Publications by authors named "Andreas Laner"

20Publications

Critical assessment of secondary findings in genes linked to primary arrhythmia syndromes.

Authors:
Isabel Diebold Ulrike Schön Florentine Scharf Anna Benet-Pagès Andreas Laner Elke Holinski-Feder Angela Abicht

Hum Mutat 2020 05 18;41(5):1025-1032. Epub 2020 Feb 18.

Department of Genomics, Medical Genetics Center Munich, Munich, Germany.

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May 2020

Prevalence of CNV-neutral structural genomic rearrangements in MLH1, MSH2, and PMS2 not detectable in routine NGS diagnostics.

Authors:
Monika Morak Verena Steinke-Lange Trisari Massdorf Anna Benet-Pages Melanie Locher Andreas Laner Katrin Kayser Stefan Aretz Elke Holinski-Feder

Fam Cancer 2020 04;19(2):161-167

Medizinische Klinik Und Poliklinik IV, Campus Innenstadt, Klinikum Der Universität München, Ziemssenstr. 1, 80336, Munich, Germany.

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April 2020

Targeted deep-intronic sequencing in a cohort of unexplained cases of suspected Lynch syndrome.

Authors:
Anke Marie Arnold Monika Morak Anna Benet-Pagès Andreas Laner Dimitrij Frishman Elke Holinski-Feder

Eur J Hum Genet 2020 05 10;28(5):597-608. Epub 2019 Dec 10.

Medizinisch Genetisches Zentrum-MGZ, Munich, Germany.

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May 2020

Full-length transcript amplification and sequencing as universal method to test mRNA integrity and biallelic expression in mismatch repair genes.

Authors:
Monika Morak Kerstin Schaefer Verena Steinke-Lange Udo Koehler Susanne Keinath Trisari Massdorf Brigitte Mauracher Nils Rahner Jessica Bailey Christiane Kling Tanja Haeusser Andreas Laner Elke Holinski-Feder

Eur J Hum Genet 2019 12 22;27(12):1808-1820. Epub 2019 Jul 22.

Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Ziemssenstr. 1, 80336, Munich, Germany.

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December 2019

Extending the critical regions for mutations in the non-coding gene in another patient with Roifman Syndrome.

Authors:
Ariane Hallermayr Janine Graf Udo Koehler Andreas Laner Brigitte Schönfeld Anna Benet-Pagès Elke Holinski-Feder

Clin Case Rep 2018 Nov 11;6(11):2224-2228. Epub 2018 Oct 11.

MGZ - Medical Genetics Center Munich Germany.

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November 2018

LAMA2 gene mutation update: Toward a more comprehensive picture of the laminin-α2 variome and its related phenotypes.

Authors:
Jorge Oliveira Angela Gruber Márcio Cardoso Ricardo Taipa Isabel Fineza Ana Gonçalves Andreas Laner Thomas L Winder Jocelyn Schroeder Julie Rath Márcia E Oliveira Emília Vieira Ana Paula Sousa José Pedro Vieira Teresa Lourenço Luciano Almendra Luís Negrão Manuela Santos Manuel Melo-Pires Teresa Coelho Johan T den Dunnen Rosário Santos Mário Sousa

Hum Mutat 2018 10 10;39(10):1314-1337. Epub 2018 Aug 10.

Unidade Multidisciplinar de Investigação Biomédica (UMIB), Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.

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October 2018

Comprehensive analysis of the promoter region in 480 patients with colorectal cancer and 1150 controls reveals new variants including one with a heritable constitutional epimutation.

Authors:
Monika Morak Ayseguel Ibisler Gisela Keller Ellen Jessen Andreas Laner Daniela Gonzales-Fassrainer Melanie Locher Trisari Massdorf Anke M Nissen Anna Benet-Pagès Elke Holinski-Feder

J Med Genet 2018 04 22;55(4):240-248. Epub 2018 Feb 22.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Bavaria, Germany.

