Andres Aguilera

Andres Aguilera

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Andres Aguilera

Publications by authors named "Andres Aguilera"

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Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.

Authors:
Diana Zatreanu Zhong Han Richard Mitter Emanuela Tumini Hannah Williams Lea Gregersen A Barbara Dirac-Svejstrup Stefania Roma Aengus Stewart Andres Aguilera Jesper Q Svejstrup

Mol Cell 2019 Oct 10;76(1):57-69.e9. Epub 2019 Sep 10.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.07.037DOI Listing
October 2019

R Loops: From Physiological to Pathological Roles.

Authors:
Tatiana García-Muse Andrés Aguilera

Cell 2019 Oct 8. Epub 2019 Oct 8.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, 41092 SEVILLE, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.08.055DOI Listing
October 2019

What causes an RNA-DNA hybrid to compromise genome integrity?

Authors:
Ana G Rondón Andrés Aguilera

DNA Repair (Amst) 2019 Sep 8;81:102660. Epub 2019 Jul 8.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, 41092, Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.102660DOI Listing
September 2019

The DNA damage response acts as a safeguard against harmful DNA-RNA hybrids of different origins.

Authors:
Sonia Barroso Emilia Herrera-Moyano Sergio Muñoz María García-Rubio Belén Gómez-González Andrés Aguilera

EMBO Rep 2019 Sep 24;20(9):e47250. Epub 2019 Jul 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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http://dx.doi.org/10.15252/embr.201847250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726908PMC
September 2019

Transcription-mediated replication hindrance: a major driver of genome instability.

Authors:
Belén Gómez-González Andrés Aguilera

Genes Dev 2019 08 23;33(15-16):1008-1026. Epub 2019 May 23.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide., 41092 Seville, Spain.

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http://dx.doi.org/10.1101/gad.324517.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672053PMC
August 2019

Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability.

Authors:
Irene Salas-Armenteros Sonia I Barroso Ana G Rondón Mónica Pérez Eloisa Andújar Rosa Luna Andrés Aguilera

Cell Rep 2019 Aug;28(6):1551-1563.e7

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville 41092, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693559PMC
August 2019

The Nup84 complex coordinates the DNA damage response to warrant genome integrity.

Authors:
Hélène Gaillard José M Santos-Pereira Andrés Aguilera

Nucleic Acids Res 2019 May;47(8):4054-4067

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, 41092 Seville, Spain.

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http://dx.doi.org/10.1093/nar/gkz066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486642PMC
May 2019

The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability.

Authors:
Emanuela Tumini Emilia Herrera-Moyano Marta San Martín-Alonso Sonia Barroso Carlos M Galmarini Andrés Aguilera

Mol Cancer Res 2019 03 14;17(3):773-782. Epub 2018 Dec 14.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, CSIC-Universidad Pablo de Olavide-Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398590PMC
March 2019

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways.

Authors:
Hannah L Klein Giedrė Bačinskaja Jun Che Anais Cheblal Rajula Elango Anastasiya Epshtein Devon M Fitzgerald Belén Gómez-González Sharik R Khan Sandeep Kumar Bryan A Leland Léa Marie Qian Mei Judith Miné-Hattab Alicja Piotrowska Erica J Polleys Christopher D Putnam Elina A Radchenko Anissia Ait Saada Cynthia J Sakofsky Eun Yong Shim Mathew Stracy Jun Xia Zhenxin Yan Yi Yin Andrés Aguilera Juan Lucas Argueso Catherine H Freudenreich Susan M Gasser Dmitry A Gordenin James E Haber Grzegorz Ira Sue Jinks-Robertson Megan C King Richard D Kolodner Andrei Kuzminov Sarah Ae Lambert Sang Eun Lee Kyle M Miller Sergei M Mirkin Thomas D Petes Susan M Rosenberg Rodney Rothstein Lorraine S Symington Pawel Zawadzki Nayun Kim Michael Lisby Anna Malkova

Microb Cell 2019 Jan 7;6(1):1-64. Epub 2019 Jan 7.

Department of Biology, University of Iowa, Iowa City, IA, USA.

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http://dx.doi.org/10.15698/mic2019.01.664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334234PMC
January 2019

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.

Authors:
Sonia Silva Lola P Camino Andrés Aguilera

Proc Natl Acad Sci U S A 2018 10 9;115(43):11024-11029. Epub 2018 Oct 9.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide, 41092 Seville, Spain

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http://www.pnas.org/lookup/doi/10.1073/pnas.1807258115
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http://dx.doi.org/10.1073/pnas.1807258115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205488PMC
October 2018

Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability.

Authors:
María García-Rubio Paula Aguilera Juan Lafuente-Barquero José F Ruiz Marie-Noelle Simon Vincent Geli Ana G Rondón Andrés Aguilera

Genes Dev 2018 07 28;32(13-14):965-977. Epub 2018 Jun 28.

Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Pablo de Olavide, 41092 Seville, Spain.

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http://dx.doi.org/10.1101/gad.311274.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075034PMC
July 2018

Detection of DNA-RNA Hybrids In Vivo.

