Andrew F Hill

Andrew F Hill

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Extracellular Vesicles and Neurodegenerative Diseases.

Authors:
Andrew F Hill

J Neurosci 2019 Nov;39(47):9269-9273

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria 3086, Australia

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http://dx.doi.org/10.1523/JNEUROSCI.0147-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867808PMC
November 2019

Novel miR-29b target regulation patterns are revealed in two different cell lines.

Sci Rep 2019 Nov 25;9(1):17449. Epub 2019 Nov 25.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.

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http://dx.doi.org/10.1038/s41598-019-53868-xDOI Listing
November 2019

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity.

Mol Neurobiol 2019 Aug 5;56(8):5471-5482. Epub 2019 Jan 5.

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1007/s12035-018-1460-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614131PMC
August 2019

The role of lipids in α-synuclein misfolding and neurotoxicity.

J Biol Chem 2019 Jun 7;294(23):9016-9028. Epub 2019 May 7.

From the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria 3086, Australia,

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http://dx.doi.org/10.1074/jbc.REV119.007500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556586PMC
June 2019

Announcing the ISEV2019 special achievement award recipients: Takahiro Ochiya and Marca Wauben.

J Extracell Vesicles 2019 22;8(1):1620080. Epub 2019 May 22.

Department of Cellular and Molecular Biology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

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http://dx.doi.org/10.1080/20013078.2019.1620080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534244PMC
May 2019

Proteomic and Post-Translational Modification Profiling of Exosome-Mimetic Nanovesicles Compared to Exosomes.

Proteomics 2019 04 3;19(8):e1800161. Epub 2019 Apr 3.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Victoria, 3086, Australia.

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http://doi.wiley.com/10.1002/pmic.201800161
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http://dx.doi.org/10.1002/pmic.201800161DOI Listing
April 2019

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth.

Mol Neurobiol 2019 Jan 19;56(1):13-28. Epub 2018 Apr 19.

Department of Pathology, The University of Melbourne, Melbourne, VIC, 3010, Australia.

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http://dx.doi.org/10.1007/s12035-018-1070-4DOI Listing
January 2019

Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies.

ACS Chem Neurosci 2018 11 3;9(11):2731-2740. Epub 2018 Jul 3.

Florey Institute of Neuroscience and Mental Health , Parkville, Melbourne , Victoria 3052 , Australia.

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http://dx.doi.org/10.1021/acschemneuro.8b00161DOI Listing
November 2018

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018

Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey.

J Extracell Vesicles 2018 24;7(1):1535745. Epub 2018 Oct 24.

Departments of Molecular and Comparative Pathobiology and Neurology, The John Hopkins University School of Medicine, Baltimore, USA.

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201809PMC
October 2018

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease.

Acta Neuropathol Commun 2018 07 5;6(1):57. Epub 2018 Jul 5.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3010, Australia.

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http://dx.doi.org/10.1186/s40478-018-0560-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032546PMC
July 2018

Outer Membrane Vesicle Size Determines Their Mechanisms of Host Cell Entry and Protein Content.

Front Immunol 2018 2;9:1466. Epub 2018 Jul 2.

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Melbourne, VIC, Australia.

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http://dx.doi.org/10.3389/fimmu.2018.01466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036113PMC
July 2018

Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography.

J Extracell Vesicles 2018 26;7(1):1490145. Epub 2018 Jun 26.

Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1080/20013078.2018.1490145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022248PMC
June 2018

Analysis of miRNA Signatures in Neurodegenerative Prion Disease.

Methods Mol Biol 2017 ;1658:67-80

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-7244-9_6DOI Listing
May 2018

Generation of Infectious Prions and Detection with the Prion-Infected Cell Assay.

Methods Mol Biol 2017 ;1658:105-118

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-7244-9_9DOI Listing
May 2018

Exosomes and their role in the intercellular trafficking of normal and disease associated prion proteins.

Mol Aspects Med 2018 04 8;60:62-68. Epub 2017 Dec 8.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2017.11.011DOI Listing
April 2018

Quantitative Analysis of Exosomal miRNA via qPCR and Digital PCR.

