Andrew F Quest

Andrew F Quest

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AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells.

Cancers (Basel) 2019 Sep 3;11(9). Epub 2019 Sep 3.

Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences and Faculty of Medicine, University of Chile, Santiago 8380000, Chile.

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http://dx.doi.org/10.3390/cancers11091299DOI Listing
September 2019

A Novel Role for Gamma-Glutamyltranspeptidase in Regulating Autophagy and Bacterial Internalization in Human Gastric Cells.

Cancers (Basel) 2019 Jun 10;11(6). Epub 2019 Jun 10.

Laboratory of Cellular Communication, Center for the Study of Exercise, Metabolism and Cancer (CEMC), Program in Cell and Molecular Biology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.

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http://dx.doi.org/10.3390/cancers11060801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627848PMC
June 2019

Curcumin-loaded nanoemulsion: a new safe and effective formulation to prevent tumor reincidence and metastasis.

Nanoscale 2018 Dec 28;10(47):22612-22622. Epub 2018 Nov 28.

Laboratory of Cellular Communication, Program of Cell and Molecular Biology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Av. Independencia 1027, Santiago 8380453, Chile.

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http://dx.doi.org/10.1039/c8nr06173dDOI Listing
December 2018

Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients.

Clin Immunol 2018 11 9;196:85-96. Epub 2018 Jun 9.

Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.06.002DOI Listing
November 2018

Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

Free Radic Biol Med 2018 08 30;124:61-78. Epub 2018 May 30.

Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile; Center for Studies of Exercise, Metabolism and Cancer Studies (CEMC), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile; Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.05.084DOI Listing
August 2018

Intracellular Ca Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration.

Int J Mol Sci 2018 Jul 26;19(8). Epub 2018 Jul 26.

Cellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile.

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http://dx.doi.org/10.3390/ijms19082179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121259PMC
July 2018

Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells.

Ther Adv Med Oncol 2018 4;10:1758835918770984. Epub 2018 May 4.

Hospital Clínico Universidad de Chile, Santos Dumont 999, Santiago 8380456, Chile; Laboratory of Endocrinology and Reproductive Biology, Hospital Clínico Universidad de Chile, Santiago, Chile; Obstetrics and Gynecology Department, Medicine School, Universidad de Chile, Santiago, Chile; Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.

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http://dx.doi.org/10.1177/1758835918770984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949935PMC
May 2018

Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins.

Mol Biol Cell 2018 02 6;29(3):326-338. Epub 2017 Dec 6.

Cellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453 Santiago, Chile

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http://dx.doi.org/10.1091/mbc.E17-03-0133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996956PMC
February 2018

Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer.

Oncotarget 2018 Feb 5;9(16):12853-12867. Epub 2018 Feb 5.

Laboratorio de Comunicaciones Celulares, Centro de Estudios en Ejercicio, Metabolismo y Cáncer (CEMC), Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad De Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.18632/oncotarget.24402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849179PMC
February 2018

and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression.

Front Microbiol 2018 22;9. Epub 2018 Jan 22.

Cellular Communication Laboratory, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.3389/fmicb.2018.00005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786524PMC
January 2018

Gastric Cancer: Nanoparticles as Tools to Improve Treatment Efficacy.

Curr Pharm Des 2016 ;22(39):5988-5997

Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. Santos Dumont 964, Independencia, Santiago, Chile.

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http://dx.doi.org/10.2174/1381612822666160712165409DOI Listing
December 2017

Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1α to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells.

Front Cell Infect Microbiol 2017 28;7:92. Epub 2017 Mar 28.

Laboratorio de Comunicaciones Celulares, Facultad De Medicina, Centro de Estudios Moleculares De la Célula, Centro de Estudios Avanzados en Enfermedades Crónicas, Programa De Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Universidad de Chile Santiago, Chile.

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http://dx.doi.org/10.3389/fcimb.2017.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368181PMC
December 2017

Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells.

Oncotarget 2017 Dec 5;8(67):111943-111965. Epub 2017 Dec 5.

Cellular Communication Laboratory, Center for Molecular Studies of the Cell (CEMC), Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.18632/oncotarget.22955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762371PMC
December 2017

Infection Is Associated with Decreased Expression of SLC5A8, a Cancer Suppressor Gene, in Young Children.