Authors:
María García-Rubio Sonia I Barroso Andrés Aguilera

Methods Mol Biol 2018 ;1672:347-361

Centro Andaluz de Biología Molecular y Medicina Regenerativa, CABIMER, Universidad de Sevilla, Av. Américo Vespucio 24, 41092, Seville, Spain.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_24DOI Listing
June 2018

Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions.

Authors:
Sarah Sertic Antonio Mollica Ilaria Campus Stefania Roma Emanuela Tumini Andrés Aguilera Marco Muzi-Falconi

Mol Cell 2018 04 15;70(1):34-47.e4. Epub 2018 Mar 15.

Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.02.017DOI Listing
April 2018

Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions.

Authors:
Sarah Sertic Antonio Mollica Ilaria Campus Stefania Roma Emanuela Tumini Andrés Aguilera Marco Muzi-Falconi

Mol Cell 2018 04;70(1):189

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http://dx.doi.org/10.1016/j.molcel.2018.03.027DOI Listing
April 2018

Epigenetic features of human telomeres.

Authors:
María D Cubiles Sonia Barroso María I Vaquero-Sedas Alicia Enguix Andrés Aguilera Miguel A Vega-Palas

Nucleic Acids Res 2018 03;46(5):2347-2355

Instituto de Bioquímica Vegetal y Fotosíntesis, CSIC-Universidad de Sevilla, IBVF (CSIC-US), Avd. Américo Vespucio n° 49, 41092 Seville, Spain.

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http://dx.doi.org/10.1093/nar/gky006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861411PMC
March 2018

Guidelines and recommendations on yeast cell death nomenclature.

Authors:
Didac Carmona-Gutierrez Maria Anna Bauer Andreas Zimmermann Andrés Aguilera Nicanor Austriaco Kathryn Ayscough Rena Balzan Shoshana Bar-Nun Antonio Barrientos Peter Belenky Marc Blondel Ralf J Braun Michael Breitenbach William C Burhans Sabrina Büttner Duccio Cavalieri Michael Chang Katrina F Cooper Manuela Côrte-Real Vítor Costa Christophe Cullin Ian Dawes Jörn Dengjel Martin B Dickman Tobias Eisenberg Birthe Fahrenkrog Nicolas Fasel Kai-Uwe Fröhlich Ali Gargouri Sergio Giannattasio Paola Goffrini Campbell W Gourlay Chris M Grant Michael T Greenwood Nicoletta Guaragnella Thomas Heger Jürgen Heinisch Eva Herker Johannes M Herrmann Sebastian Hofer Antonio Jiménez-Ruiz Helmut Jungwirth Katharina Kainz Dimitrios P Kontoyiannis Paula Ludovico Stéphen Manon Enzo Martegani Cristina Mazzoni Lynn A Megeney Chris Meisinger Jens Nielsen Thomas Nyström Heinz D Osiewacz Tiago F Outeiro Hay-Oak Park Tobias Pendl Dina Petranovic Stephane Picot Peter Polčic Ted Powers Mark Ramsdale Mark Rinnerthaler Patrick Rockenfeller Christoph Ruckenstuhl Raffael Schaffrath Maria Segovia Fedor F Severin Amir Sharon Stephan J Sigrist Cornelia Sommer-Ruck Maria João Sousa Johan M Thevelein Karin Thevissen Vladimir Titorenko Michel B Toledano Mick Tuite F-Nora Vögtle Benedikt Westermann Joris Winderickx Silke Wissing Stefan Wölfl Zhaojie J Zhang Richard Y Zhao Bing Zhou Lorenzo Galluzzi Guido Kroemer Frank Madeo

Microb Cell 2018 Jan 1;5(1):4-31. Epub 2018 Jan 1.

Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.

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http://dx.doi.org/10.15698/mic2018.01.607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772036PMC
January 2018

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.

Authors:
Alba Duch Berta Canal Sonia I Barroso María García-Rubio Gerhard Seisenbacher Andrés Aguilera Eulàlia de Nadal Francesc Posas

Nat Commun 2018 01 25;9(1):379. Epub 2018 Jan 25.

Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), E-08003, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41467-017-02756-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785523PMC
January 2018

Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability.

Authors:
Irene Salas-Armenteros Carmen Pérez-Calero Aleix Bayona-Feliu Emanuela Tumini Rosa Luna Andrés Aguilera

EMBO J 2017 12 26;36(23):3532-3547. Epub 2017 Oct 26.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide-Universidad de Sevilla, Seville, Spain

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http://dx.doi.org/10.15252/embj.201797208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709763PMC
December 2017

The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage.

Authors:
Juan Lafuente-Barquero Sarah Luke-Glaser Marco Graf Sonia Silva Belén Gómez-González Arianna Lockhart Michael Lisby Andrés Aguilera Brian Luke

PLoS Genet 2017 12 27;13(12):e1007136. Epub 2017 Dec 27.

Institute of Molecular Biology (IMB), Mainz, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1007136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760084PMC
December 2017

Gene gating at nuclear pores prevents the formation of R loops.