Methods Mol Biol 2017 ;1545:55-70

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-6728-5_5DOI Listing
February 2018

Small RNA Library Construction for Exosomal RNA from Biological Samples for the Ion Torrent PGM™ and Ion S5™ System.

Methods Mol Biol 2017 ;1545:71-90

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-6728-5_6DOI Listing
February 2018

Intercellular Resistance to BRAF Inhibition Can Be Mediated by Extracellular Vesicle-Associated PDGFRβ.

Neoplasia 2017 Nov 28;19(11):932-940. Epub 2017 Sep 28.

Olivia Newton-John Cancer Research Institute, Level 5 Olivia Newton-John Cancer and Wellness Centre, Austin Health, Studley Road, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Heidelberg, VIC 3084, Heidelberg.

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http://dx.doi.org/10.1016/j.neo.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678363PMC
November 2017

Review: Extracellular Vesicles in Joint Inflammation.

Arthritis Rheumatol 2017 07 5;69(7):1350-1362. Epub 2017 Jun 5.

Murdoch Childrens Research Institute and The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/art.40076DOI Listing
July 2017

BRAF inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells.

Proc Natl Acad Sci U S A 2017 07 6;114(29):E5930-E5939. Epub 2017 Jul 6.

Krefting Research Center, Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 405 30, Sweden;

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http://dx.doi.org/10.1073/pnas.1705206114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530690PMC
July 2017

A rigorous method to enrich for exosomes from brain tissue.

J Extracell Vesicles 2017 26;6(1):1348885. Epub 2017 Jul 26.

Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1080/20013078.2017.1348885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533148PMC
July 2017

Methodological Guidelines to Study Extracellular Vesicles.

Circ Res 2017 May;120(10):1632-1648

From the Biomedical Engineering and Physics (F.A.W.C., T.G.v.L., E.v.d.P.), Vesicle Observation Centre (F.A.W.C., A.G., T.G.v.L., E.v.d.P., G.S., R.N.), and Laboratory of Experimental Clinical Chemistry (A.G., G.S., R.N.), Academic Medical Center, University of Amsterdam, The Netherlands; Extracellular Vesicles and Membrane Repair, UMR-5248-CBMN CNRS, University of Bordeaux, IPB, Pessac, France (A.R.B.); Department of Genetics, Cell- and Immunobology, Semmelweis University, Budapest, Hungary (E.I.B.); VRCM, UMRS-1076, INSERM, Aix-Marseille University, UFR de Pharmacie, Marseille, France (F.D.-G., R.L.); Haematology and vascular biology department, CHU La Conception, APHM, Marseille, France (F.D.-G., R.L.); Exosomes Research Group, Department of Pathology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands (E.E.E.D., D.M.P.); Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden (S.E.-A., Y.L.); Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom (S.E.-A., I.M.); Bristol Heart Institute, University of Bristol, United Kingdom (C.E.); National Heart & Lung Institute, Imperial College London, United Kingdom (C.E.); 1st Chair and Department of Cardiology, Medical University of Warsaw, Poland (A.G.); Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Belgium (A.H., O.d.W.); Cancer Research Institute Ghent, Belgium (A.H., O.d.W.); Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia (A.F.H.); Department of Medicine, University of North Carolina at Chapel Hill (N.M.); Institute of Technology, University of Tartu, Estonia (I.M.); Scintillon Institute, San Diego, CA (J.P.N.); Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY (S.S.); and EV Core Facility, University of Helsinki and EV-Group, Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, Finland (P.R.M.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.309417DOI Listing
May 2017

The role of extracellular vesicles in neurodegenerative diseases.

Biochem Biophys Res Commun 2017 02 19;483(4):1178-1186. Epub 2016 Sep 19.

Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3052, Australia; Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Bundoora, Victoria 3086, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.09.090DOI Listing
February 2017

Defining the purity of exosomes required for diagnostic profiling of small RNA suitable for biomarker discovery.

RNA Biol 2017 02 22;14(2):245-258. Epub 2016 Dec 22.

b Department of Biochemistry and Genetics , La Trobe Institute for Molecular Science, La Trobe University , VIC , Australia.

