Andrew D Mesecar

Andrew D Mesecar

UNVERIFIED PROFILE

Are you Andrew D Mesecar?   Register this Author

Register author
Andrew D Mesecar

Andrew D Mesecar

Publications by authors named "Andrew D Mesecar"

Are you Andrew D Mesecar?   Register this Author

100Publications

1715Reads

46Profile Views

Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease.

Antiviral Res 2020 Feb 23;174:104661. Epub 2019 Nov 23.

Department of Biological Sciences, Purdue University, West Lafayette, IN, USA; Department of Biochemistry, Purdue University, West Lafayette, IN, USA; Center for Cancer Research, Purdue University, West Lafayette, IN, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.antiviral.2019.104661DOI Listing
February 2020

Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins.

Cell Host Microbe 2019 06 30;25(6):815-826.e4. Epub 2019 May 30.

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA; Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2019.05.004DOI Listing
June 2019

Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.

Bioorg Med Chem Lett 2018 08 26;28(15):2605-2610. Epub 2018 Jun 26.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2018.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085084PMC
August 2018

Computational modeling of the bat HKU4 coronavirus 3CL inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus.

J Mol Recognit 2017 11 13;30(11). Epub 2017 Jun 13.

Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman, Jordan.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jmr.2644
Publisher Site
http://dx.doi.org/10.1002/jmr.2644DOI Listing
November 2017

Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.

Bioorg Med Chem Lett 2017 06 8;27(11):2432-2438. Epub 2017 Apr 8.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2017.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479133PMC
June 2017

Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species.

J Mol Biol 2017 06 21;429(11):1661-1683. Epub 2017 Apr 21.

Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2017.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634334PMC
June 2017

Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme.

Arch Biochem Biophys 2016 Dec 15;612:35-45. Epub 2016 Oct 15.

Department of Biological Sciences, Purdue University, West Lafayette, IN 47906, United States; Department of Biochemistry, Purdue University, West Lafayette, IN 47906, United States; Department of Chemistry, Purdue University, West Lafayette, IN 47906, United States; Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47906, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2016.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868344PMC
December 2016

Cholesterol Sulfonation Enzyme, SULT2B1b, Modulates AR and Cell Growth Properties in Prostate Cancer.

Mol Cancer Res 2016 09 24;14(9):776-86. Epub 2016 Jun 24.

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana. Purdue University Center for Cancer Research, West Lafayette, Indiana.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-16-0137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111871PMC
September 2016

X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus.

Sci Rep 2016 05 13;6:25961. Epub 2016 May 13.

Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep25961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865815PMC
May 2016

Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes.

Chem Sci 2016 May 4;7:3117-3122. Epub 2016 Feb 4.

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 (USA); Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907 (USA); Department of Biochemistry, Purdue University, West Lafayette, IN 47907 (USA).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/C5SC03718BDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916918PMC
May 2016

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.

Bioorg Med Chem Lett 2015 Nov 13;25(22):5072-7. Epub 2015 Oct 13.

Departments of Biochemistry and Biological Sciences, Purdue University, West Lafayette, IN, USA; Centers for Cancer Research & Drug Discovery, Purdue University, West Lafayette, IN, USA; Department of Chemistry, Purdue University, West Lafayette, IN, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2015.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896745PMC
November 2015

X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions.

J Biol Chem 2015 Oct 19;290(42):25293-306. Epub 2015 Aug 19.

From the Department of Biological Sciences, the Center for Cancer Research, and the Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907 and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.662130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646180PMC
October 2015

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.

Eur J Med Chem 2015 Oct 4;103:252-68. Epub 2015 Sep 4.

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2015.08.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600463PMC
October 2015

Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS).

Bioorg Med Chem 2015 Sep 19;23(17):6036-48. Epub 2015 Jun 19.

Department of Biological Sciences, Purdue University, West Lafayette, IN, USA; Department of Chemistry, Purdue University, West Lafayette, IN, USA; Centers for Cancer Research & Drug Discovery, Purdue University, West Lafayette, IN, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09680896150053
Publisher Site
http://dx.doi.org/10.1016/j.bmc.2015.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433438PMC
September 2015

The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.

Antiviral Res 2015 Mar 29;115:21-38. Epub 2014 Dec 29.

Department of Biological Sciences, Purdue University, West Lafayette, IN, USA; Department of Chemistry, Purdue University, West Lafayette, IN, USA; Center for Drug Discovery, Purdue University, West Lafayette, IN, USA; Center for Cancer Research, Purdue University, West Lafayette, IN, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01663542140036
Publisher Site
http://dx.doi.org/10.1016/j.antiviral.2014.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896749PMC
March 2015

Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.

