Publications by authors named "Andres Aguilera"

100Publications

TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage.

Authors:
Marta Giannini Aleix Bayona-Feliu Daisy Sproviero Sonia I Barroso Cristina Cereda Andrés Aguilera

PLoS Genet 2020 12 10;16(12):e1009260. Epub 2020 Dec 10.

Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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December 2020

Origin matters: spontaneous DNA-RNA hybrids do not form in trans as a source of genome instability.

Authors:
Belén Gómez-González Andrés Aguilera

Curr Genet 2020 Oct 23. Epub 2020 Oct 23.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Seville, Spain.

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October 2020

The Sister-Chromatid Exchange Assay in Human Cells.

Authors:
Emanuela Tumini Andrés Aguilera

Methods Mol Biol 2021 ;2153:383-393

Centro Andaluz de Biología Molecular y Medicina Regenerativa, CABIMER, Universidad de Sevilla-CSIC-UPO, Seville, Spain.

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January 2021

Detection of DNA Double-Strand Breaks by γ-H2AX Immunodetection.

Authors:
Sonia I Barroso Andrés Aguilera

Methods Mol Biol 2021 ;2153:1-8

Centro Andaluz de Biología Molecular y Medicina Regenerativa, CABIMER, University of Seville-CSIC-UPO, Seville, Spain.

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January 2021

Looping the (R) Loop in DSB Repair via RNA Methylation.

Authors:
Belén Gómez-González Andrés Aguilera

Mol Cell 2020 08;79(3):361-362

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla- CSIC, Seville, Spain. Electronic address:

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August 2020

Harmful DNA:RNA hybrids are formed and in a Rad51-independent manner.

Authors:
Juan Lafuente-Barquero Maria Luisa García-Rubio Marta San Martin-Alonso Belén Gómez-González Andrés Aguilera

Elife 2020 08 4;9. Epub 2020 Aug 4.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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August 2020

Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage.

Authors:
Pedro Ortega Desiré García-Pichardo Marta San Martin-Alonso Ana G Rondón Belén Gómez-González Andrés Aguilera

Microb Cell 2020 Apr 24;7(7):190-198. Epub 2020 Apr 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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April 2020

The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops.

Authors:
Rosa Luna Ana G Rondón Carmen Pérez-Calero Irene Salas-Armenteros Andrés Aguilera

Cold Spring Harb Symp Quant Biol 2019 3;84:105-114. Epub 2020 Jun 3.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, 41092 Seville, Spain.

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June 2020

UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide.

Authors:
Carmen Pérez-Calero Aleix Bayona-Feliu Xiaoyu Xue Sonia I Barroso Sergio Muñoz Víctor M González-Basallote Patrick Sung Andrés Aguilera

Genes Dev 2020 07 21;34(13-14):898-912. Epub 2020 May 21.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla 41092, Spain.

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July 2020

Homologous recombination and Mus81 promote replication completion in response to replication fork blockage.

Authors:
Benjamin Pardo María Moriel-Carretero Thibaud Vicat Andrés Aguilera Philippe Pasero

EMBO Rep 2020 07 17;21(7):e49367. Epub 2020 May 17.

Institut de Génétique Humaine, Université de Montpellier-CNRS, Montpellier, France.

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July 2020

Histone deacetylases facilitate the accurate repair of broken forks.

Authors:
Belén Gómez-González Pedro Ortega Andrés Aguilera

Mol Cell Oncol 2020 13;7(2):1705731. Epub 2020 Jan 13.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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January 2020

Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle.

Authors:
Belén Gómez-González Sonia Barroso Emilia Herrera-Moyano Andrés Aguilera

Cell Cycle 2020 03 16;19(5):525-531. Epub 2020 Feb 16.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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March 2020

R-Loops as Promoters of Antisense Transcription.

Authors:
Ana G Rondón Andrés Aguilera

Mol Cell 2019 11;76(4):529-530

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla- CSIC, Seville, Spain. Electronic address:

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November 2019

Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion.

Authors:
Pedro Ortega Belén Gómez-González Andrés Aguilera

Nat Commun 2019 11 15;10(1):5178. Epub 2019 Nov 15.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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November 2019

R Loops: From Physiological to Pathological Roles.

Authors:
Tatiana García-Muse Andrés Aguilera

Cell 2019 10 10;179(3):604-618. Epub 2019 Oct 10.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, 41092 SEVILLE, Spain. Electronic address:

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October 2019

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.

