resection specimens obtained within 3 months were included in the study (LGUC, n = 15; HGUC, n = 13). A customized, bladder-specific NGS panel was performed; it covered 69 frequently mutated or altered genes in urothelial carcinoma (UC) that were reported by The Cancer Genome Atlas and the Catalogue of Somatic Mutations in Cancer.

Results: The sequencing results were compared between the urine cytology specimens and the corresponding bladder tumor biopsies/resections. TP53 was the most frequently identified mutation in HGUC cases (11 of 13 [85%]). PIK3CA and KDM6A were the most frequently identified mutations in LGUC: they occurred in 7 of 15 cases (47%) and in 6 of 15 cases (40%), respectively. Additional frequent mutations identified in the panel included ARID1A (n = 5), EP300 (n = 4), LRP1B (n = 3), ERBB2 (n = 2), STAG2 (n = 2), FGFR3 (n = 3), MLL (n = 2), MLL3 (n = 2), CREBBP1 (n = 1), RB1 (n = 1), and FAT4 (n = 1). Overall, the concordance between the cytology and surgical specimens was 75%. The sensitivity and specificity for identifying mutations in urine cytology specimens were 84% and 100%, respectively.

Conclusions: A bladder-specific NGS panel increases the sensitivity and specificity of urine cytology's diagnostic utility in both low- and high-grade tumors and may serve as a noninvasive surveillance method in the follow-up of patients with UC harboring known mutations.
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http://dx.doi.org/10.1002/cncy.22410DOI Listing
February 2021

Perforating and granulomatous exogenous ochronosis.

J Cutan Pathol 2021 Jan 20. Epub 2021 Jan 20.

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/cup.13807DOI Listing
January 2021

Lymphedematous verrucous changes of the genital skin: an extraintestinal manifestation of Crohn disease.

J Cutan Pathol 2021 Jan 20. Epub 2021 Jan 20.

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/cup.13723DOI Listing
January 2021

Central Centrifugal Cicatricial Alopecia: Histological progression correlates with advancing age.

J Am Acad Dermatol 2021 Jan 16. Epub 2021 Jan 16.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2021.01.028DOI Listing
January 2021

Cutaneous follicular mucinous nevus presenting with congenital grouped papules and plaques initially misdiagnosed as a cutaneous myxoma.

J Cutan Pathol 2021 Jan;48(1):1-5

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/cup.13701DOI Listing
January 2021

Nail Unit Schwannoma: An Important Consideration in the Differential Diagnosis of Soft Tissue Tumors Affecting the Nail Apparatus.

Skin Appendage Disord 2020 Nov 14;6(6):370-373. Epub 2020 Aug 14.

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Schwannoma is a tumor of schwann cell proliferation which presents as a solitary, soft, skin-colored dermal or subcutaneous papulo-nodule most commonly on the flexor part of extremities and head and neck areas. Here, we report a case of nail unit schwannoma, which is a rare tumor of the nail apparatus with only 4 other prior reports in the literature. This case illustrates the importance of including subungual schwannoma in the clinical differential diagnosis of subungual soft tissue tumors. We include a literature review which catalogs and summarizes the current knowledge regarding this unusual nail unit neoplasm.
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http://dx.doi.org/10.1159/000509041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706483PMC
November 2020

Firm, Hyperpigmented Papules Coalescing Into a Plaque in an Adult Woman With Systemic Sclerosis: Answer.

Am J Dermatopathol 2020 Dec;42(12):1003

Departments of Dermatology, and.

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http://dx.doi.org/10.1097/DAD.0000000000001768DOI Listing
December 2020

A progressive, diffuse atrophic and dyspigmented eruption.

Pediatr Dermatol 2020 Nov;37(6):1153-1155

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/pde.14345DOI Listing
November 2020

Cytologically targeted next-generation sequencing: a synergy for diagnosing urothelial carcinoma.

