Andreas Strasser

Andreas Strasser

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Andreas Strasser

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The 2019 Lasker Award: T cells and B cells, whose life and death are essential for function of the immune system.

Cell Death Differ 2019 Oct 17. Epub 2019 Oct 17.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1038/s41418-019-0432-4DOI Listing
October 2019

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3 regulatory T cells.

Immunol Cell Biol 2019 Sep 26;97(8):740-752. Epub 2019 Jun 26.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1111/imcb.12268DOI Listing
September 2019

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.

Front Immunol 2018 22;9:592. Epub 2018 Mar 22.

Molecular Genetics Unit, St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.

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http://dx.doi.org/10.3389/fimmu.2018.00592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874283PMC
May 2019

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.

Cell Rep 2019 Apr;27(2):442-454.e5

Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.048DOI Listing
April 2019

Discussion of some 'knowns' and some 'unknowns' about the tumour suppressor p53.

J Mol Cell Biol 2019 Mar;11(3):212-223

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

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http://dx.doi.org/10.1093/jmcb/mjy077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478126PMC
March 2019

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines.

Cancer Cell 2018 12;34(6):879-891

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183052
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http://dx.doi.org/10.1016/j.ccell.2018.11.004DOI Listing
December 2018

Humanized mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use.

Blood 2018 10 23;132(15):1573-1583. Epub 2018 Aug 23.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia; and.

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http://dx.doi.org/10.1182/blood-2018-06-859405DOI Listing
October 2018

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities.

Cell Rep 2018 09;24(12):3285-3295.e4

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.08.048DOI Listing
September 2018

DNA repair processes are critical mediators of p53-dependent tumor suppression.

Nat Med 2018 07 11;24(7):947-953. Epub 2018 Jun 11.

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/s41591-018-0043-5DOI Listing
July 2018

How do thymic epithelial cells die?

Cell Death Differ 2018 05 16;25(5):1002-1004. Epub 2018 Mar 16.

Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1038/s41418-018-0093-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943320PMC
May 2018

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.

Cell 2018 05;173(5):1217-1230.e17

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.04.036DOI Listing
May 2018

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility.

Cell Death Dis 2018 05 23;9(6):618. Epub 2018 May 23.

Development and Stem Cells Program, Monash Biomedicine Discovery Institute, and Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.

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http://dx.doi.org/10.1038/s41419-018-0633-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966424PMC
May 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells.

Cell Death Differ 2018 02 29;25(2):241-254. Epub 2017 Sep 29.

Institute of Cancer and Genomic Sciences and Centre for Human Virology, University of Birmingham, College of Medical and Dental Sciences, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1038/cdd.2017.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762840PMC
February 2018

Viewing BCL2 and cell death control from an evolutionary perspective.

Cell Death Differ 2018 01 3;25(1):13-20. Epub 2017 Nov 3.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://www.nature.com/doifinder/10.1038/cdd.2017.145
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http://dx.doi.org/10.1038/cdd.2017.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729521PMC
January 2018

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Cell Death Differ 2018 01 17;25(1):104-113. Epub 2017 Nov 17.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1038/cdd.2017.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729529PMC
January 2018

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice.

Cell Death Differ 2017 12 11;24(12):2032-2043. Epub 2017 Aug 11.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

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http://dx.doi.org/10.1038/cdd.2017.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686343PMC
December 2017

Loss of BIM augments resistance of ATM-deficient thymocytes to DNA damage-induced apoptosis but does not accelerate lymphoma development.

Cell Death Differ 2017 11 8;24(11):1987-1988. Epub 2017 Sep 8.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

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http://dx.doi.org/10.1038/cdd.2017.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635225PMC
November 2017

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.

Nat Commun 2017 10 18;8(1):1028. Epub 2017 Oct 18.

Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, Innrain 80, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1038/s41467-017-01022-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647323PMC
October 2017

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells.

Diabetes 2017 09 30;66(9):2446-2458. Epub 2017 Jun 30.

Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

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http://dx.doi.org/10.2337/db16-1252DOI Listing
September 2017

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.

J Exp Med 2017 Sep 10;214(9):2733-2758. Epub 2017 Aug 10.

Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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http://dx.doi.org/10.1084/jem.20161903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584121PMC
September 2017

Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms.

PLoS Genet 2017 Sep 18;13(9):e1007010. Epub 2017 Sep 18.

Molecular Genetics Unit, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1007010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619840PMC
September 2017

The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF.

Cell Death Dis 2017 08 3;8(8):e2971. Epub 2017 Aug 3.

Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia.