Authors:
Diana Zatreanu Zhong Han Richard Mitter Emanuela Tumini Hannah Williams Lea Gregersen A Barbara Dirac-Svejstrup Stefania Roma Aengus Stewart Andres Aguilera Jesper Q Svejstrup

Mol Cell 2019 10 10;76(1):57-69.e9. Epub 2019 Sep 10.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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October 2019

Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability.

Authors:
Irene Salas-Armenteros Sonia I Barroso Ana G Rondón Mónica Pérez Eloisa Andújar Rosa Luna Andrés Aguilera

Cell Rep 2019 08;28(6):1551-1563.e7

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville 41092, Spain. Electronic address:

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August 2019

The DNA damage response acts as a safeguard against harmful DNA-RNA hybrids of different origins.

Authors:
Sonia Barroso Emilia Herrera-Moyano Sergio Muñoz María García-Rubio Belén Gómez-González Andrés Aguilera

EMBO Rep 2019 09 24;20(9):e47250. Epub 2019 Jul 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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September 2019

What causes an RNA-DNA hybrid to compromise genome integrity?

Authors:
Ana G Rondón Andrés Aguilera

DNA Repair (Amst) 2019 09 8;81:102660. Epub 2019 Jul 8.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, 41092, Seville, Spain. Electronic address:

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September 2019

Transcription-mediated replication hindrance: a major driver of genome instability.

Authors:
Belén Gómez-González Andrés Aguilera

Genes Dev 2019 08 23;33(15-16):1008-1026. Epub 2019 May 23.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide., 41092 Seville, Spain.

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August 2019

The Nup84 complex coordinates the DNA damage response to warrant genome integrity.

Authors:
Hélène Gaillard José M Santos-Pereira Andrés Aguilera

Nucleic Acids Res 2019 05;47(8):4054-4067

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, 41092 Seville, Spain.

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May 2019

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways.

Authors:
Hannah L Klein Giedrė Bačinskaja Jun Che Anais Cheblal Rajula Elango Anastasiya Epshtein Devon M Fitzgerald Belén Gómez-González Sharik R Khan Sandeep Kumar Bryan A Leland Léa Marie Qian Mei Judith Miné-Hattab Alicja Piotrowska Erica J Polleys Christopher D Putnam Elina A Radchenko Anissia Ait Saada Cynthia J Sakofsky Eun Yong Shim Mathew Stracy Jun Xia Zhenxin Yan Yi Yin Andrés Aguilera Juan Lucas Argueso Catherine H Freudenreich Susan M Gasser Dmitry A Gordenin James E Haber Grzegorz Ira Sue Jinks-Robertson Megan C King Richard D Kolodner Andrei Kuzminov Sarah Ae Lambert Sang Eun Lee Kyle M Miller Sergei M Mirkin Thomas D Petes Susan M Rosenberg Rodney Rothstein Lorraine S Symington Pawel Zawadzki Nayun Kim Michael Lisby Anna Malkova

Microb Cell 2019 Jan 7;6(1):1-64. Epub 2019 Jan 7.

Department of Biology, University of Iowa, Iowa City, IA, USA.

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January 2019

The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability.

Authors:
Emanuela Tumini Emilia Herrera-Moyano Marta San Martín-Alonso Sonia Barroso Carlos M Galmarini Andrés Aguilera

Mol Cancer Res 2019 03 14;17(3):773-782. Epub 2018 Dec 14.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, CSIC-Universidad Pablo de Olavide-Universidad de Sevilla, Seville, Spain.

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March 2019

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.

Authors:
Sonia Silva Lola P Camino Andrés Aguilera

Proc Natl Acad Sci U S A 2018 10 9;115(43):11024-11029. Epub 2018 Oct 9.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide, 41092 Seville, Spain

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October 2018

Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability.

Authors:
María García-Rubio Paula Aguilera Juan Lafuente-Barquero José F Ruiz Marie-Noelle Simon Vincent Geli Ana G Rondón Andrés Aguilera

Genes Dev 2018 07 28;32(13-14):965-977. Epub 2018 Jun 28.

Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Pablo de Olavide, 41092 Seville, Spain.

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July 2018

Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions.

Authors:
Sarah Sertic Antonio Mollica Ilaria Campus Stefania Roma Emanuela Tumini Andrés Aguilera Marco Muzi-Falconi

Mol Cell 2018 04;70(1):189

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April 2018

Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions.

