Andreas Weigert

Andreas Weigert

UNVERIFIED PROFILE

Are you Andreas Weigert?   Register this Author

Register author
Andreas Weigert

Andreas Weigert

Publications by authors named "Andreas Weigert"

Are you Andreas Weigert?   Register this Author

100Publications

1612Reads

14Profile Views

Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Sep 23;1864(9):1235-1246. Epub 2019 May 23.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany; Branch for Translational Medicine and Pharmacology TMP of the Fraunhofer Institute for Molecular Biology and Applied Ecology IME, 60590 Frankfurt, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2019.05.008DOI Listing
September 2019

PGE in fibrosis and cancer: Insights into fibroblast activation.

Prostaglandins Other Lipid Mediat 2019 Aug 14;143:106339. Epub 2019 May 14.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prostaglandins.2019.106339DOI Listing
August 2019

HVEM, a cosignaling molecular switch, and its interactions with BTLA, CD160 and LIGHT.

Cell Mol Immunol 2019 Jul 3;16(7):679-682. Epub 2019 Jun 3.

Transplantation Immunobiology Section, Research Institutes of the University of Leon, Campus of Vegazana s/n, 24071, Leon, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41423-019-0241-1DOI Listing
July 2019

Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.

Oncogene 2019 Jun 28;38(24):4788-4803. Epub 2019 Feb 28.

Institute of General Pharmacology and Toxicology, pharmazentrum frankfurt /ZAFES, Hospital of the Goethe University, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-019-0758-xDOI Listing
June 2019

Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis.

Int J Mol Sci 2019 Jun 19;20(12). Epub 2019 Jun 19.

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, 60596 Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20123005DOI Listing
June 2019

The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G.

FEBS Lett 2019 Mar 27;593(5):487-498. Epub 2019 Feb 27.

Institute for Cardiovascular Physiology, Medical Faculty, Goethe University, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1873-3468.13337DOI Listing
March 2019

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype.

Nat Commun 2019 03 8;10(1):1135. Epub 2019 Mar 8.

Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-08989-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408494PMC
March 2019

Redox-signals and macrophage biology.

Mol Aspects Med 2018 10 12;63:70-87. Epub 2018 Jan 12.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology, IME, 60590 Frankfurt, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mam.2018.01.003DOI Listing
October 2018

The portal vein as a distinct immunological compartment - A comprehensive immune phenotyping study.

Hum Immunol 2018 Oct 30;79(10):716-723. Epub 2018 Jul 30.

Department of Internal Medicine 1, University Hospital Frankfurt, Frankfurt am Main, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01988859183056
Publisher Site
http://dx.doi.org/10.1016/j.humimm.2018.07.233DOI Listing
October 2018

mPGES-1 and ALOX5/-15 in tumor-associated macrophages.

Cancer Metastasis Rev 2018 09;37(2-3):317-334

Institute of Biochemistry I/Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10555-018-9731-3DOI Listing
September 2018

An in vitro test system for compounds that modulate human inflammatory macrophage polarization.

Eur J Pharmacol 2018 Aug 18;833:328-338. Epub 2018 Jun 18.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2018.06.017DOI Listing
August 2018

S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1 or Lipocalin-2.

Mediators Inflamm 2017 19;2017:7510496. Epub 2017 Jul 19.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2017/7510496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539930PMC
May 2018

Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation.

Mediators Inflamm 2017 7;2017:6059203. Epub 2017 Aug 7.

Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2017/6059203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564090PMC
May 2018

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.

Redox Biol 2018 05 22;15:12-21. Epub 2017 Nov 22.

Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany; German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2017.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723277PMC
May 2018

Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma.

Int J Mol Sci 2018 Mar 7;19(3). Epub 2018 Mar 7.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19030752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877613PMC
March 2018

Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages.

J Immunol 2018 01 11;200(2):857-868. Epub 2017 Dec 11.

Department of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1700609DOI Listing
January 2018

The RNA-binding protein HuR inhibits expression of CCL5 and limits recruitment of macrophages into tumors.

Mol Carcinog 2017 Dec 28;56(12):2620-2629. Epub 2017 Jul 28.

Medical Faculty, Institute of Biochemistry 1, Goethe-University Frankfurt, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/mc.22706
Publisher Site
http://dx.doi.org/10.1002/mc.22706DOI Listing
December 2017

Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice.

Acta Derm Venereol 2017 Oct;97(9):1087-1094

Department of Dermatology, Venereology and Allergy, Clinic of the Goethe-University, Theodor-Stern-Kai 7, DE-60590 Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-2724DOI Listing
October 2017

GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency.

