Andrew E Teschendorff

Andrew E Teschendorff

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Andrew E Teschendorff

Publications by authors named "Andrew E Teschendorff"

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EpiDISH web server: Epigenetic Dissection of Intra-Sample-Heterogeneity with online GUI.

Bioinformatics 2019 Nov 9. Epub 2019 Nov 9.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, China.

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http://dx.doi.org/10.1093/bioinformatics/btz833DOI Listing
November 2019

ebGSEA: an improved Gene Set Enrichment Analysis method for Epigenome-Wide-Association Studies.

Bioinformatics 2019 Sep;35(18):3514-3516

CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institute for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1093/bioinformatics/btz073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748733PMC
September 2019

Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome.

Commun Biol 2019 9;2:306. Epub 2019 Aug 9.

1CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031 China.

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http://dx.doi.org/10.1038/s42003-019-0554-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689007PMC
August 2019

Estimating Differentiation Potency of Single Cells Using Single-Cell Entropy (SCENT).

Methods Mol Biol 2019 ;1935:125-139

CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institute of Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1007/978-1-4939-9057-3_9DOI Listing
June 2019

Avoiding common pitfalls in machine learning omic data science.

Nat Mater 2019 05;18(5):422-427

Statistical Cancer Genomics, UCL Cancer Institute and Department of Woman's Cancer, University College London, London, UK.

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http://dx.doi.org/10.1038/s41563-018-0241-zDOI Listing
May 2019

Accounting for differential variability in detecting differentially methylated regions.

Brief Bioinform 2019 01;20(1):47-57

Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1093/bib/bbx097DOI Listing
January 2019

Detection of epigenetic field defects using a weighted epigenetic distance-based method.

Nucleic Acids Res 2019 01;47(1):e6

Department of Biostatistics, Mailman School of Public Health, Columbia University.

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http://dx.doi.org/10.1093/nar/gky882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326818PMC
January 2019

Identification of differentially methylated cell types in epigenome-wide association studies.

Nat Methods 2018 12 30;15(12):1059-1066. Epub 2018 Nov 30.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/s41592-018-0213-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277016PMC
December 2018

Cell and tissue type independent age-associated DNA methylation changes are not rare but common.

Aging (Albany NY) 2018 11;10(11):3541-3557

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institute for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.18632/aging.101666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286821PMC
November 2018

Quantifying Waddington's epigenetic landscape: a comparison of single-cell potency measures.

Brief Bioinform 2018 Oct 5. Epub 2018 Oct 5.

School of Mathematical Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.1093/bib/bby093DOI Listing
October 2018

Epigenetic clocks galore: a new improved clock predicts age-acceleration in Hutchinson Gilford Progeria Syndrome patients.

Aging (Albany NY) 2018 08;10(8):1799-1800

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institute for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.18632/aging.101533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128420PMC
August 2018

A novel cell-type deconvolution algorithm reveals substantial contamination by immune cells in saliva, buccal and cervix.

Epigenomics 2018 07 25;10(7):925-940. Epub 2018 Apr 25.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, 320 Yue Yang Road, Shanghai 200031, PR China.

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https://www.futuremedicine.com/doi/10.2217/epi-2018-0037
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http://dx.doi.org/10.2217/epi-2018-0037DOI Listing
July 2018

Tensorial blind source separation for improved analysis of multi-omic data.

Genome Biol 2018 06 8;19(1):76. Epub 2018 Jun 8.

Vienna University of Technology, Wiedner Hauptstr. 7, Vienna, A-1040, Austria.

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http://dx.doi.org/10.1186/s13059-018-1455-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994057PMC
June 2018

DNA Methylation Patterns in Normal Tissue Correlate more Strongly with Breast Cancer Status than Copy-Number Variants.

EBioMedicine 2018 May 4;31:243-252. Epub 2018 May 4.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institute for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China; Department of Women's Cancer, University College London, 74 Huntley Street, London WC1E 6AU, United Kingdom; UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street, London WC1E 6BT, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013931PMC
May 2018

Statistical and integrative system-level analysis of DNA methylation data.

Nat Rev Genet 2018 03 13;19(3):129-147. Epub 2017 Nov 13.

Medical Research Council Integrative Epidemiology Unit (MRC IEU), School of Social & Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.1038/nrg.2017.86DOI Listing
March 2018

Tumor origin detection with tissue-specific miRNA and DNA methylation markers.

Bioinformatics 2018 02;34(3):398-406

School of Computer Science and Technology.

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http://dx.doi.org/10.1093/bioinformatics/btx622DOI Listing
February 2018

ChAMP: updated methylation analysis pipeline for Illumina BeadChips.

Bioinformatics 2017 Dec;33(24):3982-3984

CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1093/bioinformatics/btx513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860089PMC
December 2017

Systems-epigenomics inference of transcription factor activity implicates aryl-hydrocarbon-receptor inactivation as a key event in lung cancer development.