J Am Soc Cytopathol 2021 Jan-Feb;10(1):94-102. Epub 2020 Oct 14.

Department of Pathology, University of Massachusetts Memorial Health Care, Worcester, Massachusetts. Electronic address:

Introduction: Cytology and cystoscopy are used to detect urothelial carcinoma (UC), but together they still fail to detect some UC cases and are not suitable for screening asymptomatic individuals. Mutations are present in more than 98% of UC, mutations have therapeutic significance, and they can be detected by next generation sequencing (NGS) in urine samples. We review the role of NGS in UC detection.

Materials And Methods: Comprehensive literature review on UC genetics, economics of NGS, and previous reports of UC detection by NGS.

Results: The raw costs of NGS have decreased to about 14,000 base pairs per penny, making it appear economically feasible to use NGS widely. Reported NGS assays fall short of predicted sensitivity. Decreased sensitivity is attributed to a low frequency of mutant alleles in many urine samples. Attempts to increase the percentage of mutant alleles, by using cell-free urinary DNA, or by using cell sorting and microfluidics, have been unsuccessful or remain unproven. However, cytologic examination can immediately enable NGS: Urine cytologies with sufficient proportions of abnormal cells could be directly triaged to NGS with high sensitivity for UC detection. For cases with a low proportion of abnormal cells, cytologically targeted microdissection of cells for NGS should maintain sensitivity and decrease sequencing costs. Cytologically targeted urothelial cells for NGS could allow a screening test for low grade UC.

Conclusions: Cytology is immediately poised to allow NGS to improve the diagnosis of UC, allowing NGS to be an ancillary test for atypical cytologies, and potentially allowing a screening test for low-grade UC.
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http://dx.doi.org/10.1016/j.jasc.2020.10.001DOI Listing
October 2020

Colposcopic endocervical brushing cytology appears to be more sensitive than histologic endocervical curettage for detecting endocervical adenocarcinoma.

J Am Soc Cytopathol 2020 Aug 27. Epub 2020 Aug 27.

Department of Pathology, University of Massachusetts Memorial Medical Center, Worcester, Massachusetts.

Introduction: Colposcopic endocervical brushing cytology (CEB) is more sensitive than endocervical curettage (ECC) for detecting squamous intraepithelial lesions. There are no data on performance of CEB for detecting endocervical adenocarcinoma.

Materials And Methods: A total of 151 patients were identified in a word search for "endocervical adenocarcinoma" in surgical pathology reports from January 2007 to June 2019. To measure sensitivity, reports of CEB or ECC samples within 1 year preceding the first surgical pathology diagnosis of at least endocervical adenocarcinoma in situ (AIS+) were examined. Specificity was measured in a cohort in which at least atypical glandular cells (AGC+) was reported in CEB or ECC.

Results: Seven CEB preceding diagnosis of AIS were identified: 6 of 7 were positive or suspicious for AIS+. One of 7 was negative and it was negative on re-review. Three of 6 positive CEB cases used cell blocks with immunohistochemistry. Seventy ECC samples preceding diagnosis of AIS were identified: 40 of 70 were diagnosed as AGC+. The sensitivities of CEB and ECC for detecting AIS+ at a threshold of AGC+ are 86% and 57% (too few patients for statistics), respectively. For specificity, 12 of 18 CEB and 9 of 25 ECC reports with AGC+ were false positive by follow-up surgical pathology. The specificities of CEB and ECC are 99.4% and 99.9%, respectively.

Conclusion: Sensitivity of CEB for detecting AIS+ (86%) is at least as high as ECC (57%). Specificity of CEB is similar to ECC. Addition of a cell block to CEB may be useful. CEB appears to be an appropriate test for follow-up of atypical glandular cells reported on Papanicolaou tests.
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http://dx.doi.org/10.1016/j.jasc.2020.08.008DOI Listing
August 2020

Firm, Hyperpigmented Papules Coalescing Into a Plaque in an Adult Woman With Systemic Sclerosis: Challenge.

