Andrew D Howard

Andrew D Howard

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Andrew D Howard

Andrew D Howard

Publications by authors named "Andrew D Howard"

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The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.

Mol Metab 2019 01 5;19:49-64. Epub 2018 Nov 5.

Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183093
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http://dx.doi.org/10.1016/j.molmet.2018.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323244PMC
January 2019

GPR40 reduces food intake and body weight through GLP-1.

Am J Physiol Endocrinol Metab 2017 07 14;313(1):E37-E47. Epub 2017 Mar 14.

Department of In Vivo Pharmacology, Merck Research Laboratories, Kenilworth, New Jersey;

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http://dx.doi.org/10.1152/ajpendo.00435.2016DOI Listing
July 2017

GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).

Endocrinology 2016 Dec 25;157(12):4561-4569. Epub 2016 Oct 25.

NNF Center for Basic Metabolic Research (J.H.E., M.H., L.V.K., A.N.M., M.S.E., A.-S.H., R.S., K.L.E., B.H., T.W.S.), Section for Metabolic Receptology; Laboratory for Molecular Pharmacology (J.H.E., M.H., L.V.K., M.S.E., A.-S.H., R.S., K.L.E., B.H., T.W.S.), Department of Neuroscience and Pharmacology; and Danish Diabetes Academy (M.S.E.), 5000 Odense, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research (P.T.), Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Merck Research Laboratories (T.J.K., A.D.H.), Kenilworth, New Jersey 07033; Cambridge Institute for Medical Research and MRC Metabolic Diseases Unit (F.M.G., F.R.), University of Cambridge, Cambridge, CB20QQ United Kingdom; Department of Drug Design and Pharmacology (H.S.H.), University of Copenhagen, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/en.2016-1334DOI Listing
December 2016

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

ACS Med Chem Lett 2016 Dec 12;7(12):1107-1111. Epub 2016 Oct 12.

Departments of Medicinal Chemistry, Discovery Pharmaceutical Sciences, Pharmacokenetics Pharmacodynamics Drug Metabolism, Diabetes Research, and Cardiometabolic Disease, Merck & Co., Inc., MRL , 126 East Lincoln Avenue, PO Box 2000, Rahway, New Jersey 07065, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150677PMC
December 2016

The ESRD Quality Incentive Program: The Current Limitations of Evidence and Data to Develop Measures, Drive Improvement, and Incentivize Outcomes.

Adv Chronic Kidney Dis 2016 Nov;23(6):377-384

Quality Health Care Advisory Group, Huntington, NY; and Metropolitan Nephrology Associates, Clinton, MD. Electronic address:

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http://dx.doi.org/10.1053/j.ackd.2016.11.007DOI Listing
November 2016

Duodenal-jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice.

Obesity (Silver Spring) 2016 09 26;24(9):1938-45. Epub 2016 Jul 26.

Cardiometabolic Disease, Merck Research Laboratories, Kenilworth, New Jersey, USA.

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http://dx.doi.org/10.1002/oby.21583DOI Listing
September 2016

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.

Endocrinology 2016 Jan 15;157(1):176-94. Epub 2015 Oct 15.

Novo Nordisk Foundation Center for Basic Metabolic Research (K.V.G., C.F.R., B.S., M.S.E., A.N.M., J.P., M.K.N., K.L.E., F.B., J.J.H., B.H., T.W.S.), Section for Metabolic Receptology and Enteroendocrinology; Laboratory for Molecular Pharmacology (K.V.G., C.F.R., M.S.E., A.N.M., M.K.N., K.L.E., B.H., T.W.S.), Department of Neuroscience and Pharmacology; and Department of Biomedical Sciences (B.S., J.P., S.S.P., J.J.H.), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark; Department of Molecular and Clinical Medicine (F.S., F.B.), Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden; Danish Diabetes Academy (M.S.E.), 5000 Odense, Denmark; Merck Research Laboratories (A.R.N., T.K., A.D.H.), Kenilworth, NJ 07033; and Department of Pharmacology (S.O.), Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2015-1600DOI Listing
January 2016

Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.

