Andrei Thomas-Tikhonenko

Andrei Thomas-Tikhonenko

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Andrei Thomas-Tikhonenko

Andrei Thomas-Tikhonenko

Publications by authors named "Andrei Thomas-Tikhonenko"

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Exons of Leukemia Suppressor Genes: Creative Assembly Required.

Trends Cancer 2018 12 28;4(12):796-798. Epub 2018 Oct 28.

Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742839PMC
December 2018

Heterogeneity of surface CD19 and CD22 expression in B lymphoblastic leukemia.

Am J Hematol 2018 11 9;93(11):E352-E355. Epub 2018 Sep 9.

Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/ajh.25235DOI Listing
November 2018

Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma.

Am J Hematol 2017 Jan 21;92(1):E11-E13. Epub 2016 Nov 21.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Pennsylvania.

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http://doi.wiley.com/10.1002/ajh.24594
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http://dx.doi.org/10.1002/ajh.24594DOI Listing
January 2017

miR-17-92 cluster components analysis in Burkitt lymphoma: overexpression of miR-17 is associated with poor prognosis.

Ann Hematol 2016 May 5;95(6):881-91. Epub 2016 Apr 5.

Programa de Pesquisa em Hemato-Oncologia Molecular, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1007/s00277-016-2653-7DOI Listing
May 2016

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.

Cancer Discov 2015 Dec 29;5(12):1282-95. Epub 2015 Oct 29.

Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Immunology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Cell & Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670800PMC
December 2015

Masking epistasis between MYC and TGF-β pathways in antiangiogenesis-mediated colon cancer suppression.

J Natl Cancer Inst 2014 Apr 13;106(4):dju043. Epub 2014 Mar 13.

Affiliations of authors: Division of Cancer Pathobiology, Center for Childhood Cancer Research (MD, GST, SH, AT-T) and Center for Biomedical Informatics (PR), Children's Hospital of Philadelphia, Philadelphia, PA; Cancer Biology Graduate Program (JC, EKD, AT-T) and Department of Pathology & Laboratory Medicine (AT-T), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Division of Experimental Pathology, Beth Israel Deaconess Medical Center (JL) and Department of Medical Oncology, Dana-Farber Cancer Institute (AB), Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/jnci/dju043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982891PMC
April 2014

MYC and the art of microRNA maintenance.

Cold Spring Harb Perspect Med 2014 Apr 15;4(8). Epub 2014 Apr 15.

Division of Cancer Pathobiology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1101/cshperspect.a014175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109576PMC
April 2014

The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop.

Blood 2013 Dec 29;122(26):4220-9. Epub 2013 Oct 29.

Division of Cancer Pathobiology/Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA;

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http://dx.doi.org/10.1182/blood-2012-12-473090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868926PMC
December 2013

Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma.

RNA 2013 Feb 18;19(2):177-90. Epub 2012 Dec 18.

Division of Cancer Pathobiology, Department of Pathology & Laboratory Medicine, Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://rnajournal.cshlp.org/cgi/doi/10.1261/rna.036467.112
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http://dx.doi.org/10.1261/rna.036467.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543081PMC
February 2013

CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.

J Clin Invest 2012 Jun 1;122(6):2257-66. Epub 2012 May 1.

Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia 19104-4399, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI45851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366393PMC
June 2012

p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers.

Cancer Res 2011 Dec 25;71(24):7490-501. Epub 2011 Oct 25.

Division of Cancer Pathobiology, Department of Pathology & Laboratory Medicine, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, PA 19104-4399, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242824PMC
December 2011

Shielding the messenger (RNA): microRNA-based anticancer therapies.

Pharmacol Ther 2011 Jul 14;131(1):18-32. Epub 2011 Apr 14.

Division of Cancer Pathobiology, Department of Pathology & Laboratory Medicine, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2011.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124007PMC
July 2011

The long reach of noncoding RNAs.

Nat Genet 2011 Jun 28;43(7):616-7. Epub 2011 Jun 28.

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http://dx.doi.org/10.1038/ng.870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265388PMC
June 2011

The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.

Cancer Res 2010 Oct 12;70(20):8233-46. Epub 2010 Oct 12.

Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007123PMC
October 2010

Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis.

Adv Cancer Res 2009 ;105:115-32

Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, United Kingdom.

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http://dx.doi.org/10.1016/S0065-230X(09)05007-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426299PMC
January 2010

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation.

Proc Natl Acad Sci U S A 2009 Mar 11;106(9):3384-9. Epub 2009 Feb 11.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.0808300106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651245PMC
March 2009

c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster.

Cancer Biol Ther 2008 Nov 4;7(11):1758-64. Epub 2008 Nov 4.

Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783585PMC
http://dx.doi.org/10.4161/cbt.7.11.6722DOI Listing
November 2008

PAX5 and B-cell neoplasms: transformation through presentation.

