Publications

ERCC1 as predictive biomarker to platinum-based chemotherapy in adrenocortical carcinomas.
Eur J Endocrinol 2018 Feb 29;178(2):183-190. Epub 2017 Nov 29.
Division of Endocrinology and DiabetesDepartment of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg, Germany




Gemcitabine-Based Chemotherapy in Adrenocortical Carcinoma: A Multicenter Study of Efficacy and Predictive Factors.
J Clin Endocrinol Metab 2017 Nov;102(11):4323-4332
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg 97070, Germany.


Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases.
Virchows Arch 2017 Oct 10;471(4):467-489. Epub 2017 Jul 10.
Institute of Pathology and Neuropathology and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.

The clinicopathologic spectrum of mature aggressive B cell lymphomas.
Virchows Arch 2017 Oct 26;471(4):453-466. Epub 2017 Aug 26.
Institute of Pathology and Neuropathology and Comprehensive Cancer Center, University Hospital Tübingen, Liebermeisterstrasse 8, 72076, Tübingen, Germany.

An analysis of the role of follicular lymphoma-associated fibroblasts to promote tumor cell viability following drug-induced apoptosis.
Leuk Lymphoma 2017 Aug 6;58(8):1922-1930. Epub 2016 Dec 6.
a Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology , University of Tübingen , Stuttgart , Germany.


Clinical Impact of the Cell-of-Origin Classification and the MYC/ BCL2 Dual Expresser Status in Diffuse Large B-Cell Lymphoma Treated Within Prospective Clinical Trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group.
J Clin Oncol 2017 Aug 19;35(22):2515-2526. Epub 2017 May 19.
Annette M. Staiger, Heike Horn, and German Ott, Institute of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart; Annette M. Staiger and Heike Horn, Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart; Annette M. Staiger and Heike Horn, University of Tuebingen, Tuebingen; Marita Ziepert and Markus Löffler, Institute for Medical Informatics, Statistics and Epidemiology, Universität Leipzig, Leipzig; Thomas F.E. Barth and Peter Möller, Institute of Pathology, Universitätsklinikum Ulm, Ulm; Heinz-Wolfram Bernd and Alfred C. Feller, Haematopathologie Luebeck, Luebeck; Wolfram Klapper and Monika Szczepanowski, Institute of Pathology, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel; Monika Szczepanowski, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel; Michael Hummel and Dido Lenze, Institute of Pathology, Campus Benjamin Franklin, Charité Universitätsmedizin; Harald Stein, Pathodiagnostik Berlin, Berlin; Martin-Leo Hansmann and Sylvia Hartmann, Dr. Senckenberg Institute of Pathology, Goethe University Hospital, Frankfurt; Georg Lenz, Translational Oncology, Albert-Schweitzer-Campus 1, University Hospital Münster, and Cluster of Excellence EXC 1003, Cells in Motion, Münster; Lorenz Trümper, Georg-August Universität, Göttingen; Norbert Schmitz, Asklepios Klinik St Georg, Hamburg; Michael Pfreundschuh, Saarland University Medical School, Homburg/Saar; Andreas Rosenwald, Institute of Pathology, Universität Würzburg and Comprehensive Cancer Center Mainfranken, Würzburg, Germany; David W. Scott, Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; and Sergio Cogliatti, Institute of Pathology, Kantonal Hospital St Gallen, St Gallen, Switzerland.


First case of human peritoneal cysticercosis mimicking peritoneal carcinosis: necessity of laparoscopy and histologic assessment for the correct diagnosis.
JMM Case Rep 2017 Jun 8;4(6):e005097. Epub 2017 Jun 8.
Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Ismaningerstrasse 25, 80333 München, Germany.

New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies.
J Clin Oncol 2017 May 14;35(15):1668-1677. Epub 2017 Mar 14.
David W. Scott, Pau Abrisqueta, Graham W. Slack, Anja Mottok, Diego Villa, Merrill Boyle, Fong Chun Chan, Christian Steidl, Joseph M. Connors, and Randy D. Gascoyne, BC Cancer Agency; Anja Mottok, Christian Steidl, and Randy D. Gascoyne, University of British Columbia, Vancouver, British Columbia; Jan Delabie, University of Toronto, Toronto, Ontario, Canada; Pau Abrisqueta, Vall d'Hebron University Hospital; Pedro Jares, Cristina Royo, Guillem Clot, Magda Pinyol, and Elias Campo, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; George W. Wright, Elaine S. Jaffe, and Louis M. Staudt, National Institutes of Health, Bethesda, MD; Hilka Rauert-Wunderlich and Andreas Rosenwald, University of Würzburg, Würzburg; German Ott, Robert Bosch Hospital and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Rita M. Braziel, Oregon Health & Sciences University, Portland, OR; Wing C. Chan and Dennis D. Weisenburger, City of Hope, Duarte, CA; James R. Cook, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH; Timothy C. Greiner and Kai Fu, University of Nebraska Medical Center, Omaha, NE; Erlend B. Smeland and Harald Holte, Oslo University Hospital, Oslo, Norway; and Lisa M. Rimsza, Mayo Clinic, Phoenix, AZ.

