Publications by authors named "Andrew D Randall"

59Publications

Impaired speed encoding and grid cell periodicity in a mouse model of tauopathy.

Elife 2020 11 26;9. Epub 2020 Nov 26.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter, Hatherly Laboratories, Exeter, United Kingdom.

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November 2020

Neurophysiological alterations in the nucleus reuniens of a mouse model of Alzheimer's disease.

Neurobiol Aging 2020 04 12;88:1-10. Epub 2019 Dec 12.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Hatherly Laboratory, Exeter, UK. Electronic address:

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April 2020

Sex-associated differences in excitability within the bed nucleus of the stria terminalis are reflective of cell-type.

Neurobiol Stress 2019 Feb 19;10:100143. Epub 2018 Dec 19.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Hatherly Laboratory, Exeter, EX4 4PS, UK.

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February 2019

Basal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes.

Diabetologia 2019 01 6;62(1):187-198. Epub 2018 Oct 6.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, EX2 5DW, UK.

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January 2019

Initiation and slow propagation of epileptiform activity from ventral to dorsal medial entorhinal cortex is constrained by an inhibitory gradient.

J Physiol 2018 06 25;596(11):2251-2266. Epub 2018 Apr 25.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Hatherly Laboratories, Prince of Wales Road, Exeter EX4 4PS, UK.

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June 2018

Muscarinic Receptor-Dependent Long Term Depression in the Perirhinal Cortex and Recognition Memory are Impaired in the rTg4510 Mouse Model of Tauopathy.

Neurochem Res 2019 Mar 26;44(3):617-626. Epub 2018 Feb 26.

School of Physiology and Pharmacology and Neuroscience, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.

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March 2019

Aging-Associated Changes to Intrinsic Neuronal Excitability in the Bed Nucleus of the Stria Terminalis Is Cell Type-Dependent.

Front Aging Neurosci 2017 22;9:424. Epub 2017 Dec 22.

Hatherly Laboratory, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom.

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December 2017

Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein.

Neurobiol Aging 2017 12 20;60:44-56. Epub 2017 Jul 20.

Institute of Clinical and Biomedical Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK.

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December 2017

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease.

Glia 2018 01 19;66(1):34-46. Epub 2017 Jul 19.

Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom.

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January 2018

Altered Synapse Stability in the Early Stages of Tauopathy.

Cell Rep 2017 03;18(13):3063-3068

Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK. Electronic address:

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March 2017

In vitro characterization of cell-level neurophysiological diversity in the rostral nucleus reuniens of adult mice.

J Physiol 2017 06 25;595(11):3549-3572. Epub 2017 Apr 25.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Hatherly Laboratory, Exeter, UK.

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June 2017

Are stem cell-derived neural cells physiologically credible?

Authors:
Andrew D Randall

J Physiol 2016 11;594(22):6569-6572

Applied Neurophysiology Group, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Prince of Wales Road, Exeter EX4 4PS, UK.

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November 2016

Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy.

J Neurosci 2016 Jan;36(2):350-63

School of Physiology and Pharmacology and Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Hatherly Laboratories, University of Exeter, Exeter EX4 4PS, United Kingdom

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January 2016

Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy.

J Neurosci 2016 Jan;36(2):312-24

School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Hatherly Laboratories, Exeter EX4 4PS, United Kingdom,

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January 2016

Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses.

J Physiol 2016 Feb;594(4):915-36

Ecole Normale Supérieure, Institut de Biologie de l'ENS (IBENS), CNRS UMR 8197 and INSERM U1024, Paris, France.

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February 2016

Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice.

Front Cell Neurosci 2015 14;9:372. Epub 2015 Oct 14.

Medical School, University of Exeter Exeter, UK ; School of Physiology and Pharmacology, University of Bristol Bristol, UK.

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November 2015

Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering.

ACS Biomater Sci Eng 2015 Jun 28;1(6):431-439. Epub 2015 Apr 28.

School of Chemistry, University of Bristol , Bristol BS8 1TS, United Kingdom ; School of Biochemistry, University of Bristol , Bristol BS8 1TD, United Kingdom ; BrisSynBio, University of Bristol , Bristol BS8 1TQ, United Kingdom.

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June 2015

Long-term culture of pluripotent stem-cell-derived human neurons on diamond--A substrate for neurodegeneration research and therapy.

Biomaterials 2015 Aug 20;61:139-49. Epub 2015 May 20.

Regenerative Medicine Laboratory, School of Clinical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom; Trinity College Institute of Neuroscience, Lloyd Institute, Trinity College, Dublin 2, Ireland. Electronic address:

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August 2015

Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide.

Hippocampus 2015 Jul 25;25(7):786-97. Epub 2015 Mar 25.

Medical School, University of Exeter, Hatherly Building, Streatham Campus, Exeter, EX4 4PS, United Kingdom.

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July 2015

Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia.

J Physiol 2016 08 2;594(16):4615-30. Epub 2015 Jan 2.

School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol, BS8 1TD, UK.

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August 2016

Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1.

Eur J Neurosci 2014 Apr;39(7):1074-90

School of Physiology and Pharmacology, University of Bristol, Medical Sciences Building, University Walk, Bristol, BS8 1TD, UK.

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April 2014

Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system.

