Publications



DualandInhibition Demonstrates Synergy against Neuroblastoma.
Clin Cancer Res 2017 Jun 16;23(11):2856-2868. Epub 2016 Dec 16.
Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.


Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.
Blood 2015 Mar 2;125(11):1759-67. Epub 2015 Feb 2.
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA;

ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma.
Cancer Cell 2014 Nov 10;26(5):682-94. Epub 2014 Nov 10.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address:

Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program.
Pediatr Blood Cancer 2013 Nov 24;60(11):1860-7. Epub 2013 Jun 24.
Hematology-Oncology Division of Oncology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania.

Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma.
Clin Cancer Res 2013 Nov 17;19(22):6173-82. Epub 2013 Sep 17.
Authors' Affiliations: Division of Oncology and Center for Childhood Cancer Research; Division of Pathology, Children's Hospital of Philadelphia; Department of Pediatrics; Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.



Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.
Sci Transl Med 2011 Nov;3(108):108ra114
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6059, USA.


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