Front Cell Infect Microbiol 2016 10;6:121. Epub 2016 Oct 10.

Center for Molecular Studies of the Cell (CEMC), Faculty of Medicine, University of ChileSantiago, Chile; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, University of ChileSantiago, Chile.

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http://dx.doi.org/10.3389/fcimb.2016.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056170PMC
September 2017

αβ Integrin regulates astrocyte reactivity.

J Neuroinflammation 2017 Sep 29;14(1):194. Epub 2017 Sep 29.

Cellular Communication Laboratory, Programme of Cellular & Molecular Biology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453, Santiago, Chile.

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http://dx.doi.org/10.1186/s12974-017-0968-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622429PMC
September 2017

Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology.

Nat Rev Cardiol 2017 06 9;14(6):342-360. Epub 2017 Mar 9.

Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas &Facultad de Medicina, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile.

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http://dx.doi.org/10.1038/nrcardio.2017.23DOI Listing
June 2017

Calcium Transport and Signaling in Mitochondria.

Compr Physiol 2017 03 16;7(2):623-634. Epub 2017 Mar 16.

Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1002/cphy.c160013DOI Listing
March 2017

Pro-inflammatory cytokines enhance ERAD and ATF6α pathway activity in salivary glands of Sjögren's syndrome patients.

J Autoimmun 2016 Dec 25;75:68-81. Epub 2016 Jul 25.

Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.07.006DOI Listing
December 2016

mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling.

Sci Rep 2016 11 3;6:36394. Epub 2016 Nov 3.

Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences &Faculty of Medicine, University of Chile, Santiago, 8380492, Chile.

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http://dx.doi.org/10.1038/srep36394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093439PMC
November 2016

Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration.

Biochim Biophys Acta 2016 09 25;1863(9):2175-88. Epub 2016 May 25.

Cellular Communication Laboratory, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453 Santiago, Chile; Advanced Center for Chronic Diseases, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453 Santiago, Chile; Biomedical Neuroscience Institute, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453 Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.05.018DOI Listing
September 2016

Therapeutic targeting of autophagy in myocardial infarction and heart failure.

Expert Rev Cardiovasc Ther 2016 Sep 28;14(9):1007-19. Epub 2016 Jun 28.

a Advanced Center for Chronic Disease (ACCDiS) & Center for Molecular Studies of the Cell (CEMC), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina , Universidad de Chile , Santiago , Chile.

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http://dx.doi.org/10.1080/14779072.2016.1202760DOI Listing
September 2016

Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer.

Curr Pharm Des 2015 ;21(29):4145-54

Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile. Santos Dumont 964, Independencia, Santiago, Chile.

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http://dx.doi.org/10.2174/1381612821666150901095538DOI Listing
August 2016

Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis.

Oncotarget 2016 May;7(20):29548-62

Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.18632/oncotarget.8794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045416PMC
May 2016

Regulation of cardiomyocyte autophagy by calcium.

Am J Physiol Endocrinol Metab 2016 Apr 16;310(8):E587-E596. Epub 2016 Feb 16.

Advanced Center for Chronic Disease and Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas and Facultad de Medicina, Universidad de Chile, Santiago, Chile;

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http://dx.doi.org/10.1152/ajpendo.00374.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835942PMC
April 2016

Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis.

Cancer Lett 2016 Mar 21;372(1):10-23. Epub 2015 Dec 21.

Laboratory of Cell Cycle and Cytoskeleton, Instituto de Histología y Embriología Dr. M. H. Burgos (IHEM-CONICET, Mendoza, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.12.004DOI Listing
March 2016

Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis.

World J Gastroenterol 2015 Dec;21(45):12742-56

Manuel A Valenzuela, Jimena Canales, Andrew FG Quest, Laboratorio de Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula, Programa de Biología Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.

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http://dx.doi.org/10.3748/wjg.v21.i45.12742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671030PMC
December 2015

ER-to-mitochondria miscommunication and metabolic diseases.

Biochim Biophys Acta 2015 Oct 11;1852(10 Pt A):2096-105. Epub 2015 Jul 11.

Advanced Center for Chronic Diseases (ACCDiS), Center for Molecular Studies of the Cell (CEMC), Faculty of Chemical & Pharmaceutical Sciences, Faculty of Medicine, University of Chile, Santiago 8380492, Chile; Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX 75235, USA; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.07.011DOI Listing
October 2015

Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation.