Am J Dermatopathol 2020 Dec;42(12):e159-e160

Departments of Dermatology, and.

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http://dx.doi.org/10.1097/DAD.0000000000001767DOI Listing
December 2020

Fibrotic trochanters: A potential mechanism for stem cell depletion in scarring alopecias.

J Cutan Pathol 2021 Mar 14;48(3):458-460. Epub 2020 Oct 14.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/cup.13855DOI Listing
March 2021

CD30-positive atypical lymphocytes in perniosis: a potential diagnostic pitfall in a benign inflammatory dermatosis.

J Cutan Pathol 2020 09;47(9):781-784

Department of Dermatology, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1111/cup.13697DOI Listing
September 2020

Shapiro xanthogranuloma: An essential diagnosis for dermatologists and dermatopathologists to recognize to avoid misdiagnosis of a hematopoietic malignancy in infants and neonates.

J Cutan Pathol 2020 Jul 26. Epub 2020 Jul 26.

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

The Shapiro xanthogranuloma is a histopathologic form of xanthogranuloma that shows closely packed monomorphous cells, which can extend into the subcutaneous fat; it usually lacks routine diagnostic features of xanthogranuloma. Herein we describe two cases of Shapiro xanthogranuloma occurring in a neonate and in an infant, which were initially thought to be hematologic malignancies. One patient's presentation as a "blueberry muffin baby" added to the diagnostic confusion. Pediatric dermatologists, dermatologists, and dermatopathologists need to be aware of the Shapiro xanthogranuloma and its clinicopathologic features to avoid misdiagnosis of a hematopoietic malignancy in neonates and infants.
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http://dx.doi.org/10.1111/cup.13823DOI Listing
July 2020

A congenital, cerebriform, yellow plaque on the ear.

Pediatr Dermatol 2020 07;37(4):736-737

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/pde.14212DOI Listing
July 2020

A solitary, firm, growing pink papule on the back of an infant.

Pediatr Dermatol 2020 07;37(4):e37-e39

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/pde.14190DOI Listing
July 2020

Multiple indurated plaques and a blister in a newborn.

Pediatr Dermatol 2020 07;37(4):e46-e48

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/pde.14204DOI Listing
July 2020

The Utility of MYB Immunohistochemistry (IHC) in Fine Needle Aspiration (FNA) Diagnosis of Adenoid Cystic Carcinoma (AdCC).

Head Neck Pathol 2020 Jul 13. Epub 2020 Jul 13.

Department of Pathology, University of Massachusetts Medical School, Worcester, MA, 01655, USA.

Differentiating adenoid cystic carcinoma (AdCC) from other basaloid neoplasm in a fine needle aspiration (FNA) sample can be challenging. Activation of MYB in AdCC by the fusion transcript MYB-NFIB has been recently demonstrated in salivary gland and other organs. The aim of this study is to evaluate the utility of MYB immunohistochemistry (IHC) in distinguishing AdCCs and other basaloid neoplasm in cytology specimens. Eighteen FNA cases, from salivary gland and other sites, and their subsequent surgical resection specimens were included in the study. Eight cases were confirmed AdCC on resection. MYB IHC was performed on slides made from cytology cell block and surgical resection paraffin blocks. Percentage and intensity of nuclear staining in tumor cells was scored as 0 to 3. The staining results were concordant between cytology specimens and their corresponding surgical resection tumors. Strong diffuse nuclear staining (score 3, N = 5) was exclusively observed in AdCC, both in cytology and surgical specimens. Only one pleomorphic adenoma and one poorly differentiated basaloid carcinoma were positive for MYB staining (score 1 to 2). Any degree of nuclear MYB labeling was seen in 100% AdCC cases (N = 8/8) compared with of 20% (N = 2/10) of all other non-AdCC cases (P = < 0.001). The sensitivity and specificity of any degree MYB positivity for AdCC in cytology specimen is 100% and 78%. The sensitivity and specificity of strong diffuse MYB labeling (score 2 to 3) for AdCC is 83% and 100% in cytology specimen. Strong diffuse nuclear staining of MYB is valuable in supporting a cytologic diagnosis of AdCC. However, weak and focal labeling of MYB should be interpreted with caution as it can be seen in benign and other malignant basaloid lesions.
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http://dx.doi.org/10.1007/s12105-020-01202-7DOI Listing
July 2020

