Publications by authors named "Andreas M Grabrucker"

53Publications

Rho GTPases in the Amygdala-A Switch for Fears?

Cells 2020 Aug 26;9(9). Epub 2020 Aug 26.

Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, V94PH61 Limerick, Ireland.

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http://dx.doi.org/10.3390/cells9091972DOI Listing
August 2020

Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders.

Front Oncol 2020 6;10:1293. Epub 2020 Aug 6.

Department of Biological Sciences, University of Limerick, Limerick, Ireland.

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http://dx.doi.org/10.3389/fonc.2020.01293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424038PMC
August 2020

Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties.

Mater Sci Eng C Mater Biol Appl 2020 Aug 23;113:110985. Epub 2020 Apr 23.

BioScience and Bioengineering Research (BioSciBer), Bernal Biomaterials, Bernal Institute, University of Limerick, Limerick, Ireland; School of Engineering, University of Limerick, Limerick, Ireland; Health Research Institute, (HRI), University of Limerick, Limerick, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.msec.2020.110985DOI Listing
August 2020

Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers.

Nanomedicine (Lond) 2020 01 9;15(2):205-214. Epub 2020 Jan 9.

Bernal Institute, University of Limerick, Limerick, V94T9PX, Ireland.

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http://dx.doi.org/10.2217/nnm-2019-0367DOI Listing
January 2020

Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice.

Front Neurosci 2019 29;13:1295. Epub 2019 Nov 29.

Department of Biological Sciences, University of Limerick, Limerick, Ireland.

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http://dx.doi.org/10.3389/fnins.2019.01295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895961PMC
November 2019

ROS-responsive "smart" polymeric conjugate: Synthesis, characterization and proof-of-concept study.

Int J Pharm 2019 Oct 31;570:118655. Epub 2019 Aug 31.

Nanotech Lab TeFarTI Group, University of Modena and Reggio Emilia, Department of Life Sciences, Modena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2019.118655DOI Listing
October 2019

Distribution and Relative Abundance of S100 Proteins in the Brain of the APP23 Alzheimer's Disease Model Mice.

Front Neurosci 2019 20;13:640. Epub 2019 Jun 20.

Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland.

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http://dx.doi.org/10.3389/fnins.2019.00640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596341PMC
June 2019

Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model.

Int J Mol Sci 2019 Apr 30;20(9). Epub 2019 Apr 30.

Cellular Neurobiology and Neuro-Nanotechnology lab, Dept. of Biological Sciences, University of Limerick, V94PH61 Limerick, Ireland.

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http://dx.doi.org/10.3390/ijms20092134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540607PMC
April 2019

Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives.

J Control Release 2019 02 18;296:202-224. Epub 2019 Jan 18.

Bernal Institute, University of Limerick, Limerick, Ireland; School of Engineering, University of Limerick, Limerick, Ireland; Health Research Institute, (HRI), University of Limerick, Limerick, Ireland; Solid State Pharmaceutical Centre, University of Limerick, Limerick, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.01.022DOI Listing
February 2019

Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome.

Front Synaptic Neurosci 2018 23;10:11. Epub 2018 May 23.

Department of Biological Sciences, University of Limerick, Limerick, Ireland.

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http://dx.doi.org/10.3389/fnsyn.2018.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974951PMC
May 2018

Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain.

Front Mol Neurosci 2017 17;10:456. Epub 2018 Jan 17.

Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland.

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http://dx.doi.org/10.3389/fnmol.2017.00456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776125PMC
January 2018

Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer's disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery.

J Trace Elem Med Biol 2018 Sep 27;49:210-221. Epub 2017 Dec 27.

Department of Biological Sciences, University of Limerick, V95PH61 Limerick, Ireland; Bernal Institute, University of Limerick, Limerick, Ireland; Health Research Institute (HRI), University of Limerick, Limerick, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jtemb.2017.12.006DOI Listing
September 2018

