Andrei Chabes

Andrei Chabes

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Andrei Chabes

Publications by authors named "Andrei Chabes"

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Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio.

Nucleic Acids Res 2020 Jan;48(1):264-277

DNA Repair Mechanisms and Cancer, German Cancer Research Center (DKFZ), Heidelberg D-69120, Germany.

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http://dx.doi.org/10.1093/nar/gkz1006DOI Listing
January 2020

dNTP production is essential for normal postnatal murine heart development.

J Biol Chem 2019 Nov 12;294(44):15889-15897. Epub 2019 Jul 12.

Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden

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http://dx.doi.org/10.1074/jbc.RA119.009492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827297PMC
November 2019

Ribonucleotides in mitochondrial DNA.

FEBS Lett 2019 Jul 24;593(13):1554-1565. Epub 2019 May 24.

Department of Medical Biochemistry and Biophysics, Umeå University, Sweden.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13
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http://dx.doi.org/10.1002/1873-3468.13440DOI Listing
July 2019

The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity.

Nucleic Acids Res 2019 05;47(8):3986-3995

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1093/nar/gkz048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486559PMC
May 2019

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme.

Nat Commun 2019 01 22;10(1):374. Epub 2019 Jan 22.

Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

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http://dx.doi.org/10.1038/s41467-018-08145-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343027PMC
January 2019

Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage.

EMBO J 2018 11 29;37(21). Epub 2018 Aug 29.

Institut de Génétique Humaine, CNRS, Equipe Labellisée Ligue contre le Cancer, Université de Montpellier, Montpellier, France

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http://emboj.embopress.org/lookup/doi/10.15252/embj.20189931
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http://dx.doi.org/10.15252/embj.201899319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213276PMC
November 2018

A mechanism for preventing asymmetric histone segregation onto replicating DNA strands.

Science 2018 09 16;361(6409):1386-1389. Epub 2018 Aug 16.

Institute for Cancer Genetics, Department of Pediatrics and Genetics and Development, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1126/science.aat8849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597248PMC
September 2018

Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in .

G3 (Bethesda) 2018 07 31;8(8):2551-2558. Epub 2018 Jul 31.

European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands

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http://dx.doi.org/10.1534/g3.118.200280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071591PMC
July 2018

Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling.

Genes Dev 2018 06 13;32(11-12):822-835. Epub 2018 Jun 13.

Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1101/gad.308148.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049512PMC
June 2018

SAMHD1 acts at stalled replication forks to prevent interferon induction.

Nature 2018 05 18;557(7703):57-61. Epub 2018 Apr 18.

Institut de Génétique Humaine, CNRS, Université de Montpellier, Laboratoire Maintien de l'Intégrité du Génome au cours de la Réplication, Ligue Contre le Cancer, Montpellier, France.

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http://www.nature.com/articles/s41586-018-0050-1
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http://dx.doi.org/10.1038/s41586-018-0050-1DOI Listing
May 2018

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.

PLoS Genet 2018 01 23;14(1):e1007129. Epub 2018 Jan 23.

Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779651PMC
January 2018

Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired.

Proc Natl Acad Sci U S A 2017 11 6;114(47):12466-12471. Epub 2017 Nov 6.

Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, Sweden;

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http://dx.doi.org/10.1073/pnas.1713085114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703314PMC
November 2017

Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress.

Mol Cell 2017 Oct 12;68(2):446-455.e3. Epub 2017 Oct 12.

Institute for Cancer Genetics and Department of Pediatrics and Genetics and Development, Columbia University, New York, NY 10032. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765173066
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http://dx.doi.org/10.1016/j.molcel.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802358PMC
October 2017

Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres.

PLoS Genet 2017 Oct 25;13(10):e1007082. Epub 2017 Oct 25.

Dept. of Molecular Microbiology & Biotechnology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.

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http://dx.doi.org/10.1371/journal.pgen.1007082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673236PMC
October 2017

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.

Nucleic Acids Res 2017 02;45(3):1200-1218

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1093/nar/gkw1149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388397PMC
February 2017

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase.