Eur J Neurosci 2014 Apr;39(7):1068-73

School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol, UK; Institute of Biomedical and Clinical Sciences, University of Exeter, The Hatherley Building, Prince of Wales Road, Exeter, EX4 4PS, UK.

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April 2014

Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells.

PLoS One 2014 19;9(3):e92557. Epub 2014 Mar 19.

School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom; Institute of Biomedical and Clinical Sciences, Medical School, University of Exeter, Exeter, United Kingdom.

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November 2014

A new player in the "synaptopathy" of Alzheimer's disease - arc/arg 3.1.

Front Neurol 2013 13;4. Epub 2013 Feb 13.

School of Physiology and Pharmacology, Faculty of Medical and Veterinary Sciences, University of Bristol Bristol, UK.

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February 2013

Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus.

PLoS One 2012 13;7(2):e30402. Epub 2012 Feb 13.

Medical Research Council Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.

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July 2012

Age-related changes to Na+ channel gating contribute to modified intrinsic neuronal excitability.

Neurobiol Aging 2012 Nov 28;33(11):2715-20. Epub 2012 Jan 28.

Pfizer-Applied Neurophysiology Group, School of Physiology and Pharmacology, University of Bristol, Bristol, UK.

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November 2012

Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596.

Front Pharmacol 2011 27;2:81. Epub 2011 Dec 27.

Pfizer Applied Neurophysiology Group, School of Physiology and Pharmacology, University of Bristol Bristol, UK.

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October 2012

Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease.

Neurobiol Aging 2011 Nov 27;32(11):2109.e1-14. Epub 2011 Jul 27.

Pfizer Applied Neurophysiology Group, University of Bristol School of Physiology and Pharmacology, Bristol, UK.

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November 2011

Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons.

Eur J Neurosci 2011 Mar 26;33(5):879-89. Epub 2011 Jan 26.

Pfizer Applied Neurophysiology Group, MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UK.

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March 2011

Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein.

Mol Brain 2010 Nov 1;3:32. Epub 2010 Nov 1.

School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol, BS8 1TD, UK.

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November 2010

A unified model of CA1/3 pyramidal cells: an investigation into excitability.

Prog Biophys Mol Biol 2011 Mar 29;105(1-2):34-48. Epub 2010 Sep 29.

Bristol Centre for Applied Nonlinear Mathematics, Department of Engineering Mathematics, University of Bristol, Queen's Building, University Walk, Bristol BS8 1TR, UK.

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March 2011

Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts.

Mol Pharmacol 2009 Dec 2;76(6):1279-89. Epub 2009 Sep 2.

Department of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol, BS81TD, UK.

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December 2009

Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons.

J Physiol 2009 Mar 26;587(Pt 6):1265-81. Epub 2009 Jan 26.

MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK.

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March 2009

The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs.

Neuropharmacology 2008 Sep 28;55(4):459-63. Epub 2008 May 28.

MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK.

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September 2008

Synaptic activation of GABA(B) receptors regulates neuronal network activity and entrainment.

Eur J Neurosci 2007 May;25(10):2982-90

Neurology and GI, GlaxoSmithKline, Harlow, Essex, UK.

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May 2007

TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation.

Eur J Pharmacol 2006 Jul 6;540(1-3):73-81. Epub 2006 May 6.

Neurology and GI CEDD, GlaxoSmithKline, New Frontiers Science Park North, Third Avenue, Harlow, Essex, CM19 5AW, UK.

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July 2006

Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones.

Neuropharmacology 2006 Jan 2;50(1):89-97. Epub 2005 Nov 2.

Neurology, GlaxoSmithKline Research and Development Ltd, New Frontiers Science Park (North), Harlow, Essex, UK.

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January 2006

Whole-cell patch clamp recording of voltage-sensitive Ca²+ channel currents: heterologous expression systems and dissociated brain neurons.

Methods Mol Biol 2005 ;312:161-79

Pharmacology Research Group, Leicester School of Pharmacy, De Montfort University, Leicester, UK.

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August 2011

Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice.

Hippocampus 2005 ;15(1):110-7

Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex, United Kingdom.

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May 2005

Discovery of small molecule antagonists of TRPV1.

Bioorg Med Chem Lett 2004 Jul;14(14):3631-4

Neurology and GI CEDD, New Frontiers Science Park, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK.

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July 2004

Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents.

Eur J Pharmacol 2003 Apr;467(1-3):77-80

Pharmacology Research Group, School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.

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April 2003

mRNA distribution analysis of human TRPC family in CNS and peripheral tissues.

Brain Res Mol Brain Res 2002 Dec;109(1-2):95-104

Neurology and GI Centre of Excellence for Drug Discovery, New Frontiers Science Park, Harlow, Essex CM19 5AW, UK.

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December 2002

Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx.

J Biol Chem 2002 Apr 22;277(14):12302-9. Epub 2002 Jan 22.

Neurology-Center of Excellence for Drug Discovery, Genetics Research, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex CM19 5AW, United Kingdom.

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April 2002

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.

Pain 2000 Nov;88(2):205-215

Department of Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Third Avenue, Harlow CM19 5AW, UK Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Third Avenue, Harlow CM19 5AW, UK Department of Bioinformatics, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Third Avenue, Harlow CM19 5AW, UK.

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November 2000