Dermatomal necrotizing infundibular crystalline folliculitis following herpes zoster in a patient on PD-1 inhibitor therapy.

J Cutan Pathol 2020 Jun;47(6):501-505

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/cup.13653DOI Listing
June 2020

Sarcoidosis: An atypical mimicker of acne keloidalis nuchae.

JAAD Case Rep 2020 May 29;6(5):397-399. Epub 2020 Apr 29.

Department of Dermatology, Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jdcr.2020.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200201PMC
May 2020

Cytologic processing of ureteral microbiopsies is associated with higher sensitivity for detection of urothelial carcinoma compared with conventional biopsy processing.

J Am Soc Cytopathol 2020 Jan - Feb;9(1):26-32. Epub 2019 Aug 8.

Department of Pathology, University of Massachusetts Memorial Health Care, Worcester, Massachusetts. Electronic address:

Introduction: Because of the high rates of false-negative or nondiagnostic ureteral Piranha microbiopsies associated with low cellularity, we assessed the effect of processing these using cytology.

Materials And Methods: We included 2 groups of 44 consecutive microbiopsies processed from formalin as a standard surgical biopsy and 22 processed by cytology. All samples were from the ureter or renal pelvis or calyx. The cytology samples were collected in alcohol-based media and were prepared with a Cellient cell block only (n = 9) or with a Cellient cell block for the visible particles, together with ThinPrep, to capture the remaining desquamated cells (n = 13).

Results: Malignancy was diagnosed in 5 of 44 conventionally processed microbiopsies (11%) compared with 14 of 22 cytologically processed microbiopsies (64%; P < 0.001), including 1 case with invasion. Nineteen site-matched biopsies from 2 patients had undergone both cytologic and surgical processing, with 8 of 8 cytologically processed biopsies diagnosed as malignant. None of the 11 surgically processed biopsies from the same patients matched for site were diagnosed as malignant. Of the 11, 2 (18%) were suspicious for high-grade urothelial carcinoma and 6 (55%) were considered atypical. Increased sensitivity from cytologic processing appears related to increased cell recovery; large numbers of well-preserved urothelial cells were identified in the ThinPrep (range, 1000-25,000 cells/slide), and a nonsignificant trend was found toward increased urothelium (defined as >200 cells/profile) in the Cellient cell blocks (14 of 22 [64%]) compared with the histologic biopsies (17 of 44 [39%]; P = 0.070).

Conclusions: Cytologic processing of ureteral microbiopsies showed superior sensitivity for detecting high-grade urothelial carcinoma, apparently owing to the increased cellular recovery.
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http://dx.doi.org/10.1016/j.jasc.2019.07.006DOI Listing
August 2019

New quantitative data on cell blocks.

Authors:
Andrew H Fischer

J Am Soc Cytopathol 2019 Mar - Apr;8(2):49-51. Epub 2018 Nov 10.

Pathology, University of Massachusetts UMMHC, Worcester, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jasc.2018.11.002DOI Listing
January 2020

Bringing Development Back into Development Studies.

Authors:
Andrew M Fischer

Dev Change 2019 Mar 8;50(2):426-444. Epub 2019 Mar 8.