Cell Rep 2016 11;17(6):1657-1670

Department of Molecular and Cellular Biochemistry, Indiana University, Simon Hall MSB, 212 South Hawthorne Drive, Bloomington, IN 47405, USA; Department of Biology, Indiana University, Simon Hall MSB, 212 South Hawthorne Drive, Bloomington, IN 47405, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134839PMC
November 2016

The mutation spectrum in genomic late replication domains shapes mammalian GC content.

Nucleic Acids Res 2016 05 16;44(9):4222-32. Epub 2016 Apr 16.

Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel

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http://dx.doi.org/10.1093/nar/gkw268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872117PMC
May 2016

Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools.

Nucleic Acids Res 2016 Feb 24;44(4):1669-80. Epub 2015 Nov 24.

Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE-901 87, Umeå, Sweden

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http://dx.doi.org/10.1093/nar/gkv1298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770217PMC
February 2016

Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection.

Methods Mol Biol 2015 ;1300:113-21

Department of Medical Biochemistry and Biophysics, Umeå University, KBC-Building, 6th Floor, Umeå, 901 87, Sweden.

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http://dx.doi.org/10.1007/978-1-4939-2596-4_8DOI Listing
January 2016

S phase block following MEC1ATR inactivation occurs without severe dNTP depletion.

Biol Open 2015 Nov 24;4(12):1739-43. Epub 2015 Nov 24.

Stem Cell Biology and Developmental Genetics, National Institute for Medical Research, MRC, London NW7 1AA, UK North West Cancer Research Institute, School of Medical Sciences, Bangor University, Bangor LL57 2UW, UK

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http://dx.doi.org/10.1242/bio.015347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736042PMC
November 2015

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.

Proc Natl Acad Sci U S A 2015 May 31;112(19):E2457-66. Epub 2015 Mar 31.

Department of Pathology, University of Washington, Seattle, WA 98195; and

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http://www.pnas.org/lookup/doi/10.1073/pnas.1422948112
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http://dx.doi.org/10.1073/pnas.1422948112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434706PMC
May 2015

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity.

Proc Natl Acad Sci U S A 2015 May 31;112(19):E2467-76. Epub 2015 Mar 31.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198; and

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http://dx.doi.org/10.1073/pnas.1422934112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434702PMC
May 2015

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.

Nat Struct Mol Biol 2015 Apr 9;22(4):291-7. Epub 2015 Mar 9.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1038/nsmb.2989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835660PMC
April 2015

Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity.

PLoS Genet 2014 Dec 4;10(12):e1004846. Epub 2014 Dec 4.

Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden; Laboratory for Molecular Infection Medicine Sweden (MIMS), Umea University, Umea, Sweden.

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http://dx.doi.org/10.1371/journal.pgen.1004846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256292PMC
December 2014

Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall.

Mol Cell 2014 Nov 23;56(4):551-63. Epub 2014 Oct 23.

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Center for Individualized Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362665PMC
November 2014

Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins.

Sci Rep 2014 Jul 2;4:5539. Epub 2014 Jul 2.

1] Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, Sweden [2] Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE 90187 Umeå, Sweden.

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http://dx.doi.org/10.1038/srep05539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078304PMC
July 2014

The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.

Mol Cell 2014 May;54(4):691-7

Institute of Human Genetics, UPR 1142, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France; Equipe Labellisée Ligue Contre le Cancer, 14 rue Corvisart, 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.04.032DOI Listing
May 2014

Pre-activation of the genome integrity checkpoint increases DNA damage tolerance.

Nucleic Acids Res 2013 Dec 17;41(22):10371-8. Epub 2013 Sep 17.

Department of Medical Biochemistry and Biophysics, Umeå University, SE 90187, Umeå, Sweden and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE 90187 Umeå, Sweden.

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http://dx.doi.org/10.1093/nar/gkt820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905891PMC
December 2013

Telomere length homeostasis responds to changes in intracellular dNTP pools.

Genetics 2013 Apr 18;193(4):1095-105. Epub 2013 Jan 18.

