Andres Aguilera

Andres Aguilera

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Andres Aguilera

Publications by authors named "Andres Aguilera"

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Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.

Mol Cell 2019 Oct 10;76(1):57-69.e9. Epub 2019 Sep 10.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.07.037DOI Listing
October 2019

R Loops: From Physiological to Pathological Roles.

Cell 2019 Oct 8. Epub 2019 Oct 8.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, 41092 SEVILLE, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.08.055DOI Listing
October 2019

What causes an RNA-DNA hybrid to compromise genome integrity?

DNA Repair (Amst) 2019 Sep 8;81:102660. Epub 2019 Jul 8.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, 41092, Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.102660DOI Listing
September 2019

The DNA damage response acts as a safeguard against harmful DNA-RNA hybrids of different origins.

EMBO Rep 2019 Sep 24;20(9):e47250. Epub 2019 Jul 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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http://dx.doi.org/10.15252/embr.201847250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726908PMC
September 2019

Transcription-mediated replication hindrance: a major driver of genome instability.

Genes Dev 2019 08 23;33(15-16):1008-1026. Epub 2019 May 23.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide., 41092 Seville, Spain.

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http://dx.doi.org/10.1101/gad.324517.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672053PMC
August 2019

Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability.

Cell Rep 2019 Aug;28(6):1551-1563.e7

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville 41092, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693559PMC
August 2019

The Nup84 complex coordinates the DNA damage response to warrant genome integrity.

Nucleic Acids Res 2019 May;47(8):4054-4067

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, 41092 Seville, Spain.

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http://dx.doi.org/10.1093/nar/gkz066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486642PMC
May 2019

The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability.

Mol Cancer Res 2019 03 14;17(3):773-782. Epub 2018 Dec 14.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, CSIC-Universidad Pablo de Olavide-Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398590PMC
March 2019

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.

Proc Natl Acad Sci U S A 2018 10 9;115(43):11024-11029. Epub 2018 Oct 9.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide, 41092 Seville, Spain

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http://www.pnas.org/lookup/doi/10.1073/pnas.1807258115
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http://dx.doi.org/10.1073/pnas.1807258115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205488PMC
October 2018

Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability.

Genes Dev 2018 07 28;32(13-14):965-977. Epub 2018 Jun 28.

Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Pablo de Olavide, 41092 Seville, Spain.

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http://dx.doi.org/10.1101/gad.311274.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075034PMC
July 2018

Detection of DNA-RNA Hybrids In Vivo.

Methods Mol Biol 2018 ;1672:347-361

Centro Andaluz de Biología Molecular y Medicina Regenerativa, CABIMER, Universidad de Sevilla, Av. Américo Vespucio 24, 41092, Seville, Spain.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_24DOI Listing
June 2018

Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions.

Mol Cell 2018 04 15;70(1):34-47.e4. Epub 2018 Mar 15.

Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.02.017DOI Listing
April 2018

Epigenetic features of human telomeres.

Nucleic Acids Res 2018 03;46(5):2347-2355

Instituto de Bioquímica Vegetal y Fotosíntesis, CSIC-Universidad de Sevilla, IBVF (CSIC-US), Avd. Américo Vespucio n° 49, 41092 Seville, Spain.

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http://dx.doi.org/10.1093/nar/gky006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861411PMC
March 2018

Guidelines and recommendations on yeast cell death nomenclature.

Microb Cell 2018 Jan 1;5(1):4-31. Epub 2018 Jan 1.

Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.

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http://dx.doi.org/10.15698/mic2018.01.607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772036PMC
January 2018

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.

Nat Commun 2018 01 25;9(1):379. Epub 2018 Jan 25.

Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), E-08003, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41467-017-02756-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785523PMC
January 2018

Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability.

EMBO J 2017 12 26;36(23):3532-3547. Epub 2017 Oct 26.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide-Universidad de Sevilla, Seville, Spain

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http://dx.doi.org/10.15252/embj.201797208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709763PMC
December 2017

Gene gating at nuclear pores prevents the formation of R loops.

Mol Cell Oncol 2018 11;5(1):e1405140. Epub 2017 Dec 11.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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http://dx.doi.org/10.1080/23723556.2017.1405140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791852PMC
December 2017

The need to regulate replication fork speed.