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http://dx.doi.org/10.1080/15476286.2016.1270005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324750PMC
February 2017

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.

Authors:
Jan Van Deun Pieter Mestdagh Patrizia Agostinis Özden Akay Sushma Anand Jasper Anckaert Zoraida Andreu Martinez Tine Baetens Els Beghein Laurence Bertier Geert Berx Janneke Boere Stephanie Boukouris Michel Bremer Dominik Buschmann James B Byrd Clara Casert Lesley Cheng Anna Cmoch Delphine Daveloose Eva De Smedt Seyma Demirsoy Victoria Depoorter Bert Dhondt Tom A P Driedonks Aleksandra Dudek Abdou Elsharawy Ilaria Floris Andrew D Foers Kathrin Gärtner Abhishek D Garg Edward Geeurickx Jan Gettemans Farzaneh Ghazavi Bernd Giebel Tom Groot Kormelink Grace Hancock Hetty Helsmoortel Andrew F Hill Vincent Hyenne Hina Kalra David Kim Joanna Kowal Sandra Kraemer Petra Leidinger Carina Leonelli Yaxuan Liang Lien Lippens Shu Liu Alessandra Lo Cicero Shaun Martin Suresh Mathivanan Prabhu Mathiyalagan Támas Matusek Gloria Milani Marta Monguió-Tortajada Liselot M Mus Dillon C Muth Andrea Németh Esther N M Nolte-'t Hoen Lorraine O'Driscoll Roberta Palmulli Michael W Pfaffl Bjarke Primdal-Bengtson Erminia Romano Quentin Rousseau Susmita Sahoo Natalia Sampaio Monisha Samuel Benjamin Scicluna Bieke Soen Anneleen Steels Johannes V Swinnen Maarit Takatalo Safia Thaminy Clotilde Théry Joeri Tulkens Isabel Van Audenhove Susanne van der Grein Alan Van Goethem Martijn J van Herwijnen Guillaume Van Niel Nadine Van Roy Alexander R Van Vliet Niels Vandamme Suzanne Vanhauwaert Glenn Vergauwen Frederik Verweij Annelynn Wallaert Marca Wauben Kenneth W Witwer Marijke I Zonneveld Olivier De Wever Jo Vandesompele An Hendrix

Nat Methods 2017 02;14(3):228-232

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1038/nmeth.4185DOI Listing
February 2017

Exosomes in the Pathology of Neurodegenerative Diseases.

J Biol Chem 2016 Dec 16;291(52):26589-26597. Epub 2016 Nov 16.

the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria 3086, Australia

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http://www.jbc.org/lookup/doi/10.1074/jbc.R116.757955
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http://dx.doi.org/10.1074/jbc.R116.757955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207170PMC
December 2016

Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.

J Neurochem 2016 10 15;139(2):162-180. Epub 2016 Sep 15.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Vic., Australia.

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http://doi.wiley.com/10.1111/jnc.13772
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http://dx.doi.org/10.1111/jnc.13772DOI Listing
October 2016

Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey.

J Extracell Vesicles 2016 31;5:32945. Epub 2016 Oct 31.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090131PMC
http://dx.doi.org/10.3402/jev.v5.32945DOI Listing
October 2016

Extracellular vesicles: interneural shuttles of complex messages.

Curr Opin Neurobiol 2016 08 13;39:101-7. Epub 2016 May 13.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2016.04.016DOI Listing
August 2016

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.

Cell Mol Neurobiol 2016 Apr 23;36(3):377-81. Epub 2016 Feb 23.

Department of Medicine, Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.

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http://link.springer.com/10.1007/s10571-015-0294-3
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http://dx.doi.org/10.1007/s10571-015-0294-3DOI Listing
April 2016

Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions.

J Biol Chem 2016 Mar 14;291(10):5128-37. Epub 2016 Jan 14.

From the Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria 3010, Australia and the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia

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http://dx.doi.org/10.1074/jbc.M115.684258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777847PMC
March 2016

Gene dysregulation is restored in the Parkinson's disease MPTP neurotoxic mice model upon treatment of the therapeutic drug Cu(II)(atsm).