Genome Biol 2017 Dec 20;18(1):236. Epub 2017 Dec 20.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China.

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http://dx.doi.org/10.1186/s13059-017-1366-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738803PMC
December 2017

Single-cell entropy for accurate estimation of differentiation potency from a cell's transcriptome.

Nat Commun 2017 06 1;8:15599. Epub 2017 Jun 1.

UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1038/ncomms15599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461595PMC
June 2017

DNA methylome analysis reveals distinct epigenetic patterns of ascending aortic dissection and bicuspid aortic valve.

Cardiovasc Res 2017 May;113(6):692-704

CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.

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http://dx.doi.org/10.1093/cvr/cvx050DOI Listing
May 2017

Cell-type deconvolution in epigenome-wide association studies: a review and recommendations.

Epigenomics 2017 05 14;9(5):757-768. Epub 2017 Mar 14.

CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.2217/epi-2016-0153DOI Listing
May 2017

A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies.

BMC Bioinformatics 2017 Feb 13;18(1):105. Epub 2017 Feb 13.

Medical Genomics, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, WC1E 6BT, London, United Kingdom.

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http://dx.doi.org/10.1186/s12859-017-1511-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307731PMC
February 2017

Correcting for cell-type heterogeneity in epigenome-wide association studies: revisiting previous analyses.

Nat Methods 2017 02;14(3):216-217

CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/nmeth.4187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659733PMC
February 2017

dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers.

Nucleic Acids Res 2017 01 28;45(D1):D812-D818. Epub 2016 Nov 28.

Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai 200031, China

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkw1079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210560PMC
January 2017

Epigenetic and genetic deregulation in cancer target distinct signaling pathway domains.

Nucleic Acids Res 2017 01 29;45(2):583-596. Epub 2016 Nov 29.

CAS Key Lab for Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, 320 Yue Yang Road, Shanghai 200031, China

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http://dx.doi.org/10.1093/nar/gkw1100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314760PMC
January 2017

The lncRNA HOTAIR impacts on mesenchymal stem cells via triple helix formation.

Nucleic Acids Res 2016 12 14;44(22):10631-10643. Epub 2016 Sep 14.

Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH University Medical School, Aachen 52074, Germany

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http://dx.doi.org/10.1093/nar/gkw802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159544PMC
December 2016

Correlation of an epigenetic mitotic clock with cancer risk.

Genome Biol 2016 10 3;17(1):205. Epub 2016 Oct 3.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046977PMC
http://dx.doi.org/10.1186/s13059-016-1064-3DOI Listing
October 2016

Menopause accelerates biological aging.

Proc Natl Acad Sci U S A 2016 08 25;113(33):9327-32. Epub 2016 Jul 25.

Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA 90095

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http://dx.doi.org/10.1073/pnas.1604558113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995944PMC
August 2016

The multi-omic landscape of transcription factor inactivation in cancer.

Genome Med 2016 08 25;8(1):89. Epub 2016 Aug 25.

Department of Women's Cancer, University College London, 74 Huntley Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1186/s13073-016-0342-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997779PMC
August 2016

Erratum to: The integrative epigenomic-transcriptomic landscape of ER positive breast cancer.

Clin Epigenetics 2016 1;8:63. Epub 2016 Jun 1.

CAS Key Lab for Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, 320 Yue Yang Road, Shanghai, 200031 China ; Department of Women's Cancer, University College London, 74 Huntley Street, London, WC1E 6BT UK ; Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT UK.

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http://dx.doi.org/10.1186/s13148-016-0231-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890493PMC
July 2016

Epigenetic drift, epigenetic clocks and cancer risk.

Epigenomics 2016 05 22;8(5):705-19. Epub 2016 Apr 22.

CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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https://www.futuremedicine.com/doi/10.2217/epi-2015-0017
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http://dx.doi.org/10.2217/epi-2015-0017DOI Listing
May 2016

Stochastic epigenetic outliers can define field defects in cancer.

BMC Bioinformatics 2016 Apr 22;17:178. Epub 2016 Apr 22.

Department of Women's Cancer, University College London, 74 Huntley Street, London, WC1E 6AU, UK.

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http://dx.doi.org/10.1186/s12859-016-1056-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840974PMC
April 2016

Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer.

Epigenetics Chromatin 2016 8;9:10. Epub 2016 Mar 8.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031 China ; Statistical Cancer Genomics, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT UK ; Department of Women's Cancer, University College London, 74 Huntley Street, London, WCIE 6AU UK.

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http://dx.doi.org/10.1186/s13072-016-0058-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782576PMC
March 2016

DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer.

Nat Commun 2016 Jan 29;7:10478. Epub 2016 Jan 29.