Bioorg Med Chem Lett 2015 Feb 6;25(3):668-72. Epub 2014 Dec 6.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Protein Studies Program, Oklahoma Medical Research Foundation, United States; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2014.11.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297543PMC
February 2015

Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities.

Virus Res 2014 Dec 7;194:184-90. Epub 2014 Feb 7.

Department of Microbiology and Immunology, Loyola University Chicago, Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virusres.2014.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125544PMC
December 2014

Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.

J Virol 2014 Nov 20;88(21):12511-27. Epub 2014 Aug 20.

Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA Department of Chemistry, Purdue University, West Lafayette, Indiana, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01294-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248884PMC
November 2014

X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases.

J Med Chem 2014 Mar 14;57(6):2393-412. Epub 2014 Mar 14.

Department of Biological Sciences, Purdue University , 915 W. State Street, West Lafayette, Indiana 47907, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm401712tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983375PMC
March 2014

A 2.2 Å resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.

Acta Crystallogr F Struct Biol Commun 2014 Mar 19;70(Pt 3):283-7. Epub 2014 Feb 19.

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053230X14002519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944686PMC
March 2014

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.

Virology 2014 Feb 22;450-451:64-70. Epub 2013 Dec 22.

Department Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine, 2160 S. First Ave., Maywood, IL 60153, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2013.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957432PMC
February 2014

Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase.

Bioorg Med Chem 2014 Jan 15;22(1):406-18. Epub 2013 Nov 15.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy and The Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2013.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914758PMC
January 2014

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding.

Bioorg Med Chem Lett 2013 Nov 7;23(22):6172-7. Epub 2013 Sep 7.

Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Specialized Chemistry Center for Probe Development (MLPCN), Nashville, TN 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2013.08.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878165PMC
November 2013

Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.

Biochemistry 2013 Feb 18;52(5):912-25. Epub 2013 Jan 18.

Eleanor Roosevelt Institute and Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi300928uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170518PMC
February 2013

Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation.

Bioorg Med Chem Lett 2012 Dec 17;22(24):7578-81. Epub 2012 Oct 17.

Moscow State University, Chemistry department, Leninskie Gory 1, Moscow, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2012.10.005DOI Listing
December 2012

Screening for natural chemoprevention agents that modify human Keap1.

Anal Biochem 2012 Feb 22;421(1):108-14. Epub 2011 Oct 22.

Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2011.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390259PMC
February 2012

Design, synthesis, and biological evaluation of potent quinoline and pyrroloquinoline ammosamide analogues as inhibitors of quinone reductase 2.

J Med Chem 2012 Jan 29;55(1):367-77. Epub 2011 Dec 29.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm201251cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262027PMC
January 2012

Development and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization.

Dis Model Mech 2011 Nov 2;4(6):822-31. Epub 2011 Aug 2.

Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.007963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209651PMC
November 2011

Identification of a glycogen synthase kinase-3β inhibitor that attenuates hyperactivity in CLOCK mutant mice.

ChemMedChem 2011 Sep 5;6(9):1593-602. Epub 2011 Jul 5.

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201100188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428230PMC
September 2011

X-ray structural studies of quinone reductase 2 nanomolar range inhibitors.

Protein Sci 2011 Jul 23;20(7):1182-95. Epub 2011 May 23.

Department of Chemistry & Biochemistry, University of Denver, Denver, Colorado 80208, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pro.647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149192PMC
July 2011

Modification of keap1 cysteine residues by sulforaphane.

Chem Res Toxicol 2011 Apr 10;24(4):515-21. Epub 2011 Mar 10.

Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S. Wood Street, Chicago, IL 60612, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/tx100389r
Publisher Site
http://dx.doi.org/10.1021/tx100389rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086360PMC
April 2011

Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284.

J Med Chem 2010 Dec 24;53(24):8688-99. Epub 2010 Nov 24.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm1011066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010278PMC
December 2010

Kinetic, thermodynamic, and structural insight into the mechanism of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis.

J Mol Biol 2010 Nov 21;404(2):202-19. Epub 2010 Sep 21.

Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2010.09.002DOI Listing
November 2010

Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3-RINGBox1 protein complex and elucidation of its quaternary structure with Keap1.

Biochem Biophys Res Commun 2010 Oct 22;400(4):471-5. Epub 2010 Aug 22.