PLoS One 2017 4;12(8):e0182646. Epub 2017 Aug 4.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Goethe University, Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182646PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544216PMC
October 2017

Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis.

Mol Immunol 2017 10 30;90:255-263. Epub 2017 Aug 30.

Institute of Biochemistry I - Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molimm.2017.08.011DOI Listing
October 2017

Iron Handling in Tumor-Associated Macrophages-Is There a New Role for Lipocalin-2?

Front Immunol 2017 20;8:1171. Epub 2017 Sep 20.

Faculty of Medicine, Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2017.01171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611490PMC
September 2017

Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity.

Cell Mol Life Sci 2017 08 12;74(16):3039-3055. Epub 2017 Apr 12.

Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-017-2518-9DOI Listing
August 2017

Cancer cell and macrophage cross-talk in the tumor microenvironment.

Curr Opin Pharmacol 2017 08 21;35:12-19. Epub 2017 May 21.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology, IME, 60590 Frankfurt, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coph.2017.04.007DOI Listing
August 2017

THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro.

Mol Immunol 2017 08 7;88:58-68. Epub 2017 Jun 7.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molimm.2017.05.027DOI Listing
August 2017

Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis.

Shock 2017 08;48(2):215-226

*Institute of Biochemistry I-Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany †Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Frankfurt, Germany ‡Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt, Germany §Department of Neurology, University Hospital Frankfurt, Frankfurt, Germany ||Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SHK.0000000000000842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263038PMC
August 2017

Killing Is Not Enough: How Apoptosis Hijacks Tumor-Associated Macrophages to Promote Cancer Progression.

Adv Exp Med Biol 2016 ;930:205-39

Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-39406-0_9DOI Listing
July 2017

Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy.

Oncotarget 2017 Jul;8(29):48436-48452

Max Planck Institute for Heart and Lung Research, Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.17061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564660PMC
July 2017

Macrophage NOS2 in Tumor Leukocytes.

Antioxid Redox Signal 2017 06 10;26(18):1023-1043. Epub 2016 Aug 10.

Institute of Biochemistry I-Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt , Frankfurt, Germany .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ars.2016.6811DOI Listing
June 2017

IL-1 family cytokines in cancer immunity - a matter of life and death.

Biol Chem 2016 11;397(11):1125-1134

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/hsz-2016-0215DOI Listing
November 2016

Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis.

J Pathol 2016 07 29;239(3):274-85. Epub 2016 Apr 29.

Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.4724DOI Listing
July 2016

Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis.

Sci Signal 2016 06 28;9(434):ra64. Epub 2016 Jun 28.

Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.aaf3241DOI Listing
June 2016

Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma.

PLoS One 2015 28;10(9):e0139073. Epub 2015 Sep 28.

Internal Medicine, University of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany; Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research, Bad Nauheim, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139073PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587668PMC
May 2016

Cellular analysis of the histamine H4 receptor in human myeloid cells.

Biochem Pharmacol 2016 Mar 13;103:74-84. Epub 2016 Jan 13.

Institute of Pharmaceutical Chemistry/ZAFES, Goethe University Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt/Main, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2016.01.007DOI Listing
March 2016

S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells.

J Immunol 2016 Feb 18;196(4):1579-90. Epub 2016 Jan 18.

Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, 60590 Frankfurt, Germany; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1403168DOI Listing
February 2016

Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses.

J Mol Cell Biol 2016 Feb 17. Epub 2016 Feb 17.

Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jmcb/mjw006DOI Listing
February 2016

Macrophage Polarization In The Tumor Microenvironment.

Redox Biol 2015 08 30;5:419. Epub 2015 Dec 30.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2015.09.028DOI Listing
August 2015

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability.

Free Radic Biol Med 2015 Jun 14;83:77-88. Epub 2015 Feb 14.

Institute of Biochemistry I-Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt am Main, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2015.02.004DOI Listing
June 2015

Response to letter regarding article, "Vitamin D promotes vascular regeneration".

Circulation 2015 06;131(22):e515-6

Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, GermanyGerman Center for Cardiovascular Research, Partner Site RheinMain, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.114.014781DOI Listing
June 2015

Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner.

Neoplasia 2015 Jun;17(6):481-9

Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Germany; German Cancer Consortium (DKTK) Heidelberg, Germany; German Cancer Research Center (DKFZ) Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14765586150006
Publisher Site
http://dx.doi.org/10.1016/j.neo.2015.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719005PMC
June 2015

Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer.

