Publications by authors named "Andrew A Grace"

96Publications

Unmasking Adenosine: The Purinergic Signalling Molecule Critical to Arrhythmia Pathophysiology and Management.

Arrhythm Electrophysiol Rev 2020 Feb;8(4):240-248

Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.15420/aer.2019.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358948PMC
February 2020

Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome.

Am J Physiol Cell Physiol 2019 09 10;317(3):C576-C583. Epub 2019 Jul 10.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1152/ajpcell.00028.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766618PMC
September 2019

Quinidine Rebooted: Contemporary Approaches to Multichannel Blockade.

JACC Clin Electrophysiol 2019 03;5(3):383-386

Cardiovascular Division, Royal Papworth Hospital National Health Service Foundation Trust, Cambridge University Health Partners, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.jacep.2019.01.015DOI Listing
March 2019

Phenotypic Landscape and Risk Management in Long QT Syndrome: Nudging Forward.

J Am Coll Cardiol 2018 04;71(15):1672-1675

Royal Papworth Hospital NHS Foundation Trust, Cambridge University Health Partners, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.jacc.2018.02.040DOI Listing
April 2018

Continuous and minimally-interrupted direct oral anticoagulant are both safe compared with vitamin K antagonist for atrial fibrillation ablation: An updated meta-analysis.

Int J Cardiol 2018 07 21;262:51-56. Epub 2018 Mar 21.

Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.03.095DOI Listing
July 2018

Age-dependent electrocardiographic changes in Pgc-1β deficient murine hearts.

Clin Exp Pharmacol Physiol 2018 02 29;45(2):174-186. Epub 2017 Nov 29.

Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1111/1440-1681.12863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814877PMC
February 2018

Age-dependent atrial arrhythmic phenotype secondary to mitochondrial dysfunction in Pgc-1β deficient murine hearts.

Mech Ageing Dev 2017 10 14;167:30-45. Epub 2017 Sep 14.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652526PMC
October 2017

Effects of ageing on pro-arrhythmic ventricular phenotypes in incrementally paced murine Pgc-1β hearts.

Pflugers Arch 2017 Dec 18;469(12):1579-1590. Epub 2017 Aug 18.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.

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http://dx.doi.org/10.1007/s00424-017-2054-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691113PMC
December 2017

Improved outcome and cost effectiveness in ablation of persistent atrial fibrillation under general anaesthetic.

Europace 2018 06;20(6):935-942

Electrophysiology Department, Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridge CB23 3RE, UK.

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http://dx.doi.org/10.1093/europace/eux057DOI Listing
June 2018

Ion channels, long QT syndrome and arrhythmogenesis in ageing.

Clin Exp Pharmacol Physiol 2017 12 20;44 Suppl 1:38-45. Epub 2017 Sep 20.

Physiological Laboratory, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/1440-1681.12721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763326PMC
December 2017

Atrial fibrillation and heart failure. Preface.

Heart Fail Clin 2013 Oct;9(4):xv

Department of Biochemistry, University of Cambridge, Hopkins Building, Tennis Court Road, CB2 1QW, UK; Papworth Hospital, Cambridge CB23 3RE, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15517136130006
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http://dx.doi.org/10.1016/j.hfc.2013.08.002DOI Listing
October 2013

Common threads in atrial fibrillation and heart failure.

Heart Fail Clin 2013 Oct;9(4):373-83, vii

Department of Biochemistry, University of Cambridge, Hopkins Building, Tennis Court Road, Cambridge CB2 1QW, UK; Papworth Hospital, Cambridge CB23 3RE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.hfc.2013.07.011DOI Listing
October 2013

Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a(+/-) hearts.

J Physiol 2013 Sep 8;591(17):4167-88. Epub 2013 Jul 8.

G. D. K. Matthews: Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.

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http://dx.doi.org/10.1113/jphysiol.2013.254938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779110PMC
September 2013

Conscious sedation and analgesia use in cardiac device implantation.

Int J Cardiol 2013 Sep 27;168(1):561-3. Epub 2013 Feb 27.

Department of Cardiology, Papworth Hospital NHS Foundation Trust, Cambridge CB23 3RE, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01675273130022
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http://dx.doi.org/10.1016/j.ijcard.2013.01.167DOI Listing
September 2013

Systems biology and cardiac arrhythmias.

Lancet 2012 Oct;380(9852):1498-508

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/S0140-6736(12)61462-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745651PMC
October 2012

Subcutaneous chronic implantable defibrillation systems in humans.

J Interv Card Electrophysiol 2012 Sep 17;34(3):325-32. Epub 2012 Mar 17.

Arrhythmia and Electrophysiology Center, University of Milan, IRCCS Policlinico San Donato, Via Morandi 30 20097 San Donato Milanese, Milan, Italy.