Future Oncol 2008 Feb;4(1):5-9

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http://dx.doi.org/10.2217/14796694.4.1.5DOI Listing
February 2008

Widespread microRNA repression by Myc contributes to tumorigenesis.

Nat Genet 2008 Jan 9;40(1):43-50. Epub 2007 Dec 9.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/ng.2007.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628762PMC
January 2008

Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells.

Cancer Res 2007 Nov;67(22):10642-6

Department of Dermatology and Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653855PMC
November 2007

Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells.

Cancer Biol Ther 2007 Sep 13;6(9):1437-41. Epub 2007 Jun 13.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2254442PMC
http://dx.doi.org/10.4161/cbt.6.9.4569DOI Listing
September 2007

p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors.

Blood 2007 Jun 6;109(11):4936-43. Epub 2007 Feb 6.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2006-10-050294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885530PMC
June 2007

Aiding and ABT'ing Treatment for Glioblastoma.

Cancer Biol Ther 2007 May 15;6(5):802-4. Epub 2007 May 15.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6051, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437540PMC
http://dx.doi.org/10.4161/cbt.6.5.4431DOI Listing
May 2007

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma.

J Clin Invest 2007 Feb 18;117(2):326-36. Epub 2007 Jan 18.

Division of Hematology/Oncology, Department of Medicine, Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1172/JCI28833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1765515PMC
February 2007

B-Lymphoma cells with epigenetic silencing of Pax5 trans-differentiate into macrophages, but not other hematopoietic lineages.

Exp Cell Res 2007 Jan 25;313(2):331-40. Epub 2006 Oct 25.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-4192, USA.

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http://dx.doi.org/10.1016/j.yexcr.2006.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839943PMC
January 2007

Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.

Nat Genet 2006 Sep 30;38(9):1060-5. Epub 2006 Jul 30.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ng1855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669546PMC
September 2006

Kit-activating mutations in AML: lessons from PU.1-induced murine erythroleukemia.

Cancer Biol Ther 2006 Jun 2;5(6):579-81. Epub 2006 Jun 2.

Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104-6051, USA.

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http://dx.doi.org/10.4161/cbt.5.6.2873DOI Listing
June 2006

Infection & neoplastic growth 101: the required reading for microbial pathogens aspiring to cause cancer.

Cancer Treat Res 2006 ;130:167-97

University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6051, USA.

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April 2006

Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis.

Mol Cell Biol 2006 Mar;26(6):2373-86

Program in Human Genetics and Molecular Biology, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1128/MCB.26.6.2373-2386.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430295PMC
March 2006

Functional validation of genes implicated in lymphomagenesis: an in vivo selection assay using a Myc-induced B-cell tumor.

Ann N Y Acad Sci 2005 Nov;1059:145-59

Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104-6051, USA.

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http://dx.doi.org/10.1196/annals.1339.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1490324PMC
November 2005

Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein.

Proc Natl Acad Sci U S A 2005 Sep 19;102(39):13968-73. Epub 2005 Sep 19.

Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0502330102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236531PMC
September 2005

Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells.

Cancer Res 2005 Mar;65(5):1904-8

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6046, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2597DOI Listing
March 2005

Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.

Mol Cell Biol 2004 Oct;24(19):8541-55

Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 415 Curie Blvd., CRB 437A, Philadelphia, PA 19104, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.24.19.8541-8555.2004
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http://dx.doi.org/10.1128/MCB.24.19.8541-8555.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516765PMC
October 2004

An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth.

Cancer Biol Ther 2003 Nov-Dec;2(6):687-93

Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6051, USA.

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September 2004

B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.

Nat Immunol 2004 Aug 18;5(8):853-61. Epub 2004 Jul 18.

Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/ni1099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635547PMC
August 2004

Whence thrombospondin?

Cancer Biol Ther 2004 Apr 29;3(4):406-7. Epub 2004 Apr 29.

Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6051, USA.

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http://dx.doi.org/10.4161/cbt.3.4.737DOI Listing
April 2004

Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway.

Blood 2003 Mar 24;101(5):1950-5. Epub 2002 Oct 24.

Departments of Pathobiology, Pathology and Laboratory Medicine, and Animal Biology, University of Pennsylvania, Philadelphia, PA 19104-6051, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-06-17
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http://dx.doi.org/10.1182/blood-2002-06-1797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547547PMC
March 2003

Infection and cancer: the common vein.

Cytokine Growth Factor Rev 2003 Feb;14(1):67-77

Department of Pathobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia 19104-6051, USA.

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http://dx.doi.org/10.1016/s1359-6101(02)00071-0DOI Listing
February 2003

A non-transgenic mouse model for B-cell lymphoma: in vivo infection of p53-null bone marrow progenitors by a Myc retrovirus is sufficient for tumorigenesis.

Oncogene 2002 Mar;21(12):1922-7

Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, PA 19104-6051, USA.

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http://www.nature.com/articles/1205244
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http://dx.doi.org/10.1038/sj.onc.1205244DOI Listing
March 2002