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http://www.nature.com/doifinder/10.1038/cddis.2017.361
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http://dx.doi.org/10.1038/cddis.2017.361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596551PMC
August 2017

Cell death and thymic tolerance.

Immunol Rev 2017 05;277(1):9-20

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1111/imr.12532DOI Listing
May 2017

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.

Cell Death Differ 2017 03 13;24(3):523-533. Epub 2017 Jan 13.

The Walter & Eliza Hall Institute for Medical Research, Parkville, Melbourne, VIC 3052, Australia.

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http://dx.doi.org/10.1038/cdd.2016.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344212PMC
March 2017

TNF-induced chronic inflammation does not affect tumorigenesis driven by p53 loss.

Cell Death Dis 2017 01 12;8(1):e2550. Epub 2017 Jan 12.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1038/cddis.2016.470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386377PMC
January 2017

BCL-2: Long and winding path from discovery to therapeutic target.

Biochem Biophys Res Commun 2017 01 3;482(3):459-469. Epub 2017 Feb 3.

Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.10.100DOI Listing
January 2017

RIPK1 inhibits ZBP1-driven necroptosis during development.

Nature 2016 12 7;540(7631):129-133. Epub 2016 Nov 7.

Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature20559DOI Listing
December 2016

Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1).

Br J Haematol 2016 09 25;174(6):962-9. Epub 2016 May 25.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic., Australia.

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http://dx.doi.org/10.1111/bjh.14155DOI Listing
September 2016

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

Immunity 2016 09 11;45(3):513-526. Epub 2016 Aug 11.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040700PMC
September 2016

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.

J Exp Med 2016 09 12;213(10):2039-48. Epub 2016 Sep 12.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia

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http://dx.doi.org/10.1084/jem.20150477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030795PMC
September 2016

Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection.

Eur J Immunol 2016 06;46(6):1427-37

Department of Biochemistry CIIL, University of Lausanne, Epalinges, Switzerland.

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http://dx.doi.org/10.1002/eji.201545857DOI Listing
June 2016

BCL2-modifying factor promotes germ cell loss during murine oogenesis.

Reproduction 2016 May 25;151(5):553-62. Epub 2016 Feb 25.

Development and Stem Cells ProgramMonash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia

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http://dx.doi.org/10.1530/REP-15-0561DOI Listing
May 2016

Tumor-Suppressor Functions of the TP53 Pathway.

Cold Spring Harb Perspect Med 2016 05 2;6(5). Epub 2016 May 2.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1101/cshperspect.a026062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852799PMC
May 2016

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

Cell Rep 2016 Mar 18;14(8):1858-66. Epub 2016 Feb 18.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.059DOI Listing
March 2016

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.

Cell Rep 2016 Mar 3;14(10):2337-47. Epub 2016 Mar 3.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; The Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.02.039DOI Listing
March 2016

Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies.

Nat Rev Cancer 2016 Feb;16(2):99-109

Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/nrc.2015.17DOI Listing
February 2016

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.

Cell Rep 2016 Feb 28;14(6):1488-1499. Epub 2016 Jan 28.

St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia; Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Fitzroy, VIC 3065, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.012DOI Listing
February 2016

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

Nat Microbiol 2016 Feb 24;1:15034. Epub 2016 Feb 24.

Department of Biochemistry and Molecular Biology and the Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia.

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http://dx.doi.org/10.1038/nmicrobiol.2015.34DOI Listing
February 2016

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells.

Diabetes 2015 Sep 6;64(9):3229-38. Epub 2015 May 6.

St. Vincent's Institute, Fitzroy, Australia Department of Medicine, The University of Melbourne, St. Vincent's Hospital, Fitzroy, Australia

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http://dx.doi.org/10.2337/db14-1851DOI Listing
September 2015

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress.

Blood 2015 May 6;125(21):3273-80. Epub 2015 Apr 6.

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Australia; and.

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http://dx.doi.org/10.1182/blood-2015-01-621250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440882PMC
May 2015

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

Immunity 2015 May 12;42(5):890-902. Epub 2015 May 12.

Immunology Division, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Australia, Darlinghurst, NSW 2010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.04.010DOI Listing
May 2015

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival.

Nat Cell Biol 2015 Apr 2;17(4):365-75. Epub 2015 Mar 2.

1] ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1038/ncb3117DOI Listing
April 2015

Bcl-2 antagonists kill plasmacytoid dendritic cells from lupus-prone mice and dampen interferon-α production.

Arthritis Rheumatol 2015 Mar;67(3):797-808

The Walter & Eliza Hall Institute of Medical Research and University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/art.38966DOI Listing
March 2015

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.