Authors:
Hélène Gaillard Francisco García-Benítez Andrés Aguilera

Mol Cell Oncol 2018 11;5(1):e1405140. Epub 2017 Dec 11.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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http://dx.doi.org/10.1080/23723556.2017.1405140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791852PMC
December 2017

The need to regulate replication fork speed.

Authors:
Belén Gómez-González Andrés Aguilera

Science 2017 11;358(6364):722-723

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla, Avenida Américo Vespucio 24, 41092 Seville, Spain.

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http://dx.doi.org/10.1126/science.aaq0678DOI Listing
November 2017

Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability.

Authors:
Francisco García-Benítez Hélène Gaillard Andrés Aguilera

Proc Natl Acad Sci U S A 2017 10 25;114(41):10942-10947. Epub 2017 Sep 25.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide-Universidad de Sevilla, 41092 Seville, Spain

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http://dx.doi.org/10.1073/pnas.1707845114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642707PMC
October 2017

Differential effect of the overexpression of Rad2/XPG family endonucleases on genome integrity in yeast and human cells.

Authors:
Sonia Jimeno Emilia Herrera-Moyano Pedro Ortega Andrés Aguilera

DNA Repair (Amst) 2017 09 3;57:66-75. Epub 2017 Jul 3.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER Universidad de Sevilla - CSIC - Universidad Pablo de Olavide Av. Américo Vespucio 24, 41092 Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.06.030DOI Listing
September 2017

Correction for Muñoz-Galván et al., "Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange".

Authors:
Sandra Muñoz-Galván Cristina Tous Miguel G Blanco Erin K Schwartz Kirk T Ehmsen Stephen C West Wolf-Dietrich Heyer Andrés Aguilera

Mol Cell Biol 2017 06 16;37(11). Epub 2017 May 16.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-CSIC, Seville, Spain.

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http://mcb.asm.org/lookup/doi/10.1128/MCB.00161-17
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http://dx.doi.org/10.1128/MCB.00161-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440645PMC
June 2017

Histone Mutants Separate R Loop Formation from Genome Instability Induction.

Authors:
Desiré García-Pichardo Juan C Cañas María L García-Rubio Belén Gómez-González Ana G Rondón Andrés Aguilera

Mol Cell 2017 Jun;66(5):597-609.e5

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville 41092, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.05.014DOI Listing
June 2017

The Role of Replication-Associated Repair Factors on R-Loops.

Authors:
Vaibhav Bhatia Emilia Herrera-Moyano Andrés Aguilera Belén Gómez-González

Genes (Basel) 2017 Jun 27;8(7). Epub 2017 Jun 27.

Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Av. Américo Vespucio 24, 41092 Seville, Spain.

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http://dx.doi.org/10.3390/genes8070171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541304PMC
June 2017

DNA-RNA hybrids: the risks of DNA breakage during transcription.

Authors:
Andrés Aguilera Belén Gómez-González

Nat Struct Mol Biol 2017 May;24(5):439-443

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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http://dx.doi.org/10.1038/nsmb.3395DOI Listing
May 2017

A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination.

Authors:
Sandra Muñoz-Galván María García-Rubio Pedro Ortega Jose F Ruiz Sonia Jimeno Benjamin Pardo Belén Gómez-González Andrés Aguilera

PLoS Genet 2017 May 5;13(5):e1006781. Epub 2017 May 5.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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http://dx.doi.org/10.1371/journal.pgen.1006781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438189PMC
May 2017

Roles of human POLD1 and POLD3 in genome stability.

Authors:
Emanuela Tumini Sonia Barroso Carmen Pérez -Calero Andrés Aguilera

Sci Rep 2016 12 15;6:38873. Epub 2016 Dec 15.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avd. Américo Vespucio s/n, 41092 Seville, Spain.

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http://dx.doi.org/10.1038/srep38873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156928PMC
December 2016

FANCD2 Facilitates Replication through Common Fragile Sites.

Authors:
Advaitha Madireddy Settapong T Kosiyatrakul Rebecca A Boisvert Emilia Herrera-Moyano María L García-Rubio Jeannine Gerhardt Elizabeth A Vuono Nichole Owen Zi Yan Susan Olson Andrés Aguilera Niall G Howlett Carl L Schildkraut

Mol Cell 2016 10;64(2):388-404

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683400PMC
October 2016

Transcription-replication conflicts: how they occur and how they are resolved.

Authors:
Tatiana García-Muse Andrés Aguilera

Nat Rev Mol Cell Biol 2016 09 20;17(9):553-63. Epub 2016 Jul 20.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas, Seville 41092, Spain.

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http://www.nature.com/articles/nrm.2016.88
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http://dx.doi.org/10.1038/nrm.2016.88DOI Listing
September 2016

Correction: The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development.

Authors:
Maikel Castellano-Pozo Tatiana García-Muse Andrés Aguilera

PLoS One 2016;11(7):e0160138. Epub 2016 Jul 21.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160138PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956278PMC
July 2016

Transcription as a Threat to Genome Integrity.