Department of Women's Cancer, University College London, Medical School Building, Room 340, 74 Huntley Street, London WC1E 6AU, UK.

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http://dx.doi.org/10.1038/ncomms10478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740178PMC
January 2016

The integrative epigenomic-transcriptomic landscape of ER positive breast cancer.

Clin Epigenetics 2015 9;7:126. Epub 2015 Dec 9.

CAS Key Lab for Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, 320 Yue Yang Road, 200031 Shanghai, China ; Department of Women's Cancer, University College London, 74 Huntley Street, London, WC1E 6BT UK ; Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT UK.

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http://dx.doi.org/10.1186/s13148-015-0159-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673726PMC
December 2015

Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest.

Stem Cell Reports 2015 Nov;5(5):829-842

Department of Cancer Biology, UCL Cancer Institute, University College London, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK; Samantha Dickson Brain Cancer Unit, University College London, London WC1E 6BT, UK; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649264PMC
November 2015

Biomedical data integration, modeling, and simulation in the era of big data and translational medicine.

Biomed Res Int 2014 24;2014:731546. Epub 2014 Jul 24.

Institute of Health Sciences, Anhui University, Hefei 230601, China.

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http://www.hindawi.com/journals/bmri/2014/731546/
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http://dx.doi.org/10.1155/2014/731546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131419PMC
September 2015

An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer.

Genome Biol 2015 Jul 14;16:140. Epub 2015 Jul 14.

Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China.

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http://dx.doi.org/10.1186/s13059-015-0699-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501092PMC
July 2015

Denoising perturbation signatures reveal an actionable AKT-signaling gene module underlying a poor clinical outcome in endocrine-treated ER+ breast cancer.

Genome Biol 2015 Apr 2;16:61. Epub 2015 Apr 2.

CAS Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China.

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http://dx.doi.org/10.1186/s13059-015-0630-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399757PMC
April 2015

Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer.

PLoS Comput Biol 2015 Mar 20;11(3):e1004115. Epub 2015 Mar 20.

Statistical Cancer Genomics, Paul O'Gorman Building, UCL Cancer Institute, University College London, London WC1E 6BT, UK; CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, 320 Yue Yang Road, Shanghai 200031, China.

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http://dx.doi.org/10.1371/journal.pcbi.1004115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368751PMC
March 2015

An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging.

PLoS Genet 2015 Feb 18;11(2):e1004996. Epub 2015 Feb 18.

Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, Shanghai, China; Statistical Genomics Group, UCL Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334892PMC
February 2015

A systems-level integrative framework for genome-wide DNA methylation and gene expression data identifies differential gene expression modules under epigenetic control.

Bioinformatics 2014 Aug 2;30(16):2360-6. Epub 2014 May 2.

Computational Systems Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health and Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, London WC1E 6BT, UKComputational Systems Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health and Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1093/bioinformatics/btu316DOI Listing
August 2014

The dynamics of DNA methylation covariation patterns in carcinogenesis.

PLoS Comput Biol 2014 Jul 10;10(7):e1003709. Epub 2014 Jul 10.

Key Laboratory of Systems Biology, SIBS-Nordisk Translational Research Centre for PreDiabetes, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1371/journal.pcbi.1003709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091688PMC
July 2014

A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival.

Genome Med 2014 27;6(6):47. Epub 2014 Jun 27.

Department of Women's Cancer, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, 74 Huntley Street, London WC1E 6 AU, UK.

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http://dx.doi.org/10.1186/gm567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110671PMC
July 2014

Signalling entropy: A novel network-theoretical framework for systems analysis and interpretation of functional omic data.

Methods 2014 Jun 24;67(3):282-93. Epub 2014 Mar 24.

Department of Mathematics, King's College London, London WC2R 2LS, UK.

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http://dx.doi.org/10.1016/j.ymeth.2014.03.013DOI Listing
June 2014

Comparisons of non-Gaussian statistical models in DNA methylation analysis.

Int J Mol Sci 2014 Jun 16;15(6):10835-54. Epub 2014 Jun 16.

Pattern Recognition and Intelligent System Lab.,Beijing University of Posts and Telecommunications, No. 10 Xitucheng Road,Beijing 100876, China.

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http://dx.doi.org/10.3390/ijms150610835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100184PMC
June 2014

ChAMP: 450k Chip Analysis Methylation Pipeline.

Bioinformatics 2014 Feb 12;30(3):428-30. Epub 2013 Dec 12.

Medical Genomics, and Statistical Genomics, UCL Cancer Institute, University College London, London WC1E 6BT, UK, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Shanghai 200031, China and Institute of Environmental Medicine, Karolinska Instytutet, 17177 Stockholm, Sweden.