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April 2018

Loss of MSH2 and MSH6 due to heterozygous germline defects in MSH3 and MSH6.

Authors:
Monika Morak Sarah Käsbauer Martina Kerscher Andreas Laner Anke M Nissen Anna Benet-Pagès Hans K Schackert Gisela Keller Trisari Massdorf Elke Holinski-Feder

Fam Cancer 2017 Oct;16(4):491-500

Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Ziemssenstr. 1, 80336, Munich, Germany.

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October 2017

Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis.

Authors:
Ronja Adam Isabel Spier Bixiao Zhao Michael Kloth Jonathan Marquez Inga Hinrichsen Jutta Kirfel Aylar Tafazzoli Sukanya Horpaopan Siegfried Uhlhaas Dietlinde Stienen Nicolaus Friedrichs Janine Altmüller Andreas Laner Stefanie Holzapfel Sophia Peters Katrin Kayser Holger Thiele Elke Holinski-Feder Giancarlo Marra Glen Kristiansen Markus M Nöthen Reinhard Büttner Gabriela Möslein Regina C Betz Angela Brieger Richard P Lifton Stefan Aretz

Am J Hum Genet 2016 Aug 28;99(2):337-51. Epub 2016 Jul 28.

Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Center for Hereditary Tumor Syndromes, University of Bonn, 53127 Bonn, Germany. Electronic address:

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August 2016

Exome sequencing identifies potential novel candidate genes in patients with unexplained colorectal adenomatous polyposis.

Authors:
Isabel Spier Martin Kerick Dmitriy Drichel Sukanya Horpaopan Janine Altmüller Andreas Laner Stefanie Holzapfel Sophia Peters Ronja Adam Bixiao Zhao Tim Becker Richard P Lifton Elke Holinski-Feder Sven Perner Holger Thiele Markus M Nöthen Per Hoffmann Bernd Timmermann Michal R Schweiger Stefan Aretz

Fam Cancer 2016 Apr;15(2):281-8

Institute of Human Genetics, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.

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April 2016

Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases.

Authors:
Isabel Spier Dmitriy Drichel Martin Kerick Jutta Kirfel Sukanya Horpaopan Andreas Laner Stefanie Holzapfel Sophia Peters Ronja Adam Bixiao Zhao Tim Becker Richard P Lifton Sven Perner Per Hoffmann Glen Kristiansen Bernd Timmermann Markus M Nöthen Elke Holinski-Feder Michal R Schweiger Stefan Aretz

J Med Genet 2016 Mar 27;53(3):172-9. Epub 2015 Nov 27.

Institute of Human Genetics, University of Bonn, Bonn, Germany Center for Hereditary Tumor Syndromes, University of Bonn, Bonn, Germany.

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March 2016

Phosphatidylinositol 3-kinase (PI3K) signalling regulates insulin-like-growth factor binding protein-2 (IGFBP-2) production in human adipocytes.

Authors:
Franziska Wilhelm Franziska Kässner Gordian Schmid Jürgen Kratzsch Andreas Laner Martin Wabitsch Antje Körner Wieland Kiess Antje Garten

Growth Horm IGF Res 2015 Jun 11;25(3):115-20. Epub 2015 Apr 11.

University Hospital for Children and Adolescents, Center for Pediatric Research Leipzig (CPL), Germany. Electronic address:

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June 2015

Genome-wide CNV analysis in 221 unrelated patients and targeted high-throughput sequencing reveal novel causative candidate genes for colorectal adenomatous polyposis.

Authors:
Sukanya Horpaopan Isabel Spier Alexander M Zink Janine Altmüller Stefanie Holzapfel Andreas Laner Stefanie Vogt Siegfried Uhlhaas Stefanie Heilmann Dietlinde Stienen Sandra M Pasternack Kathleen Keppler Ronja Adam Katrin Kayser Susanne Moebus Markus Draaken Franziska Degenhardt Hartmut Engels Andrea Hofmann Markus M Nöthen Verena Steinke Alberto Perez-Bouza Stefan Herms Elke Holinski-Feder Holger Fröhlich Holger Thiele Per Hoffmann Stefan Aretz

Int J Cancer 2015 Mar 30;136(6):E578-89. Epub 2014 Sep 30.