Authors:
Sarah Sertic Antonio Mollica Ilaria Campus Stefania Roma Emanuela Tumini Andrés Aguilera Marco Muzi-Falconi

Mol Cell 2018 04 15;70(1):34-47.e4. Epub 2018 Mar 15.

Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy. Electronic address:

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April 2018

Gene gating at nuclear pores prevents the formation of R loops.

Authors:
Hélène Gaillard Francisco García-Benítez Andrés Aguilera

Mol Cell Oncol 2018 11;5(1):e1405140. Epub 2017 Dec 11.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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December 2017

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.

Authors:
Alba Duch Berta Canal Sonia I Barroso María García-Rubio Gerhard Seisenbacher Andrés Aguilera Eulàlia de Nadal Francesc Posas

Nat Commun 2018 01 25;9(1):379. Epub 2018 Jan 25.

Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), E-08003, Barcelona, Spain.

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January 2018

Epigenetic features of human telomeres.

Authors:
María D Cubiles Sonia Barroso María I Vaquero-Sedas Alicia Enguix Andrés Aguilera Miguel A Vega-Palas

Nucleic Acids Res 2018 03;46(5):2347-2355

Instituto de Bioquímica Vegetal y Fotosíntesis, CSIC-Universidad de Sevilla, IBVF (CSIC-US), Avd. Américo Vespucio n° 49, 41092 Seville, Spain.

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March 2018

Guidelines and recommendations on yeast cell death nomenclature.

Authors:
Didac Carmona-Gutierrez Maria Anna Bauer Andreas Zimmermann Andrés Aguilera Nicanor Austriaco Kathryn Ayscough Rena Balzan Shoshana Bar-Nun Antonio Barrientos Peter Belenky Marc Blondel Ralf J Braun Michael Breitenbach William C Burhans Sabrina Büttner Duccio Cavalieri Michael Chang Katrina F Cooper Manuela Côrte-Real Vítor Costa Christophe Cullin Ian Dawes Jörn Dengjel Martin B Dickman Tobias Eisenberg Birthe Fahrenkrog Nicolas Fasel Kai-Uwe Fröhlich Ali Gargouri Sergio Giannattasio Paola Goffrini Campbell W Gourlay Chris M Grant Michael T Greenwood Nicoletta Guaragnella Thomas Heger Jürgen Heinisch Eva Herker Johannes M Herrmann Sebastian Hofer Antonio Jiménez-Ruiz Helmut Jungwirth Katharina Kainz Dimitrios P Kontoyiannis Paula Ludovico Stéphen Manon Enzo Martegani Cristina Mazzoni Lynn A Megeney Chris Meisinger Jens Nielsen Thomas Nyström Heinz D Osiewacz Tiago F Outeiro Hay-Oak Park Tobias Pendl Dina Petranovic Stephane Picot Peter Polčic Ted Powers Mark Ramsdale Mark Rinnerthaler Patrick Rockenfeller Christoph Ruckenstuhl Raffael Schaffrath Maria Segovia Fedor F Severin Amir Sharon Stephan J Sigrist Cornelia Sommer-Ruck Maria João Sousa Johan M Thevelein Karin Thevissen Vladimir Titorenko Michel B Toledano Mick Tuite F-Nora Vögtle Benedikt Westermann Joris Winderickx Silke Wissing Stefan Wölfl Zhaojie J Zhang Richard Y Zhao Bing Zhou Lorenzo Galluzzi Guido Kroemer Frank Madeo

Microb Cell 2018 Jan 1;5(1):4-31. Epub 2018 Jan 1.

Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.

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January 2018

The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage.

Authors:
Juan Lafuente-Barquero Sarah Luke-Glaser Marco Graf Sonia Silva Belén Gómez-González Arianna Lockhart Michael Lisby Andrés Aguilera Brian Luke

PLoS Genet 2017 12 27;13(12):e1007136. Epub 2017 Dec 27.

Institute of Molecular Biology (IMB), Mainz, Germany.

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December 2017

The need to regulate replication fork speed.

Authors:
Belén Gómez-González Andrés Aguilera

Science 2017 11;358(6364):722-723

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla, Avenida Américo Vespucio 24, 41092 Seville, Spain.

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November 2017

Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability.