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http://dx.doi.org/10.1007/s10840-012-9665-6DOI Listing
September 2012

Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome.

Am J Physiol Heart Circ Physiol 2012 Apr 27;302(7):H1510-23. Epub 2012 Jan 27.

Department of Cardiovascular Diseases, Union Hospital, Huazhong University of Sciences and Technology, Wuhan, Peoples' Republic of China.

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http://www.physiology.org/doi/10.1152/ajpheart.00357.2011
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http://dx.doi.org/10.1152/ajpheart.00357.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330789PMC
April 2012

Ventricular arrhythmogenesis following slowed conduction in heptanol-treated, Langendorff-perfused mouse hearts.

J Physiol Sci 2012 Mar 5;62(2):79-92. Epub 2012 Jan 5.

Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1007/s12576-011-0187-2DOI Listing
March 2012

Refractory dispersion promotes conduction disturbance and arrhythmias in a Scn5a (+/-) mouse model.

Pflugers Arch 2011 Oct 21;462(4):495-504. Epub 2011 Jul 21.

Physiological Laboratory, University of Cambridge, Downing Site, Cambridge, CB2 3EG, UK.

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http://dx.doi.org/10.1007/s00424-011-0989-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170477PMC
October 2011

Totally subcutaneous implantable cardioverter defibrillator with an alternative, right parasternal, electrode placement.

Pacing Clin Electrophysiol 2012 Sep 14;35(9):e254-7. Epub 2011 Mar 14.

Institute for Genetics of Heart Diseases, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1111/j.1540-8159.2011.03043.xDOI Listing
September 2012

Progressive Conduction Diseases.

Card Electrophysiol Clin 2010 Dec;2(4):509-519

Department of Biochemistry, University of Cambridge, Downing Site, CB2 1QW, UK; Department of Cardiology, Papworth Hospital, Cambridge CB23 3RE, UK.

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http://dx.doi.org/10.1016/j.ccep.2010.09.007DOI Listing
December 2010

Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse model.

Am J Physiol Heart Circ Physiol 2011 Feb 19;300(2):H605-16. Epub 2010 Nov 19.

Physiological Laboratory, Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 3EG, UK.

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http://ajpheart.physiology.org/content/ajpheart/300/2/H605.f
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http://ajpheart.physiology.org/cgi/doi/10.1152/ajpheart.0082
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http://dx.doi.org/10.1152/ajpheart.00824.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044044PMC
February 2011

In vivo studies of Scn5a+/- mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities.

J Electrocardiol 2010 Sep-Oct;43(5):433-9. Epub 2010 Jul 17.

Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.jelectrocard.2010.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712183PMC
January 2011

Atrial arrhythmogenic properties in wild-type and Scn5a+/- murine hearts.

Exp Physiol 2010 Oct 9;95(10):994-1007. Epub 2010 Jul 9.

Physiological Laboratory, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1113/expphysiol.2010.053868DOI Listing
October 2010

Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts.

Cardiovasc Res 2011 Mar 9;89(4):794-804. Epub 2010 Jul 9.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.

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http://dx.doi.org/10.1093/cvr/cvq229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039245PMC
March 2011

Increased right ventricular repolarization gradients promote arrhythmogenesis in a murine model of Brugada syndrome.

J Cardiovasc Electrophysiol 2010 Oct;21(10):1153-9

Physiological Laboratory, University of Cambridge, Downing Site, Cambridge, United Kingdom.

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http://dx.doi.org/10.1111/j.1540-8167.2010.01767.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084998PMC
October 2010

Effects of flecainide and quinidine on action potential and ventricular arrhythmogenic properties in Scn3b knockout mice.

Clin Exp Pharmacol Physiol 2010 Aug 4;37(8):782-9. Epub 2010 Feb 4.

Physiological Laboratory, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1440-1681.2010.05369.xDOI Listing
August 2010

Alternans in genetically modified langendorff-perfused murine hearts modeling catecholaminergic polymorphic ventricular tachycardia.

Front Physiol 2010 28;1:126. Epub 2010 Oct 28.

Physiological Laboratory, Department of Physiology, Development and Neuroscience, University of Cambridge Cambridge, UK.

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http://dx.doi.org/10.3389/fphys.2010.00126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059940PMC
May 2011

Activation of purinergic receptors by ATP induces ventricular tachycardia by membrane depolarization and modifications of Ca2+ homeostasis.

J Mol Cell Cardiol 2009 Nov 10;47(5):622-33. Epub 2009 Aug 10.

Department of Biochemistry, Hopkins Building; University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.