Department of Biochemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2010.08.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868348PMC
October 2010

Pleiotropic mechanisms facilitated by resveratrol and its metabolites.

Biochem J 2010 Jul;429(2):273-82

Department of Medicinal Chemistry and Pharmacognosy and Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20091857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265359PMC
July 2010

Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer.

Bioorg Med Chem 2010 Jul 24;18(14):5352-66. Epub 2010 May 24.

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and The Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2010.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903642PMC
July 2010

Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.

J Virol 2010 May 24;84(9):4619-29. Epub 2010 Feb 24.

Department of Microbiology and Immunology, Loyola University Medical Center, Bldg. 105, Rm. 3929, 2160 South First Avenue, Maywood, IL 60153, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02406-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863753PMC
May 2010

A universal, fully automated high throughput screening assay for pyrophosphate and phosphate release from enzymatic reactions.

Comb Chem High Throughput Screen 2010 Jan;13(1):27-38

Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, IL 60607-7173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/138620710790218203DOI Listing
January 2010

Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.

J Nat Prod 2009 Dec;72(12):2158-62

Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Illinois 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/np900549eDOI Listing
December 2009

Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans.

J Mol Biol 2009 Oct 22;393(1):36-57. Epub 2009 Jul 22.

Department of Medicinal Chemistry and Pharmacognosy, Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2009.06.083DOI Listing
October 2009

Structural basis for thermostability revealed through the identification and characterization of a highly thermostable phosphotriesterase-like lactonase from Geobacillus stearothermophilus.

Arch Biochem Biophys 2009 Aug 16;488(2):109-20. Epub 2009 Jul 16.

Department of Medicinal Chemistry and Pharmacognosy and the Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2009.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433624PMC
August 2009

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

Biochem J 2009 Jul 29;422(1):171-80. Epub 2009 Jul 29.

Center for Pharmaceutical Biotechnology and the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20090471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865926PMC
July 2009

Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.

J Med Chem 2009 Apr;52(7):1873-84

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and the Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jm801335z
Publisher Site
http://dx.doi.org/10.1021/jm801335zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673050PMC
April 2009

Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.

J Mol Biol 2009 Mar 10;386(4):1038-53. Epub 2009 Jan 10.

Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2009.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654403PMC
March 2009

Kinetic and X-ray structural evidence for negative cooperativity in substrate binding to nicotinate mononucleotide adenylyltransferase (NMAT) from Bacillus anthracis.

J Mol Biol 2009 Jan 19;385(3):867-88. Epub 2008 Oct 19.

Department of Medicinal Chemistry and Pharmacognosy & the Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2008.10.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654404PMC
January 2009

Structural and mechanistic analysis of trans-3-chloroacrylic acid dehalogenase activity.

Acta Crystallogr D Biol Crystallogr 2008 Dec 18;64(Pt 12):1277-82. Epub 2008 Nov 18.

Center of Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0907444908034707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631126PMC
December 2008

Bacillus anthracis o-succinylbenzoyl-CoA synthetase: reaction kinetics and a novel inhibitor mimicking its reaction intermediate.

Biochemistry 2008 Nov;47(47):12434-47

Center for Pharmaceutical Biotechnology, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, 900 South Ashland Avenue, Chicago, Illinois 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi801311dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710618PMC
November 2008

Prospective type 1 and type 2 disulfides of Keap1 protein.

Chem Res Toxicol 2008 Oct 26;21(10):2051-60. Epub 2008 Aug 26.

Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx800226mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821167PMC
October 2008

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.

Proc Natl Acad Sci U S A 2008 Oct 13;105(42):16119-24. Epub 2008 Oct 13.

Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0805240105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571001PMC
October 2008

Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.

Biochem J 2008 Jul;413(1):81-91

Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The University of Illinois at Chicago, 900 S. Ashland Ave M/C 870, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20071373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265362PMC
July 2008

Viral destruction of cell surface receptors.

Proc Natl Acad Sci U S A 2008 Jul 23;105(26):8807-8. Epub 2008 Jun 23.

Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0804355105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2449321PMC
July 2008

Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2.

Mol Nutr Food Res 2008 Jun;52 Suppl 1:S84-94

The Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mnfr.200700249DOI Listing
June 2008

Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Bioorg Med Chem Lett 2008 Jun 4;18(12):3565-9. Epub 2008 May 4.

Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2008.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526048PMC
June 2008

Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery.

Virus Res 2008 Apr 29;133(1):63-73. Epub 2007 Mar 29.

Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, IL 60607, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virusres.2007.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036818PMC
April 2008

Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent.