Livin/BIRC7 expression as malignancy marker in adrenocortical tumors.
Oncotarget 2017 Feb;8(6):9323-9338
Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital of Wuerzburg, Germany.

Contrary melanoma-associated antigen-A expression at the tumor front and center: A comparative analysis of stage I and IV head and neck squamous cell carcinoma.
Oncol Lett 2016 Oct 3;12(4):2942-2947. Epub 2016 Aug 3.
Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, D-97070 Würzburg, Germany.


Prognostic Value of Ki-67 Index, Cytology, and Growth Pattern in Mantle-Cell Lymphoma: Results From Randomized Trials of the European Mantle Cell Lymphoma Network.
J Clin Oncol 2016 Apr 29;34(12):1386-94. Epub 2016 Feb 29.
Eva Hoster, Roswitha Forstpointner, Christian Schmidt, Wolfgang Hiddemann, Michael Unterhalt, and Martin H. Dreyling, University Hospital Munich; Eva Hoster, University of Munich, Munich; Andreas Rosenwald, University of Würzburg, Würzburg; Heinz-Wolfram Bernd, University Hospital Schleswig-Holstein, Lübeck; Sylvia Hartmann, University Hospital of Frankfurt, Frankfurt am Main; Christoph Loddenkemper, University Hospital Berlin Charité; Christoph Loddenkemper, Pathologie PathoTres, Berlin; Thomas F.E. Barth, University Medical Center Ulm; Stephan Stilgenbauer, University of Ulm, Ulm; Michael Hallek, Universität zu Köln, Köln; Ursula Vehling-Kaiser, Tagesklinik Hämatologie Onkologie, Landshut; Lothar Kanz, University of Tübingen, Tübingen; Michael Pfreundschuh, Universitätsklinik des Saarlandes, Homburg; Wolfram Klapper, University of Kiel, Kiel, Germany; Françoise Berger, LYSA Group; Nicole Brousse, Hopital Necker; Catherine Thieblemont, Hôpital Saint Louis; Olivier Hermine, University Paris Descartes; Olivier Hermine, Université Sorbonne Paris Cité, Paris; Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Bénite; Réda Bouabdallah, Service d'Hématologie, Marseille; Vincent Ribrag, Institut Gustave Roussy, Villejuif, France; Stefano Pileri, University of Bologna, Bologna, Italy; Grzegorz Rymkiewicz, The Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland; Roman Kodet, Charles University, Prague, Czech Republic; and Johanna C. Kluin-Nelemans, University of Groningen, Groningen, The Netherlands.

Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma.
Cancer Cell 2016 Apr;29(4):494-507
Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA. Electronic address:


A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.
Cancer Cell 2015 Dec;28(6):743-757
Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany; Comprehensive Cancer Center Mainfranken, University of Würzburg, Josef-Schneider-Straße 6, 97080 Würzburg, Germany. Electronic address:

Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells.
Endocrinology 2015 Nov 25;156(11):3895-908. Epub 2015 Aug 25.
Department of Internal Medicine I, Endocrinology and Diabetes Unit (S.S., I.S., E.C., F.G., A.G., I.W., M.B., C.L.R., T.D., B.A., M.F.), University Hospital Würzburg, 97080 Würzburg, Germany; Comprehensive Cancer Center Mainfranken (S.S., A.R., M.F., M.K.), 97080 Würzburg, Germany; Institute of Pathology (E.L., A.R.), University of Würzburg, 97080 Würzburg, Germany; Institute of Clinical Chemistry and Laboratory Medicine (S.M., G.L., G.S.), University Hospital Regensburg, 93053 Regensburg, Germany; Department of Nuclear Medicine (A.S.), University Hospital Würzburg, 97080 Würzburg, Germany; and Clinical Chemistry and Laboratory Medicine (S.K., M.F.), University Hospital Würzburg, 97080 Würzburg, Germany.

Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens.
Proc Natl Acad Sci U S A 2015 Nov 19;112(44):13447-54. Epub 2015 Oct 19.
Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

Allele-specific PCR is a powerful tool for the detection of the MYD88 L265P mutation in diffuse large B cell lymphoma and decalcified bone marrow samples.
Br J Haematol 2015 Oct 30;171(1):145-8. Epub 2015 Mar 30.
Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.

Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling.
Am J Surg Pathol 2015 Oct;39(10):1322-30
*Department of Pathology and Microbiology ¶Department of Biostatistics, College of Public Health ##Department of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE †Metabolism Branch **Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD ∥Department of Pathology, City of Hope National Medical Center, Duarte, CA #Department of Pathology, University of Arizona, Tucson, AZ §§Department of Clinical Pathology, Oregon Health and Science University, Portland, OR ∥∥Department of Molecular Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH ‡Institute of Pathology, Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg ¶¶Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany §British Columbia Cancer Agency, Centre for Lymphoid Cancer, University of British Columbia, Vancouver, BC, Canada ††Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain ‡‡Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway.