This article challenges Horner and Hulme's call to move from 'international development' to 'global development' with a reaffirmation of the classical traditions of development studies. With some adaptation to fit the changing contemporary context, these traditions not only remain relevant but also recover vital insights that have been obscured in the various fashionable re-imaginings of development. In particular, development thinking and agendas in the past were much more radical and ambitious in addressing the imperatives of redistribution and progressive forms of transformation in the context of stark asymmetries of wealth and power. Such ambition is still needed to address the nature and scale of challenges that continue to face the bulk of countries in the world, particularly given the persistence if not deepening of asymmetries. This reaffirmation is elaborated by addressing three major weaknesses in Horner and Hulme's arguments. First, they do not actually define development, but instead treat it as simply poverty and inequality dynamics, which are better understood as outcomes rather than causes. Second, despite their assertion that the study of (international) development was primarily concerned with between-country inequalities, this is not true. Domestic inequality was in fact central to both development theory and policy since the origins of the field. Third, the authors ignore the rise of neoliberalism from the late 1970s onwards and the profound crisis that this caused to development outside of East Asia and perhaps India, which the jargon of 'global' implicitly obfuscates and even condones. Rather, the experiences of East Asia and in particular China arguably vindicate classical approaches in development studies.
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http://dx.doi.org/10.1111/dech.12490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472494PMC
March 2019

Debt and development in historical perspective: The external constraints of late industrialisation revisited through South Korea and Brazil.

Authors:
Andrew M Fischer

World Econ 2018 Dec 15;41(12):3359-3378. Epub 2018 Feb 15.

Institute of Social Studies The Hague Erasmus University Rotterdam The Netherlands.

Current debates about the role of external finance in development mostly overlook the insights from early development economics that late industrialisation generates a structural tendency to run trade deficits, thereby exacerbating rather than relieving external foreign exchange constraints. The developmental role of external finance is therefore based on its strategic marginal contribution to relieve such constraints. External debt in particular also allows countries to pursue industrial strategies without reliance on foreign direct investment. These insights are revisited in this paper as a critical input to both mainstream and heterodox contemporary scholarship on debt and development. While the mainstream generally avoids discussion of state-led industrial policy, the heterodox has converged on a view that developing countries should avoid external finance. The contrasting external account histories of South Korea and Brazil are examined to demonstrate the validity of the classic insights and the contemporary fallacies. While the South Korean case speaks much to its geopolitical context, this does not necessarily refute the principle that post-war late development engenders an intensive demand for external finance, which must be met if industrialisation strategies are not to be stymied, as in the case of Brazil, no matter how effectively domestic strategies are conceived and implemented.
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http://dx.doi.org/10.1111/twec.12625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386149PMC
December 2018

An Automatable Method for Determining Adequacy of Thyroid Fine-Needle Aspiration Samples.

Arch Pathol Lab Med 2019 09 24;143(9):1084-1088. Epub 2018 Oct 24.

From the Department of Pathology, City of Hope National Medical Center, Duarte, California (Dr Schmolze); and the Department of Pathology, University of Massachusetts Medical School, Worcester (Dr Fischer).

Context.—: Thyroid nodules are a common clinical problem. Cytologic evaluation via fine-needle aspiration is often employed in the diagnostic workup, and rapid on-site assessment of adequacy can help ensure an adequate sample is obtained. However, rapid on-site assessment of adequacy only examines part of the sample, a part that may not then be available for ancillary testing. Moreover, the procedure is time-consuming and poorly reimbursed.

Objective.—: To develop an automatable fluorescence-based image analysis system for assessing the adequacy of thyroid fine-needle aspirations that uses the entire aspirated sample.

Design.—: There were 12 previously diagnosed cases that served as a training set, and 11 cases were used for validation of an image analysis algorithm. The samples were fluorescently stained and imaged using a fluorescent microscope. The images were assessed for adequacy by an image analysis algorithm. Following image analysis, a ThinPrep slide was prepared and blindly scored by a cytopathologist. The standard and computer-derived results were then compared.

