Andres Berdeja

Andres Berdeja

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Andres Berdeja

Andres Berdeja

Publications by authors named "Andres Berdeja"

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16Publications

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Comparison of duplex stabilizing properties of 2'-fluorinated nucleic acid analogues with furanose and non-furanose sugar rings.

J Org Chem 2014 Sep 27;79(18):8877-81. Epub 2014 Aug 27.

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc. , 2855 Gazelle Court, Carlsbad, California 92010, United States.

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http://dx.doi.org/10.1021/jo501381qDOI Listing
September 2014

Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.

Chem Commun (Camb) 2012 Aug 22;48(66):8195-7. Epub 2012 May 22.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1039/c2cc32286bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404228PMC
August 2012

Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway.

Arthritis Res Ther 2012 Feb 21;14(1):R38. Epub 2012 Feb 21.

Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, USA.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar3750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392838PMC
February 2012

Synthesis and biophysical characterization of R-6'-Me-α-L-LNA modified oligonucleotides.

Bioorg Med Chem Lett 2011 Feb 31;21(4):1122-5. Epub 2010 Dec 31.

Department of Medicinal Chemistry, Isis Pharmaceuticals, 1891 Rutherford Road, Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.12.119DOI Listing
February 2011

Replacing the 2'-oxygen with an exocyclic methylene group reverses the stabilization effects of α-L-LNA.

Bioorg Med Chem Lett 2011 Jan 14;21(1):588-91. Epub 2010 Oct 14.

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc, 1891 Rutherford Road, Carlsbad, CA 92008, United States.

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http://dx.doi.org/10.1016/j.bmcl.2010.10.025DOI Listing
January 2011

An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.

J Am Chem Soc 2010 Oct;132(42):14942-50

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc., 1891 Rutherford Road, Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1021/ja105875eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993159PMC
October 2010

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

J Org Chem 2010 Mar;75(5):1569-81

Department of Medicinal Chemistry, Isis Pharmaceuticals, 1896 Rutherford Road, Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1021/jo902560fDOI Listing
March 2010

Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.

J Biol Chem 2009 Jan 18;284(4):2535-48. Epub 2008 Nov 18.

Department of Molecular and Structural Biology, Isis Pharmaceuticals, Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1074/jbc.M803748200DOI Listing
January 2009

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

J Med Chem 2005 Feb;48(4):901-4

Department of Medicinal Chemistry, Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1021/jm049167jDOI Listing
February 2005