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http://dx.doi.org/10.1016/j.yjmcc.2009.08.001DOI Listing
November 2009

Empirical correlation of triggered activity and spatial and temporal re-entrant substrates with arrhythmogenicity in a murine model for Jervell and Lange-Nielsen syndrome.

Pflugers Arch 2009 Sep 9;458(5):819-35. Epub 2009 May 9.

Physiological Laboratory, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.

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http://dx.doi.org/10.1007/s00424-009-0671-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719739PMC
September 2009

Risk stratification for sudden cardiac death.

Prog Biophys Mol Biol 2008 Oct-Nov;98(2-3):340-6. Epub 2009 Feb 6.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, UK.

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http://dx.doi.org/10.1016/j.pbiomolbio.2009.01.013DOI Listing
May 2009

Anti-arrhythmic effects of cyclopiazonic acid in Langendorff-perfused murine hearts.

Prog Biophys Mol Biol 2008 Oct-Nov;98(2-3):281-8. Epub 2009 Jan 24.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.

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http://dx.doi.org/10.1016/j.pbiomolbio.2009.01.004DOI Listing
May 2009

Arrhythmogenic substrate and its modification by nicorandil in a murine model of long QT type 3 syndrome.

Prog Biophys Mol Biol 2008 Oct-Nov;98(2-3):267-80. Epub 2009 Jan 24.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.

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http://dx.doi.org/10.1016/j.pbiomolbio.2009.01.006DOI Listing
May 2009

Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties.

Prog Biophys Mol Biol 2008 Oct-Nov;98(2-3):251-66. Epub 2009 Jan 24.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom.

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http://dx.doi.org/10.1016/j.pbiomolbio.2009.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764399PMC
May 2009

Cardiac arrhythmogenesis is a major clinical problem.

Prog Biophys Mol Biol 2008 Oct-Nov;98(2-3):119. Epub 2009 Feb 10.

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http://dx.doi.org/10.1016/j.pbiomolbio.2009.02.001DOI Listing
May 2009

Atrial arrhythmogenesis in wild-type and Scn5a+/delta murine hearts modelling LQT3 syndrome.

Pflugers Arch 2009 Jul 28;458(3):443-57. Epub 2009 Jan 28.

Cardiovascular Biology Group, Physiological Laboratory, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/s00424-008-0633-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691533PMC
July 2009

Ventricular arrhythmogenesis: insights from murine models.

Prog Biophys Mol Biol 2008 Oct-Nov;98(2-3):208-18. Epub 2008 Nov 9.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, UK.

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http://dx.doi.org/10.1016/j.pbiomolbio.2008.10.011DOI Listing
May 2009

Dispersions of repolarization and ventricular arrhythmogenesis: lessons from animal models.

Prog Biophys Mol Biol 2008 Oct-Nov;98(2-3):219-29. Epub 2008 Nov 7.

Cardiovascular Research Centre, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.pbiomolbio.2008.10.008DOI Listing
May 2009

Arrhythmogenic actions of the Ca2+ channel agonist FPL-64716 in Langendorff-perfused murine hearts.

Exp Physiol 2009 Feb 31;94(2):240-54. Epub 2008 Oct 31.

Physiological Laboratory, University of Cambridge, UK.

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http://dx.doi.org/10.1113/expphysiol.2008.044669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705814PMC
February 2009

The cardiac sodium channel mutation delQKP 1507-1509 is associated with the expanding phenotypic spectrum of LQT3, conduction disorder, dilated cardiomyopathy, and high incidence of youth sudden death.

Europace 2008 Nov 12;10(11):1329-35. Epub 2008 Aug 12.

1Department of Paediatrics, First Affiliated Hospital, Cardiovascular Ion Channel Disease Laboratory, Medical College of Xi'an Jiaotong University, Xi'an, Peoples Republic of China.

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http://dx.doi.org/10.1093/europace/eun202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573028PMC
November 2008

Similarities and contrasts in ryanodine receptor localization and function in osteoclasts and striated muscle cells.

Ann N Y Acad Sci 2007 Nov;1116:255-70

Physiological Laboratory, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1196/annals.1402.064DOI Listing
November 2007

Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.

Pflugers Arch 2008 Jan 18;455(4):653-66. Epub 2007 Aug 18.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.

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http://dx.doi.org/10.1007/s00424-007-0327-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2082653PMC
January 2008

A quantitative analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.

Pflugers Arch 2007 Sep 17;454(6):925-36. Epub 2007 Apr 17.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.

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http://dx.doi.org/10.1007/s00424-007-0255-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627988PMC
September 2007

SCN5A and sinoatrial node pacemaker function.

Cardiovasc Res 2007 Jun 19;74(3):356-65. Epub 2007 Jan 19.