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http://www.ideal-ageing.eu/uploads/publicaties/2014_morris_b
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http://bioinformatics.oxfordjournals.org/content/early/2013/
Web Search
http://bioinformatics.oxfordjournals.org/cgi/doi/10.1093/bio
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http://dx.doi.org/10.1093/bioinformatics/btt684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904520PMC
February 2014

Epigenetic aging: insights from network biology.

Aging (Albany NY) 2013 Oct;5(10):719-20

Statistical Cancer Genomics, UCL Cancer Institute;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838773PMC
http://dx.doi.org/10.18632/aging.100610DOI Listing
October 2013

Cellular network entropy as the energy potential in Waddington's differentiation landscape.

Sci Rep 2013 Oct 24;3:3039. Epub 2013 Oct 24.

1] Statistical Cancer Genomics, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, United Kingdom [2] Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London WC1E6BT United Kingdom.

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http://dx.doi.org/10.1038/srep03039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807110PMC
October 2013

A variational Bayes beta mixture model for feature selection in DNA methylation studies.

J Bioinform Comput Biol 2013 Aug 18;11(4):1350005. Epub 2013 Mar 18.

KTH-Royal Institute of Technology, School of Electrical Engineering, SE-100 44, Stockholm, Sweden.

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http://dx.doi.org/10.1142/S0219720013500054DOI Listing
August 2013

Distinctive topology of age-associated epigenetic drift in the human interactome.

Proc Natl Acad Sci U S A 2013 Aug 12;110(35):14138-43. Epub 2013 Aug 12.

Statistical Cancer Genomics, University College London Cancer Institute, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1307242110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761591PMC
August 2013

Network transfer entropy and metric space for causality inference.

Phys Rev E Stat Nonlin Soft Matter Phys 2013 May 31;87(5):052814. Epub 2013 May 31.

Department of Computer Science, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1103/PhysRevE.87.052814DOI Listing
May 2013

Differential network entropy reveals cancer system hallmarks.

Sci Rep 2012 13;2:802. Epub 2012 Nov 13.

Statistical Cancer Genomics, UCL Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1038/srep00802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496163PMC
April 2013

Epigenetics makes its mark on women-specific cancers--an opportunity to redefine oncological approaches?

Gynecol Oncol 2013 Jan 1;128(1):134-143. Epub 2012 Oct 1.

Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00908258120078
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http://dx.doi.org/10.1016/j.ygyno.2012.09.027DOI Listing
January 2013

Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions.

Bioinformatics 2012 Jun 6;28(11):1487-94. Epub 2012 Apr 6.

Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London, UK.

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http://dx.doi.org/10.1093/bioinformatics/bts170DOI Listing
June 2012

A comparison of feature selection and classification methods in DNA methylation studies using the Illumina Infinium platform.

BMC Bioinformatics 2012 Apr 24;13:59. Epub 2012 Apr 24.

Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1186/1471-2105-13-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364843PMC
April 2012

Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation.

Genome Med 2012 Mar 27;4(3):24. Epub 2012 Mar 27.

Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1186/gm323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446274PMC
March 2012

DART: Denoising Algorithm based on Relevance network Topology improves molecular pathway activity inference.

BMC Bioinformatics 2011 Oct 19;12:403. Epub 2011 Oct 19.

Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-12-403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228554PMC
October 2011

Prognostic gene network modules in breast cancer hold promise.

Breast Cancer Res 2010 8;12(6):317. Epub 2010 Dec 8.

Medical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, London WC1E 6BT, UK.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/bcr2774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046436PMC
September 2011

Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies.

Bioinformatics 2011 Jun 6;27(11):1496-505. Epub 2011 Apr 6.

Statistical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, London WC1E 6BT, UK.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btr171DOI Listing
June 2011

Improved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modules.

BMC Cancer 2010 Nov 4;10:604. Epub 2010 Nov 4.

Breast Cancer Functional Genomics Laboratory, Department of Oncology University of Cambridge, Cancer Research UK Cambridge Research Institute, Li Ka-Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-10-604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991308PMC
November 2010

Increased entropy of signal transduction in the cancer metastasis phenotype.

BMC Syst Biol 2010 Jul 30;4:104. Epub 2010 Jul 30.

Medical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.

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http://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0
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http://dx.doi.org/10.1186/1752-0509-4-104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925356PMC
July 2010

Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer.

Int J Cancer 2009 Dec;125(11):2687-96

Strangeways Research Laboratory, Departments of Public Health and Primary Care and Oncology, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, United Kingdom.

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http://doi.wiley.com/10.1002/ijc.24678
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http://dx.doi.org/10.1002/ijc.24678DOI Listing
December 2009

The breast cancer somatic 'muta-ome': tackling the complexity.

Breast Cancer Res 2009 30;11(2):301. Epub 2009 Mar 30.

Medical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1186/bcr2236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688941PMC
August 2009