Authors:
Irene Salas-Armenteros Carmen Pérez-Calero Aleix Bayona-Feliu Emanuela Tumini Rosa Luna Andrés Aguilera

EMBO J 2017 12 26;36(23):3532-3547. Epub 2017 Oct 26.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide-Universidad de Sevilla, Seville, Spain

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December 2017

Detection of DNA-RNA Hybrids In Vivo.

Authors:
María García-Rubio Sonia I Barroso Andrés Aguilera

Methods Mol Biol 2018 ;1672:347-361

Centro Andaluz de Biología Molecular y Medicina Regenerativa, CABIMER, Universidad de Sevilla, Av. Américo Vespucio 24, 41092, Seville, Spain.

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June 2018

Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability.

Authors:
Francisco García-Benítez Hélène Gaillard Andrés Aguilera

Proc Natl Acad Sci U S A 2017 10 25;114(41):10942-10947. Epub 2017 Sep 25.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide-Universidad de Sevilla, 41092 Seville, Spain

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October 2017

Differential effect of the overexpression of Rad2/XPG family endonucleases on genome integrity in yeast and human cells.

Authors:
Sonia Jimeno Emilia Herrera-Moyano Pedro Ortega Andrés Aguilera

DNA Repair (Amst) 2017 09 3;57:66-75. Epub 2017 Jul 3.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER Universidad de Sevilla - CSIC - Universidad Pablo de Olavide Av. Américo Vespucio 24, 41092 Seville, Spain. Electronic address:

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September 2017

The Role of Replication-Associated Repair Factors on R-Loops.

Authors:
Vaibhav Bhatia Emilia Herrera-Moyano Andrés Aguilera Belén Gómez-González

Genes (Basel) 2017 Jun 27;8(7). Epub 2017 Jun 27.

Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Av. Américo Vespucio 24, 41092 Seville, Spain.

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June 2017

Histone Mutants Separate R Loop Formation from Genome Instability Induction.

Authors:
Desiré García-Pichardo Juan C Cañas María L García-Rubio Belén Gómez-González Ana G Rondón Andrés Aguilera

Mol Cell 2017 Jun;66(5):597-609.e5

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville 41092, Spain. Electronic address:

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June 2017

Correction for Muñoz-Galván et al., "Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange".

Authors:
Sandra Muñoz-Galván Cristina Tous Miguel G Blanco Erin K Schwartz Kirk T Ehmsen Stephen C West Wolf-Dietrich Heyer Andrés Aguilera

Mol Cell Biol 2017 06 16;37(11). Epub 2017 May 16.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-CSIC, Seville, Spain.

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June 2017

A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination.

Authors:
Sandra Muñoz-Galván María García-Rubio Pedro Ortega Jose F Ruiz Sonia Jimeno Benjamin Pardo Belén Gómez-González Andrés Aguilera

PLoS Genet 2017 May 5;13(5):e1006781. Epub 2017 May 5.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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May 2017

DNA-RNA hybrids: the risks of DNA breakage during transcription.

Authors:
Andrés Aguilera Belén Gómez-González

Nat Struct Mol Biol 2017 May;24(5):439-443

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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May 2017

Roles of human POLD1 and POLD3 in genome stability.

Authors:
Emanuela Tumini Sonia Barroso Carmen Pérez -Calero Andrés Aguilera

Sci Rep 2016 12 15;6:38873. Epub 2016 Dec 15.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avd. Américo Vespucio s/n, 41092 Seville, Spain.

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December 2016

FANCD2 Facilitates Replication through Common Fragile Sites.

Authors:
Advaitha Madireddy Settapong T Kosiyatrakul Rebecca A Boisvert Emilia Herrera-Moyano María L García-Rubio Jeannine Gerhardt Elizabeth A Vuono Nichole Owen Zi Yan Susan Olson Andrés Aguilera Niall G Howlett Carl L Schildkraut

Mol Cell 2016 10;64(2):388-404

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

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October 2016

Correction: The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development.

Authors:
Maikel Castellano-Pozo Tatiana García-Muse Andrés Aguilera

PLoS One 2016;11(7):e0160138. Epub 2016 Jul 21.

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July 2016

Transcription-replication conflicts: how they occur and how they are resolved.

Authors:
Tatiana García-Muse Andrés Aguilera

Nat Rev Mol Cell Biol 2016 09 20;17(9):553-63. Epub 2016 Jul 20.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas, Seville 41092, Spain.

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September 2016

Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening.