Authors:
Hélène Gaillard Andrés Aguilera

Annu Rev Biochem 2016 Jun 24;85:291-317. Epub 2016 Mar 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla, Sevilla 41092, Spain; email: ,

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http://www.annualreviews.org/doi/10.1146/annurev-biochem-060
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http://dx.doi.org/10.1146/annurev-biochem-060815-014908DOI Listing
June 2016

Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening.

Authors:
Sandra Gavaldá José M Santos-Pereira María L García-Rubio Rosa Luna Andrés Aguilera

PLoS Genet 2016 Apr 1;12(4):e1005966. Epub 2016 Apr 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1371/journal.pgen.1005966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818039PMC
April 2016

High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast.

Authors:
Sabrina L Andersen Aimee Zhang Margaret Dominska María Moriel-Carretero Emilia Herrera-Moyano Andrés Aguilera Thomas D Petes

PLoS Genet 2016 Mar 11;12(3):e1005938. Epub 2016 Mar 11.

Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788294PMC
March 2016

Npl3, a new link between RNA-binding proteins and the maintenance of genome integrity.

Authors:
José M Santos-Pereira Ana B Herrero Sergio Moreno Andrés Aguilera

Cell Cycle 2014 2;13(10):1524-9. Epub 2014 Apr 2.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER; Universidad de Sevilla-CSIC; Seville, Spain.

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http://www.tandfonline.com/doi/abs/10.4161/cc.28708
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http://dx.doi.org/10.4161/cc.28708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050157PMC
February 2016

Methods to study transcription-coupled repair in chromatin.

Authors:
Hélène Gaillard Ralf Erik Wellinger Andrés Aguilera

Methods Mol Biol 2015 ;1288:273-88

Genetics, CABIMER, Universidad de Sevilla-CSIC, Avenida Américo Vespucio s/n, 41092, Seville, Spain.

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http://dx.doi.org/10.1007/978-1-4939-2474-5_15DOI Listing
December 2015

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.

Authors:
María L García-Rubio Carmen Pérez-Calero Sonia I Barroso Emanuela Tumini Emilia Herrera-Moyano Iván V Rosado Andrés Aguilera

PLoS Genet 2015 Nov 19;11(11):e1005674. Epub 2015 Nov 19.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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https://dx.plos.org/10.1371/journal.pgen.1005674
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http://dx.doi.org/10.1371/journal.pgen.1005674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652862PMC
November 2015

Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression.

Authors:
Mónica Bravo Fabio Nicolini Katarzyna Starowicz Sonia Barroso Carmela Calés Andrés Aguilera Miguel Vidal

J Cell Sci 2015 Oct 13;128(19):3660-71. Epub 2015 Aug 13.

Biología Celular y Molecular, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain

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http://dx.doi.org/10.1242/jcs.173021DOI Listing
October 2015

R loops: new modulators of genome dynamics and function.

Authors:
José M Santos-Pereira Andrés Aguilera

Nat Rev Genet 2015 Oct 15;16(10):583-97. Epub 2015 Sep 15.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Av. Américo Vespucio s/n, Seville 41092, Spain.

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http://www.nature.com/articles/nrg3961
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http://dx.doi.org/10.1038/nrg3961DOI Listing
October 2015

A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome.

Authors:
María Moriel-Carretero Emilia Herrera-Moyano Andrés Aguilera

Rare Dis 2015 7;3(1):e1079362. Epub 2015 Aug 7.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER; Universidad de Sevilla ; Seville, Spain.

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http://dx.doi.org/10.1080/21675511.2015.1079362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588225PMC
October 2015

Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system.

Authors:
Ruth Stuckey Néstor García-Rodríguez Andrés Aguilera Ralf Erik Wellinger

Proc Natl Acad Sci U S A 2015 May 20;112(18):5779-84. Epub 2015 Apr 20.

Department of Molecular Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa-Universidad de Sevilla, 41092 Seville, Spain

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http://www.pnas.org/lookup/doi/10.1073/pnas.1501769112
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426422PMC
May 2015

Replication stress and cancer.

Authors:
Hélène Gaillard Tatiana García-Muse Andrés Aguilera

Nat Rev Cancer 2015 May;15(5):276-89

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Av. Américo Vespucio s/n, Sevilla 41092, Spain.

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http://www.nature.com/articles/nrc3916
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May 2015

Interdependence of the rad50 hook and globular domain functions.

Authors:
Marcel Hohl Tomasz Kochańczyk Cristina Tous Andrés Aguilera Artur Krężel John H J Petrini

Mol Cell 2015 Feb 15;57(3):479-91. Epub 2015 Jan 15.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527088PMC
February 2015

RNA polymerase II contributes to preventing transcription-mediated replication fork stalls.

Authors:
Irene Felipe-Abrio Juan Lafuente-Barquero María L García-Rubio Andrés Aguilera

EMBO J 2015 Jan 1;34(2):236-50. Epub 2014 Dec 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain

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http://dx.doi.org/10.15252/embj.201488544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337070PMC
January 2015

Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability.