Chem Res Toxicol 2007 Dec 13;20(12):1878-84. Epub 2007 Oct 13.

The Center for Pharmaceutical Biotechnology, and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx700217cDOI Listing
December 2007

Sites of alkylation of human Keap1 by natural chemoprevention agents.

J Am Soc Mass Spectrom 2007 Dec 2;18(12):2226-32. Epub 2007 Oct 2.

Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, Illinois, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jasms.2007.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2144741PMC
December 2007

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors.

Bioorg Med Chem Lett 2007 Nov 19;17(21):5876-80. Epub 2007 Aug 19.

Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.08.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2112940PMC
November 2007

An ELISA method to measure inhibition of the COX enzymes.

Nat Protoc 2006 ;1(4):1915-21

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, College of Pharmacy, Nursing and Health Sciences, and The Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2006.308DOI Listing
October 2007

Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63.

J Virol 2007 Jun 28;81(11):6007-18. Epub 2007 Mar 28.

Department of Microbiology and Immunology, Loyola University Medical Center, 2160 South First Avenue, Bldg. 105, Rm. 3929, Maywood, IL 60153, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02747-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900296PMC
June 2007

Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy.

Annu Rep Med Chem 2007 Feb;41:183-196

Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, IN 47907.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0065-7743(06)41011-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718771PMC
February 2007

Deubiquitinating activity of the SARS-CoV papain-like protease.

Adv Exp Med Biol 2006 ;581:37-41

Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-0-387-33012-9_5DOI Listing
December 2006

Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme.

Proc Natl Acad Sci U S A 2006 Apr 31;103(15):5717-22. Epub 2006 Mar 31.

Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0510851103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458639PMC
April 2006

Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia.

Bioorg Med Chem 2006 Feb 10;14(4):960-72. Epub 2005 Oct 10.

Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2005.09.012DOI Listing
February 2006

Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza.

Planta Med 2006 Feb;72(3):255-60

Department of Pharmacognosy, Faculty of Pharmacy Mahidol University, Bangkok, Thailand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-2005-873171DOI Listing
February 2006

Miliusanes, a class of cytotoxic agents from Miliusa sinensis.

J Med Chem 2006 Jan;49(2):693-708

Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Illinois 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm0509492DOI Listing
January 2006

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity.

J Virol 2005 Dec;79(24):15189-98

Department of Microbiology and Immunology, Loyola University Chicago, Stritch School of Medicine, 2160 South First Avenue, Bldg. 105, Maywood, IL 60153, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.79.24.15189-15198.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1316023PMC
December 2005

Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.

J Med Chem 2005 Nov;48(22):6767-71

Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm050548mDOI Listing
November 2005

Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site.

Arch Biochem Biophys 2005 Oct 6;442(2):169-79. Epub 2005 Sep 6.

Biochemistry and Biophysics Department, Texas A&M University, College Station, TX 77843-2128, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2005.08.012DOI Listing
October 2005

Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.

Anal Chem 2005 Oct;77(19):6407-14

Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 South Wood Street, Chicago, Illinois 60612-7231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac050892rDOI Listing
October 2005

Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.

Chem Res Toxicol 2005 Aug;18(8):1296-305

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx050058xDOI Listing
August 2005

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.

Biochemistry 2005 Jul;44(27):9417-29

Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi0474923DOI Listing
July 2005

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.

Proc Natl Acad Sci U S A 2005 Jul 8;102(29):10070-5. Epub 2005 Jul 8.

Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0502402102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177374PMC
July 2005

Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa.

Bioorg Med Chem Lett 2004 Oct;14(20):5165-70

Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 S. Ashland Avenue, m/c 870, Chicago, IL 60607-7173, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S0960894X0400955
Publisher Site
http://dx.doi.org/10.1016/j.bmcl.2004.07.054DOI Listing
October 2004

New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.

J Nat Prod 2004 Jun;67(6):994-8

Institute of Chemistry, National Center for Science and Technology, Nghia Do, Tu Liem, Hanoi, Vietnam.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/np030469iDOI Listing
June 2004

Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase.

Chem Res Toxicol 2004 Apr;17(4):512-20

Department of Medicinal Chemistry and Pharmacognosy (M/C 781), College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612,USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/tx0342464
Publisher Site
http://dx.doi.org/10.1021/tx0342464DOI Listing
April 2004

Antimycobacterial Naphthopyrones from Senna obliqua.

J Nat Prod 2004 Feb;67(2):225-7

Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/np030348iDOI Listing
February 2004