Cardiovascular Group, School of Medicine, The University of Manchester, Manchester, M13, 9NT, UK.

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http://dx.doi.org/10.1016/j.cardiores.2007.01.009DOI Listing
June 2007

The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts.

Pflugers Arch 2007 May 13;454(2):209-22. Epub 2007 Feb 13.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, UK.

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http://dx.doi.org/10.1007/s00424-007-0217-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839769PMC
May 2007

A missense mutation (G604S) in the S5/pore region of HERG causes long QT syndrome in a Chinese family with a high incidence of sudden unexpected death.

Eur J Pediatr 2007 Sep 14;166(9):927-33. Epub 2006 Dec 14.

Department of Pediatrics, First Affiliated Hospital, Cardiovascular Ion Channel Disease Laboratory, Ministry of Education, Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.

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http://dx.doi.org/10.1007/s00431-006-0346-2DOI Listing
September 2007

Mechanisms of ventricular arrhythmogenesis in mice following targeted disruption of KCNE1 modelling long QT syndrome 5.

J Physiol 2007 Jan 9;578(Pt 1):99-114. Epub 2006 Nov 9.

Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1113/jphysiol.2006.118133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075126PMC
January 2007

Proton NMR analysis of plasma is a weak predictor of coronary artery disease.

Nat Med 2006 Jun 28;12(6):705-10. Epub 2006 May 28.

Department of Biochemistry, University of Cambridge, Building O, Downing Site, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1038/nm1432DOI Listing
June 2006

Implantation of a cardioverter-defibrillator in a patient with cardiac amyloidosis.

Nat Clin Pract Cardiovasc Med 2006 Feb;3(2):110-4; quiz 115

Papworth Hospital, Papworth Everard.

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http://dx.doi.org/10.1038/ncpcardio0461DOI Listing
February 2006

Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis.

Am J Physiol Heart Circ Physiol 2005 Oct 27;289(4):H1584-93. Epub 2005 May 27.

Physiological Laboratory, University of Cambridge, Downing St., Cambridge, CB2 3EG, U.K.

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http://dx.doi.org/10.1152/ajpheart.01250.2004DOI Listing
October 2005

A functional analysis of mouse models of cardiac disease through metabolic profiling.

J Biol Chem 2005 Mar 16;280(9):7530-9. Epub 2004 Nov 16.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M410200200DOI Listing
March 2005

Nifedipine and diltiazem suppress ventricular arrhythmogenesis and calcium release in mouse hearts.

Pflugers Arch 2004 Nov 30;449(2):150-8. Epub 2004 Jul 30.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom.

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http://dx.doi.org/10.1007/s00424-004-1321-2DOI Listing
November 2004

Permanent pacemakers: should straightened atrial leads be repositioned?

Pacing Clin Electrophysiol 2003 Nov;26(11):2142-5

Papworth Hospital, Cambridgeshire, The United Kingdom.

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http://dx.doi.org/10.1046/j.1460-9592.2003.00333.xDOI Listing
November 2003

Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human atrium and recombinant receptors.

Naunyn Schmiedebergs Arch Pharmacol 2003 Dec 8;368(6):496-503. Epub 2003 Nov 8.

Department of Physiology, University of Cambridge, Downing Street, CB2 3EG, Cambridge, UK.

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http://link.springer.com/10.1007/s00210-003-0835-z
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http://dx.doi.org/10.1007/s00210-003-0835-zDOI Listing
December 2003

Sudden death in noncoronary heart disease is associated with delayed paced ventricular activation.

Circulation 2003 May 12;107(20):2595-600. Epub 2003 May 12.

Department of Cardiology, Papworth Hospital, University of Cambridge, Cambridge CB3 8RE, UK.

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http://dx.doi.org/10.1161/01.CIR.0000068342.96569.A1DOI Listing
May 2003

Catheter cryoablation of supraventricular arrhythmias: a painless alternative to radiofrequency energy.

Pacing Clin Electrophysiol 2003 Jan;26(1P2):500-3

Cardiac Electrophysiology Unit, Papworth Hospital, Cambridge CB3 8RE, UK.

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http://dx.doi.org/10.1046/j.1460-9592.2003.00081.xDOI Listing
January 2003

Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a.

Proc Natl Acad Sci U S A 2002 Apr 23;99(9):6210-5. Epub 2002 Apr 23.

Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom.

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http://dx.doi.org/10.1073/pnas.082121299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122928PMC
April 2002

Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium.

Br J Pharmacol 2002 Jan;135(2):451-61

Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW.

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http://doi.wiley.com/10.1038/sj.bjp.0704450
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http://dx.doi.org/10.1038/sj.bjp.0704450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573134PMC
January 2002