Science 2017 11;358(6364):722-723

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla, Avenida Américo Vespucio 24, 41092 Seville, Spain.

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http://dx.doi.org/10.1126/science.aaq0678DOI Listing
November 2017

Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability.

Proc Natl Acad Sci U S A 2017 10 25;114(41):10942-10947. Epub 2017 Sep 25.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide-Universidad de Sevilla, 41092 Seville, Spain

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http://dx.doi.org/10.1073/pnas.1707845114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642707PMC
October 2017

Differential effect of the overexpression of Rad2/XPG family endonucleases on genome integrity in yeast and human cells.

DNA Repair (Amst) 2017 09 3;57:66-75. Epub 2017 Jul 3.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER Universidad de Sevilla - CSIC - Universidad Pablo de Olavide Av. Américo Vespucio 24, 41092 Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.06.030DOI Listing
September 2017

Histone Mutants Separate R Loop Formation from Genome Instability Induction.

Mol Cell 2017 Jun;66(5):597-609.e5

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville 41092, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.05.014DOI Listing
June 2017

The Role of Replication-Associated Repair Factors on R-Loops.

Genes (Basel) 2017 Jun 27;8(7). Epub 2017 Jun 27.

Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Av. Américo Vespucio 24, 41092 Seville, Spain.

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http://dx.doi.org/10.3390/genes8070171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541304PMC
June 2017

DNA-RNA hybrids: the risks of DNA breakage during transcription.

Nat Struct Mol Biol 2017 May;24(5):439-443

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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http://dx.doi.org/10.1038/nsmb.3395DOI Listing
May 2017

A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination.

PLoS Genet 2017 May 5;13(5):e1006781. Epub 2017 May 5.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

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http://dx.doi.org/10.1371/journal.pgen.1006781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438189PMC
May 2017

Roles of human POLD1 and POLD3 in genome stability.

Sci Rep 2016 12 15;6:38873. Epub 2016 Dec 15.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avd. Américo Vespucio s/n, 41092 Seville, Spain.

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http://dx.doi.org/10.1038/srep38873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156928PMC
December 2016

Transcription-replication conflicts: how they occur and how they are resolved.

Nat Rev Mol Cell Biol 2016 09 20;17(9):553-63. Epub 2016 Jul 20.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas, Seville 41092, Spain.

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http://www.nature.com/articles/nrm.2016.88
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http://dx.doi.org/10.1038/nrm.2016.88DOI Listing
September 2016

Transcription as a Threat to Genome Integrity.

Annu Rev Biochem 2016 Jun 24;85:291-317. Epub 2016 Mar 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla, Sevilla 41092, Spain; email: ,

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http://www.annualreviews.org/doi/10.1146/annurev-biochem-060
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http://dx.doi.org/10.1146/annurev-biochem-060815-014908DOI Listing
June 2016

Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening.

PLoS Genet 2016 Apr 1;12(4):e1005966. Epub 2016 Apr 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1371/journal.pgen.1005966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818039PMC
April 2016

High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast.

PLoS Genet 2016 Mar 11;12(3):e1005938. Epub 2016 Mar 11.

Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788294PMC
March 2016

Npl3, a new link between RNA-binding proteins and the maintenance of genome integrity.

Cell Cycle 2014 2;13(10):1524-9. Epub 2014 Apr 2.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER; Universidad de Sevilla-CSIC; Seville, Spain.

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http://www.tandfonline.com/doi/abs/10.4161/cc.28708
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http://dx.doi.org/10.4161/cc.28708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050157PMC
February 2016

Methods to study transcription-coupled repair in chromatin.

Methods Mol Biol 2015 ;1288:273-88

Genetics, CABIMER, Universidad de Sevilla-CSIC, Avenida Américo Vespucio s/n, 41092, Seville, Spain.

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http://dx.doi.org/10.1007/978-1-4939-2474-5_15DOI Listing
December 2015

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.

PLoS Genet 2015 Nov 19;11(11):e1005674. Epub 2015 Nov 19.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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https://dx.plos.org/10.1371/journal.pgen.1005674
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http://dx.doi.org/10.1371/journal.pgen.1005674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652862PMC
November 2015

Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression.

J Cell Sci 2015 Oct 13;128(19):3660-71. Epub 2015 Aug 13.

