Publications by authors named "Andrew Aguirre"

44Publications

The Human and Mouse Enteric Nervous System at Single-Cell Resolution.

Cell 2020 Sep 3;182(6):1606-1622.e23. Epub 2020 Sep 3.

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute and Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.08.003DOI Listing
September 2020

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.

Cancer Cell 2020 Aug 18;38(2):198-211.e8. Epub 2020 Jun 18.

David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Dartmouth Norris Cotton Cancer Center, Lebanon, NH 03766, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.05.010DOI Listing
August 2020

Biomarker-Guided Development of DNA Repair Inhibitors.

Mol Cell 2020 06 26;78(6):1070-1085. Epub 2020 May 26.

Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316088PMC
June 2020

Defining and Targeting Adaptations to Oncogenic KRAS Inhibition Using Quantitative Temporal Proteomics.

Cell Rep 2020 03;30(13):4584-4599.e4

Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.03.021DOI Listing
March 2020

Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.

J Med Chem 2020 02 30;63(4):1624-1641. Epub 2020 Jan 30.

Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493195PMC
February 2020

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.

Cell Rep 2019 10;29(1):118-134.e8

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, MA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918830PMC
October 2019

Oncogenic NRG1 Fusions: A New Hope for Targeted Therapy in Pancreatic Cancer.

Authors:
Andrew J Aguirre

Clin Cancer Res 2019 08 4;25(15):4589-4591. Epub 2019 Jun 4.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679796PMC
August 2019

Refining Classification of Pancreatic Cancer Subtypes to Improve Clinical Care.

Authors:
Andrew J Aguirre

Gastroenterology 2018 12 9;155(6):1689-1691. Epub 2018 Nov 9.

Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts and Broad Institute of MIT and Harvard, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.11.004DOI Listing
December 2018

Advances in the Genetics and Biology of Pancreatic Cancer.

Cancer J 2017 Nov/Dec;23(6):315-320

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http://dx.doi.org/10.1097/PPO.0000000000000286DOI Listing
July 2018

Synthetic Lethal Vulnerabilities in -Mutant Cancers.

Cold Spring Harb Perspect Med 2018 08 1;8(8). Epub 2018 Aug 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/cshperspect.a031518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990478PMC
August 2018

ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition.

Cell Rep 2017 02;18(6):1543-1557

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313047PMC
February 2017

Functional Genomic Characterization of Cancer Genomes.

Cold Spring Harb Symp Quant Biol 2016 4;81:237-246. Epub 2016 Nov 4.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/sqb.2016.81.031070DOI Listing
February 2018

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.

Cancer Discov 2016 08 3;6(8):914-29. Epub 2016 Jun 3.

Dana-Farber Cancer Institute, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972686PMC
August 2016

ARID1B is a specific vulnerability in ARID1A-mutant cancers.

Nat Med 2014 Mar 23;20(3):251-4. Epub 2014 Feb 23.

1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA. [3] Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. [4] Broad Institute of Harvard and MIT, Boston, Massachusetts, USA. [5] Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954704PMC
March 2014

High-resolution global profiling of genomic alterations with long oligonucleotide microarray.

Cancer Res 2004 Jul;64(14):4744-8

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-1241DOI Listing
July 2004

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.

Genes Dev 2003 Dec 17;17(24):3112-26. Epub 2003 Dec 17.

Department of Medical Oncology, Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1158703
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http://dx.doi.org/10.1101/gad.1158703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC305262PMC
December 2003