Cell Rep 2015 Mar 26;10(8):1422-32. Epub 2015 Feb 26.

Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia. Electronic address:

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http://www.cell.com/cms/attachment/2035453127/2051016123/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221112471500110
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2015.02.002DOI Listing
March 2015

Maintaining dendritic cell viability in culture.

Mol Immunol 2015 Feb 28;63(2):264-7. Epub 2014 Jul 28.

The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Vic. 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Vic. 3010, Australia; Burnet Institute, Melbourne, Vic. 3004, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2014.07.011DOI Listing
February 2015

MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice.

Blood 2014 Dec 3;124(26):3939-46. Epub 2014 Nov 3.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia; and The Department of Medical Biology, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1182/blood-2014-09-601567DOI Listing
December 2014

The physiological relevance of death receptor-mediated apoptosis.

Authors:
Andreas Strasser

Nat Rev Mol Cell Biol 2014 Oct 10;15(10):633. Epub 2014 Sep 10.

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/nrm3875DOI Listing
October 2014

PUMA regulates germ cell loss and primordial follicle endowment in mice.

Reproduction 2014 Aug 23;148(2):211-9. Epub 2014 May 23.

MIMR-PHI Institute of Medical Research27-31 Wright Street, Clayton, Victoria 3168, AustraliaDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria, AustraliaThe Walter and Eliza Hall Institute of Medical ResearchMelbourne, Victoria, AustraliaDepartment of Medical BiologyThe University of Melbourne, Melbourne, Victoria, AustraliaMIMR-PHI Institute of Medical Research27-31 Wright Street, Clayton, Victoria 3168, AustraliaDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria, AustraliaThe Walter and Eliza Hall Institute of Medical ResearchMelbourne, Victoria, AustraliaDepartment of Medical BiologyThe University of Melbourne, Melbourne, Victoria, Australia

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http://www.reproduction-online.org/content/early/2014/05/23/
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http://www.reproduction-online.org/cgi/doi/10.1530/REP-13-06
Publisher Site
http://dx.doi.org/10.1530/REP-13-0666DOI Listing
August 2014

Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained.

Blood 2014 Aug 1;124(7):1099-109. Epub 2014 Jul 1.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia; and Departments of Medical Biology and.

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http://dx.doi.org/10.1182/blood-2014-04-570770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133484PMC
August 2014

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells.

Nat Commun 2014 Aug 14;5:4539. Epub 2014 Aug 14.

1] The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1038/ncomms5539DOI Listing
August 2014

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.

Cell Rep 2014 Jun 29;7(6):1796-808. Epub 2014 May 29.

III. Medizinische Klink, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.008DOI Listing
June 2014

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.

Nat Med 2014 Mar 2;20(3):283-90. Epub 2014 Feb 2.

1] Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. [2] Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1038/nm.3442DOI Listing
March 2014

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.

Nat Commun 2014 Mar 17;5:3455. Epub 2014 Mar 17.

1] The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia [2] Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.

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http://www.nature.com/articles/ncomms4455
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http://dx.doi.org/10.1038/ncomms4455DOI Listing
March 2014

It's not over until the FAT lady sings.

EMBO J 2014 Feb 17;33(3):173-5. Epub 2014 Jan 17.

The Walter and Eliza Hall Institute, Melbourne, Australia.

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http://dx.doi.org/10.1002/embj.201387542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989611PMC
February 2014

Is SIRT2 required for necroptosis?

Nature 2014 Feb;506(7489):E4-6

1] The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/nature13024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005920PMC
February 2014

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein.

EMBO Rep 2013 Nov 24;14(11):992-8. Epub 2013 Sep 24.

1] The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia [2] Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/embor.2013.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818073PMC
November 2013

The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death.

Immunity 2013 Sep 5;39(3):573-83. Epub 2013 Sep 5.

Department of Immunology, Monash University, Melbourne, VIC 3004, Australia; Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.immuni.2013.05.019DOI Listing
September 2013

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Immunity 2013 Sep 5;39(3):443-53. Epub 2013 Sep 5.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2013.06.018DOI Listing
September 2013

p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

Cell Rep 2013 May 9;3(5):1339-45. Epub 2013 May 9.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.celrep.2013.04.012DOI Listing
May 2013

Role of p63 and the Notch pathway in cochlea development and sensorineural deafness.

Proc Natl Acad Sci U S A 2013 Apr 15;110(18):7300-5. Epub 2013 Apr 15.

Biochemistry Laboratory Istituto Dermopatico Dell'Immacolata, c/o Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00133 Rome, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645580PMC
April 2013