Biochem Biophys Res Commun 2015 Aug 10;464(2):642-6. Epub 2015 Jul 10.

Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.06.176DOI Listing
August 2015

Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia severity.

Curr Alzheimer Res 2014 ;11(9):892-8

Departamento de Neurologia y Neurocirugia, Hospital Clinico Universidad de Chile, Santos Dumont 999, Independencia, Santiago de Chile. CP: 8380430.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378649PMC
July 2015

Tumor suppression and promotion by autophagy.

Biomed Res Int 2014 18;2014:603980. Epub 2014 Sep 18.

Laboratory of Cellular Communication, Advanced Center for Chronic Diseases (ACCDiS) and Center for Molecular Studies of the Cell, Program in Cell and Molecular Biology, Biomedical Sciences Institute (ICBM), Faculty of Medicine, University of Chile, 8380492 Santiago, Chile.

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http://dx.doi.org/10.1155/2014/603980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189854PMC
June 2015

Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells.

Biochim Biophys Acta 2015 May 5;1852(5):693-708. Epub 2015 Jan 5.

Laboratory of Cellular Communication, Center for Molecular Studies of the Cell (CEMC), Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Santiago de Chile, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.12.021DOI Listing
May 2015

Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins.

Front Physiol 2015 10;6:105. Epub 2015 Apr 10.

Physiology and Biophysics Program, Institute of Biomedical Sciences, School of Medicine, University of Chile Santiago, Chile ; Biomedical Neuroscience Institute, School of Medicine, University of Chile Santiago, Chile ; Center for Molecular Studies of the Cell, School of Medicine, University of Chile Santiago, Chile.

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http://dx.doi.org/10.3389/fphys.2015.00105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392612PMC
April 2015

Thy-1-interacting molecules and cellular signaling in cis and trans.

Int Rev Cell Mol Biol 2013 ;305:163-216

Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany.

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http://dx.doi.org/10.1016/B978-0-12-407695-2.00004-4DOI Listing
September 2014

Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion.

J Cell Sci 2014 Jun 21;127(Pt 11):2401-6. Epub 2014 Mar 21.

Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Calle Sergio Livingstone 943, Santiago, Chile Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.141689
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http://dx.doi.org/10.1242/jcs.141689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074264PMC
June 2014

Organelle communication: signaling crossroads between homeostasis and disease.

Int J Biochem Cell Biol 2014 May 15;50:55-9. Epub 2014 Feb 15.

Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile; Instituto Ciencias Biomedicas, Facultad Medicina, Universidad de Chile, Santiago 8380492, Chile; Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX 75235, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.01.019DOI Listing
May 2014

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models.

Melanoma Res 2014 Apr;24(2):108-19

aCellular Communication Laboratory, Center for Molecular Studies of the Cell (CEMC), Advanced Center for Chronic Diseases (ACCDiS), School of Medicine, Universidad de Chile bDepartment of Surgery, Hospital Clinico Universidad de Chile cAndes Biotechnologies, Fundación Ciencias y Vida dSchool of Biological Sciences, Universidad Andres Bello, Santiago, Chile eDivision of Biomedical Sciences, St. George's, University of London, London, UK fFreie Universität Berlin - Institut für Pharmakologie, Berlin, Germany.

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http://dx.doi.org/10.1097/CMR.0000000000000046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999137PMC
April 2014

Editorial: Signaling in cell migration and disease.

Curr Mol Med 2014 Feb;14(2):197-8

Independencia 1027, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.2174/156652401402140207163024DOI Listing
February 2014

Helicobacter pylori-induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma-glutamyl transpeptidase activity.

J Infect Dis 2013 Oct 11;208(7):1131-41. Epub 2013 Jul 11.

Laboratory of Cellular Communication, Center for Molecular Studies of the Cell, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1093/infdis/jit286DOI Listing
October 2013

Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells.

J Cell Sci 2013 Sep 26;126(Pt 17):3835-47. Epub 2013 Jun 26.

Department of Basic and Communitarian Sciences, Faculty of Dentistry, Universidad de Chile, Santiago 8380-492, Chile.

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http://dx.doi.org/10.1242/jcs.119727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074302PMC
September 2013

Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death.

Biochim Biophys Acta 2013 Aug 16;1832(8):1334-44. Epub 2013 Apr 16.