Department of Cellular, Molecular and Biophysical Studies, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1534/genetics.112.149120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606089PMC
April 2013

Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA.

Mol Cell 2013 Mar 31;49(5):1010-5. Epub 2013 Jan 31.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595360PMC
March 2013

Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant.

Mol Cell Biol 2012 Nov 27;32(21):4445-54. Epub 2012 Aug 27.

Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1128/MCB.01062-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486156PMC
November 2012

A top-down view on DNA replication and recombination from 9,000 feet above sea level.

Genome Biol 2011 27;12(4):304. Epub 2011 Apr 27.

Department of Medical Biochemistry and Biophysics, Umeå University, SE 90187 Umeå, Sweden.

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http://dx.doi.org/10.1186/gb-2011-12-4-304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218856PMC
February 2012

Lesion bypass by S. cerevisiae Pol ζ alone.

DNA Repair (Amst) 2011 Aug 31;10(8):826-34. Epub 2011 May 31.

Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.dnarep.2011.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146559PMC
August 2011

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.

Nucleic Acids Res 2011 Mar 20;39(4):1360-71. Epub 2010 Oct 20.

Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, Sweden.

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http://dx.doi.org/10.1093/nar/gkq829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045583PMC
March 2011

Break-induced replication is highly inaccurate.

PLoS Biol 2011 Feb 15;9(2):e1000594. Epub 2011 Feb 15.

Department of Biology, School of Science, IUPUI, Indianapolis, Indiana, United States of America.

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http://dx.plos.org/10.1371/journal.pbio.1000594
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http://dx.doi.org/10.1371/journal.pbio.1000594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039667PMC
February 2011

Genome instability due to ribonucleotide incorporation into DNA.

Nat Chem Biol 2010 Oct 22;6(10):774-81. Epub 2010 Aug 22.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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http://www.nature.com/doifinder/10.1038/nchembio.424
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http://dx.doi.org/10.1038/nchembio.424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942972PMC
October 2010

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint.

Nucleic Acids Res 2010 Jul 9;38(12):3975-83. Epub 2010 Mar 9.

Department of Medical Biochemistry and Biophysics, Umeå University, SE 90187 Umeå, Sweden.

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http://dx.doi.org/10.1093/nar/gkq128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896522PMC
July 2010

Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants.

Nucleic Acids Res 2010 Mar 3;38(4):1195-203. Epub 2009 Dec 3.

Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12209, USA.

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http://dx.doi.org/10.1093/nar/gkp1064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831302PMC
March 2010

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases.

Proc Natl Acad Sci U S A 2010 Mar 1;107(11):4949-54. Epub 2010 Mar 1.

Laboratory of Molecular Genetics and Laboratory of Structural Biology, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1073/pnas.0914857107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841928PMC
March 2010

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.

Nucleic Acids Res 2008 Oct 4;36(17):5660-7. Epub 2008 Sep 4.

Department of Medical Biochemistry and Biophysics, Umeå University, SE 901 87 Umeå, Sweden.

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http://dx.doi.org/10.1093/nar/gkn555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553575PMC
October 2008

Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.

Proc Natl Acad Sci U S A 2007 Jan 16;104(4):1183-8. Epub 2007 Jan 16.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0610585104
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http://dx.doi.org/10.1073/pnas.0610585104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783093PMC
January 2007

DNA building blocks at the foundation of better survival.

Cell Cycle 2003 May-Jun;2(3):171-3

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.4161/cc.2.3.354DOI Listing
September 2003

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase.

Cell 2003 Feb;112(3):391-401

Department of Medical Biochemistry and Biophysics, Umeå University, SE 901 87 Umeå, Sweden.

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http://dx.doi.org/10.1016/s0092-8674(03)00075-8DOI Listing
February 2003

Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex.

J Biol Chem 2002 May 13;277(21):18574-8. Epub 2002 Mar 13.

Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, Sweden.

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http://dx.doi.org/10.1074/jbc.M201553200DOI Listing
May 2002

Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

Cell 2002 May;109(5):563-73

Department of Molecular Biology, The Scripts Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)00753-5DOI Listing
May 2002