Am J Respir Crit Care Med 2015 Feb;191(4):437-47

1 Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, German Center for Lung Research, Bad Nauheim, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201406-1137OCDOI Listing
February 2015

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.

Pain 2014 Oct 17;155(10):2161-70. Epub 2014 Aug 17.

Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University Medical School, Frankfurt am Main, Germany; Institute of Pharmacology and Toxicology, ZBAF, Witten/Herdecke University, Witten, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pain.2014.08.013DOI Listing
October 2014

Vitamin D promotes vascular regeneration.

Circulation 2014 Sep 11;130(12):976-86. Epub 2014 Jul 11.

From the Institute for Cardiovascular Physiology (M.S.K.W., M.S.L., C.K., J.V., C.S., K.S., R.P.B.), Institute of Biochemistry I (N.D., A.W., B.B.), Institute for Biostatistics and Mathematical Modeling (E.H.), Institute of Pharmaceutical Chemistry/Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (D.S.), Goethe University, Frankfurt, Germany; German Center for Cardiovascular Research, Partner Site RheinMain, Frankfurt, Germany (M.S.L., C.K., C.S., E.H., S.O., K.S., R.P.B.); Cardiovascular Division, King's College London British Heart Foundation Center of Excellence, London, United Kingdom (A.M.S.); Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (S.O.); Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium (G.C.); and Department of Endocrinology and Diabetes, Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany (K.B.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.114.010650DOI Listing
September 2014

Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages.

Pain 2014 Mar 11;155(3):545-55. Epub 2013 Dec 11.

Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, Hospital of the Goethe-University, Frankfurt, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pain.2013.12.006DOI Listing
March 2014

PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.

Biochem Pharmacol 2014 Feb 16;87(4):625-35. Epub 2013 Dec 16.

pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology (TMP), Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2013.12.006DOI Listing
February 2014

Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration.

Eur J Immunol 2013 Dec 29;43(12):3306-13. Epub 2013 Aug 29.

Institute of Biochemistry I/ZAFES, Goethe-University Frankfurt, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201343441DOI Listing
December 2013

L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects.

Hypertension 2013 Dec 30;62(6):1098-104. Epub 2013 Sep 30.

Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01986DOI Listing
December 2013

Endo-PDI is required for TNFα-induced angiogenesis.

Free Radic Biol Med 2013 Dec 5;65:1398-1407. Epub 2013 Oct 5.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität, 60590 Frankfurt am Main, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08915849130063
Publisher Site
http://dx.doi.org/10.1016/j.freeradbiomed.2013.09.028DOI Listing
December 2013

Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation.

Int J Cancer 2013 Oct 22;133(7):1578-88. Epub 2013 Apr 22.

Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.28181DOI Listing
October 2013

Redox control of inflammation in macrophages.

Antioxid Redox Signal 2013 Aug 6;19(6):595-637. Epub 2013 Mar 6.

Faculty of Medicine, Institute of Biochemistry I-Pathobiochemistry, Goethe-University Frankfurt, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ars.2012.4785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718318PMC
August 2013

Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophages.

Carcinogenesis 2013 Apr 14;34(4):850-7. Epub 2012 Dec 14.

Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgs387DOI Listing
April 2013

RNAi screen in apoptotic cancer cell-stimulated human macrophages reveals co-regulation of IL-6/IL-10 expression.

Immunobiology 2013 Jan 2;218(1):40-51. Epub 2012 Feb 2.

Goethe-University Frankfurt, Institute of Biochemistry I/ZAFES, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imbio.2012.01.019DOI Listing
January 2013

Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine.

J Mol Med (Berl) 2012 Dec 17;90(12):1473-86. Epub 2012 Jun 17.

pharmazentrum frankfurt, ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, Hs 74, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00109-012-0927-7
Publisher Site
http://dx.doi.org/10.1007/s00109-012-0927-7DOI Listing
December 2012

The multi-faceted roles of prostaglandin E2 in cancer-infiltrating mononuclear phagocyte biology.

Immunobiology 2012 Dec 11;217(12):1225-32. Epub 2012 May 11.

Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imbio.2012.05.001DOI Listing
December 2012

IRES-dependent translation of egr2 is induced under inflammatory conditions.

RNA 2012 Oct 22;18(10):1910-20. Epub 2012 Aug 22.

Institute of Biochemistry I, Goethe-University Frankfurt, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1261/rna.033019.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446713PMC
October 2012

HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo.