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

Authors:
Sébastien Küry Geeske M van Woerden Thomas Besnard Martina Proietti Onori Xénia Latypova Meghan C Towne Megan T Cho Trine E Prescott Melissa A Ploeg Stephan Sanders Holly A F Stessman Aurora Pujol Ben Distel Laurie A Robak Jonathan A Bernstein Anne-Sophie Denommé-Pichon Gaëtan Lesca Elizabeth A Sellars Jonathan Berg Wilfrid Carré Øyvind Løvold Busk Bregje W M van Bon Jeff L Waugh Matthew Deardorff George E Hoganson Katherine B Bosanko Diana S Johnson Tabib Dabir Øystein Lunde Holla Ajoy Sarkar Kristian Tveten Julitta de Bellescize Geir J Braathen Paulien A Terhal Dorothy K Grange Arie van Haeringen Christina Lam Ghayda Mirzaa Jennifer Burton Elizabeth J Bhoj Jessica Douglas Avni B Santani Addie I Nesbitt Katherine L Helbig Marisa V Andrews Amber Begtrup Sha Tang Koen L I van Gassen Jane Juusola Kimberly Foss Gregory M Enns Ute Moog Katrin Hinderhofer Nagarajan Paramasivam Sharyn Lincoln Brandon H Kusako Pierre Lindenbaum Eric Charpentier Catherine B Nowak Elouan Cherot Thomas Simonet Claudia A L Ruivenkamp Sihoun Hahn Catherine A Brownstein Fan Xia Sébastien Schmitt Wallid Deb Dominique Bonneau Mathilde Nizon Delphine Quinquis Jamel Chelly Gabrielle Rudolf Damien Sanlaville Philippe Parent Brigitte Gilbert-Dussardier Annick Toutain Vernon R Sutton Jenny Thies Lisenka E L M Peart-Vissers Pierre Boisseau Marie Vincent Andreas M Grabrucker Christèle Dubourg Wen-Hann Tan Nienke E Verbeek Martin Granzow Gijs W E Santen Jay Shendure Bertrand Isidor Laurent Pasquier Richard Redon Yaping Yang Matthew W State Tjitske Kleefstra Benjamin Cogné Slavé Petrovski Kyle Retterer Evan E Eichler Jill A Rosenfeld Pankaj B Agrawal Stéphane Bézieau Sylvie Odent Ype Elgersma Sandra Mercier

Am J Hum Genet 2017 Nov;101(5):768-788

CHU Nantes, Service de Génétique Médicale, 9 quai Moncousu, 44093 Nantes Cedex 1, France.

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http://dx.doi.org/10.1016/j.ajhg.2017.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673671PMC
November 2017

Object Phobia and Altered RhoA Signaling in Amygdala of Mice Lacking RICH2.

Front Mol Neurosci 2017 8;10:180. Epub 2017 Jun 8.

Cellular Neurobiology and Neuro-Nanotechnology Laboratory, Department of Biological Sciences, University of LimerickLimerick, Ireland.

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http://dx.doi.org/10.3389/fnmol.2017.00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462907PMC
June 2017

Extracerebral Dysfunction in Animal Models of Autism Spectrum Disorder.

Adv Anat Embryol Cell Biol 2017 ;224:159-187

WG Molecular Analysis of Synaptopathies, Department of Neurology, Neurocenter of Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1007/978-3-319-52498-6_9DOI Listing
June 2018

Molecular and Cellular Mechanisms of Synaptopathies.

Neural Plast 2017 30;2017:2643943. Epub 2017 Apr 30.

IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20156 Milan, Italy.

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http://dx.doi.org/10.1155/2017/2643943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429942PMC
April 2018

Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates.

Int J Pharm 2017 Jun 8;526(1-2):413-424. Epub 2017 May 8.

WG Molecular Analysis of Synaptopathies, Neurology Dept., Neurocenter of Ulm University, Ulm, Germany; Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany; Department of Biological Sciences, University of Limerick, V95PH61 Limerick, Ireland.

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http://dx.doi.org/10.1016/j.ijpharm.2017.05.015DOI Listing
June 2017

Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies.

Neural Plast 2016 4;2016:8051861. Epub 2016 Oct 4.

WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University, 89081 Ulm, Germany; Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1155/2016/8051861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067329PMC
September 2017

Activity and circadian rhythm influence synaptic Shank3 protein levels in mice.

J Neurochem 2016 09 15;138(6):887-95. Epub 2016 Jul 15.

WG Molecular Analysis of Synaptopathies, Department of Neurology, Neurocenter of Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1111/jnc.13709DOI Listing
September 2016

The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons.

Front Synaptic Neurosci 2016 24;8:13. Epub 2016 May 24.

Institute for Anatomy and Cell Biology, Ulm UniversityUlm, Germany; Department of Neurology, Ulm UniversityUlm, Germany.

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http://dx.doi.org/10.3389/fnsyn.2016.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877498PMC
June 2016

Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells.

Neural Plast 2016 9;2016:3760702. Epub 2016 May 9.

Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany; WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1155/2016/3760702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876239PMC
December 2016

Nanoparticle transport across the blood brain barrier.

Tissue Barriers 2016 Jan-Mar;4(1):e1153568. Epub 2016 Feb 25.

Pharmaceutical Technology, Te.Far.T.I. Group, Department of Life Sciences, University of Modena and Reggio Emilia ; Modena, Italy.

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http://dx.doi.org/10.1080/21688370.2016.1153568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836460PMC
February 2018

Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency.