Sci Rep 2016 Mar 1;6:22398. Epub 2016 Mar 1.

Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Victoria, 3010, Australia.

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http://dx.doi.org/10.1038/srep22398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772163PMC
March 2016

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's Disease.

Int J Mol Sci 2016 Feb 6;17(2):173. Epub 2016 Feb 6.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3083, Australia.

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http://dx.doi.org/10.3390/ijms17020173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783907PMC
February 2016

Lipid metabolism in patients infected with Nef-deficient HIV-1 strain.

Atherosclerosis 2016 Jan 30;244:22-8. Epub 2015 Oct 30.

Baker IDI Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.10.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698210PMC
January 2016

Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation.

Nat Struct Mol Biol 2015 Dec 16;22(12):1008-15. Epub 2015 Nov 16.

Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/nsmb.3127DOI Listing
December 2015

The secret life of extracellular vesicles in metal homeostasis and neurodegeneration.

Biol Cell 2015 Nov 24;107(11):389-418. Epub 2015 Jun 24.

Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1111/boc.201500030DOI Listing
November 2015

iSRAP - a one-touch research tool for rapid profiling of small RNA-seq data.

J Extracell Vesicles 2015 9;4:29454. Epub 2015 Nov 9.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia.

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http://dx.doi.org/10.3402/jev.v4.29454DOI Listing
November 2015

PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning.

Neurobiol Dis 2015 Sep 17;81:176-85. Epub 2015 Feb 17.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.02.008DOI Listing
September 2015

Not a day without microRNA.

Curr Opin Lipidol 2015 Aug;26(4):355-6

aBaker IDI Heart and Diabetes Institute bLa Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/MOL.0000000000000200DOI Listing
August 2015

Extracellular vesicles--Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases.

Semin Cell Dev Biol 2015 Apr 20;40:89-96. Epub 2015 Feb 20.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2015.02.007DOI Listing
April 2015

EVpedia: a community web portal for extracellular vesicles research.

Bioinformatics 2015 Mar 10;31(6):933-9. Epub 2014 Nov 10.

Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Section of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, NY, USA, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, USA, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, INSERM, UMR837 JEAN-PIERRE Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, BIO21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, UK, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, MA, USA, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai M

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http://bioinformatics.oxfordjournals.org/content/31/6/933.fu
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http://dx.doi.org/10.1093/bioinformatics/btu741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375401PMC
March 2015

The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes.

J Biol Chem 2015 Feb 10;290(6):3455-67. Epub 2014 Dec 10.

From the Department of Biochemistry and Molecular Biology, The University of Melbourne, VIC 3010, Australia and the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia

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http://dx.doi.org/10.1074/jbc.M114.605253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319014PMC
February 2015

Dual role of Src kinase in governing neuronal survival.

Brain Res 2015 Jan 31;1594:1-14. Epub 2014 Oct 31.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville 3010, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2014.10.040DOI Listing
January 2015

Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine.

Kidney Int 2014 Aug 18;86(2):433-44. Epub 2013 Dec 18.

1] Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia [2] Bio21 Molecular Science and Biotechnology Institute, Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/ki.2013.502DOI Listing
August 2014

C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to α-cleavage.

Biochem J 2014 Apr;459(1):103-15

§Mental Health Research Institute, University of Melbourne, Parkville, VIC 3010, Australia.

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http://dx.doi.org/10.1042/BJ20131378DOI Listing
April 2014

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell.

J Biol Chem 2014 Mar 14;289(10):6669-80. Epub 2014 Jan 14.

From the Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, and.

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http://dx.doi.org/10.1074/jbc.M113.520189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945328PMC
March 2014

Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood.

J Extracell Vesicles 2014 26;3. Epub 2014 Mar 26.

Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia ; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.3402/jev.v3.23743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968297PMC
March 2014

ISEV position paper: extracellular vesicle RNA analysis and bioinformatics.

J Extracell Vesicles 2013 23;2. Epub 2013 Dec 23.

Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.3402/jev.v2i0.22859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873759PMC
December 2013

Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis.