Blood 2012 Oct 30;120(15):3001-6. Epub 2012 Aug 30.

Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-03-417022DOI Listing
October 2012

Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration.

J Pathol 2011 Dec;225(4):597-608

CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.2982DOI Listing
December 2011

S1P regulation of macrophage functions in the context of cancer.

Anticancer Agents Med Chem 2011 Nov;11(9):818-29

Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe-University Frankfurt, Germany.

View Article

Download full-text PDF

Source
November 2011

Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.

FASEB J 2011 Jul 30;25(7):2408-17. Epub 2011 Mar 30.

Goethe-University, Institute of Biochemistry, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.10-179473DOI Listing
July 2011

Peroxisome proliferator-activated receptor γ-induced T cell apoptosis reduces survival during polymicrobial sepsis.

Am J Respir Crit Care Med 2011 Jul 25;184(1):64-74. Epub 2011 Feb 25.

Institute of Biochemistry I, Faculty of Medicine, Intensive Care Medicine and Pain Therapy, University Hospital, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201010-1585OCDOI Listing
July 2011

Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death.

Cancer Chemother Pharmacol 2011 May 6;67(5):1167-78. Epub 2010 Aug 6.

Institute of Pharmaceutical Chemistry, Biozentrum, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00280-010-1413-yDOI Listing
May 2011

Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB.

Cell Mol Life Sci 2011 May 15;68(10):1815-27. Epub 2010 Oct 15.

Faculty of Medicine, Institute of Biochemistry I, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-010-0537-xDOI Listing
May 2011

Neuromediators in inflammation--a macrophage/nerve connection.

Immunobiology 2010 Sep-Oct;215(9-10):674-84. Epub 2010 Jun 4.

Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01712985100009
Publisher Site
http://dx.doi.org/10.1016/j.imbio.2010.05.027DOI Listing
March 2011

Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.

J Biol Chem 2011 Jan 12;286(3):2331-42. Epub 2010 Nov 12.

Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Hospital of the Goethe-University, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.157362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023527PMC
January 2011

Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses.

Carcinogenesis 2010 Oct 28;31(10):1863-72. Epub 2010 Apr 28.

Institute of Biochemistry I--Pathobiochemistry/Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgq088DOI Listing
October 2010

Technical advance: Generation of human pDC equivalents from primary monocytes using Flt3-L and their functional validation under hypoxia.

J Leukoc Biol 2010 Aug 18;88(2):413-24. Epub 2010 May 18.

Institute of Biochemistry I/ZAFES, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.0809543DOI Listing
August 2010

Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.

Blood 2010 Apr 2;115(17):3531-40. Epub 2010 Mar 2.

Institute of Biochemistry I/Zentrum für Arzneimittelforschung, -Entwicklung und -Sicherheit (ZAFES), Goethe-University Frankfurt, Frankfurt, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-10-243444DOI Listing
April 2010

Regulation of macrophage function by sphingosine-1-phosphate.

Immunobiology 2009 21;214(9-10):748-60. Epub 2009 Jul 21.

Institute of Biochemistry I/ZAFES, Goethe-University Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imbio.2009.06.003DOI Listing
December 2009

The liaison between apoptotic cells and macrophages--the end programs the beginning.

Biol Chem 2009 May-Jun;390(5-6):379-90

Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe University Frankfurt, D-60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/BC.2009.048DOI Listing
July 2009

Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants.

Mol Biol Cell 2009 Mar 7;20(5):1280-8. Epub 2009 Jan 7.

Goethe-University, Institute of Biochemistry I/ZAFES, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.e08-10-1005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649271PMC
March 2009

Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells.

Mol Cancer Res 2009 Mar 24;7(3):393-401. Epub 2009 Feb 24.

Faculty of Medicine, Institute of Biochemistry I/ZAFES, Goethe-University, Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-08-0156DOI Listing
March 2009

Tumor-associated macrophages as targets for tumor immunotherapy.

Immunotherapy 2009 Jan;1(1):83-95

Goethe-University Frankfurt, Institute of Biochemistry I - Pathobiochemistry, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/1750743X.1.1.83
Publisher Site
http://dx.doi.org/10.2217/1750743X.1.1.83DOI Listing
January 2009

Nitric oxide, apoptosis and macrophage polarization during tumor progression.

Nitric Oxide 2008 Sep 29;19(2):95-102. Epub 2008 Apr 29.

Institute of Biochemistry I/ZAFES, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.niox.2008.04.021DOI Listing
September 2008