Front Behav Neurosci 2016 3;10:37. Epub 2016 Mar 3.

Institute for Anatomy and Cell Biology, Ulm UniversityUlm, Germany; WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm UniversityUlm, Germany.

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http://dx.doi.org/10.3389/fnbeh.2016.00037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776245PMC
March 2016

Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.

Mol Brain 2016 Mar 11;9:28. Epub 2016 Mar 11.

WG Molecular Analysis of Synaptopathies, Neurology Department, Ulm University, Albert-Einstein-Allee 11, D-89081, Ulm, Germany.

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http://dx.doi.org/10.1186/s13041-016-0206-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788860PMC
March 2016

Emerging Use of Nanotechnology in the Treatment of Neurological Disorders.

Curr Pharm Des 2015 ;21(22):3111-30

WG Molecular Analysis of Synaptopathies, Neurology Department, Ulm University, Albert-Einstein- Allee 11, D-89081 Ulm, Germany.

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http://dx.doi.org/10.2174/1381612821666150531164124DOI Listing
May 2016

Zinc in gut-brain interaction in autism and neurological disorders.

Neural Plast 2015 23;2015:972791. Epub 2015 Mar 23.

WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University, 89081 Ulm, Germany ; Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1155/2015/972791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386645PMC
November 2015

Effects of trace metal profiles characteristic for autism on synapses in cultured neurons.

Neural Plast 2015 23;2015:985083. Epub 2015 Feb 23.

WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University, 89081 Ulm, Germany ; Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1155/2015/985083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352758PMC
November 2015

Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses.

Biometals 2014 Aug 10;27(4):715-30. Epub 2014 Jul 10.

WG molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.

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http://link.springer.com/10.1007/s10534-014-9764-1
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http://dx.doi.org/10.1007/s10534-014-9764-1DOI Listing
August 2014

Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release.

Int J Pharm 2014 Aug 2;471(1-2):349-57. Epub 2014 Jun 2.

Pharmaceutical Technology, Te.Far.T.I. group, Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, Modena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2014.05.054DOI Listing
August 2014

Characterization of biometal profiles in neurological disorders.

Metallomics 2014 May;6(5):960-77

Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.

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http://xlink.rsc.org/?DOI=C4MT00008K
Publisher Site
http://dx.doi.org/10.1039/c4mt00008kDOI Listing
May 2014

Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport.

J Control Release 2014 Mar 11;177:96-107. Epub 2014 Jan 11.

WG Molecular Analysis of Synaptopathies, Neurology Dept., Neurocenter of Ulm University, Ulm, Germany; Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.01.004DOI Listing
March 2014

The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation.

Exp Neurol 2014 Mar 29;253:126-37. Epub 2013 Dec 29.

WG Molecular Analysis of Synaptopathies, Neurology Dept., Neurocenter of Ulm University, Albert-Einstein Allee 11, 89081 Ulm, Germany; Institute for Anatomy and Cell Biology, Ulm University, Albert-Einstein Allee 11, 89081 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2013.12.015DOI Listing
March 2014

Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution.

J Control Release 2014 Jan 5;174:195-201. Epub 2013 Dec 5.

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2013.11.023DOI Listing
January 2014

A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders.

Dev Neurobiol 2014 Feb 11;74(2):136-46. Epub 2013 Sep 11.

Neurology Department, WG Molecular Analysis of Synaptopathies, Neurocenter of Ulm University, Ulm, Germany; Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1002/dneu.22089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272576PMC
February 2014

Environmental factors in autism.

Front Psychiatry 2012 18;3:118. Epub 2013 Jan 18.

WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University Ulm, Germany.

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http://dx.doi.org/10.3389/fpsyt.2012.00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548163PMC
January 2013

Brain-Delivery of Zinc-Ions as Potential Treatment for Neurological Diseases: Mini Review.

Drug Deliv Lett 2011 Sep;1(1):13-23

Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220161PMC
http://dx.doi.org/10.2174/2210303111101010013DOI Listing
September 2011

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies.

Trends Cell Biol 2011 Oct 15;21(10):594-603. Epub 2011 Aug 15.

Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1016/j.tcb.2011.07.003DOI Listing
October 2011

Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences.

PLoS One 2011 Mar 23;6(3):e17851. Epub 2011 Mar 23.

Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017851PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063171PMC
March 2011

Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses.

J Biol Chem 2009 Oct 24;284(42):29146-57. Epub 2009 Aug 24.

Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1074/jbc.M109.020628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781459PMC
October 2009

Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system.

J Neurosci Methods 2009 Jul 22;181(2):227-34. Epub 2009 May 22.

Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.jneumeth.2009.05.008DOI Listing
July 2009