Authors:
Julie Sollier Caroline Townsend Stork María L García-Rubio Renee D Paulsen Andrés Aguilera Karlene A Cimprich

Mol Cell 2014 Dec 26;56(6):777-85. Epub 2014 Nov 26.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272638PMC
December 2014

The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne syndrome-like phenotypes.

Authors:
Emilia Herrera-Moyano María Moriel-Carretero Beth A Montelone Andrés Aguilera

PLoS Genet 2014 Dec 11;10(12):e1004859. Epub 2014 Dec 11.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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https://dx.plos.org/10.1371/journal.pgen.1004859
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263401PMC
December 2014

A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions.

Authors:
José M Santos-Pereira María L García-Rubio Cristina González-Aguilera Rosa Luna Andrés Aguilera

Nucleic Acids Res 2014 Oct 7;42(19):12000-14. Epub 2014 Oct 7.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, 41092 Seville, Spain

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http://dx.doi.org/10.1093/nar/gku906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231764PMC
October 2014

Transcription and recombination: when RNA meets DNA.

Authors:
Andrés Aguilera Hélène Gaillard

Cold Spring Harb Perspect Biol 2014 Aug 1;6(8). Epub 2014 Aug 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla, 41092 Seville, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107990PMC
August 2014

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

Authors:
Vaibhav Bhatia Sonia I Barroso María L García-Rubio Emanuela Tumini Emilia Herrera-Moyano Andrés Aguilera

Nature 2014 Jul 1;511(7509):362-5. Epub 2014 Jun 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain.

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http://www.nature.com/articles/nature13374
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July 2014

Causes of genome instability.

Authors:
Andrés Aguilera Tatiana García-Muse

Annu Rev Genet 2013 31;47:1-32. Epub 2013 Jul 31.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla, 41092 Seville, Spain; email:

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http://www.annualreviews.org/doi/10.1146/annurev-genet-11121
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April 2014

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts.

Authors:
Emilia Herrera-Moyano Xénia Mergui María L García-Rubio Sonia Barroso Andrés Aguilera

Genes Dev 2014 Apr 17;28(7):735-48. Epub 2014 Mar 17.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, 41092 Seville, Spain.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.234070.113
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015491PMC
April 2014

Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae.

Authors:
Hélène Gaillard Andrés Aguilera

PLoS Genet 2014 Mar 6;10(3):e1004203. Epub 2014 Mar 6.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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March 2014

R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity.

Authors:
Sandra Gavaldá Mercedes Gallardo Rosa Luna Andrés Aguilera

PLoS One 2013 7;8(6):e65541. Epub 2013 Jun 7.

Departamento de Biología Molecular, Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676323PMC
January 2014

Yeast pol4 promotes tel1-regulated chromosomal translocations.

Authors:
Jose F Ruiz Benjamin Pardo Guillermo Sastre-Moreno Andrés Aguilera Luis Blanco

PLoS Genet 2013 18;9(7):e1003656. Epub 2013 Jul 18.

Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid/CSIC, Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715435PMC
January 2014

Transcription-associated genome instability.

Authors:
Hélène Gaillard Emilia Herrera-Moyano Andrés Aguilera

Chem Rev 2013 Nov 18;113(11):8638-61. Epub 2013 Apr 18.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla , Av. Américo Vespucio s/n, 41092 Seville, Spain.

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November 2013

R loops are linked to histone H3 S10 phosphorylation and chromatin condensation.

Authors:
Maikel Castellano-Pozo José M Santos-Pereira Ana G Rondón Sonia Barroso Eloisa Andújar Mónica Pérez-Alegre Tatiana García-Muse Andrés Aguilera

Mol Cell 2013 Nov 7;52(4):583-90. Epub 2013 Nov 7.

Department of Molecular Biology, Universidad de Sevilla-CSIC, Avenida Américo Vespucio, 41092 Seville, Spain.

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http://dx.doi.org/10.1016/j.molcel.2013.10.006DOI Listing
November 2013

The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability.

Authors:
José M Santos-Pereira Ana B Herrero María L García-Rubio Antonio Marín Sergio Moreno Andrés Aguilera

Genes Dev 2013 Nov;27(22):2445-58

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas (CSIC), 41092 Seville, Spain;

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http://dx.doi.org/10.1101/gad.229880.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841734PMC
November 2013

The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.

Authors:
Maikel Castellano-Pozo Tatiana García-Muse Andrés Aguilera

PLoS One 2012 20;7(12):e52447. Epub 2012 Dec 20.

Department of Molecular Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla, Sevilla, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052447PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527488PMC
June 2013

Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid.

Authors:
Sandra Muñoz-Galván Sonia Jimeno Rodney Rothstein Andrés Aguilera

PLoS Genet 2013 24;9(1):e1003237. Epub 2013 Jan 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://dx.plos.org/10.1371/journal.pgen.1003237
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554610PMC
May 2013

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.

Authors:
Sandra Muñoz-Galván Ana López-Saavedra Stephen P Jackson Pablo Huertas Felipe Cortés-Ledesma Andrés Aguilera

Nucleic Acids Res 2013 Feb 18;41(3):1669-83. Epub 2012 Dec 18.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Seville, Spain.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gks1274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561951PMC
February 2013

Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis.

