Andrew Elia

Andrew Elia

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Andrew Elia

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Endothelin-1-mediated cerebral ischemia in mice: early cellular events and the role of caspase-3.

Apoptosis 2019 08;24(7-8):578-595

Department of Pharmaceutical Sciences, University of Toronto, 144 College St. Rm 962, Toronto, ON, M5S 3M2, Canada.

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http://dx.doi.org/10.1007/s10495-019-01541-zDOI Listing
August 2019

New Directions in the Treatment of Glioblastoma.

Semin Neurol 2018 02 16;38(1):50-61. Epub 2018 Mar 16.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1055/s-0038-1623534DOI Listing
February 2018

Glioblastoma in elderly patients: solid conclusions built on shifting sand?

Neuro Oncol 2018 01;20(2):174-183

Neurology Clinic & German Consortium for Translational Cancer Research (DKTK), Heidelberg University Medical Center & DKFZ, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777484PMC
January 2018

E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.

Proc Natl Acad Sci U S A 2017 02 30;114(7):E1148-E1157. Epub 2017 Jan 30.

The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada;

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http://dx.doi.org/10.1073/pnas.1621355114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320996PMC
February 2017

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Cancer Cell 2016 08 14;30(2):337-348. Epub 2016 Jul 14.

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada; The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022794PMC
August 2016

Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Proc Natl Acad Sci U S A 2016 06 13;113(26):E3676-85. Epub 2016 Jun 13.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605;

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http://dx.doi.org/10.1073/pnas.1525620113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932944PMC
June 2016

Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.

Proc Natl Acad Sci U S A 2016 06 13;113(26):E3667-75. Epub 2016 Jun 13.

Division of Genetics, Department of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1602827113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932963PMC
June 2016

RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.

Mol Cell 2015 Oct;60(2):280-93

Department of Genetics, Harvard Medical School; Division of Genetics, Brigham and Women's Hospital; Howard Hughes Medical Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609029PMC
October 2015

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.

Mol Cell 2015 Sep 4;59(5):867-81. Epub 2015 Jun 4.

Department of Genetics, Harvard Medical School; Division of Genetics, Brigham and Women's Hospital; Howard Hughes Medical Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560960PMC
September 2015

NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis.

PLoS Genet 2015 Mar 13;11(3):e1005029. Epub 2015 Mar 13.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359108PMC
March 2015

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

Cancer Cell 2015 Feb 22;27(2):211-22. Epub 2015 Jan 22.

The Campbell Family Institute for Breast Cancer Research, University Health Network, 620 University Avenue, Toronto, ON M5G 2M9, Canada; Department of Medical Biophysics, University Health Network, 620 University Avenue, Toronto, ON M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.019DOI Listing
February 2015

Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex.

Nat Med 2014 May 20;20(5):484-92. Epub 2014 Apr 20.

1] Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada. [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [3] Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. [4] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. [5] Division of Endocrinology and Metabolism, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nm.3527DOI Listing
May 2014

Largen: a molecular regulator of mammalian cell size control.

Mol Cell 2014 Mar;53(6):904-15

The Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON M5G 2C1, Canada; Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.02.028DOI Listing
March 2014

Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.

Proc Natl Acad Sci U S A 2013 Sep 14;110(36):14723-8. Epub 2013 Aug 14.

Toronto General Research Institute and McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON, Canada M5G 1L7.

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http://dx.doi.org/10.1073/pnas.1303386110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767525PMC
September 2013

A role for PVRL4-driven cell-cell interactions in tumorigenesis.

Elife 2013 Apr 30;2:e00358. Epub 2013 Apr 30.

Department of Genetics , Harvard Medical School , Boston , United States ; Division of Genetics , Howard Hughes Medical Institute, Brigham and Women's Hospital , Boston , United States.

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http://dx.doi.org/10.7554/eLife.00358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641523PMC
April 2013

Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila.

Nat Struct Mol Biol 2013 Feb 6;20(2):202-9. Epub 2013 Jan 6.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.2477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674866PMC
February 2013

2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.

Proc Natl Acad Sci U S A 2012 Dec 3;109(51):21034-9. Epub 2012 Dec 3.

Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada M5G 2C1.

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http://dx.doi.org/10.1073/pnas.1215558110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529073PMC
December 2012

BRCA1 as tumor suppressor: lord without its RING?

Breast Cancer Res 2012 Apr 10;14(2):306. Epub 2012 Apr 10.

