Publications by authors named "Andrew B Ward"

100Publications

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein.

Structure 2020 Dec 22. Epub 2020 Dec 22.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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December 2020

Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail.

iScience 2020 Dec 20;23(12):101836. Epub 2020 Nov 20.

Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

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December 2020

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody.

PLoS Pathog 2020 12 4;16(12):e1009089. Epub 2020 Dec 4.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America.

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December 2020

Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity.

Immunity 2020 12 25;53(6):1272-1280.e5. Epub 2020 Nov 25.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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December 2020

A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide.

Cell Rep 2020 Nov;33(8):108428

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, International AIDS Vaccine Initiative Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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November 2020

Visualization of the HIV-1 Env glycan shield across scales.

Proc Natl Acad Sci U S A 2020 11 22;117(45):28014-28025. Epub 2020 Oct 22.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037;

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November 2020

An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain.

Cell Rep 2020 10 29;33(3):108274. Epub 2020 Sep 29.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. Electronic address:

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October 2020

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody.

bioRxiv 2020 Sep 21. Epub 2020 Sep 21.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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September 2020

Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques.

Cell Rep 2020 09;32(10):108122

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI, New York, NY 10004, USA. Electronic address:

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September 2020

Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells.

Protein Sci 2020 09 14;29(9):1975-1982. Epub 2020 Aug 14.

Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.

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September 2020

Structural basis of broad HIV neutralization by a vaccine-induced cow antibody.

Sci Adv 2020 May 27;6(22):eaba0468. Epub 2020 May 27.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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May 2020

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions.

Structure 2020 08 19;28(8):897-909.e6. Epub 2020 May 19.

School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. Electronic address:

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August 2020

Innovations in structure-based antigen design and immune monitoring for next generation vaccines.

Curr Opin Immunol 2020 08 22;65:50-56. Epub 2020 Apr 22.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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August 2020

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies.

Cell Rep 2020 04;31(4):107583

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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April 2020

Mapping Polyclonal Antibody Responses in Non-human Primates Vaccinated with HIV Env Trimer Subunit Vaccines.

Cell Rep 2020 03;30(11):3755-3765.e7

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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March 2020

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.

Immunity 2020 02 4;52(2):388-403.e12. Epub 2020 Feb 4.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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February 2020

Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein.

J Mol Biol 2020 02 27;432(4):1048-1063. Epub 2019 Dec 27.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. Electronic address:

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February 2020

Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice.

Cell Host Microbe 2019 12 19;26(6):715-728.e8. Epub 2019 Nov 19.

The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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December 2019

Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.

Cell Host Microbe 2019 12 19;26(6):729-738.e4. Epub 2019 Nov 19.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. Electronic address:

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December 2019

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.

Immunity 2019 11 12;51(5):915-929.e7. Epub 2019 Nov 12.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, Neutralizing Antibody Center at The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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November 2019

SOS and IP Modifications Predominantly Affect the Yield but Not Other Properties of SOSIP.664 HIV-1 Env Glycoprotein Trimers.

J Virol 2019 12 12;94(1). Epub 2019 Dec 12.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA

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December 2019

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics.

PLoS Pathog 2019 07 15;15(7):e1007920. Epub 2019 Jul 15.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.

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July 2019

Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics.

Proc Natl Acad Sci U S A 2019 07 11;116(30):15194-15199. Epub 2019 Jul 11.

Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993;

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July 2019

Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.

Cell Host Microbe 2019 06;25(6):873-883.e5

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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June 2019

Structures of the otopetrin proton channels Otop1 and Otop3.

Nat Struct Mol Biol 2019 06 3;26(6):518-525. Epub 2019 Jun 3.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.

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June 2019

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors.

Nat Commun 2019 05 28;10(1):2342. Epub 2019 May 28.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, HZ-102, La Jolla, CA, 92037, USA.

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May 2019

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template.

Cell Rep 2019 05;27(8):2426-2441.e6

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02114, USA. Electronic address:

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May 2019

A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface.

Cell 2019 05;177(5):1136-1152.e18

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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May 2019

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance.

Cell 2019 05 9;177(5):1153-1171.e28. Epub 2019 May 9.

Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (Scripps CHAVI-ID), The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:

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May 2019

Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex.

Acta Crystallogr F Struct Biol Commun 2019 May 24;75(Pt 5):340-347. Epub 2019 Apr 24.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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May 2019

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor.

Molecules 2019 Apr 22;24(8). Epub 2019 Apr 22.

Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Rooms 10307, 10309, and 10315, 245 North 15th Street, Philadelphia, PA 19102, USA.

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April 2019

The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization.

Cell Rep 2019 04;27(2):586-598.e6

Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Center of Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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April 2019

Antibody responses to viral infections: a structural perspective across three different enveloped viruses.

Nat Microbiol 2019 05 18;4(5):734-747. Epub 2019 Mar 18.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.

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May 2019

Playing Chess with HIV.

Authors:
Andrew B Ward

Immunity 2019 02;50(2):283-285

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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February 2019

Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.

Nat Commun 2019 02 15;10(1):763. Epub 2019 Feb 15.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.

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February 2019

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains.

PLoS Biol 2019 02 4;17(2):e3000139. Epub 2019 Feb 4.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.

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February 2019

Fluorescent Trimeric Hemagglutinins Reveal Multivalent Receptor Binding Properties.

J Mol Biol 2019 02 29;431(4):842-856. Epub 2018 Dec 29.

Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, the Netherlands. Electronic address:

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February 2019

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.

Immunity 2019 01 11;50(1):241-252.e6. Epub 2018 Dec 11.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Electronic address:

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January 2019

Deception through Mimicry: A Cellular Antiviral Strategy.

Cell 2018 12;175(7):1728-1729

Department of Integrative Structural and Computational Biology, the Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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December 2018

Cryo-EM structure of the mechanically activated ion channel OSCA1.2.

Elife 2018 11 1;7. Epub 2018 Nov 1.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, California, United States.

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November 2018

OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels.

Elife 2018 11 1;7. Epub 2018 Nov 1.

Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, California, United States.

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November 2018

Cryo-EM structure of circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts.

Sci Adv 2018 10 10;4(10):eaau8529. Epub 2018 Oct 10.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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October 2018

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers.

Cell Rep 2018 09;24(12):3324-3338.e5

Imperial College London, Department of Medicine, Division of Infectious Diseases, Section of Virology, Norfolk Place, London W2 1PG, UK. Electronic address:

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September 2018

Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.

Cell Rep 2018 09;24(10):2723-2732.e4

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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September 2018

Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization.

Immunity 2018 08 7;49(2):288-300.e8. Epub 2018 Aug 7.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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August 2018

Structure of the human volume regulated anion channel.

Elife 2018 08 10;7. Epub 2018 Aug 10.

Department of Neuroscience, Howard Hughes Medical Institute, The Scripps Research Institute, La Jolla, United States.

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August 2018

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.

Immunity 2018 08 17;49(2):363-374.e10. Epub 2018 Jul 17.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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August 2018

Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design.

Cell Rep 2018 06;23(11):3249-3261

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center and Collaboration of AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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June 2018

Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers .

J Virol 2018 07 13;92(13). Epub 2018 Jun 13.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA

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July 2018