Authors:
Hélène Gaillard Andrés Aguilera

Biochim Biophys Acta 2013 Jan 6;1829(1):141-50. Epub 2012 Oct 6.

Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1016/j.bbagrm.2012.09.008DOI Listing
January 2013

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

Authors:
Alba Duch Irene Felipe-Abrio Sonia Barroso Gilad Yaakov María García-Rubio Andrés Aguilera Eulàlia de Nadal Francesc Posas

Nature 2013 Jan 25;493(7430):116-9. Epub 2012 Nov 25.

Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona E-08003, Spain.

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http://www.nature.com/doifinder/10.1038/nature11675
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January 2013

R-loops cause replication impairment and genome instability during meiosis.

Authors:
Maikel Castellano-Pozo Tatiana García-Muse Andrés Aguilera

EMBO Rep 2012 Oct 10;13(10):923-9. Epub 2012 Aug 10.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2012.119
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http://dx.doi.org/10.1038/embor.2012.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463965PMC
October 2012

Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.

Authors:
Benjamin Pardo Andrés Aguilera

PLoS Genet 2012 Sep 27;8(9):e1002979. Epub 2012 Sep 27.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Sevilla, Spain.

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https://dx.plos.org/10.1371/journal.pgen.1002979
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459980PMC
September 2012

New clues to understand the role of THO and other functionally related factors in mRNP biogenesis.

Authors:
Rosa Luna Ana G Rondón Andrés Aguilera

Biochim Biophys Acta 2012 Jun 20;1819(6):514-20. Epub 2011 Dec 20.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av Américo Vespucio s/n, 41092 Sevilla, Spain. rlvarp@is/es

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June 2012

Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange.

Authors:
Sandra Muñoz-Galván Cristina Tous Miguel G Blanco Erin K Schwartz Kirk T Ehmsen Stephen C West Wolf-Dietrich Heyer Andrés Aguilera

Mol Cell Biol 2012 May 21;32(9):1592-603. Epub 2012 Feb 21.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-CSIC, Seville, Spain.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00111-12
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http://dx.doi.org/10.1128/MCB.00111-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347241PMC
May 2012

R loops: from transcription byproducts to threats to genome stability.

Authors:
Andrés Aguilera Tatiana García-Muse

Mol Cell 2012 Apr;46(2):115-24

CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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April 2012

Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor.

Authors:
Alvaro Peña Kamil Gewartowski Seweryn Mroczek Jorge Cuéllar Aleksandra Szykowska Andrzej Prokop Mariusz Czarnocki-Cieciura Jan Piwowarski Cristina Tous Andrés Aguilera José L Carrascosa José María Valpuesta Andrzej Dziembowski

EMBO J 2012 Mar 7;31(6):1605-16. Epub 2012 Feb 7.

Department of Structure of Macromolecules, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2012.10
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http://dx.doi.org/10.1038/emboj.2012.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321177PMC
March 2012

Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes.

Authors:
María L García-Rubio Andrés Aguilera

Nucleic Acids Res 2012 Feb 13;40(3):1050-64. Epub 2011 Oct 13.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n 41092 Sevilla, and Departamento de Genética, Universidad de Sevilla, 41012 Sevilla, Spain.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkr840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273821PMC
February 2012

Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.

Authors:
María S Domínguez-Sánchez Sonia Barroso Belén Gómez-González Rosa Luna Andrés Aguilera

PLoS Genet 2011 Dec 1;7(12):e1002386. Epub 2011 Dec 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla - Consejo Superior de Investigaciones Científicas (CSIC), Sevilla, Spain.

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https://dx.plos.org/10.1371/journal.pgen.1002386
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228816PMC
December 2011

Genetic and molecular analysis of mitotic recombination in Saccharomyces cerevisiae.

Authors:
Belén Gómez-González José F Ruiz Andrés Aguilera

Methods Mol Biol 2011 ;745:151-72

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://dx.doi.org/10.1007/978-1-61779-129-1_10DOI Listing
September 2011

Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1.

Authors:
María Moriel-Carretero Cristina Tous Andrés Aguilera

Proc Natl Acad Sci U S A 2011 Sep 29;108(37):15300-5. Epub 2011 Aug 29.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-Consejo Superior de Investigaciones Cientificas, 41092 Seville, Spain.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1107425108
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174667PMC
September 2011

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.

Authors:
Marcel Hohl Youngho Kwon Sandra Muñoz Galván Xiaoyu Xue Cristina Tous Andrés Aguilera Patrick Sung John H J Petrini

Nat Struct Mol Biol 2011 Sep 4;18(10):1124-31. Epub 2011 Sep 4.

Laboratory of Chromosome Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.2116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190017PMC
September 2011

Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability.