Centro de Estudios Moleculares de la Célula, Facultad de Ciencias Químicas y Farmacéuticas & Facultad Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.bbadis.2013.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118291PMC
August 2013

E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells.

Pigment Cell Melanoma Res 2013 Jul 11;26(4):555-70. Epub 2013 Apr 11.

Laboratorio de Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula (CEMC), Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1111/pcmr.12085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695072PMC
July 2013

FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X(7).

J Cell Physiol 2013 Feb;228(2):485-93

Centro de Estudios Moleculares de la Célula, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1002/jcp.24159DOI Listing
February 2013

Biomimetic, mild chemical synthesis of CdTe-GSH quantum dots with improved biocompatibility.

PLoS One 2012 23;7(1):e30741. Epub 2012 Jan 23.

Laboratorio de Microbiología Molecular, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030741PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264638PMC
June 2012

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics.

Int J Biochem Cell Biol 2012 Jan 2;44(1):16-20. Epub 2011 Nov 2.

Centro Estudios Moleculares de la Celula, Facultad Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.biocel.2011.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118286PMC
January 2012

Progesterone utilizes distinct membrane pools of tissue factor to increase coagulation and invasion and these effects are inhibited by TFPI.

J Cell Physiol 2011 Dec;226(12):3278-85

Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile.

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http://dx.doi.org/10.1002/jcp.22689DOI Listing
December 2011

Is survivin the potential Achilles' heel of cancer?

Adv Cancer Res 2011 ;111:1-37

Laboratory of Gene Immunotherapy, Fundacion Ciencia para la Vida, Santiago, Chile.

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http://dx.doi.org/10.1016/B978-0-12-385524-4.00001-5DOI Listing
October 2011

Age-dependent increases in apoptosis/necrosis ratios in human lymphocytes exposed to oxidative stress.

J Gerontol A Biol Sci Med Sci 2011 Jul 15;66(7):732-40. Epub 2011 Apr 15.

Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Independencia, CP.

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http://dx.doi.org/10.1093/gerona/glr039DOI Listing
July 2011

TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway.

J Cell Physiol 2011 Jan;226(1):103-9

Centro de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://doi.wiley.com/10.1002/jcp.22310
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http://dx.doi.org/10.1002/jcp.22310DOI Listing
January 2011

Helicobacter pylori-induced loss of the inhibitor-of-apoptosis protein survivin is linked to gastritis and death of human gastric cells.

J Infect Dis 2010 Oct;202(7):1021-30

Laboratory of Cellular Communication, Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Facultad de Medicina, Instituto de Ciencias Biomédicas, Universidad de Chile, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1086/656143DOI Listing
October 2010

Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection against mouse melanoma.

Cancer Immunol Immunother 2010 Jan 14;59(1):81-92. Epub 2009 Jun 14.

Immune and Gene Therapy Laboratory, Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00262-009-0725-4
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http://dx.doi.org/10.1007/s00262-009-0725-4DOI Listing
January 2010

Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression.

Mol Biol Cell 2009 Apr 25;20(8):2297-310. Epub 2009 Feb 25.

Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Departmento de Cirugía, Hospital Clínico, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1091/mbc.e08-09-0939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669036PMC
April 2009

Caveolin-1: an ambiguous partner in cell signalling and cancer.

J Cell Mol Med 2008 Aug 8;12(4):1130-50. Epub 2008 Apr 8.

FONDAP Centre for Molecular Studies of the Cell, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1111/j.1582-4934.2008.00331.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865655PMC
August 2008

Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication.

Biochim Biophys Acta 2008 Jun 20;1783(6):1111-20. Epub 2008 Feb 20.

Program of Cell and Molecular Biology, FONDAP, Center for Molecular Studies of the Cell (CEMC), Institute of Biomedical Sciences (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.bbamcr.2008.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587321PMC
June 2008

Cell death by necrosis, a regulated way to go.

Curr Mol Med 2008 May;8(3):187-206

Centro FONDAP de Estudios Moleculares de la Célula (CEMC), Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.2174/156652408784221289DOI Listing
May 2008

Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells.

Free Radic Biol Med 2008 Mar 23;44(6):1146-60. Epub 2007 Dec 23.

Centro FONDAP Estudios Moleculares de la Celula (CEMC), Instituto Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.12.017DOI Listing
March 2008

E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription.

