Publications by authors named "Andrew Drury"

6 Publications

  • Page 1 of 1

Detection of SARS-CoV-2 infection in asymptomatic populations using the DiaSorin molecular Simplexa and Roche Cobas EUA assays.

Diagn Microbiol Infect Dis 2021 Jul 31;102(1):115513. Epub 2021 Jul 31.

OhioHealth Laboratory Services, OhioHealth, Columbus, OH, USA; CORPath Pathology Services, LLC, Columbus, OH, USA.

Identification of asymptomatic patients is necessary to control the COVID-19 pandemic and testing is one of the measures to detect this population. We evaluated the clinical correlation of the DiaSorin Molecular Simplexa COVID-19 Direct (DiaSorin Molecular) and Roche Cobas 6800 SARS-CoV-2 (Roche) assays using 253 oropharyngeal (OP) swab specimens collected from asymptomatic patients. Agreement between DiaSorin Molecular and Roche was 97% (95% CI, 0.94 to 0.99), with a κ statistic of 0.90 (95% CI, 0.83 to 0.97) and a PPA of 89% (95% CI, 0.76 to 0.96) and NPA of 99% (95% CI, 0.97 to 0.99). Simple regression analysis of Ct values revealed a regression line of y = 1.065*X - 5.537 with a Pearson's r of 0.8542, indicating a good correlation between both platforms. The DiaSorin Molecular assay demonstrates clinical performance comparable to that of Roche in this population.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
July 2021

Systematic Review of Surgical and Nonsurgical Interventions in Normal Men Complaining of Small Penis Size.

Sex Med Rev 2020 01 23;8(1):158-180. Epub 2019 Apr 23.

Department of Urology, King's College Hospital and King's College London, London, UK. Electronic address:

Introduction: Evidence on penile enhancement interventions is lacking. Nonetheless, many non-evidence-based solutions are readily available.

Aim: To investigate enhancement and nonenhancement interventions in men without penile abnormalities seeking to increase penis size.

Methods: We performed a systematic review with no time restrictions adhering to the PRISMA guidelines. Studies with fewer than 10 cases or including men with organic penile pathologies or previous penile surgeries were excluded.

Main Outcome Measures: When available, treatment efficacy was evaluated based on patient satisfaction, penile size increase, and complications.

Results: We included 17 studies, assessing a total of 21 interventions in 1,192 men screened, with 773 followed up after nonsurgical (n = 248) or surgical (n = 525) treatment. The quality of the studies was poor in terms of methodology for patient selection and outcomes assessment. The vast majority of series reported normal penile size. Among nonsurgical treatments, extenders increased flaccid length (but by <2 cm), injectables increased girth but were associated with a high complication rate, and vacuum devices did not increase size. Surgical interventions included suspensory ligament incision (the most used method; n = 12), tissue grafting (autologous, n = 2; dermal fat, n = 3, ex vivo, n = 2), flaps (n = 2), and penile disassembly (n = 1). Some men reported a significant size increase; however, complications were not infrequent, and none of the techniques was externally validated. When provided, counseling was effective, with the majority of men coming to understand that their penis was normal and unwilling to undergo any further treatment.

Conclusion: Treatment of small penis in normal men is supported by scant, low-quality evidence. Structured counseling should be always performed, with extenders eventually used by those still seeking enhancement. Injectables and surgery should remain a last option, considered unethical outside of clinical trials. Marra G, Drury A, Tran L, et al. Systematic Review of Surgical and Nonsurgical Interventions in Normal Men Complaining of Small Penis Size. Sex Med Rev 2020;8:158-180.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
January 2020

HIV and mental illness in Malawi and the neuropsychiatric sequelae of efavirenz.

Malawi Med J 2018 03;30(1):40-45

Scotland Malawi Mental Health Education Project.

Introduction: Little is published about mental disorders in Malawi, specifically in relation to Human Immunodeficiency Virus (HIV) and it's treatment. Efavirenz is a medication commonly used as part of triple therapy for HIV treatment. Indeed, in 2013, Malawi introduced 5A with Efavirenz as part of it's 1st line treatment for HIV. There exists some literature documenting known psychiatric side effects of Efavirenz, which include anxiety, mood changes, nightmares, psychosis and suicidal ideation. Little is known about what features are most common in the presentation and what factors in the patient and drug which may make this reaction more likely.

Aim: The aim of this commentary is to review the association between HIV and psychiatric disorder, and consider the neuropsychiatric side-effects of Efavirenz.

Method: An evaluative literature review was completed by means of multiple electronic database search as well as an additional manual search to obtain published works identified through the electronic search. Search terms used were: Efavirenz, Acquired Immunodeficiency Syndrome, Africa, Antiretroviral Therapy, Developing Countries, Malawi, Mental Disorders, Public Health, and Psychiatry.

Conclusion: This is an important area of study, as potentially large numbers of individuals with HIV are being placed on Efavirenz as first line treatment, yet 60% may experience some form of neuropsychiatric side effects.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
March 2018

Re-audit of physical examination on admission.

Psychiatr Danub 2011 Sep;23 Suppl 1:S57-61

Aubrey Lewis House Maudsley Hospital, Denmark Hill, London, UK.

Re-audit of the physical examination of older adults admitted to one of two inpatient Older Adult wards at the Maudsley Hospital found that on admission, only 58% of patients had a brief physical examination and 43% had a full physical examination, and after 72 hours only 65% had a full physical examination. This is a slight improvement on the previous audit but still falls short of the target of 90% of patients having a full physical examination within 72 hours of admission. Recommendations include education of junior and senior doctors of the need for physical examination via presentation of audit and distribution of results, consideration of the use of a proforma to gather information on physical examination which may have been done in an acute hospital and a further re-audit to see if outcomes have improved.
View Article and Find Full Text PDF

Download full-text PDF

September 2011

Co-operation with another player in a financially rewarded guessing game activates regions implicated in theory of mind.

Soc Neurosci 2006 ;1(3-4):385-95

Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK.

Functional imaging studies have identified a network of brain regions associated with theory of mind (ToM); the attribution of mental states to other people. Similar regions have also been observed in studies where people play games that involve either competing or co-operating with another person. Such games are thought to place implicit demands on ToM processes. Co-operation with others has also been shown to elicit brain responses in areas associated with the processing of reward, suggesting that co-operation is an intrinsically rewarding process. In this study, we used a factorial design to assess the interaction between co-operation and the availability of financial rewards in a guessing game. Twelve subjects were scanned with functional magnetic resonance imaging (fMRI) while they performed a guessing game with and without co-operation, and under both these conditions with and without financial reward. The main effect of co-operation was associated with neural responses in theory of mind regions, while the main effect of financial reward was associated with neural responses in reward regions. Critically the response to reward in medial orbitofrontal cortex was significantly enhanced when subjects were co-operating. This suggests that rewards achieved through co-operation are more valuable than rewards achieved alone.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
December 2008