Biología Celular y Molecular, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain

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http://dx.doi.org/10.1242/jcs.173021DOI Listing
October 2015

R loops: new modulators of genome dynamics and function.

Nat Rev Genet 2015 Oct 15;16(10):583-97. Epub 2015 Sep 15.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Av. Américo Vespucio s/n, Seville 41092, Spain.

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http://www.nature.com/articles/nrg3961
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http://dx.doi.org/10.1038/nrg3961DOI Listing
October 2015

A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome.

Rare Dis 2015 7;3(1):e1079362. Epub 2015 Aug 7.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER; Universidad de Sevilla ; Seville, Spain.

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http://dx.doi.org/10.1080/21675511.2015.1079362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588225PMC
October 2015

Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system.

Proc Natl Acad Sci U S A 2015 May 20;112(18):5779-84. Epub 2015 Apr 20.

Department of Molecular Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa-Universidad de Sevilla, 41092 Seville, Spain

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http://www.pnas.org/lookup/doi/10.1073/pnas.1501769112
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http://dx.doi.org/10.1073/pnas.1501769112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426422PMC
May 2015

Replication stress and cancer.

Nat Rev Cancer 2015 May;15(5):276-89

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Av. Américo Vespucio s/n, Sevilla 41092, Spain.

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http://www.nature.com/articles/nrc3916
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http://dx.doi.org/10.1038/nrc3916DOI Listing
May 2015

Interdependence of the rad50 hook and globular domain functions.

Mol Cell 2015 Feb 15;57(3):479-91. Epub 2015 Jan 15.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140096
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http://dx.doi.org/10.1016/j.molcel.2014.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527088PMC
February 2015

RNA polymerase II contributes to preventing transcription-mediated replication fork stalls.

EMBO J 2015 Jan 1;34(2):236-50. Epub 2014 Dec 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain

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http://dx.doi.org/10.15252/embj.201488544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337070PMC
January 2015

Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability.

Mol Cell 2014 Dec 26;56(6):777-85. Epub 2014 Nov 26.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272638PMC
December 2014

The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne syndrome-like phenotypes.

PLoS Genet 2014 Dec 11;10(12):e1004859. Epub 2014 Dec 11.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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https://dx.plos.org/10.1371/journal.pgen.1004859
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http://dx.doi.org/10.1371/journal.pgen.1004859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263401PMC
December 2014

A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions.

Nucleic Acids Res 2014 Oct 7;42(19):12000-14. Epub 2014 Oct 7.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, 41092 Seville, Spain

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http://dx.doi.org/10.1093/nar/gku906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231764PMC
October 2014

Transcription and recombination: when RNA meets DNA.

Cold Spring Harb Perspect Biol 2014 Aug 1;6(8). Epub 2014 Aug 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla, 41092 Seville, Spain.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a016543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107990PMC
August 2014

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

Nature 2014 Jul 1;511(7509):362-5. Epub 2014 Jun 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain.

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http://www.nature.com/articles/nature13374
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http://dx.doi.org/10.1038/nature13374DOI Listing
July 2014

Causes of genome instability.

Annu Rev Genet 2013 31;47:1-32. Epub 2013 Jul 31.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla, 41092 Seville, Spain; email:

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http://www.annualreviews.org/doi/10.1146/annurev-genet-11121
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http://dx.doi.org/10.1146/annurev-genet-111212-133232DOI Listing
April 2014

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts.

Genes Dev 2014 Apr 17;28(7):735-48. Epub 2014 Mar 17.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, 41092 Seville, Spain.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.234070.113
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http://dx.doi.org/10.1101/gad.234070.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015491PMC
April 2014

Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae.

PLoS Genet 2014 Mar 6;10(3):e1004203. Epub 2014 Mar 6.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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https://dx.plos.org/10.1371/journal.pgen.1004203
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http://dx.doi.org/10.1371/journal.pgen.1004203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945788PMC
March 2014

R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity.

PLoS One 2013 7;8(6):e65541. Epub 2013 Jun 7.

Departamento de Biología Molecular, Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Seville, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065541PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676323PMC
January 2014

Yeast pol4 promotes tel1-regulated chromosomal translocations.

PLoS Genet 2013 18;9(7):e1003656. Epub 2013 Jul 18.

Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid/CSIC, Madrid, Spain.