Authors:
María Del Carmen Díaz de la Loza Mercedes Gallardo María Luisa García-Rubio Alicia Izquierdo Enrique Herrero Andrés Aguilera Ralf Erik Wellinger

Nucleic Acids Res 2011 Aug 21;39(14):6002-15. Epub 2011 Apr 21.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Avd Américo Vespucio, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1093/nar/gkr193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152343PMC
August 2011

Nab2 functions in the metabolism of RNA driven by polymerases II and III.

Authors:
Cristina González-Aguilera Cristina Tous Reyes Babiano Jesús de la Cruz Rosa Luna Andrés Aguilera

Mol Biol Cell 2011 Aug 16;22(15):2729-40. Epub 2011 Jun 16.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-Consejo Superior de Investigaciones Científicas, 41092 Seville, Spain.

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http://www.molbiolcell.org/doi/10.1091/mbc.e11-01-0055
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145548PMC
August 2011

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.

Authors:
Rodrigo Bermejo Thelma Capra Rachel Jossen Arianna Colosio Camilla Frattini Walter Carotenuto Andrea Cocito Ylli Doksani Hannah Klein Belén Gómez-González Andrés Aguilera Yuki Katou Katsuhiko Shirahige Marco Foiani

Cell 2011 Jul;146(2):233-46

Fondazione Istituto FIRC di Oncologia Molecolare (IFOM) at IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1016/j.cell.2011.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160733PMC
July 2011

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.

Authors:
Belén Gómez-González María García-Rubio Rodrigo Bermejo Hélène Gaillard Katsuhiko Shirahige Antonio Marín Marco Foiani Andrés Aguilera

EMBO J 2011 Jun 24;30(15):3106-19. Epub 2011 Jun 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160181PMC
http://dx.doi.org/10.1038/emboj.2011.206DOI Listing
June 2011

A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors.

Authors:
Cristina Tous Ana G Rondón María García-Rubio Cristina González-Aguilera Rosa Luna Andrés Aguilera

EMBO J 2011 May 8;30(10):1953-64. Epub 2011 Apr 8.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2011.109
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http://dx.doi.org/10.1038/emboj.2011.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098481PMC
May 2011

New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.

Authors:
Sonia Jimeno Cristina Tous María L García-Rubio Michael Ranes Cristina González-Aguilera Antonio Marín Andrés Aguilera

Mol Cell Biol 2011 Feb 13;31(4):674-85. Epub 2010 Dec 13.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Seville, Spain.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01188-10
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028642PMC
February 2011

3D Stationary electric current density in a spherical tumor treated with low direct current: an analytical solution.

Authors:
Rolando Placeres Jiménez Ana Elisa Bergues Pupo Jesús Manuel Bergues Cabrales Javier Antonio González Joa Luis Enrique Bergues Cabrales Juan José Godina Nava Andrés Ramírez Aguilera Miguel Angel O'Farril Mateus Manuel Verdecia Jarque Soraida Candida Acosta Brooks

Bioelectromagnetics 2011 Feb 28;32(2):120-30. Epub 2010 Oct 28.

Departamento de Física, Universidad Federal Sao Carlos-SP, Brazil.

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http://doi.wiley.com/10.1002/bem.20611
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February 2011

Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.

Authors:
María S Domínguez-Sánchez Carmen Sáez Miguel A Japón Andrés Aguilera Rosa Luna

BMC Cancer 2011 Feb 17;11:77. Epub 2011 Feb 17.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av, Américo Vespucio s/n, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1186/1471-2407-11-77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050854PMC
February 2011

AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.

Authors:
José F Ruiz Belén Gómez-González Andrés Aguilera

PLoS Genet 2011 Feb 24;7(2):e1002009. Epub 2011 Feb 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://dx.doi.org/10.1371/journal.pgen.1002009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044682PMC
February 2011

Yeast Sen1 helicase protects the genome from transcription-associated instability.

Authors:
Hannah E Mischo Belén Gómez-González Pawel Grzechnik Ana G Rondón Wu Wei Lars Steinmetz Andrés Aguilera Nick J Proudfoot

Mol Cell 2011 Jan;41(1):21-32

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1016/j.molcel.2010.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314950PMC
January 2011

Modified Gompertz equation for electrotherapy murine tumor growth kinetics: predictions and new hypotheses.

Authors:
Luis E Bergues Cabrales Juan J Godina Nava Andrés Ramírez Aguilera Javier A González Joa Héctor M Camué Ciria Maraelys Morales González Miriam Fariñas Salas Manuel Verdecia Jarque Tamara Rubio González Miguel A O'Farril Mateus Soraida C Acosta Brooks Fabiola Suárez Palencia Lisset Ortiz Zamora María C Céspedes Quevedo Sarah Edward Seringe Vladimir Crombet Cuitié Idelisa Bergues Cabrales Gustavo Sierra González

BMC Cancer 2010 Oct 28;10:589. Epub 2010 Oct 28.

Departamento de Física, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Laboratorio de Estimulación Magnética, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Ap. Post. 14- 740, México, DF 07000, México 07360, Distrito Federal, México.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988748PMC
October 2010

The THO complex as a key mRNP biogenesis factor in development and cell differentiation.