Department of Genetics, Harvard Medical School, 77 Ave, Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/bcr3118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446363PMC
April 2012

Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate.

Proc Natl Acad Sci U S A 2011 Jun 31;108(24):9845-50. Epub 2011 May 31.

Division of Genetics, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1106136108
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http://dx.doi.org/10.1073/pnas.1106136108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116415PMC
June 2011

Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.

Proc Natl Acad Sci U S A 2010 Aug 2;107(32):13984-90. Epub 2010 Aug 2.

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada M5G 2C1.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1008136107
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http://dx.doi.org/10.1073/pnas.1008136107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922567PMC
August 2010

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay.

Proc Natl Acad Sci U S A 2010 Jul 21;107(27):12186-91. Epub 2010 Jun 21.

Campbell Family Cancer Research Institute and Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1073/pnas.1007336107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901484PMC
July 2010

Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.

Proc Natl Acad Sci U S A 2010 Feb 1;107(7):2995-3000. Epub 2010 Feb 1.

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1000101107
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http://dx.doi.org/10.1073/pnas.1000101107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840296PMC
February 2010

Stereotactic radiation treatment for benign meningiomas.

Neurosurg Focus 2007 ;23(4):E5

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.3171/FOC-07/10/E5DOI Listing
December 2007

Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.

Proc Natl Acad Sci U S A 2006 Feb 30;103(6):1834-9. Epub 2006 Jan 30.

The Campbell Family Institute for Breast Cancer Research and the Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1.

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http://dx.doi.org/10.1073/pnas.0510847103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413671PMC
February 2006

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis.

Cell 2005 May;121(4):579-591

The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Ontario M5G 2C1, Canada; Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Ontario M5G 2C1, Canada; Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2005.03.016DOI Listing
May 2005

The C2 domain of PKCdelta is a phosphotyrosine binding domain.

Cell 2005 Apr;121(2):271-80

Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cell.2005.02.019DOI Listing
April 2005

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.

Mol Cell 2005 Jan;17(1):37-48

Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.molcel.2004.11.021DOI Listing
January 2005

grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.

Proc Natl Acad Sci U S A 2004 Oct 18;101(43):15358-63. Epub 2004 Oct 18.

Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Room 7-411, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1073/pnas.0406613101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524460PMC
October 2004

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.

EMBO J 2004 Sep 2;23(18):3677-88. Epub 2004 Sep 2.

Division of Cellular & Molecular Biology, Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.emboj.7600371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517611PMC
September 2004

Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase.

J Biol Chem 2004 Jun 20;279(26):27059-68. Epub 2004 Apr 20.

Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02130, USA.

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http://dx.doi.org/10.1074/jbc.M314258200DOI Listing
June 2004

Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.

Cancer Res 2004 Mar;64(6):1959-65

Advanced Medical Discovery Institute, University Health Network, 620 University Avenue, Suite 706, Toronto, Ontario M5G 2C1, Canada.

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http://dx.doi.org/10.1158/0008-5472.can-03-2270DOI Listing
March 2004

The Polo-box domain: a molecular integrator of mitotic kinase cascades and Polo-like kinase function.

Cell Cycle 2004 Feb;3(2):128-31

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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February 2004

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.

Cell 2003 Oct;115(1):83-95

Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/s0092-8674(03)00725-6DOI Listing
October 2003

The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.

Nat Immunol 2003 Sep 17;4(9):899-906. Epub 2003 Aug 17.

Advanced Medical Discovery Institute, Ontario Cancer Institute, and Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada.

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http://dx.doi.org/10.1038/ni967DOI Listing
September 2003

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.

Nat Genet 2003 Feb 6;33(2):129-37. Epub 2003 Jan 6.

Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 4 Blackfan Circle, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/ng1076
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http://dx.doi.org/10.1038/ng1076DOI Listing
February 2003

Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.

Science 2003 Feb;299(5610):1228-31

Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1079079DOI Listing
February 2003

Generation and characterization of Smac/DIABLO-deficient mice.

Mol Cell Biol 2002 May;22(10):3509-17

Amgen Institute and Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada M5G 2C1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133802PMC
http://dx.doi.org/10.1128/mcb.22.10.3509-3517.2002DOI Listing
May 2002

Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.

Blood 2002 Jan;99(2):618-26

Amgen Institute and Department of Oncologic Pathology, Ontario Cancer Institute, Toronto, Canada.

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http://dx.doi.org/10.1182/blood.v99.2.618DOI Listing
January 2002