Authors:
Sandra Gavaldá José M Santos-Pereira María L García-Rubio Rosa Luna Andrés Aguilera

PLoS Genet 2016 Apr 1;12(4):e1005966. Epub 2016 Apr 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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April 2016

Transcription as a Threat to Genome Integrity.

Authors:
Hélène Gaillard Andrés Aguilera

Annu Rev Biochem 2016 Jun 24;85:291-317. Epub 2016 Mar 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla, Sevilla 41092, Spain; email: ,

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June 2016

High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast.

Authors:
Sabrina L Andersen Aimee Zhang Margaret Dominska María Moriel-Carretero Emilia Herrera-Moyano Andrés Aguilera Thomas D Petes

PLoS Genet 2016 Mar 11;12(3):e1005938. Epub 2016 Mar 11.

Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America.

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March 2016

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.

Authors:
María L García-Rubio Carmen Pérez-Calero Sonia I Barroso Emanuela Tumini Emilia Herrera-Moyano Iván V Rosado Andrés Aguilera

PLoS Genet 2015 Nov 19;11(11):e1005674. Epub 2015 Nov 19.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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November 2015

A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome.

Authors:
María Moriel-Carretero Emilia Herrera-Moyano Andrés Aguilera

Rare Dis 2015 7;3(1):e1079362. Epub 2015 Aug 7.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER; Universidad de Sevilla ; Seville, Spain.

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October 2015

R loops: new modulators of genome dynamics and function.

Authors:
José M Santos-Pereira Andrés Aguilera

Nat Rev Genet 2015 Oct 15;16(10):583-97. Epub 2015 Sep 15.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Av. Américo Vespucio s/n, Seville 41092, Spain.

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October 2015

Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression.

Authors:
Mónica Bravo Fabio Nicolini Katarzyna Starowicz Sonia Barroso Carmela Calés Andrés Aguilera Miguel Vidal

J Cell Sci 2015 Oct 13;128(19):3660-71. Epub 2015 Aug 13.

Biología Celular y Molecular, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain

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October 2015

Replication stress and cancer.

Authors:
Hélène Gaillard Tatiana García-Muse Andrés Aguilera

Nat Rev Cancer 2015 May;15(5):276-89

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Av. Américo Vespucio s/n, Sevilla 41092, Spain.

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May 2015

Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system.

Authors:
Ruth Stuckey Néstor García-Rodríguez Andrés Aguilera Ralf Erik Wellinger

Proc Natl Acad Sci U S A 2015 May 20;112(18):5779-84. Epub 2015 Apr 20.

Department of Molecular Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa-Universidad de Sevilla, 41092 Seville, Spain

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May 2015

Methods to study transcription-coupled repair in chromatin.

Authors:
Hélène Gaillard Ralf Erik Wellinger Andrés Aguilera

Methods Mol Biol 2015 ;1288:273-88

Genetics, CABIMER, Universidad de Sevilla-CSIC, Avenida Américo Vespucio s/n, 41092, Seville, Spain.

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December 2015

Interdependence of the rad50 hook and globular domain functions.

Authors:
Marcel Hohl Tomasz Kochańczyk Cristina Tous Andrés Aguilera Artur Krężel John H J Petrini

Mol Cell 2015 Feb 15;57(3):479-91. Epub 2015 Jan 15.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. Electronic address:

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February 2015

The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne syndrome-like phenotypes.

Authors:
Emilia Herrera-Moyano María Moriel-Carretero Beth A Montelone Andrés Aguilera

PLoS Genet 2014 Dec 11;10(12):e1004859. Epub 2014 Dec 11.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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December 2014

RNA polymerase II contributes to preventing transcription-mediated replication fork stalls.

Authors:
Irene Felipe-Abrio Juan Lafuente-Barquero María L García-Rubio Andrés Aguilera

EMBO J 2015 Jan 1;34(2):236-50. Epub 2014 Dec 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain

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January 2015

Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability.

Authors:
Julie Sollier Caroline Townsend Stork María L García-Rubio Renee D Paulsen Andrés Aguilera Karlene A Cimprich

Mol Cell 2014 Dec 26;56(6):777-85. Epub 2014 Nov 26.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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December 2014

A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions.

Authors:
José M Santos-Pereira María L García-Rubio Cristina González-Aguilera Rosa Luna Andrés Aguilera

Nucleic Acids Res 2014 Oct 7;42(19):12000-14. Epub 2014 Oct 7.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, 41092 Seville, Spain

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October 2014

Transcription and recombination: when RNA meets DNA.