Traffic 2013 Sep 8;14(9):997-1013. Epub 2013 Jul 8.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.

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http://dx.doi.org/10.1111/tra.12088DOI Listing
September 2013

The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies.

Front Genet 2013 8;4:150. Epub 2013 Aug 8.

Department of Biochemistry and Molecular Biology, The University of Melbourne Melbourne, VIC, Australia ; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne Melbourne, VIC, Australia.

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http://dx.doi.org/10.3389/fgene.2013.00150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737441PMC
August 2013

Polyglutamine aggregation in Huntington and related diseases.

Adv Exp Med Biol 2012 ;769:125-40

Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1007/978-1-4614-5434-2_8DOI Listing
June 2013

Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles.

Cell 2013 May 15;153(5):1120-33. Epub 2013 May 15.

Division of Infection and Immunity, the Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.cell.2013.04.029DOI Listing
May 2013

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.

J Biol Chem 2013 Apr 11;288(14):9696-709. Epub 2013 Feb 11.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1074/jbc.M112.419713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617272PMC
April 2013

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells.

Nucleic Acids Res 2012 Nov 10;40(21):10937-49. Epub 2012 Sep 10.

Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1093/nar/gks832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505968PMC
November 2012

Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?

Front Physiol 2012 3;3:124. Epub 2012 May 3.

Department of Biochemistry and Molecular Biology, The University of Melbourne Melbourne, VIC 3010, Australia.

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http://dx.doi.org/10.3389/fphys.2012.00124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342525PMC
October 2012

Prion-infected cells regulate the release of exosomes with distinct ultrastructural features.

FASEB J 2012 Oct 5;26(10):4160-73. Epub 2012 Jul 5.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville Victoria 3010, Australia.

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http://dx.doi.org/10.1096/fj.11-202077DOI Listing
October 2012

Both IFN-γ and IL-17 are required for the development of severe autoimmune gastritis.

Eur J Immunol 2012 Oct 15;42(10):2574-83. Epub 2012 Aug 15.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/eji.201142341DOI Listing
October 2012

The prion protein preference of sporadic Creutzfeldt-Jakob disease subtypes.

J Biol Chem 2012 Oct 28;287(43):36465-72. Epub 2012 Aug 28.

Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1074/jbc.M112.368803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476312PMC
October 2012

Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues.

Clin Sci (Lond) 2012 May;122(9):409-19

Illawarra Health and Medical Research Institute, School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia.

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http://dx.doi.org/10.1042/CS20110257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259697PMC
May 2012

Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport.

Exp Cell Res 2012 Mar 5;318(5):464-77. Epub 2012 Jan 5.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.yexcr.2011.12.023DOI Listing
March 2012

An Escherichia coli cell-free system for recombinant protein synthesis on a milligram scale.

Methods Mol Biol 2011 ;752:17-28

St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-60327-223-0_2DOI Listing
October 2011

APP involvement in retinogenesis of mice.

Acta Neuropathol 2011 Mar 27;121(3):351-63. Epub 2010 Oct 27.

Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Paris 6, INSERM, 15 rue de l'Ecole de Médecine, Paris, France.

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http://dx.doi.org/10.1007/s00401-010-0762-2DOI Listing
March 2011

Overview and recent advances in neuropathology. Part 2: Neurodegeneration.

Pathology 2011 Feb;43(2):93-102

Mental Health Research Institute, University of Melbourne, Parkville, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S00313025163304
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http://dx.doi.org/10.1097/PAT.0b013e3283426eeeDOI Listing
February 2011

The brain to gut pathway: a possible route of prion transmission.

Gut 2010 Dec;59(12):1643-51

Department of Pathology, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1136/gut.2010.222620DOI Listing
December 2010

Modulation of amyloid precursor protein processing by synthetic ceramide analogues.

Biochim Biophys Acta 2010 Aug 26;1801(8):887-95. Epub 2010 May 26.

Prince of Wales Medical Research Institute, Randwick, NSW 2031, Australia.

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http://dx.doi.org/10.1016/j.bbalip.2010.05.012DOI Listing
August 2010