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https://dx.plos.org/10.1371/journal.pgen.1003656
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http://dx.doi.org/10.1371/journal.pgen.1003656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715435PMC
January 2014

Transcription-associated genome instability.

Chem Rev 2013 Nov 18;113(11):8638-61. Epub 2013 Apr 18.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla , Av. Américo Vespucio s/n, 41092 Seville, Spain.

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http://dx.doi.org/10.1021/cr400017yDOI Listing
November 2013

R loops are linked to histone H3 S10 phosphorylation and chromatin condensation.

Mol Cell 2013 Nov 7;52(4):583-90. Epub 2013 Nov 7.

Department of Molecular Biology, Universidad de Sevilla-CSIC, Avenida Américo Vespucio, 41092 Seville, Spain.

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http://dx.doi.org/10.1016/j.molcel.2013.10.006DOI Listing
November 2013

The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability.

Genes Dev 2013 Nov;27(22):2445-58

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas (CSIC), 41092 Seville, Spain;

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http://dx.doi.org/10.1101/gad.229880.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841734PMC
November 2013

The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.

PLoS One 2012 20;7(12):e52447. Epub 2012 Dec 20.

Department of Molecular Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla, Sevilla, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527488PMC
June 2013

Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid.

PLoS Genet 2013 24;9(1):e1003237. Epub 2013 Jan 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554610PMC
May 2013

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.

Nucleic Acids Res 2013 Feb 18;41(3):1669-83. Epub 2012 Dec 18.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Seville, Spain.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gks1274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561951PMC
February 2013

Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis.

Biochim Biophys Acta 2013 Jan 6;1829(1):141-50. Epub 2012 Oct 6.

Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1016/j.bbagrm.2012.09.008DOI Listing
January 2013

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

Nature 2013 Jan 25;493(7430):116-9. Epub 2012 Nov 25.

Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona E-08003, Spain.

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http://www.nature.com/doifinder/10.1038/nature11675
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January 2013

R-loops cause replication impairment and genome instability during meiosis.

EMBO Rep 2012 Oct 10;13(10):923-9. Epub 2012 Aug 10.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2012.119
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463965PMC
October 2012

Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.

PLoS Genet 2012 Sep 27;8(9):e1002979. Epub 2012 Sep 27.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Sevilla, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459980PMC
September 2012

New clues to understand the role of THO and other functionally related factors in mRNP biogenesis.

Biochim Biophys Acta 2012 Jun 20;1819(6):514-20. Epub 2011 Dec 20.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av Américo Vespucio s/n, 41092 Sevilla, Spain. rlvarp@is/es

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http://dx.doi.org/10.1016/j.bbagrm.2011.11.012DOI Listing
June 2012

R loops: from transcription byproducts to threats to genome stability.

Mol Cell 2012 Apr;46(2):115-24

CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.molcel.2012.04.009DOI Listing
April 2012

Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes.

Nucleic Acids Res 2012 Feb 13;40(3):1050-64. Epub 2011 Oct 13.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n 41092 Sevilla, and Departamento de Genética, Universidad de Sevilla, 41012 Sevilla, Spain.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkr840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273821PMC
February 2012

Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.

PLoS Genet 2011 Dec 1;7(12):e1002386. Epub 2011 Dec 1.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla - Consejo Superior de Investigaciones Científicas (CSIC), Sevilla, Spain.

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https://dx.plos.org/10.1371/journal.pgen.1002386
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228816PMC
December 2011

Genetic and molecular analysis of mitotic recombination in Saccharomyces cerevisiae.

Methods Mol Biol 2011 ;745:151-72

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://dx.doi.org/10.1007/978-1-61779-129-1_10DOI Listing
September 2011

Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1.

Proc Natl Acad Sci U S A 2011 Sep 29;108(37):15300-5. Epub 2011 Aug 29.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-Consejo Superior de Investigaciones Cientificas, 41092 Seville, Spain.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1107425108
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174667PMC
September 2011

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.

Nat Struct Mol Biol 2011 Sep 4;18(10):1124-31. Epub 2011 Sep 4.

Laboratory of Chromosome Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.2116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190017PMC
September 2011

Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability.

Nucleic Acids Res 2011 Aug 21;39(14):6002-15. Epub 2011 Apr 21.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Avd Américo Vespucio, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1093/nar/gkr193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152343PMC
August 2011

Nab2 functions in the metabolism of RNA driven by polymerases II and III.