Authors:
Andrés Aguilera Hélène Gaillard

Cold Spring Harb Perspect Biol 2014 Aug 1;6(8). Epub 2014 Aug 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla, 41092 Seville, Spain.

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August 2014

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

Authors:
Vaibhav Bhatia Sonia I Barroso María L García-Rubio Emanuela Tumini Emilia Herrera-Moyano Andrés Aguilera

Nature 2014 Jul 1;511(7509):362-5. Epub 2014 Jun 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain.

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July 2014

Npl3, a new link between RNA-binding proteins and the maintenance of genome integrity.

Authors:
José M Santos-Pereira Ana B Herrero Sergio Moreno Andrés Aguilera

Cell Cycle 2014 2;13(10):1524-9. Epub 2014 Apr 2.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER; Universidad de Sevilla-CSIC; Seville, Spain.

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February 2016

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts.

Authors:
Emilia Herrera-Moyano Xénia Mergui María L García-Rubio Sonia Barroso Andrés Aguilera

Genes Dev 2014 Apr 17;28(7):735-48. Epub 2014 Mar 17.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, 41092 Seville, Spain.

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April 2014

Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae.

Authors:
Hélène Gaillard Andrés Aguilera

PLoS Genet 2014 Mar 6;10(3):e1004203. Epub 2014 Mar 6.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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March 2014

The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability.

Authors:
José M Santos-Pereira Ana B Herrero María L García-Rubio Antonio Marín Sergio Moreno Andrés Aguilera

Genes Dev 2013 Nov;27(22):2445-58

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas (CSIC), 41092 Seville, Spain;

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November 2013

R loops are linked to histone H3 S10 phosphorylation and chromatin condensation.

Authors:
Maikel Castellano-Pozo José M Santos-Pereira Ana G Rondón Sonia Barroso Eloisa Andújar Mónica Pérez-Alegre Tatiana García-Muse Andrés Aguilera

Mol Cell 2013 Nov 7;52(4):583-90. Epub 2013 Nov 7.

Department of Molecular Biology, Universidad de Sevilla-CSIC, Avenida Américo Vespucio, 41092 Seville, Spain.

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November 2013

Causes of genome instability.

Authors:
Andrés Aguilera Tatiana García-Muse

Annu Rev Genet 2013 31;47:1-32. Epub 2013 Jul 31.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla, 41092 Seville, Spain; email:

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April 2014

Yeast pol4 promotes tel1-regulated chromosomal translocations.

Authors:
Jose F Ruiz Benjamin Pardo Guillermo Sastre-Moreno Andrés Aguilera Luis Blanco

PLoS Genet 2013 18;9(7):e1003656. Epub 2013 Jul 18.

Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid/CSIC, Madrid, Spain.

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January 2014

R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity.

Authors:
Sandra Gavaldá Mercedes Gallardo Rosa Luna Andrés Aguilera

PLoS One 2013 7;8(6):e65541. Epub 2013 Jun 7.

Departamento de Biología Molecular, Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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January 2014

Transcription-associated genome instability.

Authors:
Hélène Gaillard Emilia Herrera-Moyano Andrés Aguilera

Chem Rev 2013 Nov 18;113(11):8638-61. Epub 2013 Apr 18.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla , Av. Américo Vespucio s/n, 41092 Seville, Spain.

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November 2013

Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid.

Authors:
Sandra Muñoz-Galván Sonia Jimeno Rodney Rothstein Andrés Aguilera

PLoS Genet 2013 24;9(1):e1003237. Epub 2013 Jan 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Sevilla, Spain.

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May 2013

The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.

Authors:
Maikel Castellano-Pozo Tatiana García-Muse Andrés Aguilera

PLoS One 2012 20;7(12):e52447. Epub 2012 Dec 20.

Department of Molecular Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla, Sevilla, Spain.

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June 2013

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.

Authors:
Sandra Muñoz-Galván Ana López-Saavedra Stephen P Jackson Pablo Huertas Felipe Cortés-Ledesma Andrés Aguilera

Nucleic Acids Res 2013 Feb 18;41(3):1669-83. Epub 2012 Dec 18.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Seville, Spain.

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February 2013

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

Authors:
Alba Duch Irene Felipe-Abrio Sonia Barroso Gilad Yaakov María García-Rubio Andrés Aguilera Eulàlia de Nadal Francesc Posas

Nature 2013 Jan 25;493(7430):116-9. Epub 2012 Nov 25.

Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona E-08003, Spain.

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January 2013

Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.

Authors:
Benjamin Pardo Andrés Aguilera

PLoS Genet 2012 Sep 27;8(9):e1002979. Epub 2012 Sep 27.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Sevilla, Spain.

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September 2012

Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis.

Authors:
Hélène Gaillard Andrés Aguilera

Biochim Biophys Acta 2013 Jan 6;1829(1):141-50. Epub 2012 Oct 6.

Universidad de Sevilla, Sevilla, Spain.

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January 2013

R-loops cause replication impairment and genome instability during meiosis.

Authors:
Maikel Castellano-Pozo Tatiana García-Muse Andrés Aguilera

EMBO Rep 2012 Oct 10;13(10):923-9. Epub 2012 Aug 10.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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October 2012

R loops: from transcription byproducts to threats to genome stability.

Authors:
Andrés Aguilera Tatiana García-Muse

Mol Cell 2012 Apr;46(2):115-24

CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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April 2012

Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange.

Authors:
Sandra Muñoz-Galván Cristina Tous Miguel G Blanco Erin K Schwartz Kirk T Ehmsen Stephen C West Wolf-Dietrich Heyer Andrés Aguilera

Mol Cell Biol 2012 May 21;32(9):1592-603. Epub 2012 Feb 21.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-CSIC, Seville, Spain.

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May 2012

Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor.

Authors:
Alvaro Peña Kamil Gewartowski Seweryn Mroczek Jorge Cuéllar Aleksandra Szykowska Andrzej Prokop Mariusz Czarnocki-Cieciura Jan Piwowarski Cristina Tous Andrés Aguilera José L Carrascosa José María Valpuesta Andrzej Dziembowski

EMBO J 2012 Mar 7;31(6):1605-16. Epub 2012 Feb 7.

Department of Structure of Macromolecules, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.

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March 2012

New clues to understand the role of THO and other functionally related factors in mRNP biogenesis.

Authors:
Rosa Luna Ana G Rondón Andrés Aguilera

Biochim Biophys Acta 2012 Jun 20;1819(6):514-20. Epub 2011 Dec 20.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av Américo Vespucio s/n, 41092 Sevilla, Spain. rlvarp@is/es

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June 2012

Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.

Authors:
María S Domínguez-Sánchez Sonia Barroso Belén Gómez-González Rosa Luna Andrés Aguilera

PLoS Genet 2011 Dec 1;7(12):e1002386. Epub 2011 Dec 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla - Consejo Superior de Investigaciones Científicas (CSIC), Sevilla, Spain.

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December 2011

Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes.

Authors:
María L García-Rubio Andrés Aguilera

Nucleic Acids Res 2012 Feb 13;40(3):1050-64. Epub 2011 Oct 13.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n 41092 Sevilla, and Departamento de Genética, Universidad de Sevilla, 41012 Sevilla, Spain.

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February 2012

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.

Authors:
Marcel Hohl Youngho Kwon Sandra Muñoz Galván Xiaoyu Xue Cristina Tous Andrés Aguilera Patrick Sung John H J Petrini

Nat Struct Mol Biol 2011 Sep 4;18(10):1124-31. Epub 2011 Sep 4.

Laboratory of Chromosome Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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September 2011

Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1.

Authors:
María Moriel-Carretero Cristina Tous Andrés Aguilera

Proc Natl Acad Sci U S A 2011 Sep 29;108(37):15300-5. Epub 2011 Aug 29.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-Consejo Superior de Investigaciones Cientificas, 41092 Seville, Spain.

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September 2011

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.

Authors:
Rodrigo Bermejo Thelma Capra Rachel Jossen Arianna Colosio Camilla Frattini Walter Carotenuto Andrea Cocito Ylli Doksani Hannah Klein Belén Gómez-González Andrés Aguilera Yuki Katou Katsuhiko Shirahige Marco Foiani

Cell 2011 Jul;146(2):233-46

Fondazione Istituto FIRC di Oncologia Molecolare (IFOM) at IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy.

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July 2011

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.

Authors:
Belén Gómez-González María García-Rubio Rodrigo Bermejo Hélène Gaillard Katsuhiko Shirahige Antonio Marín Marco Foiani Andrés Aguilera

EMBO J 2011 Jun 24;30(15):3106-19. Epub 2011 Jun 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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June 2011

Nab2 functions in the metabolism of RNA driven by polymerases II and III.