Results.—: The algorithm was optimized using the 12 cases in the training set and then applied to the 11 test cases. A total of 8 of 8 adequate samples in the test group were correctly scored as adequate, and 2 of 3 cases that were inadequate were correctly scored as inadequate by the algorithm. One case was erroneously designated as not adequate by the algorithm.

Conclusions.—: Our results demonstrate the feasibility of automating thyroid adequacy assessment using a fluorescent labeling technique followed by computer image analysis.
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http://dx.doi.org/10.5858/arpa.2018-0072-OADOI Listing
September 2019

A New, Firm, Solitary Nodule in a Patient With HIV/AIDS: Answer.

Am J Dermatopathol 2018 Nov;40(11):861

Pathology, University of Colorado School of Medicine, Aurora, CO.

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http://dx.doi.org/10.1097/DAD.0000000000000914DOI Listing
November 2018

The difficulty in interpreting gene expression profiling in BAP-negative melanocytic tumors.

J Cutan Pathol 2018 May 12. Epub 2018 May 12.

Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado.

Background: BAP-negative melanocytic tumors were unrecognized in the medical literature until 2011. While the clinical significance of these tumors is poorly understood, there is concern such lesions represent processes in transition, and malignant degeneration is a concern. We investigated use of a 23-gene expression profiling (23-GEP) test for distinction from melanoma with the aim of better characterizing the biologic potential of such tumors.

Methods: Twenty BAP-negative melanocytic tumors, subjected to 23-GEP (Myriad Genetic Laboratories, Inc. [Salt Lake City, Utah]) testing, were retrospectively analyzed.

Results: Tumors exhibited varying degrees of atypia and aberrant immunohistochemical profiles. 23-GEP testing revealed a "malignant" genetic signature in four cases, a "benign" signature in 15 cases, and an "indeterminate" signature in one case. Array-based comparative genomic hybridization (aCGH) testing was performed for two cases with a "malignant" 23-GEP signature, but the aCGH result conflicted with 23-GEP, and supported benignity. Conversely, in one case with a "benign" 23-GEP result, aCGH testing supported assessment as melanoma. Moreover, evolving melanoma could not be wholly excluded by histopathological analysis in 2 "benign" cases.

Conclusions: BAP-negative melanocytic tumors remain a diagnostic dilemma for dermatopathologists. A widely marketed 23-GEP test may not be useful in distinguishing these tumors from spitzoid melanoma, at least in comparison to aCGH technology.
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http://dx.doi.org/10.1111/cup.13277DOI Listing
May 2018

Stewart-Treves syndrome in a spinal cord injury patient with amplification.

JAAD Case Rep 2017 Nov 6;3(6):515-518. Epub 2017 Nov 6.

Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2017.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729014PMC
November 2017

Inter-annual variation in the density of anthropogenic debris in the Tasman Sea.

Mar Pollut Bull 2017 Nov 8;124(1):51-55. Epub 2017 Jul 8.

Australian Nuclear Science and Technology Organisation (ANSTO), Life Sciences Division Bioanalytics Group, Lucas Heights, New South Wales 2234, Australia.

An increasing number of studies highlight the risk of plastic pollution in the marine environment. However, systematic longitudinal data on the distribution and abundance of plastic debris remain sparse. Here we present the results of a two-year study of plastic pollution within the Tasman Sea, contrasted with a further year of data from the same region, in order to document how the density of debris varies across years in this area. Surface net tows were collected between Hobart, Tasmania and Sydney, Australia during the spring of 2013 and 2014 and compared with a subset of data from autumn 2012 from the same region. Substantial inter-annual variation in mean plastic abundance was observed over the three year period, ranging from to 248.04-3711.64pieceskm, confirming the need for multiple years of sampling to fully estimate the extent of, and trends in, plastic pollution.
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http://dx.doi.org/10.1016/j.marpolbul.2017.07.010DOI Listing
November 2017