Mol Cell Biol 2007 Nov 4;27(21):7703-17. Epub 2007 Sep 4.

FONDAP Center for Molecular Studies of the Cell, Facultad de Medicina, Universidad de Chile, Av. Independencia 1027, Santiago, Chile.

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http://dx.doi.org/10.1128/MCB.01991-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169068PMC
November 2007

Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin.

J Cell Sci 2006 May 11;119(Pt 9):1812-23. Epub 2006 Apr 11.

Laboratory of Cellular Communications, FONDAP Center for Molecular Studies of the Cell (CEMC), Facultad de Medicina, Universidad de Chile, Av. Independencia 1027, Santiago, Chile.

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http://dx.doi.org/10.1242/jcs.02894DOI Listing
May 2006

Beyond apoptosis: nonapoptotic cell death in physiology and disease.

Biochem Cell Biol 2005 Oct;83(5):579-88

Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1139/o05-065DOI Listing
October 2005

Tissue factor is regulated by epidermal growth factor in normal and malignant human endometrial epithelial cells.

Thromb Haemost 2005 Aug;94(2):444-53

Departamento de Endocrinología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago.

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http://dx.doi.org/10.1160/TH05-01-0066DOI Listing
August 2005

Supramolecular complex formation in cell signaling and disease: an update on a recurrent theme in cell life and death.

Biol Res 2004 ;37(1):29-43

Program of Morphology, FONDAP Center for Molecular Studies of the Cell (CEMC)-ICBM (Instituto de Ciencias Biomédicas)-Faculty of Medicine, University of Chile.

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http://dx.doi.org/10.4067/s0716-97602004000100004DOI Listing
September 2004

Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes.

J Biol Chem 2004 Sep 25;279(37):39139-45. Epub 2004 Jun 25.

Programs of Morphology and Cell and Molecular Biology, FONDAP Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027-A, Santiago, Chile.

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http://dx.doi.org/10.1074/jbc.M403439200DOI Listing
September 2004

Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase Calpha.

J Biol Chem 2004 Sep 19;279(37):39122-31. Epub 2004 Jul 19.

Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 7, Chile.

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http://dx.doi.org/10.1074/jbc.M401044200DOI Listing
September 2004

Cell volume regulation in response to hypotonicity is impaired in HeLa cells expressing a protein kinase Calpha mutant lacking kinase activity.

J Biol Chem 2004 Apr 11;279(17):17681-9. Epub 2004 Feb 11.

Instituto de Ciencias Biomédicas and Centro de Estudios Moleculares de la Célula Facultad de Medicina, Universidad de Chile, Santiago 6530499, Santiago, Chile.

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http://dx.doi.org/10.1074/jbc.M304506200DOI Listing
April 2004

Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease.

Biochem Cell Biol 2004 Feb;82(1):129-44

Centro FONDAP de Estudios Molecualrs de la Célula, Programa de Biología Celular y Molecular, Universidad de Chile, Indepencia 1027, Santiago, Chile.

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http://dx.doi.org/10.1139/o03-071DOI Listing
February 2004

Introduction to supramolecular complex formation in cell signaling and disease.

Biol Res 2002 ;35(2):117-25

Program of Morphology, Laboratory of Cellular Communication, ICBM (Instituto de Ciencias Biomédicas)-Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile.

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http://dx.doi.org/10.4067/s0716-97602002000200002DOI Listing
February 2003

Caveolae and caveolae-like membrane domains in cellular signaling and disease: identification of downstream targets for the tumor suppressor protein caveolin-1.

Biol Res 2002 ;35(2):151-67

Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 7, Chile.

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http://dx.doi.org/10.4067/s0716-97602002000200006DOI Listing
February 2003

Caveolin-1-mediated post-transcriptional regulation of inducible nitric oxide synthase in human colon carcinoma cells.

Biol Res 2002 ;35(2):169-76

Institute of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.4067/s0716-97602002000200007DOI Listing
February 2003

Signaling triggered by Thy-1 interaction with beta 3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function.

Biol Res 2002 ;35(2):231-8

Program of Morphology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile.

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http://dx.doi.org/10.4067/s0716-97602002000200015DOI Listing
February 2003

Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase.

J Cell Sci 2002 Dec;115(Pt 23):4671-83

Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1242/jcs.00153DOI Listing
December 2002