Intraparotid classical and nodular lymphocyte-predominant Hodgkin lymphoma: pattern analysis with emphasis on associated lymphadenoma-like proliferations.
Am J Surg Pathol 2015 Sep;39(9):1206-12
*Institute of Pathology, University Hospital, Erlangen †Comprehensive Cancer Center Mainfranken, Institute of Pathology, University of Würzburg, Würzburg ‡Institute of Pathology, Klinikum Augsburg, Augsburg §Laboratory for Dermatohistology & Oral Pathology ∥Institute of Pathology, Ludwig Maximilian University, München, Germany.






Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.
Cancer Cell 2015 Apr;27(4):516-32
Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA; Department of Pathology and NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA. Electronic address:



Diffuse large B-cell lymphomas of immunoblastic type are a major reservoir for MYC-IGH translocations.
Am J Surg Pathol 2015 Jan;39(1):61-6
*Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology †Department of Internal Medicine II, Hematology and Oncology, Robert-Bosch-Krankenhaus ‡Department of Ear, Nose and Throat Surgery, Marienhospital, Stuttgart ∥Institute of Pathology, University of Würzburg, Comprehensive Cancer Center Mainfranken (CCCM), Würzburg ¶Institute of Pathology, Caritas-Hospital, Bad Mergentheim, Germany §Hematopathology Unit, Pathology Department, Hospital Clínic and University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma.
Blood 2015 Jan 30;125(1):124-32. Epub 2014 Oct 30.
Department of Medicine A, Translational Oncology, Albert-Schweitzer Campus 1, University Hospital Münster, Münster, Germany; Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Cells in Motion Cluster of Excellence, Münster, Germany;

Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity.
Proc Natl Acad Sci U S A 2015 Jan 12;112(4):1125-30. Epub 2015 Jan 12.
Department of Molecular Pathology, Institute of Pathology, and Center for Interdisciplinary Clinical Research, University Hospital Würzburg, 97078 Würzburg, Germany Comprehensive Cancer Center Mainfranken, Julius Maximilian University of Würzburg, 97080 Würzburg, Germany; and

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma.
Nature 2014 Dec 28;516(7530):254-8. Epub 2014 Sep 28.
1] Department of Microbiology and Immunology, University of California, San Francisco, California, 94143, USA [2] Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA.


Elevated serum free light chains do not predict outcome of elderly patients with aggressive CD20(+) B-cell lymphomas.
Br J Haematol 2014 Nov 27;167(3):430-4. Epub 2014 Jun 27.
Department of Internal Medicine I, Oncology, Haematology, Clinical Immunology and Rheumatology, Saarland University Medical School, Homburg, Germany.






PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform.
Br J Haematol 2014 Aug 26;166(4):529-39. Epub 2014 Apr 26.
Division of Haematology and Oncology, Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.



Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.
Cancer Discov 2014 Apr 3;4(4):480-93. Epub 2014 Feb 3.
1Lymphoid Malignancies Branch, 2Laboratory of Pathology, 3Experimental Immunology Branch, Center for Cancer Research; 4Biometric Research Branch, DCTD, National Cancer Institute; 5Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland; 6Department of Pathology, University of Arizona, Tucson, Arizona; 7Oregon Health and Science University, Portland, Oregon; 8Cleveland Clinic Pathology and Laboratory Medicine Institute, Cleveland, Ohio; 9Department of Pathology, City of Hope National Medical Center, Duarte, California; 10Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska; 11Department of Pathology, University of Würzburg, Würzburg; 12Department of Clinical Pathology, Robert-Bosch-Krankenhaus; 13Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart, Germany; 14British Columbia Cancer Agency, Vancouver, British Columbia, Canada; 15Hospital Clinic, University of Barcelona, Barcelona, Spain; 16Pathology Clinic, 17Institute for Cancer Research, Rikshospitalet University Hospital; 18Center for Cancer Biomedicine, Faculty Division of the Norwegian Radium Hospital, University of Oslo, Oslo, Norway; and 19Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.


Detection of rearrangements and transcriptional up-regulation of ALK in FFPE lung cancer specimens using a novel, sensitive, quantitative reverse transcription polymerase chain reaction assay.
J Thorac Oncol 2014 Mar;9(3):307-15
*Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Germany; †Institute of Pathology, University of Würzburg, Würzburg, Germany; ‡Center for Pulmonology and Thoracic Surgery, Klinik Schillerhöhe, Stuttgart-Gerlingen, Germany; and § Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and Department of Clinical Pharmacology, University Hospital, Tübingen, Germany.





From CLL to Multiple Myeloma - Spleen Tyrosine Kinase (SYK) influences multiple myeloma cell survival and migration.
Br J Haematol 2016 09 22;174(6):985-9. Epub 2015 Oct 22.
Department of Haematology, Oncology and Stem Cell Transplantation, University Medical Centre Freiburg, Freiburg, Germany.








Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis.
Int Arch Allergy Immunol 2016 1;171(2):141-154. Epub 2016 Dec 1.
Division of Pediatric Rheumatology, and Special Immunology, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.




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