Authors:
Sonia Jimeno Andrés Aguilera

J Biol 2010 28;9(1). Epub 2010 Jan 28.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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http://jbiol.biomedcentral.com/articles/10.1186/jbiol217
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871528PMC
August 2010

The interface between transcription and mRNP export: from THO to THSC/TREX-2.

Authors:
Ana G Rondón Sonia Jimeno Andrés Aguilera

Biochim Biophys Acta 2010 Aug 19;1799(8):533-8. Epub 2010 Jun 19.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Av. Americo Vespucio s/n, 41092 Sevilla, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S187493991000079
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August 2010

A postincision-deficient TFIIH causes replication fork breakage and uncovers alternative Rad51- or Pol32-mediated restart mechanisms.

Authors:
María Moriel-Carretero Andrés Aguilera

Mol Cell 2010 Mar;37(5):690-701

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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March 2010

Transcription at the proximity of the nuclear pore: a role for the THP1-SAC3-SUS1-CDC31 (THSC) complex.

Authors:
Rosa Luna Cristina González-Aguilera Andrés Aguilera

RNA Biol 2009 Apr-Jun;6(2):145-8. Epub 2009 Apr 8.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Seville, Spain.

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http://dx.doi.org/10.4161/rna.6.2.7803DOI Listing
February 2010

The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants.

Authors:
Belén Gómez-González Irene Felipe-Abrio Andrés Aguilera

Mol Cell Biol 2009 Oct 3;29(19):5203-13. Epub 2009 Aug 3.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Seville, Spain.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00402-09
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747986PMC
October 2009

Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replication.

Authors:
José F Ruiz Belén Gómez-González Andrés Aguilera

Mol Cell Biol 2009 Oct 3;29(20):5441-54. Epub 2009 Aug 3.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1128/MCB.00256-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756893PMC
October 2009

The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress.

Authors:
Gilad Yaakov Alba Duch María García-Rubio Josep Clotet Javier Jimenez Andrés Aguilera Francesc Posas

Mol Biol Cell 2009 Aug 28;20(15):3572-82. Epub 2009 May 28.

Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1091/mbc.e09-02-0129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719575PMC
August 2009

R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX.

Authors:
Belén Gómez-González Andrés Aguilera

Nucleic Acids Res 2009 Jul 18;37(13):4315-21. Epub 2009 May 18.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1093/nar/gkp385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715242PMC
July 2009

The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae.

Authors:
Francisco Conde Esther Refolio Violeta Cordón-Preciado Felipe Cortés-Ledesma Luis Aragón Andrés Aguilera Pedro A San-Segundo

Genetics 2009 Jun 30;182(2):437-46. Epub 2009 Mar 30.

Universidad de Salamanca, Salamanca, Spain.

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http://dx.doi.org/10.1534/genetics.109.101899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691753PMC
June 2009

Methods to study transcription-coupled repair in chromatin.

Authors:
Hélène Gaillard Ralf Erik Wellinger Andrés Aguilera

Methods Mol Biol 2009 ;523:141-59

CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://link.springer.com/10.1007/978-1-59745-190-1_10
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May 2009

Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery.

Authors:
Marius Boulos Faza Stefan Kemmler Sonia Jimeno Cristina González-Aguilera Andrés Aguilera Ed Hurt Vikram Govind Panse

J Cell Biol 2009 Mar 16;184(6):833-46. Epub 2009 Mar 16.

Institute of Biochemistry, ETH Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1083/jcb.200810059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699155PMC
March 2009

Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair.

Authors:
Hélène Gaillard Cristina Tous Javier Botet Cristina González-Aguilera Maria José Quintero Laia Viladevall María L García-Rubio Alfonso Rodríguez-Gil Antonio Marín Joaquín Ariño José Luis Revuelta Sebastián Chávez Andrés Aguilera

PLoS Genet 2009 Feb 6;5(2):e1000364. Epub 2009 Feb 6.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://dx.doi.org/10.1371/journal.pgen.1000364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629578PMC
February 2009

A novel class of mRNA-containing cytoplasmic granules are produced in response to UV-irradiation.

Authors:
Hélène Gaillard Andrés Aguilera

Mol Biol Cell 2008 Nov 3;19(11):4980-92. Epub 2008 Sep 3.

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Centro Andaluz de Biología Molecular and Medicina Regenativa CABIMER, 41092 Sevilla, Spain.

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http://www.molbiolcell.org/doi/10.1091/mbc.e08-02-0193
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575145PMC
November 2008

A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants.

Authors:
Sonia Jimeno Maria García-Rubio Rosa Luna Andrés Aguilera

Mol Genet Genomics 2008 Oct 6;280(4):327-36. Epub 2008 Aug 6.

Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1007/s00438-008-0368-8DOI Listing
October 2008

CDK targets Sae2 to control DNA-end resection and homologous recombination.

Authors:
Pablo Huertas Felipe Cortés-Ledesma Alessandro A Sartori Andrés Aguilera Stephen P Jackson

Nature 2008 Oct 20;455(7213):689-92. Epub 2008 Aug 20.

The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/nature07215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635538PMC
October 2008