Mol Biol Cell 2011 Aug 16;22(15):2729-40. Epub 2011 Jun 16.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-Consejo Superior de Investigaciones Científicas, 41092 Seville, Spain.

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http://www.molbiolcell.org/doi/10.1091/mbc.e11-01-0055
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http://dx.doi.org/10.1091/mbc.E11-01-0055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145548PMC
August 2011

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.

EMBO J 2011 Jun 24;30(15):3106-19. Epub 2011 Jun 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160181PMC
http://dx.doi.org/10.1038/emboj.2011.206DOI Listing
June 2011

A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors.

EMBO J 2011 May 8;30(10):1953-64. Epub 2011 Apr 8.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2011.109
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http://dx.doi.org/10.1038/emboj.2011.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098481PMC
May 2011

Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.

BMC Cancer 2011 Feb 17;11:77. Epub 2011 Feb 17.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av, Américo Vespucio s/n, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1186/1471-2407-11-77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050854PMC
February 2011

AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.

PLoS Genet 2011 Feb 24;7(2):e1002009. Epub 2011 Feb 24.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://dx.doi.org/10.1371/journal.pgen.1002009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044682PMC
February 2011

The THO complex as a key mRNP biogenesis factor in development and cell differentiation.

J Biol 2010 28;9(1). Epub 2010 Jan 28.

Centro Andaluz de Biología Molecular y Medicina Regenerativa, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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http://jbiol.biomedcentral.com/articles/10.1186/jbiol217
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871528PMC
August 2010

The interface between transcription and mRNP export: from THO to THSC/TREX-2.

Biochim Biophys Acta 2010 Aug 19;1799(8):533-8. Epub 2010 Jun 19.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Av. Americo Vespucio s/n, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.bbagrm.2010.06.002DOI Listing
August 2010

A postincision-deficient TFIIH causes replication fork breakage and uncovers alternative Rad51- or Pol32-mediated restart mechanisms.

Mol Cell 2010 Mar;37(5):690-701

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.molcel.2010.02.008DOI Listing
March 2010

Transcription at the proximity of the nuclear pore: a role for the THP1-SAC3-SUS1-CDC31 (THSC) complex.

RNA Biol 2009 Apr-Jun;6(2):145-8. Epub 2009 Apr 8.

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Seville, Spain.

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http://dx.doi.org/10.4161/rna.6.2.7803DOI Listing
February 2010

The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants.

Mol Cell Biol 2009 Oct 3;29(19):5203-13. Epub 2009 Aug 3.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Seville, Spain.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00402-09
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http://dx.doi.org/10.1128/MCB.00402-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747986PMC
October 2009

Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replication.

Mol Cell Biol 2009 Oct 3;29(20):5441-54. Epub 2009 Aug 3.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1128/MCB.00256-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756893PMC
October 2009

The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress.

Mol Biol Cell 2009 Aug 28;20(15):3572-82. Epub 2009 May 28.

Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1091/mbc.e09-02-0129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719575PMC
August 2009

R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX.

Nucleic Acids Res 2009 Jul 18;37(13):4315-21. Epub 2009 May 18.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1093/nar/gkp385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715242PMC
July 2009

Methods to study transcription-coupled repair in chromatin.

Methods Mol Biol 2009 ;523:141-59

CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain.

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http://link.springer.com/10.1007/978-1-59745-190-1_10
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May 2009

A novel class of mRNA-containing cytoplasmic granules are produced in response to UV-irradiation.

Mol Biol Cell 2008 Nov 3;19(11):4980-92. Epub 2008 Sep 3.

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Centro Andaluz de Biología Molecular and Medicina Regenativa CABIMER, 41092 Sevilla, Spain.

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http://www.molbiolcell.org/doi/10.1091/mbc.e08-02-0193
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http://dx.doi.org/10.1091/mbc.e08-02-0193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575145PMC
November 2008

A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants.

Mol Genet Genomics 2008 Oct 6;280(4):327-36. Epub 2008 Aug 6.

Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1007/s00438-008-0368-8DOI Listing
October 2008

CDK targets Sae2 to control DNA-end resection and homologous recombination.

Nature 2008 Oct 20;455(7213):689-92. Epub 2008 Aug 20.

The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/nature07215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635538PMC
October 2008