Institute of Human Genetics, University of Bonn, Bonn, Germany.

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March 2015

Biallelic MUTYH mutations can mimic Lynch syndrome.

Authors:
Monika Morak Barbara Heidenreich Gisela Keller Heather Hampel Andreas Laner Albert de la Chapelle Elke Holinski-Feder

Eur J Hum Genet 2014 Nov 12;22(11):1334-7. Epub 2014 Feb 12.

1] Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany [2] MGZ - Medizinisch Genetisches Zentrum, Munich, Germany.

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November 2014

Sirolimus treatment of severe PTEN hamartoma tumor syndrome: case report and in vitro studies.

Authors:
Gordian L Schmid Franziska Kässner Holm H Uhlig Antje Körner Jürgen Kratzsch Norman Händel Fred-P Zepp Frank Kowalzik Andreas Laner Sven Starke Franziska K Wilhelm Susanne Schuster Adrian Viehweger Wolfgang Hirsch Wieland Kiess Antje Garten

Pediatr Res 2014 Apr 23;75(4):527-34. Epub 2013 Dec 23.

Hospital for Children & Adolescents, Department of Women and Child Health, Center for Pediatric Research Leipzig, University of Leipzig, Leipzig, Germany.

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April 2014

Escherichia coli-cloned CFTR loci relevant for human artificial chromosome therapy.

Authors:
Lucia Rocchi Carla Braz Sonja Cattani Anabela Ramalho Sulith Christan Marlene Edlinger Fiorentina Ascenzioni Andreas Laner Simone Kraner Margarida Amaral Dirk Schindelhauer

Hum Gene Ther 2010 Sep;21(9):1077-92

Life Sciences Center Weihenstephan, Technical University Munich, Freising, Germany.

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September 2010

Report on de-novo mutation in the MSH2 gene as a rare event in hereditary nonpolyposis colorectal cancer.

Authors:
Monika Morak Andreas Laner Michael Scholz Trisari Madorf Elke Holinski-Feder

Eur J Gastroenterol Hepatol 2008 Nov;20(11):1101-5

Department of Internal Medicine, Campus Innenstadt, University Hospital, Ludwig-Maximilians-University, Munich, Germany.

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November 2008

Targeting of the glucocorticoid hormone receptor with plasmid DNA comprising glucocorticoid response elements improves nonviral gene transfer efficiency in the lungs of mice.

Authors:
Petra Dames Andreas Laner Christof Maucksch Manish Kumar Aneja Carsten Rudolph

J Gene Med 2007 Sep;9(9):820-9

Department of Pediatrics, Ludwig-Maximilians University, Lindwurmstrasse 2a, 80337, Munich, Germany.

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September 2007

Interaction of polyamine gene vectors with RNA leads to the dissociation of plasmid DNA-carrier complexes.

Authors:
Stephanie Huth Florian Hoffmann Katharina von Gersdorff Andreas Laner Dietrich Reinhardt Joseph Rosenecker Carsten Rudolph

J Gene Med 2006 Dec;8(12):1416-24

Department of Pediatrics, Ludwig-Maximilians-University, 80337 Munich, Germany.

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December 2006

Gene delivery systems--gene therapy vectors for cystic fibrosis.

Authors:
Daniel Klink Dirk Schindelhauer Andreas Laner Torry Tucker Zsuzsanna Bebok Erik M Schwiebert A Christopher Boyd Bob J Scholte

J Cyst Fibros 2004 Aug;3 Suppl 2:203-12

Department of Cell Biology, Erasmus MC, Erasmus University, P.O. Box 1738, Rotterdam DR 3000, The Netherlands.

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August 2004