Authors:
Cristina González-Aguilera Cristina Tous Reyes Babiano Jesús de la Cruz Rosa Luna Andrés Aguilera

Mol Biol Cell 2011 Aug 16;22(15):2729-40. Epub 2011 Jun 16.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-Consejo Superior de Investigaciones Científicas, 41092 Seville, Spain.

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August 2011

Genetic and molecular analysis of mitotic recombination in Saccharomyces cerevisiae.

Authors:
Belén Gómez-González José F Ruiz Andrés Aguilera

Methods Mol Biol 2011 ;745:151-72

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-CSIC, Sevilla, Spain.

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September 2011

Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability.

Authors:
María Del Carmen Díaz de la Loza Mercedes Gallardo María Luisa García-Rubio Alicia Izquierdo Enrique Herrero Andrés Aguilera Ralf Erik Wellinger

Nucleic Acids Res 2011 Aug 21;39(14):6002-15. Epub 2011 Apr 21.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Avd Américo Vespucio, 41092 Sevilla, Spain.

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August 2011

A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors.

Authors:
Cristina Tous Ana G Rondón María García-Rubio Cristina González-Aguilera Rosa Luna Andrés Aguilera

EMBO J 2011 May 8;30(10):1953-64. Epub 2011 Apr 8.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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May 2011

AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.

Authors:
José F Ruiz Belén Gómez-González Andrés Aguilera

PLoS Genet 2011 Feb 24;7(2):e1002009. Epub 2011 Feb 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Sevilla, Spain.

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February 2011

Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.

Authors:
María S Domínguez-Sánchez Carmen Sáez Miguel A Japón Andrés Aguilera Rosa Luna

BMC Cancer 2011 Feb 17;11:77. Epub 2011 Feb 17.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av, Américo Vespucio s/n, 41092 Sevilla, Spain.

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February 2011

3D Stationary electric current density in a spherical tumor treated with low direct current: an analytical solution.

Authors:
Rolando Placeres Jiménez Ana Elisa Bergues Pupo Jesús Manuel Bergues Cabrales Javier Antonio González Joa Luis Enrique Bergues Cabrales Juan José Godina Nava Andrés Ramírez Aguilera Miguel Angel O'Farril Mateus Manuel Verdecia Jarque Soraida Candida Acosta Brooks

Bioelectromagnetics 2011 Feb 28;32(2):120-30. Epub 2010 Oct 28.

Departamento de Física, Universidad Federal Sao Carlos-SP, Brazil.

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February 2011

Yeast Sen1 helicase protects the genome from transcription-associated instability.

Authors:
Hannah E Mischo Belén Gómez-González Pawel Grzechnik Ana G Rondón Wu Wei Lars Steinmetz Andrés Aguilera Nick J Proudfoot

Mol Cell 2011 Jan;41(1):21-32

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

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January 2011

New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.

Authors:
Sonia Jimeno Cristina Tous María L García-Rubio Michael Ranes Cristina González-Aguilera Antonio Marín Andrés Aguilera

Mol Cell Biol 2011 Feb 13;31(4):674-85. Epub 2010 Dec 13.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Seville, Spain.

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February 2011

Modified Gompertz equation for electrotherapy murine tumor growth kinetics: predictions and new hypotheses.

Authors:
Luis E Bergues Cabrales Juan J Godina Nava Andrés Ramírez Aguilera Javier A González Joa Héctor M Camué Ciria Maraelys Morales González Miriam Fariñas Salas Manuel Verdecia Jarque Tamara Rubio González Miguel A O'Farril Mateus Soraida C Acosta Brooks Fabiola Suárez Palencia Lisset Ortiz Zamora María C Céspedes Quevedo Sarah Edward Seringe Vladimir Crombet Cuitié Idelisa Bergues Cabrales Gustavo Sierra González

BMC Cancer 2010 Oct 28;10:589. Epub 2010 Oct 28.

Departamento de Física, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Laboratorio de Estimulación Magnética, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Ap. Post. 14- 740, México, DF 07000, México 07360, Distrito Federal, México.

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October 2010

The interface between transcription and mRNP export: from THO to THSC/TREX-2.

Authors:
Ana G Rondón Sonia Jimeno Andrés Aguilera

Biochim Biophys Acta 2010 Aug 19;1799(8):533-8. Epub 2010 Jun 19.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Av. Americo Vespucio s/n, 41092 Sevilla, Spain.

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August 2010