Mol Endocrinol 2015 Sep 28;29(9):1243-53. Epub 2015 Jul 28.

Departments of Metabolic Disorders-Diabetes (J.S., Y.F., N.A.T., A.D.H., Y.-P.Z.) and Target Validation (J.L., H.H.Z.) and Laboratory of Animal Research (X.S.), Merck Research Laboratories, Rahway, New Jersey 07065; Department of Biochemistry (M.P.K., M.R., M.S., A.D.A.), University of Wisconsin, Madison, Wisconsin 53076; Sarah W. Stedman Nutrition and Metabolism Center (H.E.H., C.B.N.), Duke University Medical Center, Durham, North Carolina 27704; and Department of Surgery/Transplant (Y.W.), University of Illinois at Chicago, Chicago, Illinois 60612.

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https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
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http://dx.doi.org/10.1210/me.2014-1335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552436PMC
September 2015

Correlates of change in health care worker seasonal influenza vaccination rates among dialysis facilities.

Am J Infect Control 2015 Apr 10;43(4):409-11. Epub 2015 Feb 10.

Metropolitan Nephrology Associates, Alexandria, VA.

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http://dx.doi.org/10.1016/j.ajic.2014.12.011DOI Listing
April 2015

GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.

Mol Metab 2015 Jan 24;4(1):3-14. Epub 2014 Oct 24.

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen N, Denmark ; Department of Neuroscience and Pharmacology, University of Copenhagen, DK-2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.molmet.2014.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314522PMC
January 2015

The Quality Incentive Program and how it will influence your practice.

Authors:
Andrew D Howard

Nephrol News Issues 2013 Jan;27(1):20-3

Metropolitan Nephrology Associates, Alexandria, VA, USA.

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January 2013

3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists.

Bioorg Med Chem Lett 2011 Jun 8;21(11):3390-4. Epub 2011 Apr 8.

Merck Research Laboratories, Merck & Co., Inc., 126 E. Lincoln Ave., PO Box 2000, Rahway, NJ 07065-0900, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.03.114DOI Listing
June 2011

Design of potent and selective GPR119 agonists for type II diabetes.

Bioorg Med Chem Lett 2011 May 22;21(9):2665-9. Epub 2010 Dec 22.

Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 2000 Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.12.086DOI Listing
May 2011

Improving influenza vaccination in dialysis facilities.

Am J Med Qual 2010 Nov-Dec;25(6):416-28. Epub 2010 May 14.

Mid-Atlantic Renal Coalition, Midlothian, VA 23113, USA.

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http://journals.sagepub.com/doi/10.1177/1062860610367957
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http://dx.doi.org/10.1177/1062860610367957DOI Listing
March 2011

4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

Bioorg Med Chem Lett 2006 Oct 17;16(20):5275-9. Epub 2006 Aug 17.

Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.08.008DOI Listing
October 2006

Long-term posttransplantation care: the expanding role of community nephrologists.

Authors:
Andrew D Howard

Am J Kidney Dis 2006 Apr;47(4 Suppl 2):S111-24

Metropolitan Nephrology Associates, Alexandria, VA 22306, USA.

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http://dx.doi.org/10.1053/j.ajkd.2005.12.040DOI Listing
April 2006

Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice.

Endocrinology 2006 Mar 8;147(3):1517-26. Epub 2005 Dec 8.

Department of Pharmacology, Merck Research Laboratories, P.O. Box 2000, RY80Y-150, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1210/en.2005-0993DOI Listing
March 2006

Characterization of the bombesin-like peptide receptor family in primates.

Genomics 2004 Jul;84(1):139-46

Department of Metabolic Disorders, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08887543040003
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http://dx.doi.org/10.1016/j.ygeno.2004.01.008DOI Listing
July 2004

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats.

Eur J Pharmacol 2003 Aug;475(1-3):37-47

Department of Pharmacology, Merck Research Laboratories, PO Box 2000, Building RY80Y-150, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/s0014-2999(03)02146-0DOI Listing
August 2003

Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula.

Eur J Pharmacol 2002 Nov;454(1):71-9

Department of Pharmacology, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/s0014-2999(02)02479-2DOI Listing
November 2002